UniProtKB - Q9ULX9 (MAFF_HUMAN)
Protein
Transcription factor MafF
Gene
MAFF
Organism
Homo sapiens (Human)
Status
Functioni
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846).3 Publications
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- blood coagulation Source: Reactome
- in utero embryonic development Source: Ensembl
- parturition Source: ProtInc
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of epidermal cell differentiation Source: GO_Central
- skeletal muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Stress response, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9ULX9 |
Reactomei | R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | Q9ULX9 |
SIGNORi | Q9ULX9 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor MafFAlternative name(s): U-Maf V-maf musculoaponeurotic fibrosarcoma oncogene homolog F |
Gene namesi | Name:MAFF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000185022.11 |
HGNCi | HGNC:6780, MAFF |
MIMi | 604877, gene |
neXtProti | NX_Q9ULX9 |
Subcellular locationi
Nucleus
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23764 |
OpenTargetsi | ENSG00000185022 |
PharmGKBi | PA30538 |
Miscellaneous databases
Pharosi | Q9ULX9, Tbio |
Polymorphism and mutation databases
BioMutai | MAFF |
DMDMi | 21542145 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076497 | 1 – 164 | Transcription factor MafFAdd BLAST | 164 |
Proteomic databases
EPDi | Q9ULX9 |
jPOSTi | Q9ULX9 |
MassIVEi | Q9ULX9 |
PaxDbi | Q9ULX9 |
PeptideAtlasi | Q9ULX9 |
PRIDEi | Q9ULX9 |
ProteomicsDBi | 85150 [Q9ULX9-1] 85151 [Q9ULX9-2] |
PTM databases
iPTMneti | Q9ULX9 |
PhosphoSitePlusi | Q9ULX9 |
Expressioni
Tissue specificityi
Expressed in the term myometrium and kidney.
Inductioni
By oxidative stress.1 Publication
Gene expression databases
Bgeei | ENSG00000185022, Expressed in amniotic fluid and 236 other tissues |
ExpressionAtlasi | Q9ULX9, baseline and differential |
Genevisiblei | Q9ULX9, HS |
Organism-specific databases
HPAi | ENSG00000185022, Tissue enhanced (placenta) |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 117264, 38 interactors |
IntActi | Q9ULX9, 19 interactors |
MINTi | Q9ULX9 |
STRINGi | 9606.ENSP00000345393 |
Miscellaneous databases
RNActi | Q9ULX9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 114 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 51 – 76 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 79 – 93 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4196, Eukaryota |
GeneTreei | ENSGT00940000161112 |
HOGENOMi | CLU_112948_0_1_1 |
InParanoidi | Q9ULX9 |
OMAi | RSIKMDP |
OrthoDBi | 1395389at2759 |
PhylomeDBi | Q9ULX9 |
TreeFami | TF325689 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR033531, MafF IPR008917, TF_DNA-bd_sf IPR024874, Transcription_factor_Maf_fam |
PANTHERi | PTHR10129, PTHR10129, 1 hit PTHR10129:SF25, PTHR10129:SF25, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9ULX9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT
60 70 80 90 100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM
110 120 130 140 150
RLELDALRGK CEALQGFARS VAAARGPATL VAPASVITIV KSTPGSGSGP
160
AHGPDPAHGP ASCS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB0QY70 | B0QY70_HUMAN | Transcription factor MafF | MAFF | 125 | Annotation score: | ||
B0QY71 | B0QY71_HUMAN | Transcription factor MafF | MAFF | 93 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 116 | G → A in BAA86871 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043029 | 1 – 29 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB025247 mRNA Translation: BAA86871.1 AJ010857 mRNA Translation: CAB52435.1 AK002001 mRNA Translation: BAA92029.1 AK300932 mRNA Translation: BAG62561.1 AL021977 Genomic DNA No translation available. BC015037 mRNA Translation: AAH15037.1 BC067751 mRNA Translation: AAH67751.1 |
CCDSi | CCDS13968.1 [Q9ULX9-1] CCDS54528.1 [Q9ULX9-2] |
PIRi | JC7112 |
RefSeqi | NP_001155044.1, NM_001161572.1 [Q9ULX9-1] NP_001155045.1, NM_001161573.1 [Q9ULX9-1] NP_001155046.1, NM_001161574.1 [Q9ULX9-2] NP_036455.1, NM_012323.3 [Q9ULX9-1] |
Genome annotation databases
Ensembli | ENST00000338483; ENSP00000345393; ENSG00000185022 [Q9ULX9-1] ENST00000407965; ENSP00000384094; ENSG00000185022 [Q9ULX9-1] ENST00000426621; ENSP00000388882; ENSG00000185022 [Q9ULX9-1] ENST00000538320; ENSP00000442060; ENSG00000185022 [Q9ULX9-1] ENST00000538999; ENSP00000441482; ENSG00000185022 [Q9ULX9-2] |
GeneIDi | 23764 |
KEGGi | hsa:23764 |
UCSCi | uc003avc.4, human [Q9ULX9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB025247 mRNA Translation: BAA86871.1 AJ010857 mRNA Translation: CAB52435.1 AK002001 mRNA Translation: BAA92029.1 AK300932 mRNA Translation: BAG62561.1 AL021977 Genomic DNA No translation available. BC015037 mRNA Translation: AAH15037.1 BC067751 mRNA Translation: AAH67751.1 |
CCDSi | CCDS13968.1 [Q9ULX9-1] CCDS54528.1 [Q9ULX9-2] |
PIRi | JC7112 |
RefSeqi | NP_001155044.1, NM_001161572.1 [Q9ULX9-1] NP_001155045.1, NM_001161573.1 [Q9ULX9-1] NP_001155046.1, NM_001161574.1 [Q9ULX9-2] NP_036455.1, NM_012323.3 [Q9ULX9-1] |
3D structure databases
SMRi | Q9ULX9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117264, 38 interactors |
IntActi | Q9ULX9, 19 interactors |
MINTi | Q9ULX9 |
STRINGi | 9606.ENSP00000345393 |
PTM databases
iPTMneti | Q9ULX9 |
PhosphoSitePlusi | Q9ULX9 |
Polymorphism and mutation databases
BioMutai | MAFF |
DMDMi | 21542145 |
Proteomic databases
EPDi | Q9ULX9 |
jPOSTi | Q9ULX9 |
MassIVEi | Q9ULX9 |
PaxDbi | Q9ULX9 |
PeptideAtlasi | Q9ULX9 |
PRIDEi | Q9ULX9 |
ProteomicsDBi | 85150 [Q9ULX9-1] 85151 [Q9ULX9-2] |
Protocols and materials databases
Antibodypediai | 12337, 141 antibodies |
DNASUi | 23764 |
Genome annotation databases
Ensembli | ENST00000338483; ENSP00000345393; ENSG00000185022 [Q9ULX9-1] ENST00000407965; ENSP00000384094; ENSG00000185022 [Q9ULX9-1] ENST00000426621; ENSP00000388882; ENSG00000185022 [Q9ULX9-1] ENST00000538320; ENSP00000442060; ENSG00000185022 [Q9ULX9-1] ENST00000538999; ENSP00000441482; ENSG00000185022 [Q9ULX9-2] |
GeneIDi | 23764 |
KEGGi | hsa:23764 |
UCSCi | uc003avc.4, human [Q9ULX9-1] |
Organism-specific databases
CTDi | 23764 |
DisGeNETi | 23764 |
EuPathDBi | HostDB:ENSG00000185022.11 |
GeneCardsi | MAFF |
HGNCi | HGNC:6780, MAFF |
HPAi | ENSG00000185022, Tissue enhanced (placenta) |
MIMi | 604877, gene |
neXtProti | NX_Q9ULX9 |
OpenTargetsi | ENSG00000185022 |
PharmGKBi | PA30538 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4196, Eukaryota |
GeneTreei | ENSGT00940000161112 |
HOGENOMi | CLU_112948_0_1_1 |
InParanoidi | Q9ULX9 |
OMAi | RSIKMDP |
OrthoDBi | 1395389at2759 |
PhylomeDBi | Q9ULX9 |
TreeFami | TF325689 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULX9 |
Reactomei | R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | Q9ULX9 |
SIGNORi | Q9ULX9 |
Miscellaneous databases
BioGRID-ORCSi | 23764, 20 hits in 861 CRISPR screens |
ChiTaRSi | MAFF, human |
GeneWikii | MAFF_(gene) |
GenomeRNAii | 23764 |
Pharosi | Q9ULX9, Tbio |
PROi | PR:Q9ULX9 |
RNActi | Q9ULX9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185022, Expressed in amniotic fluid and 236 other tissues |
ExpressionAtlasi | Q9ULX9, baseline and differential |
Genevisiblei | Q9ULX9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR033531, MafF IPR008917, TF_DNA-bd_sf IPR024874, Transcription_factor_Maf_fam |
PANTHERi | PTHR10129, PTHR10129, 1 hit PTHR10129:SF25, PTHR10129:SF25, 1 hit |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MAFF_HUMAN | |
Accessioni | Q9ULX9Primary (citable) accession number: Q9ULX9 Secondary accession number(s): B4DV49, Q9Y525 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2002 |
Last sequence update: | June 20, 2002 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM