AKAP8L

Functionⁱ

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).1 Publication6 Publications

(Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.1 Publication

(Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.1 Publication

(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	391 – 413	C2H2 AKAP95-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	484 – 507	C2H2 AKAP95-type 2PROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

DEAD/H-box RNA helicase binding
Source: UniProtKB
Traceable author statementⁱ
- 10748171
DNA binding Source: InterPro
histone deacetylase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16980585
lamin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11034899
metal ion binding Source: UniProtKB-KW
protein kinase A regulatory subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle G2/M phase transition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16980585
mitotic chromosome condensation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11034899
mRNA processing
Source: UniProtKB
Inferred from direct assayⁱ
- 17594903
nuclear envelope disassembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11034899
positive regulation of histone deacetylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16980585
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11884601
regulation of histone phosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16980585
regulation of mRNA export from nucleus
Source: UniProtKB
Inferred from direct assayⁱ
- 11402034
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: A-kinase anchor protein 8-like Short name: AKAP8-like protein Alternative name(s): Helicase A-binding protein 95 Short name: HAP95 Homologous to AKAP95 protein Short name: HA95 Neighbor of A-kinase-anchoring protein 95 Short name: Neighbor of AKAP95
Gene namesⁱ	Name:AKAP8L Synonyms:NAKAP, NAKAP95 ORF Names:HRIHFB2018
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000011243.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29857 AKAP8L
MIMⁱ	609475 gene
neXtProtⁱ	NX_Q9ULX6

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26993
Open Targets More...OpenTargetsⁱ	ENSG00000011243
PharmGKBⁱ	PA134867364

Polymorphism and mutation databases

BioMutaⁱ	AKAP8L
DMDMⁱ	296439446

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000075384	1 – 646	A-kinase anchor protein 8-likeAdd BLAST		646

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	208	Asymmetric dimethylarginine; alternateCombined sources	1
Modified residueⁱ	208	Omega-N-methylarginine; alternateCombined sources	1
Modified residueⁱ	217	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	237	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	247	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	257	N6-acetyllysineCombined sources	1
Modified residueⁱ	267	PhosphothreonineCombined sources	1
Modified residueⁱ	283	PhosphoserineCombined sources	1
Modified residueⁱ	292	PhosphothreonineCombined sources	1
Modified residueⁱ	297	PhosphoserineCombined sources	1
Modified residueⁱ	552	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.1 Publication

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9ULX6
PaxDbⁱ	Q9ULX6
PeptideAtlas More...PeptideAtlasⁱ	Q9ULX6
PRIDEⁱ	Q9ULX6
ProteomicsDBⁱ	85148

PTM databases

iPTMnetⁱ	Q9ULX6
PhosphoSitePlusⁱ	Q9ULX6

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Expressed in the brain cortex (at protein level).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000011243 Expressed in 215 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_AKAP8L
ExpressionAtlasⁱ	Q9ULX6 baseline and differential
Genevisibleⁱ	Q9ULX6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042485 HPA042546

HPAⁱ

HPA042485
HPA042546

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus) with DHX9 (via RGG region) (PubMed:10748171, PubMed:11402034). Interacts with TMPO isoform Beta, PRPF40A, RNF43, lamin-B (PubMed:11034899, PubMed:12538639 PubMed:16391387, PubMed:18313049). Interacts with HDAC3; increased during mitosis (PubMed:16980585). Interacts with EBV EBNA-LP (PubMed:11160753). Interacts with HIV-1 reverse transcriptase/ribonuclease H (PubMed:25034436).8 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P29991	3	EBI-357530,EBI-8826747	From Dengue virus type 2 (strain 16681-PDK53).
HDAC3	O15379	5	EBI-357530,EBI-607682
Prpf40a	Q9R1C7	3	EBI-357530,EBI-645554	From Mus musculus.
RNF43	Q68DV7	2	EBI-357530,EBI-1647060

GO - Molecular functionⁱ

DEAD/H-box RNA helicase binding
Source: UniProtKB
Traceable author statementⁱ
- 10748171
histone deacetylase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16980585
lamin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11034899
protein kinase A regulatory subunit binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117940, 42 interactors
CORUMⁱ	Q9ULX6
Database of interacting proteins More...DIPⁱ	DIP-27541N
IntActⁱ	Q9ULX6, 89 interactors
Molecular INTeraction database More...MINTⁱ	Q9ULX6
STRINGⁱ	9606.ENSP00000380557

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULX6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 268	Sufficient for activation of CTE-mediated expression1 PublicationAdd BLAST		268

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	274 – 279	Nuclear localization signalSequence analysis	6
Motifⁱ	280 – 296	Nuclear export signal (NES)1 PublicationAdd BLAST	17
Motifⁱ	362 – 364	Nuclear localization signalSequence analysis	3

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	41 – 52	Gly/Tyr-richAdd BLAST	12
Compositional biasⁱ	589 – 597	Pro-rich	9
Compositional biasⁱ	602 – 608	Pro-rich	7

Sequence similaritiesⁱ

Belongs to the AKAP95 family.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	391 – 413	C2H2 AKAP95-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	484 – 507	C2H2 AKAP95-type 2PROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IIFX Eukaryota ENOG410YCRZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063777
HOGENOMⁱ	HOG000169111
HOVERGENⁱ	HBG104297
InParanoidⁱ	Q9ULX6
KEGG Orthology (KO) More...KOⁱ	K15978
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0836
PhylomeDBⁱ	Q9ULX6
TreeFamⁱ	TF105407

Family and domain databases

InterProⁱ	View protein in InterPro IPR007071 AKAP95 IPR034736 ZF_C2H2_AKAP95
PANTHERⁱ	PTHR12190 PTHR12190, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04988 AKAP95, 1 hit
PROSITEⁱ	View protein in PROSITE PS51799 ZF_C2H2_AKAP95, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9ULX6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG 
        60         70         80         90        100
YGQDNTTNYG YGMATSHSWE MPSSDTNANT SASGSASADS VLSRINQRLD 
       110        120        130        140        150
MVPHLETDMM QGGVYGSGGE RYDSYESCDS RAVLSERDLY RSGYDYSELD 
       160        170        180        190        200
PEMEMAYEGQ YDAYRDQFRM RGNDTFGPRA QGWARDARSG RPMASGYGRM 
       210        220        230        240        250
WEDPMGARGQ CMSGASRLPS LFSQNIIPEY GMFQGMRGGG AFPGGSRFGF 
       260        270        280        290        300
GFGNGMKQMR RTWKTWTTAD FRTKKKKRKQ GGSPDEPDSK ATRTDCSDNS 
       310        320        330        340        350
DSDNDEGTEG EATEGLEGTE AVEKGSRVDG EDEEGKEDGR EEGKEDPEKG 
       360        370        380        390        400
ALTTQDENGQ TKRKLQAGKK SQDKQKKRQR DRMVERIQFV CSLCKYRTFY 
       410        420        430        440        450
EDEMASHLDS KFHKEHFKYV GTKLPKQTAD FLQEYVTNKT KKTEELRKTV 
       460        470        480        490        500
EDLDGLIQQI YRDQDLTQEI AMEHFVKKVE AAHCAACDLF IPMQFGIIQK 
       510        520        530        540        550
HLKTMDHNRN RRLMMEQSKK SSLMVARSIL NNKLISKKLE RYLKGENPFT 
       560        570        580        590        600
DSPEEEKEQE EAEGGALDEG AQGEAAGISE GAEGVPAQPP VPPEPAPGAV 
       610        620        630        640 
SPPPPPPPEE EEEGAVPLLG GALQRQIRGI PGLDVEDDEE GGGGAP

Length:646

Mass (Da):71,640

Last modified:September 12, 2018 - v4

Checksum:ⁱCBC265BF25996BA2

GO

Isoform 2 (identifier: Q9ULX6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
61-121: Missing.

« Hide

        10         20         30         40         50
MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG 
        60         70         80         90        100
YGQDNTTNYG YDSYESCDSR AVLSERDLYR SGYDYSELDP EMEMAYEGQY 
       110        120        130        140        150
DAYRDQFRMR GNDTFGPRAQ GWARDARSGR PMASGYGRMW EDPMGARGQC 
       160        170        180        190        200
MSGASRLPSL FSQNIIPEYG MFQGMRGGGA FPGGSRFGFG FGNGMKQMRR 
       210        220        230        240        250
TWKTWTTADF RTKKKKRKQG GSPDEPDSKA TRTDCSDNSD SDNDEGTEGE 
       260        270        280        290        300
ATEGLEGTEA VEKGSRVDGE DEEGKEDGRE EGKEDPEKGA LTTQDENGQT 
       310        320        330        340        350
KRKLQAGKKS QDKQKKRQRD RMVERIQFVC SLCKYRTFYE DEMASHLDSK 
       360        370        380        390        400
FHKEHFKYVG TKLPKQTADF LQEYVTNKTK KTEELRKTVE DLDGLIQQIY 
       410        420        430        440        450
RDQDLTQEIA MEHFVKKVEA AHCAACDLFI PMQFGIIQKH LKTMDHNRNR 
       460        470        480        490        500
RLMMEQSKKS SLMVARSILN NKLISKKLER YLKGENPFTD SPEEEKEQEE 
       510        520        530        540        550
AEGGALDEGA QGEAAGISEG AEGVPAQPPV PPEPAPGAVS PPPPPPPEEE 
       560        570        580 
EEGAVPLLGG ALQRQIRGIP GLDVEDDEEG GGGAP

Show »

Length:585

Mass (Da):65,221

Checksum:ⁱ6315372DFB1DAF9E

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

V9GZ50	V9GZ50_HUMAN	A kinase (PRKA) anchor protein 8-li... A kinase (PRKA) anchor protein 8-like, isoform CRA_c (A-kinase anchor protein 8-like)	AKAP8L hCG_36782	431	Annotation score:
M0R010	M0R010_HUMAN	A-kinase anchor protein 8-like A-kinase anchor protein 8-like	AKAP8L	161	Annotation score:
M0QYT7	M0QYT7_HUMAN	A-kinase anchor protein 8-like A-kinase anchor protein 8-like	AKAP8L	162	Annotation score:
M0R008	M0R008_HUMAN	A-kinase anchor protein 8-like A-kinase anchor protein 8-like	AKAP8L	66	Annotation score:
M0R1Y5	M0R1Y5_HUMAN	A-kinase anchor protein 8-like A-kinase anchor protein 8-like	AKAP8L	109	Annotation score:
M0R1L5	M0R1L5_HUMAN	A-kinase anchor protein 8-like A-kinase anchor protein 8-like	AKAP8L	45	Annotation score:

Sequence cautionⁱ

The sequence AAF86048 differs from that shown. Reason: Frameshift at position 553.Curated

The sequence BAA34791 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	100	D → N in AAF86048 (PubMed:10748171).Curated	1
Sequence conflictⁱ	189	S → N in AAF86048 (PubMed:10748171).Curated	1
Sequence conflictⁱ	351 – 358	ALTTQDEN → EFSWGAWC in BAA34791 (PubMed:9853615).Curated	8
Sequence conflictⁱ	599 – 616	AVSPP…EEGAV → GRVAATAAAPRRRRRRAPW in AAF86048 (PubMed:10748171).CuratedAdd BLAST	18
Sequence conflictⁱ	641 – 646	GGGGAP → EGRRGRPV in AAF86048 (PubMed:10748171).Curated	6

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_068822	458	Q → H1 PublicationCorresponds to variant dbSNP:rs2058322Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044426	61 – 121	Missing in isoform 2. 1 PublicationAdd BLAST		61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB025905 mRNA Translation: BAA85003.1 AJ243467 mRNA Translation: CAB65092.1 AF199414 mRNA Translation: AAF86048.1 Frameshift. AK295956 mRNA Translation: BAG58736.1 AB451326 mRNA Translation: BAG70140.1 AB451469 mRNA Translation: BAG70283.1 AC005785 Genomic DNA No translation available. AC006128 Genomic DNA No translation available. KF456508 Genomic DNA No translation available. KF456511 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84475.1 BC000713 mRNA Translation: AAH00713.1 AB015332 mRNA Translation: BAA34791.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46005.1 [Q9ULX6-1] CCDS77249.1 [Q9ULX6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001278407.1, NM_001291478.1 [Q9ULX6-2] NP_055186.3, NM_014371.3 [Q9ULX6-1]
UniGeneⁱ	Hs.399800

Genome annotation databases

Ensemblⁱ	ENST00000397410; ENSP00000380557; ENSG00000011243 [Q9ULX6-1] ENST00000595465; ENSP00000470952; ENSG00000011243 [Q9ULX6-2]
GeneIDⁱ	26993
KEGGⁱ	hsa:26993
UCSC genome browser More...UCSCⁱ	uc002naw.2 human [Q9ULX6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULX6	A kinase (PRKA) anchor protein 8-like, isoform CRA_d		HUMAN		386	UniRef100_Q9ULX6

Protein	Similar proteins		Species	Score	Length	Source
Q9ULX6	A kinase (PRKA) anchor protein 8-like, isoform CRA_d		HUMAN		386	UniRef90_Q9ULX6
A-kinase anchoring protein 8 like		SAIBB		655
Uncharacterized protein		AOTNA		654
Uncharacterized protein		Cebus capucinus imitator		649
Uncharacterized protein		RHIRO		647
+53
Q9ULX6-2	A-kinase anchor protein 8-like isoform X1		TARSY		666	UniRef90_Q9ULX6-2
A-kinase anchoring protein 8 like		GORGO		646
Uncharacterized protein DKFZp434L0650 (Fragment)		HUMAN		98
Uncharacterized protein		Cebus capucinus imitator		614
AKAP8L isoform 4		PONAB		585
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9ULX6	A-kinase anchor protein 8-like		MOUSE		642	UniRef50_Q9ULX6
A kinase (PRKA) anchor protein 8-like, isoform CRA_d		HUMAN		386
A-kinase anchoring protein 8 like		SAIBB		655
Uncharacterized protein		AOTNA		654
Uncharacterized protein		Cebus capucinus imitator		649
+339

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB025905 mRNA Translation: BAA85003.1 AJ243467 mRNA Translation: CAB65092.1 AF199414 mRNA Translation: AAF86048.1 Frameshift. AK295956 mRNA Translation: BAG58736.1 AB451326 mRNA Translation: BAG70140.1 AB451469 mRNA Translation: BAG70283.1 AC005785 Genomic DNA No translation available. AC006128 Genomic DNA No translation available. KF456508 Genomic DNA No translation available. KF456511 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84475.1 BC000713 mRNA Translation: AAH00713.1 AB015332 mRNA Translation: BAA34791.1 Different initiation.
CCDSⁱ	CCDS46005.1 [Q9ULX6-1] CCDS77249.1 [Q9ULX6-2]
RefSeqⁱ	NP_001278407.1, NM_001291478.1 [Q9ULX6-2] NP_055186.3, NM_014371.3 [Q9ULX6-1]
UniGeneⁱ	Hs.399800

3D structure databases

ProteinModelPortalⁱ	Q9ULX6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117940, 42 interactors
CORUMⁱ	Q9ULX6
DIPⁱ	DIP-27541N
IntActⁱ	Q9ULX6, 89 interactors
MINTⁱ	Q9ULX6
STRINGⁱ	9606.ENSP00000380557

PTM databases

iPTMnetⁱ	Q9ULX6
PhosphoSitePlusⁱ	Q9ULX6

Polymorphism and mutation databases

BioMutaⁱ	AKAP8L
DMDMⁱ	296439446

Proteomic databases

EPDⁱ	Q9ULX6
PaxDbⁱ	Q9ULX6
PeptideAtlasⁱ	Q9ULX6
PRIDEⁱ	Q9ULX6
ProteomicsDBⁱ	85148

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26993
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000397410; ENSP00000380557; ENSG00000011243 [Q9ULX6-1] ENST00000595465; ENSP00000470952; ENSG00000011243 [Q9ULX6-2]
GeneIDⁱ	26993
KEGGⁱ	hsa:26993
UCSCⁱ	uc002naw.2 human [Q9ULX6-1]

Organism-specific databases

CTDⁱ	26993
DisGeNETⁱ	26993
EuPathDBⁱ	HostDB:ENSG00000011243.17
GeneCardsⁱ	AKAP8L
H-InvDBⁱ	HIX0014850 HIX0115658
HGNCⁱ	HGNC:29857 AKAP8L
HPAⁱ	HPA042485 HPA042546
MIMⁱ	609475 gene
neXtProtⁱ	NX_Q9ULX6
OpenTargetsⁱ	ENSG00000011243
PharmGKBⁱ	PA134867364
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIFX Eukaryota ENOG410YCRZ LUCA
GeneTreeⁱ	ENSGT00530000063777
HOGENOMⁱ	HOG000169111
HOVERGENⁱ	HBG104297
InParanoidⁱ	Q9ULX6
KOⁱ	K15978
OrthoDBⁱ	EOG091G0836
PhylomeDBⁱ	Q9ULX6
TreeFamⁱ	TF105407

Miscellaneous databases

ChiTaRSⁱ	AKAP8L human
GeneWikiⁱ	AKAP8L
GenomeRNAiⁱ	26993
Protein Ontology More...PROⁱ	PR:Q9ULX6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011243 Expressed in 215 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_AKAP8L
ExpressionAtlasⁱ	Q9ULX6 baseline and differential
Genevisibleⁱ	Q9ULX6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007071 AKAP95 IPR034736 ZF_C2H2_AKAP95
PANTHERⁱ	PTHR12190 PTHR12190, 1 hit
Pfamⁱ	View protein in Pfam PF04988 AKAP95, 1 hit
PROSITEⁱ	View protein in PROSITE PS51799 ZF_C2H2_AKAP95, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AKP8L_HUMAN
Accessionⁱ	Q9ULX6Primary (citable) accession number: Q9ULX6 Secondary accession number(s): B4DJ74 , B5BU90, O94792, Q96J58, Q9NRQ0, Q9UGM0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	September 12, 2018
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - Q9ULX6 (AKP8L_HUMAN)

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A-kinase anchor protein 8-like

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ