MAFF

Functionⁱ

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846).3 Publications

GO - Molecular functionⁱ

RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 23332764
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: Reactome
in utero embryonic development Source: Ensembl
parturition
Source: ProtInc
Traceable author statementⁱ
- 10527846
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12490281
regulation of epidermal cell differentiation Source: Ensembl
skeletal muscle cell differentiation Source: Ensembl
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 10527846

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	Q9ULX9
SIGNORⁱ	Q9ULX9

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor MafF Alternative name(s): U-Maf V-maf musculoaponeurotic fibrosarcoma oncogene homolog F
Gene namesⁱ	Name:MAFF
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185022.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6780 MAFF
MIMⁱ	604877 gene
neXtProtⁱ	NX_Q9ULX9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23764
Open Targets More...OpenTargetsⁱ	ENSG00000185022
PharmGKBⁱ	PA30538

Polymorphism and mutation databases

BioMutaⁱ	MAFF
DMDMⁱ	21542145

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076497	1 – 164	Transcription factor MafFAdd BLAST		164

Proteomic databases

EPDⁱ	Q9ULX9
PaxDbⁱ	Q9ULX9
PeptideAtlas More...PeptideAtlasⁱ	Q9ULX9
PRIDEⁱ	Q9ULX9
ProteomicsDBⁱ	85150 85151 [Q9ULX9-2]

PTM databases

iPTMnetⁱ	Q9ULX9
PhosphoSitePlusⁱ	Q9ULX9

Expressionⁱ

Tissue specificityⁱ

Expressed in the term myometrium and kidney.

Inductionⁱ

By oxidative stress.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000185022 Expressed in 226 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_MAFF
ExpressionAtlasⁱ	Q9ULX9 baseline and differential
Genevisibleⁱ	Q9ULX9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025341 HPA055371

HPAⁱ

CAB025341
HPA055371

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

BioGridⁱ	117264, 35 interactors
IntActⁱ	Q9ULX9, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q9ULX9
STRINGⁱ	9606.ENSP00000345393

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULX9
SMRⁱ	Q9ULX9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	51 – 114	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	51 – 76	Basic motifPROSITE-ProRule annotationAdd BLAST		26
Regionⁱ	79 – 93	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the bZIP family. Maf subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG4196 Eukaryota ENOG41102C7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074549
HOGENOMⁱ	HOG000045475
HOVERGENⁱ	HBG001725
InParanoidⁱ	Q9ULX9
KEGG Orthology (KO) More...KOⁱ	K09037
OMAⁱ	NRQLKLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H46
PhylomeDBⁱ	Q9ULX9
TreeFamⁱ	TF325689

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR004826 bZIP_Maf IPR033531 MafF IPR008917 TF_DNA-bd_sf IPR024874 Transciption_factor_Maf_fam
PANTHERⁱ	PTHR10129 PTHR10129, 1 hit PTHR10129:SF25 PTHR10129:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03131 bZIP_Maf, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9ULX9-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVDPLSSKA LKIKRELSEN TPHLSDEALM GLSVRELNRH LRGLSAEEVT 
        60         70         80         90        100
RLKQRRRTLK NRGYAASCRV KRVCQKEELQ KQKSELEREV DKLARENAAM 
       110        120        130        140        150
RLELDALRGK CEALQGFARS VAAARGPATL VAPASVITIV KSTPGSGSGP 
       160 
AHGPDPAHGP ASCS

Length:164

Mass (Da):17,760

Last modified:June 20, 2002 - v2

Checksum:ⁱFC34D9FF317E5EE1

GO

Isoform 2 (identifier: Q9ULX9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-29: Missing.

« Hide

        10         20         30         40         50
MGLSVRELNR HLRGLSAEEV TRLKQRRRTL KNRGYAASCR VKRVCQKEEL 
        60         70         80         90        100
QKQKSELERE VDKLARENAA MRLELDALRG KCEALQGFAR SVAAARGPAT 
       110        120        130 
LVAPASVITI VKSTPGSGSG PAHGPDPAHG PASCS

Note: No experimental confirmation available.

Show »

Length:135

Mass (Da):14,569

Checksum:ⁱ54E949F996CCE45A

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B0QY70	B0QY70_HUMAN	Transcription factor MafF Transcription factor MafF	MAFF	125	Annotation score:
B0QY71	B0QY71_HUMAN	Transcription factor MafF Transcription factor MafF	MAFF	93	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	116	G → A in BAA86871 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043029	1 – 29	Missing in isoform 2. 1 PublicationAdd BLAST		29

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB025247 mRNA Translation: BAA86871.1 AJ010857 mRNA Translation: CAB52435.1 AK002001 mRNA Translation: BAA92029.1 AK300932 mRNA Translation: BAG62561.1 AL021977 Genomic DNA No translation available. BC015037 mRNA Translation: AAH15037.1 BC067751 mRNA Translation: AAH67751.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13968.1 [Q9ULX9-1] CCDS54528.1 [Q9ULX9-2]
PIRⁱ	JC7112
NCBI Reference Sequences More...RefSeqⁱ	NP_001155044.1, NM_001161572.1 [Q9ULX9-1] NP_001155045.1, NM_001161573.1 [Q9ULX9-1] NP_001155046.1, NM_001161574.1 [Q9ULX9-2] NP_036455.1, NM_012323.3 [Q9ULX9-1]
UniGeneⁱ	Hs.517617

Genome annotation databases

Ensemblⁱ	ENST00000338483; ENSP00000345393; ENSG00000185022 [Q9ULX9-1] ENST00000407965; ENSP00000384094; ENSG00000185022 [Q9ULX9-1] ENST00000426621; ENSP00000388882; ENSG00000185022 [Q9ULX9-1] ENST00000538320; ENSP00000442060; ENSG00000185022 [Q9ULX9-1] ENST00000538999; ENSP00000441482; ENSG00000185022 [Q9ULX9-2]
GeneIDⁱ	23764
KEGGⁱ	hsa:23764
UCSC genome browser More...UCSCⁱ	uc003avc.4 human [Q9ULX9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULX9	Isoform 2 of Transcription factor MafF		HUMAN		135	UniRef90_Q9ULX9
Uncharacterized protein		NOMLE		170
Transcription factor MafF isoform a		CALJA		164
Uncharacterized protein		Cebus capucinus imitator		164
Uncharacterized protein		AOTNA		164
+19

Protein	Similar proteins		Species	Score	Length	Source
Q9ULX9	Transcription factor MafG		CHICK		162	UniRef50_Q9ULX9
Transcription factor MafK		MOUSE		156
Transcription factor MafF		BOVIN		172
Isoform 2 of Transcription factor MafF		HUMAN		135
Uncharacterized protein		NOMLE		170
+270

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB025247 mRNA Translation: BAA86871.1 AJ010857 mRNA Translation: CAB52435.1 AK002001 mRNA Translation: BAA92029.1 AK300932 mRNA Translation: BAG62561.1 AL021977 Genomic DNA No translation available. BC015037 mRNA Translation: AAH15037.1 BC067751 mRNA Translation: AAH67751.1
CCDSⁱ	CCDS13968.1 [Q9ULX9-1] CCDS54528.1 [Q9ULX9-2]
PIRⁱ	JC7112
RefSeqⁱ	NP_001155044.1, NM_001161572.1 [Q9ULX9-1] NP_001155045.1, NM_001161573.1 [Q9ULX9-1] NP_001155046.1, NM_001161574.1 [Q9ULX9-2] NP_036455.1, NM_012323.3 [Q9ULX9-1]
UniGeneⁱ	Hs.517617

3D structure databases

ProteinModelPortalⁱ	Q9ULX9
SMRⁱ	Q9ULX9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117264, 35 interactors
IntActⁱ	Q9ULX9, 6 interactors
MINTⁱ	Q9ULX9
STRINGⁱ	9606.ENSP00000345393

PTM databases

iPTMnetⁱ	Q9ULX9
PhosphoSitePlusⁱ	Q9ULX9

Polymorphism and mutation databases

BioMutaⁱ	MAFF
DMDMⁱ	21542145

Proteomic databases

EPDⁱ	Q9ULX9
PaxDbⁱ	Q9ULX9
PeptideAtlasⁱ	Q9ULX9
PRIDEⁱ	Q9ULX9
ProteomicsDBⁱ	85150 85151 [Q9ULX9-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23764
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000338483; ENSP00000345393; ENSG00000185022 [Q9ULX9-1] ENST00000407965; ENSP00000384094; ENSG00000185022 [Q9ULX9-1] ENST00000426621; ENSP00000388882; ENSG00000185022 [Q9ULX9-1] ENST00000538320; ENSP00000442060; ENSG00000185022 [Q9ULX9-1] ENST00000538999; ENSP00000441482; ENSG00000185022 [Q9ULX9-2]
GeneIDⁱ	23764
KEGGⁱ	hsa:23764
UCSCⁱ	uc003avc.4 human [Q9ULX9-1]

Organism-specific databases

CTDⁱ	23764
DisGeNETⁱ	23764
EuPathDBⁱ	HostDB:ENSG00000185022.11
GeneCardsⁱ	MAFF
HGNCⁱ	HGNC:6780 MAFF
HPAⁱ	CAB025341 HPA055371
MIMⁱ	604877 gene
neXtProtⁱ	NX_Q9ULX9
OpenTargetsⁱ	ENSG00000185022
PharmGKBⁱ	PA30538
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4196 Eukaryota ENOG41102C7 LUCA
GeneTreeⁱ	ENSGT00550000074549
HOGENOMⁱ	HOG000045475
HOVERGENⁱ	HBG001725
InParanoidⁱ	Q9ULX9
KOⁱ	K09037
OMAⁱ	NRQLKLR
OrthoDBⁱ	EOG091G0H46
PhylomeDBⁱ	Q9ULX9
TreeFamⁱ	TF325689

Enzyme and pathway databases

Reactomeⁱ	R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	Q9ULX9
SIGNORⁱ	Q9ULX9

Miscellaneous databases

ChiTaRSⁱ	MAFF human
GeneWikiⁱ	MAFF_(gene)
GenomeRNAiⁱ	23764
Protein Ontology More...PROⁱ	PR:Q9ULX9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185022 Expressed in 226 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_MAFF
ExpressionAtlasⁱ	Q9ULX9 baseline and differential
Genevisibleⁱ	Q9ULX9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR004826 bZIP_Maf IPR033531 MafF IPR008917 TF_DNA-bd_sf IPR024874 Transciption_factor_Maf_fam
PANTHERⁱ	PTHR10129 PTHR10129, 1 hit PTHR10129:SF25 PTHR10129:SF25, 1 hit
Pfamⁱ	View protein in Pfam PF03131 bZIP_Maf, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
SUPFAMⁱ	SSF47454 SSF47454, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAFF_HUMAN
Accessionⁱ	Q9ULX9Primary (citable) accession number: Q9ULX9 Secondary accession number(s): B4DV49, Q9Y525
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
	Last sequence update:	June 20, 2002
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9ULX9 (MAFF_HUMAN)

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Transcription factor MafF

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ