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Protein

Carbonic anhydrase 14

Gene

CA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+1 Publication

Activity regulationi

Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).8 Publications

Kineticsi

  1. KM=7.9 mM for CO21 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei84Proton acceptorBy similarity1
    Metal bindingi109Zinc; catalytic1 Publication1
    Metal bindingi111Zinc; catalytic1 Publication1
    Metal bindingi135Zinc; catalytic1 Publication1
    Active sitei144By similarity1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionLyase
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi4.2.1.1 2681
    ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide
    SABIO-RKiQ9ULX7

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbonic anhydrase 14 (EC:4.2.1.1)
    Alternative name(s):
    Carbonate dehydratase XIV
    Carbonic anhydrase XIV
    Short name:
    CA-XIV
    Gene namesi
    Name:CA14
    ORF Names:UNQ690/PRO1335
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 1

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000118298.10
    HGNCiHGNC:1372 CA14
    MIMi604832 gene
    neXtProtiNX_Q9ULX7

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini16 – 290ExtracellularSequence analysisAdd BLAST275
    Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
    Topological domaini312 – 337CytoplasmicSequence analysisAdd BLAST26

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi23632
    OpenTargetsiENSG00000118298
    PharmGKBiPA25988

    Chemistry databases

    ChEMBLiCHEMBL3510
    DrugBankiDB00819 Acetazolamide
    DB08846 Ellagic Acid
    DB00909 Zonisamide
    GuidetoPHARMACOLOGYi2598

    Polymorphism and mutation databases

    BioMutaiCA14
    DMDMi8928036

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Signal peptidei1 – 15Sequence analysisAdd BLAST15
    ChainiPRO_000000425116 – 337Carbonic anhydrase 14Add BLAST322

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Disulfide bondi40 ↔ 2211 Publication
    Glycosylationi213N-linked (GlcNAc...) asparagine1 Publication1
    Modified residuei325PhosphoserineCombined sources1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    EPDiQ9ULX7
    PaxDbiQ9ULX7
    PeptideAtlasiQ9ULX7
    PRIDEiQ9ULX7
    ProteomicsDBi85149

    PTM databases

    iPTMnetiQ9ULX7
    PhosphoSitePlusiQ9ULX7

    Expressioni

    Tissue specificityi

    High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.

    Gene expression databases

    BgeeiENSG00000118298 Expressed in 147 organ(s), highest expression level in pigmented layer of retina
    CleanExiHS_CA14
    ExpressionAtlasiQ9ULX7 baseline and differential
    GenevisibleiQ9ULX7 HS

    Organism-specific databases

    HPAiHPA008482

    Interactioni

    Protein-protein interaction databases

    BioGridi117162, 48 interactors
    IntActiQ9ULX7, 1 interactor
    STRINGi9606.ENSP00000358107

    Chemistry databases

    BindingDBiQ9ULX7

    Structurei

    Secondary structure

    1337
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliQ9ULX7
    SMRiQ9ULX7
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini20 – 278Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST259

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni217 – 218Substrate bindingBy similarity2

    Sequence similaritiesi

    Belongs to the alpha-carbonic anhydrase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0382 Eukaryota
    COG3338 LUCA
    GeneTreeiENSGT00760000118915
    HOGENOMiHOG000112637
    HOVERGENiHBG002837
    InParanoidiQ9ULX7
    KOiK01672
    OMAiYPECGSN
    OrthoDBiEOG091G0XFM
    PhylomeDBiQ9ULX7
    TreeFamiTF316425

    Family and domain databases

    Gene3Di3.10.200.10, 1 hit
    InterProiView protein in InterPro
    IPR001148 CA_dom
    IPR036398 CA_dom_sf
    IPR023561 Carbonic_anhydrase_a-class
    IPR018431 Carbonic_anhydrase_CA14
    PANTHERiPTHR18952 PTHR18952, 1 hit
    PTHR18952:SF84 PTHR18952:SF84, 1 hit
    PfamiView protein in Pfam
    PF00194 Carb_anhydrase, 1 hit
    SMARTiView protein in SMART
    SM01057 Carb_anhydrase, 1 hit
    SUPFAMiSSF51069 SSF51069, 1 hit
    PROSITEiView protein in PROSITE
    PS51144 ALPHA_CA_2, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9ULX7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLFSALLLEV IWILAADGGQ HWTYEGPHGQ DHWPASYPEC GNNAQSPIDI
    60 70 80 90 100
    QTDSVTFDPD LPALQPHGYD QPGTEPLDLH NNGHTVQLSL PSTLYLGGLP
    110 120 130 140 150
    RKYVAAQLHL HWGQKGSPGG SEHQINSEAT FAELHIVHYD SDSYDSLSEA
    160 170 180 190 200
    AERPQGLAVL GILIEVGETK NIAYEHILSH LHEVRHKDQK TSVPPFNLRE
    210 220 230 240 250
    LLPKQLGQYF RYNGSLTTPP CYQSVLWTVF YRRSQISMEQ LEKLQGTLFS
    260 270 280 290 300
    TEEEPSKLLV QNYRALQPLN QRMVFASFIQ AGSSYTTGEM LSLGVGILVG
    310 320 330
    CLCLLLAVYF IARKIRKKRL ENRKSVVFTS AQATTEA
    Length:337
    Mass (Da):37,668
    Last modified:May 1, 2000 - v1
    Checksum:i6E101C44EA70A700
    GO

    Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    U3KPU6U3KPU6_HUMAN
    Carbonic anhydrase 14
    CA14
    130Annotation score:
    U3KQH0U3KQH0_HUMAN
    Carbonic anhydrase 14
    CA14
    42Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti229V → A in BAC11191 (PubMed:14702039).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB025904 mRNA Translation: BAA85002.1
    AY358689 mRNA Translation: AAQ89052.1
    AK074765 mRNA Translation: BAC11191.1
    BT020054 mRNA Translation: AAV38857.1
    AL138795 Genomic DNA Translation: CAI22810.1
    BC034412 mRNA Translation: AAH34412.1
    CCDSiCCDS947.1
    RefSeqiNP_036245.1, NM_012113.2
    UniGeneiHs.528988

    Genome annotation databases

    EnsembliENST00000369111; ENSP00000358107; ENSG00000118298
    GeneIDi23632
    KEGGihsa:23632
    UCSCiuc001etx.5 human

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB025904 mRNA Translation: BAA85002.1
    AY358689 mRNA Translation: AAQ89052.1
    AK074765 mRNA Translation: BAC11191.1
    BT020054 mRNA Translation: AAV38857.1
    AL138795 Genomic DNA Translation: CAI22810.1
    BC034412 mRNA Translation: AAH34412.1
    CCDSiCCDS947.1
    RefSeqiNP_036245.1, NM_012113.2
    UniGeneiHs.528988

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4LU3X-ray2.00A16-290[»]
    5CJFX-ray1.83A16-291[»]
    ProteinModelPortaliQ9ULX7
    SMRiQ9ULX7
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi117162, 48 interactors
    IntActiQ9ULX7, 1 interactor
    STRINGi9606.ENSP00000358107

    Chemistry databases

    BindingDBiQ9ULX7
    ChEMBLiCHEMBL3510
    DrugBankiDB00819 Acetazolamide
    DB08846 Ellagic Acid
    DB00909 Zonisamide
    GuidetoPHARMACOLOGYi2598

    PTM databases

    iPTMnetiQ9ULX7
    PhosphoSitePlusiQ9ULX7

    Polymorphism and mutation databases

    BioMutaiCA14
    DMDMi8928036

    Proteomic databases

    EPDiQ9ULX7
    PaxDbiQ9ULX7
    PeptideAtlasiQ9ULX7
    PRIDEiQ9ULX7
    ProteomicsDBi85149

    Protocols and materials databases

    DNASUi23632
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000369111; ENSP00000358107; ENSG00000118298
    GeneIDi23632
    KEGGihsa:23632
    UCSCiuc001etx.5 human

    Organism-specific databases

    CTDi23632
    DisGeNETi23632
    EuPathDBiHostDB:ENSG00000118298.10
    GeneCardsiCA14
    HGNCiHGNC:1372 CA14
    HPAiHPA008482
    MIMi604832 gene
    neXtProtiNX_Q9ULX7
    OpenTargetsiENSG00000118298
    PharmGKBiPA25988
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0382 Eukaryota
    COG3338 LUCA
    GeneTreeiENSGT00760000118915
    HOGENOMiHOG000112637
    HOVERGENiHBG002837
    InParanoidiQ9ULX7
    KOiK01672
    OMAiYPECGSN
    OrthoDBiEOG091G0XFM
    PhylomeDBiQ9ULX7
    TreeFamiTF316425

    Enzyme and pathway databases

    BRENDAi4.2.1.1 2681
    ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide
    SABIO-RKiQ9ULX7

    Miscellaneous databases

    ChiTaRSiCA14 human
    GeneWikiiCA14
    GenomeRNAii23632
    PROiPR:Q9ULX7
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000118298 Expressed in 147 organ(s), highest expression level in pigmented layer of retina
    CleanExiHS_CA14
    ExpressionAtlasiQ9ULX7 baseline and differential
    GenevisibleiQ9ULX7 HS

    Family and domain databases

    Gene3Di3.10.200.10, 1 hit
    InterProiView protein in InterPro
    IPR001148 CA_dom
    IPR036398 CA_dom_sf
    IPR023561 Carbonic_anhydrase_a-class
    IPR018431 Carbonic_anhydrase_CA14
    PANTHERiPTHR18952 PTHR18952, 1 hit
    PTHR18952:SF84 PTHR18952:SF84, 1 hit
    PfamiView protein in Pfam
    PF00194 Carb_anhydrase, 1 hit
    SMARTiView protein in SMART
    SM01057 Carb_anhydrase, 1 hit
    SUPFAMiSSF51069 SSF51069, 1 hit
    PROSITEiView protein in PROSITE
    PS51144 ALPHA_CA_2, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiCAH14_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULX7
    Secondary accession number(s): Q5TB24, Q8NCF4
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: November 7, 2018
    This is version 162 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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