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UniProtKB - Q9ULX9 (MAFF_HUMAN)

Entry version 179 (25 May 2022)
Sequence version 2 (20 Jun 2002)
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Protein

Transcription factor MafF

Gene

MAFF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385).

However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056).

May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULX9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983231, Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9ULX9

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9ULX9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor MafF
Alternative name(s):
U-Maf
V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAFF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6780, MAFF

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604877, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULX9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185022

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23764

Open Targets

More...OpenTargetsi		ENSG00000185022

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30538

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULX9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MAFF

Domain mapping of disease mutations (DMDM)

More...DMDMi		21542145

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000764971 – 164Transcription factor MafFAdd BLAST164

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULX9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULX9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULX9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9ULX9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULX9

PeptideAtlas

More...PeptideAtlasi		Q9ULX9

PRoteomics IDEntifications database

More...PRIDEi		Q9ULX9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85150 [Q9ULX9-1]
85151 [Q9ULX9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the term myometrium and kidney.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By oxidative stress.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185022, Expressed in amniotic fluid and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULX9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULX9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185022, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homo- or heterodimer.

Interacts with MIP (PubMed:16549056). Forms high affinity heterodimers with members of the CNC-bZIP family such as NFE2L1/NRF1 (PubMed:8932385).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117264, 43 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6480, bZIP transcription factor complex, ATF3-MAFF
CPX-7085, bZIP transcription factor complex, BATF2-MAFF
CPX-7103, bZIP transcription factor complex, BATF3-MAFF

Protein interaction database and analysis system

More...IntActi		Q9ULX9, 30 interactors

Molecular INTeraction database

More...MINTi		Q9ULX9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345393

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULX9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9ULX9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULX9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15
Regioni141 – 164DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4196, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161112

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_112948_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULX9

Identification of Orthologs from Complete Genome Data

More...OMAi		MGENTPH

Database of Orthologous Groups

More...OrthoDBi		1395389at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULX9

TreeFam database of animal gene trees

More...TreeFami		TF325689

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004827, bZIP
IPR004826, bZIP_Maf
IPR046347, bZIP_sf
IPR033531, MafF
IPR008917, TF_DNA-bd_sf
IPR024874, Transcription_factor_Maf_fam

The PANTHER Classification System

More...PANTHERi		PTHR10129, PTHR10129, 1 hit
PTHR10129:SF25, PTHR10129:SF25, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03131, bZIP_Maf, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00338, BRLZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47454, SSF47454, 1 hit
SSF57959, SSF57959, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50217, BZIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULX9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT 
        60         70         80         90        100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM 
       110        120        130        140        150
RLELDALRGK CEALQGFARS VAAARGPATL VAPASVITIV KSTPGSGSGP 
       160 
AHGPDPAHGP ASCS
Length:164
Mass (Da):17,760
Last modified:June 20, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC34D9FF317E5EE1
GO
Isoform 2 (identifier: Q9ULX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:135
Mass (Da):14,569
Checksum:i54E949F996CCE45A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0QY70B0QY70_HUMAN
Transcription factor MafF
MAFF
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0QY71B0QY71_HUMAN
Transcription factor MafF
MAFF
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116G → A in BAA86871 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430291 – 29Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB025247 mRNA Translation: BAA86871.1
AJ010857 mRNA Translation: CAB52435.1
AK002001 mRNA Translation: BAA92029.1
AK300932 mRNA Translation: BAG62561.1
AL021977 Genomic DNA No translation available.
BC015037 mRNA Translation: AAH15037.1
BC067751 mRNA Translation: AAH67751.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13968.1 [Q9ULX9-1]
CCDS54528.1 [Q9ULX9-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC7112

NCBI Reference Sequences

More...RefSeqi		NP_001155044.1, NM_001161572.1 [Q9ULX9-1]
NP_001155045.1, NM_001161573.1 [Q9ULX9-1]
NP_001155046.1, NM_001161574.1 [Q9ULX9-2]
NP_036455.1, NM_012323.3 [Q9ULX9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000338483.7; ENSP00000345393.2; ENSG00000185022.12
ENST00000407965.1; ENSP00000384094.1; ENSG00000185022.12
ENST00000426621.6; ENSP00000388882.2; ENSG00000185022.12
ENST00000538320.5; ENSP00000442060.1; ENSG00000185022.12
ENST00000538999.1; ENSP00000441482.1; ENSG00000185022.12 [Q9ULX9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23764

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23764

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000338483.7; ENSP00000345393.2; NM_012323.4; NP_036455.1

UCSC genome browser

More...UCSCi		uc003avc.4, human [Q9ULX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025247 mRNA Translation: BAA86871.1
AJ010857 mRNA Translation: CAB52435.1
AK002001 mRNA Translation: BAA92029.1
AK300932 mRNA Translation: BAG62561.1
AL021977 Genomic DNA No translation available.
BC015037 mRNA Translation: AAH15037.1
BC067751 mRNA Translation: AAH67751.1
CCDSiCCDS13968.1 [Q9ULX9-1]
CCDS54528.1 [Q9ULX9-2]
PIRiJC7112
RefSeqiNP_001155044.1, NM_001161572.1 [Q9ULX9-1]
NP_001155045.1, NM_001161573.1 [Q9ULX9-1]
NP_001155046.1, NM_001161574.1 [Q9ULX9-2]
NP_036455.1, NM_012323.3 [Q9ULX9-1]

3D structure databases

AlphaFoldDBiQ9ULX9
SMRiQ9ULX9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117264, 43 interactors
ComplexPortaliCPX-6480, bZIP transcription factor complex, ATF3-MAFF
CPX-7085, bZIP transcription factor complex, BATF2-MAFF
CPX-7103, bZIP transcription factor complex, BATF3-MAFF
IntActiQ9ULX9, 30 interactors
MINTiQ9ULX9
STRINGi9606.ENSP00000345393

PTM databases

iPTMnetiQ9ULX9
PhosphoSitePlusiQ9ULX9

Genetic variation databases

BioMutaiMAFF
DMDMi21542145

Proteomic databases

EPDiQ9ULX9
jPOSTiQ9ULX9
MassIVEiQ9ULX9
MaxQBiQ9ULX9
PaxDbiQ9ULX9
PeptideAtlasiQ9ULX9
PRIDEiQ9ULX9
ProteomicsDBi85150 [Q9ULX9-1]
85151 [Q9ULX9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12337, 160 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		23764

Genome annotation databases

EnsembliENST00000338483.7; ENSP00000345393.2; ENSG00000185022.12
ENST00000407965.1; ENSP00000384094.1; ENSG00000185022.12
ENST00000426621.6; ENSP00000388882.2; ENSG00000185022.12
ENST00000538320.5; ENSP00000442060.1; ENSG00000185022.12
ENST00000538999.1; ENSP00000441482.1; ENSG00000185022.12 [Q9ULX9-2]
GeneIDi23764
KEGGihsa:23764
MANE-SelectiENST00000338483.7; ENSP00000345393.2; NM_012323.4; NP_036455.1
UCSCiuc003avc.4, human [Q9ULX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23764
DisGeNETi23764

GeneCards: human genes, protein and diseases

More...GeneCardsi		MAFF
HGNCiHGNC:6780, MAFF
HPAiENSG00000185022, Low tissue specificity
MIMi604877, gene
neXtProtiNX_Q9ULX9
OpenTargetsiENSG00000185022
PharmGKBiPA30538
VEuPathDBiHostDB:ENSG00000185022

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4196, Eukaryota
GeneTreeiENSGT00940000161112
HOGENOMiCLU_112948_0_1_1
InParanoidiQ9ULX9
OMAiMGENTPH
OrthoDBi1395389at2759
PhylomeDBiQ9ULX9
TreeFamiTF325689

Enzyme and pathway databases

PathwayCommonsiQ9ULX9
ReactomeiR-HSA-983231, Factors involved in megakaryocyte development and platelet production
SignaLinkiQ9ULX9
SIGNORiQ9ULX9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23764, 28 hits in 1091 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MAFF, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MAFF_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23764
PharosiQ9ULX9, Tbio

Protein Ontology

More...PROi		PR:Q9ULX9
RNActiQ9ULX9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185022, Expressed in amniotic fluid and 237 other tissues
ExpressionAtlasiQ9ULX9, baseline and differential
GenevisibleiQ9ULX9, HS

Family and domain databases

InterProiView protein in InterPro
IPR004827, bZIP
IPR004826, bZIP_Maf
IPR046347, bZIP_sf
IPR033531, MafF
IPR008917, TF_DNA-bd_sf
IPR024874, Transcription_factor_Maf_fam
PANTHERiPTHR10129, PTHR10129, 1 hit
PTHR10129:SF25, PTHR10129:SF25, 1 hit
PfamiView protein in Pfam
PF03131, bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
SUPFAMiSSF47454, SSF47454, 1 hit
SSF57959, SSF57959, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAFF_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULX9
Secondary accession number(s): B4DV49, Q9Y525
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: May 25, 2022
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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