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UniProtKB - Q9ULX6 (AKP8L_HUMAN)

Entry version 191 (07 Oct 2020)
Sequence version 4 (12 Sep 2018)
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Protein

A-kinase anchor protein 8-like

Gene

AKAP8L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).1 Publication6 Publications
(Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.1 Publication
(Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.1 Publication
(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri391 – 413C2H2 AKAP95-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 507C2H2 AKAP95-type 2PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, mRNA processing, mRNA splicing, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULX6

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9ULX6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 8-like
Short name:
AKAP8-like protein
Alternative name(s):
Helicase A-binding protein 95
Short name:
HAP95
Homologous to AKAP95 protein
Short name:
HA95
Neighbor of A-kinase-anchoring protein 95
Short name:
Neighbor of AKAP95
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP8L
Synonyms:NAKAP, NAKAP95
ORF Names:HRIHFB2018
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000011243.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:29857, AKAP8L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609475, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULX6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26993

Open Targets

More...OpenTargetsi		ENSG00000011243

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134867364

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULX6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AKAP8L

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000753841 – 646A-kinase anchor protein 8-likeAdd BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei208Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei208Omega-N-methylarginine; alternateCombined sources1
Modified residuei217Omega-N-methylarginineCombined sources1
Modified residuei237Omega-N-methylarginineCombined sources1
Modified residuei247Omega-N-methylarginineCombined sources1
Modified residuei257N6-acetyllysineCombined sources1
Modified residuei267PhosphothreonineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei292PhosphothreonineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULX6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULX6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULX6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULX6

PeptideAtlas

More...PeptideAtlasi		Q9ULX6

PRoteomics IDEntifications database

More...PRIDEi		Q9ULX6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85148 [Q9ULX6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed in the brain cortex (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011243, Expressed in left lobe of thyroid gland and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULX6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULX6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011243, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with DHX9 (via RGG region) (PubMed:10748171, PubMed:11402034).

Interacts with TMPO isoform Beta, PRPF40A, RNF43, lamin-B (PubMed:11034899, PubMed:12538639 PubMed:16391387, PubMed:18313049).

Interacts with HDAC3; increased during mitosis (PubMed:16980585).

Interacts with EBV EBNA-LP (PubMed:11160753).

Interacts with HIV-1 reverse transcriptase/ribonuclease H (PubMed:25034436).

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9ULX6
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-357530,EBI-11096309
ATPAF2 [Q8N5M1]3EBI-357530,EBI-1166928
CARHSP1 [Q9Y2V2]3EBI-357530,EBI-718719
CATSPER1 [Q8NEC5]3EBI-357530,EBI-744545
CCDC120 [Q96HB5]3EBI-357530,EBI-744556
CCDC24 [Q8N4L8]3EBI-357530,EBI-1104933
CNNM3 [Q8NE01]3EBI-357530,EBI-741032
CREB5 - isoform 3 [Q02930-3]3EBI-357530,EBI-10192698
CSTF2 [P33240]3EBI-357530,EBI-711360
CSTF2T [Q9H0L4]3EBI-357530,EBI-747012
DGCR6 [Q14129]3EBI-357530,EBI-12206931
DMRT3 [Q9NQL9]3EBI-357530,EBI-9679045
ENKD1 [Q9H0I2]3EBI-357530,EBI-744099
FAM214B [Q7L5A3]3EBI-357530,EBI-745689
FAM222B [Q8WU58]3EBI-357530,EBI-2807642
FOXD4 [Q12950]3EBI-357530,EBI-11317801
FRS3 [O43559]3EBI-357530,EBI-725515
GPANK1 [O95872]3EBI-357530,EBI-751540
GPS2 [Q13227]3EBI-357530,EBI-713355
HDAC3 [O15379]5EBI-357530,EBI-607682
HEMK1 [Q9Y5R4]3EBI-357530,EBI-10329202
HGS [O14964]3EBI-357530,EBI-740220
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-357530,EBI-12056251
INCA1 [Q0VD86]3EBI-357530,EBI-6509505
KPRP [Q5T749]3EBI-357530,EBI-10981970
LAGE3 [Q14657]3EBI-357530,EBI-1052105
MPLKIP [Q8TAP9]3EBI-357530,EBI-11603426
MYOZ1 [Q9NP98]3EBI-357530,EBI-744402
MYPOP [Q86VE0]3EBI-357530,EBI-2858213
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-357530,EBI-11022007
PCDHB14 [Q9Y5E9]3EBI-357530,EBI-10329013
PEF1 [Q9UBV8]3EBI-357530,EBI-724639
PITX1 [P78337]3EBI-357530,EBI-748265
PKN1 [Q16512]3EBI-357530,EBI-602382
PLEKHN1 - isoform 3 [Q494U1-3]3EBI-357530,EBI-12014286
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-357530,EBI-12000762
PRKAA2 [P54646]3EBI-357530,EBI-1383852
RAMAC [Q9BTL3]3EBI-357530,EBI-744023
RNF43 [Q68DV7]2EBI-357530,EBI-1647060
RTP5 [Q14D33]3EBI-357530,EBI-10217913
RUSC1 [Q9BVN2]3EBI-357530,EBI-6257312
SAMD4A - isoform 3 [Q9UPU9-3]3EBI-357530,EBI-11986417
SAXO1 [Q8IYX7]3EBI-357530,EBI-3957636
SH3RF2 [Q8TEC5]3EBI-357530,EBI-2130111
SNRPC [P09234]3EBI-357530,EBI-766589
TEKT4 [Q8WW24]3EBI-357530,EBI-750487
TEKT5 [Q96M29]3EBI-357530,EBI-10239812
TENT5B [Q96A09]3EBI-357530,EBI-752030
TFAP2D [Q7Z6R9]3EBI-357530,EBI-11952651
TIAL1 - isoform 2 [Q01085-2]3EBI-357530,EBI-11064654
TLE5 - isoform 2 [Q08117-2]3EBI-357530,EBI-11741437
TMSB4X [P62328]3EBI-357530,EBI-712598
TRIB3 [Q96RU7]3EBI-357530,EBI-492476
TSGA10IP [Q3SY00]3EBI-357530,EBI-10241197
TYK2 [P29597]3EBI-357530,EBI-1383454
WDR25 - isoform 2 [Q64LD2-2]3EBI-357530,EBI-12032042
ZIC1 [Q15915]3EBI-357530,EBI-11963196
ZNF366 [Q8N895]3EBI-357530,EBI-2813661
ZNF785 [A8K8V0]3EBI-357530,EBI-3925400
Prpf40a [Q9R1C7] from Mus musculus.3EBI-357530,EBI-645554
Serine protease NS3 (PRO_0000308465) from Dengue virus type 2 (strain 16681-PDK53).3EBI-357530,EBI-8826747

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117940, 127 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9ULX6

Database of interacting proteins

More...DIPi		DIP-27541N

Protein interaction database and analysis system

More...IntActi		Q9ULX6, 116 interactors

Molecular INTeraction database

More...MINTi		Q9ULX6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380557

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULX6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULX6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 268Sufficient for activation of CTE-mediated expression1 PublicationAdd BLAST268

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi274 – 279Nuclear localization signalSequence analysis6
Motifi280 – 296Nuclear export signal (NES)1 PublicationAdd BLAST17
Motifi362 – 364Nuclear localization signalSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 52Gly/Tyr-richAdd BLAST12
Compositional biasi589 – 597Pro-rich9
Compositional biasi602 – 608Pro-rich7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP95 family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri391 – 413C2H2 AKAP95-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 507C2H2 AKAP95-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSFC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063777

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024193_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULX6

KEGG Orthology (KO)

More...KOi		K15978

Identification of Orthologs from Complete Genome Data

More...OMAi		NWKMWDA

Database of Orthologous Groups

More...OrthoDBi		902224at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULX6

TreeFam database of animal gene trees

More...TreeFami		TF105407

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007071, AKAP95
IPR034736, ZF_C2H2_AKAP95

The PANTHER Classification System

More...PANTHERi		PTHR12190, PTHR12190, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04988, AKAP95, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51799, ZF_C2H2_AKAP95, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG 
        60         70         80         90        100
YGQDNTTNYG YGMATSHSWE MPSSDTNANT SASGSASADS VLSRINQRLD 
       110        120        130        140        150
MVPHLETDMM QGGVYGSGGE RYDSYESCDS RAVLSERDLY RSGYDYSELD 
       160        170        180        190        200
PEMEMAYEGQ YDAYRDQFRM RGNDTFGPRA QGWARDARSG RPMASGYGRM 
       210        220        230        240        250
WEDPMGARGQ CMSGASRLPS LFSQNIIPEY GMFQGMRGGG AFPGGSRFGF 
       260        270        280        290        300
GFGNGMKQMR RTWKTWTTAD FRTKKKKRKQ GGSPDEPDSK ATRTDCSDNS 
       310        320        330        340        350
DSDNDEGTEG EATEGLEGTE AVEKGSRVDG EDEEGKEDGR EEGKEDPEKG 
       360        370        380        390        400
ALTTQDENGQ TKRKLQAGKK SQDKQKKRQR DRMVERIQFV CSLCKYRTFY 
       410        420        430        440        450
EDEMASHLDS KFHKEHFKYV GTKLPKQTAD FLQEYVTNKT KKTEELRKTV 
       460        470        480        490        500
EDLDGLIQQI YRDQDLTQEI AMEHFVKKVE AAHCAACDLF IPMQFGIIQK 
       510        520        530        540        550
HLKTMDHNRN RRLMMEQSKK SSLMVARSIL NNKLISKKLE RYLKGENPFT 
       560        570        580        590        600
DSPEEEKEQE EAEGGALDEG AQGEAAGISE GAEGVPAQPP VPPEPAPGAV 
       610        620        630        640 
SPPPPPPPEE EEEGAVPLLG GALQRQIRGI PGLDVEDDEE GGGGAP
Length:646
Mass (Da):71,640
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBC265BF25996BA2
GO
Isoform 2 (identifier: Q9ULX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-121: Missing.

Show »
Length:585
Mass (Da):65,221
Checksum:i6315372DFB1DAF9E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ50V9GZ50_HUMAN
A kinase (PRKA) anchor protein 8-li...
AKAP8L hCG_36782
431Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1Y5M0R1Y5_HUMAN
A-kinase anchor protein 8-like
AKAP8L
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R008M0R008_HUMAN
A-kinase anchor protein 8-like
AKAP8L
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYT7M0QYT7_HUMAN
A-kinase anchor protein 8-like
AKAP8L
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R010M0R010_HUMAN
A-kinase anchor protein 8-like
AKAP8L
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1L5M0R1L5_HUMAN
A-kinase anchor protein 8-like
AKAP8L
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF86048 differs from that shown. Reason: Frameshift.Curated
The sequence BAA34791 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100D → N in AAF86048 (PubMed:10748171).Curated1
Sequence conflicti189S → N in AAF86048 (PubMed:10748171).Curated1
Sequence conflicti351 – 358ALTTQDEN → EFSWGAWC in BAA34791 (PubMed:9853615).Curated8
Sequence conflicti599 – 616AVSPP…EEGAV → GRVAATAAAPRRRRRRAPW in AAF86048 (PubMed:10748171).CuratedAdd BLAST18
Sequence conflicti641 – 646GGGGAP → EGRRGRPV in AAF86048 (PubMed:10748171).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068822458Q → H1 PublicationCorresponds to variant dbSNP:rs2058322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04442661 – 121Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB025905 mRNA Translation: BAA85003.1
AJ243467 mRNA Translation: CAB65092.1
AF199414 mRNA Translation: AAF86048.1 Frameshift.
AK295956 mRNA Translation: BAG58736.1
AB451326 mRNA Translation: BAG70140.1
AB451469 mRNA Translation: BAG70283.1
AC005785 Genomic DNA No translation available.
AC006128 Genomic DNA No translation available.
KF456508 Genomic DNA No translation available.
KF456511 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84475.1
BC000713 mRNA Translation: AAH00713.1
AB015332 mRNA Translation: BAA34791.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46005.1 [Q9ULX6-1]
CCDS77249.1 [Q9ULX6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001278407.1, NM_001291478.1 [Q9ULX6-2]
NP_055186.3, NM_014371.3 [Q9ULX6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397410; ENSP00000380557; ENSG00000011243 [Q9ULX6-1]
ENST00000595465; ENSP00000470952; ENSG00000011243 [Q9ULX6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26993

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26993

UCSC genome browser

More...UCSCi		uc002naw.2, human [Q9ULX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025905 mRNA Translation: BAA85003.1
AJ243467 mRNA Translation: CAB65092.1
AF199414 mRNA Translation: AAF86048.1 Frameshift.
AK295956 mRNA Translation: BAG58736.1
AB451326 mRNA Translation: BAG70140.1
AB451469 mRNA Translation: BAG70283.1
AC005785 Genomic DNA No translation available.
AC006128 Genomic DNA No translation available.
KF456508 Genomic DNA No translation available.
KF456511 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84475.1
BC000713 mRNA Translation: AAH00713.1
AB015332 mRNA Translation: BAA34791.1 Different initiation.
CCDSiCCDS46005.1 [Q9ULX6-1]
CCDS77249.1 [Q9ULX6-2]
RefSeqiNP_001278407.1, NM_001291478.1 [Q9ULX6-2]
NP_055186.3, NM_014371.3 [Q9ULX6-1]

3D structure databases

SMRiQ9ULX6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117940, 127 interactors
CORUMiQ9ULX6
DIPiDIP-27541N
IntActiQ9ULX6, 116 interactors
MINTiQ9ULX6
STRINGi9606.ENSP00000380557

PTM databases

iPTMnetiQ9ULX6
PhosphoSitePlusiQ9ULX6

Polymorphism and mutation databases

BioMutaiAKAP8L
DMDMi296439446

Proteomic databases

EPDiQ9ULX6
jPOSTiQ9ULX6
MassIVEiQ9ULX6
PaxDbiQ9ULX6
PeptideAtlasiQ9ULX6
PRIDEiQ9ULX6
ProteomicsDBi85148 [Q9ULX6-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7497, 180 antibodies

The DNASU plasmid repository

More...DNASUi		26993

Genome annotation databases

EnsembliENST00000397410; ENSP00000380557; ENSG00000011243 [Q9ULX6-1]
ENST00000595465; ENSP00000470952; ENSG00000011243 [Q9ULX6-2]
GeneIDi26993
KEGGihsa:26993
UCSCiuc002naw.2, human [Q9ULX6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26993
DisGeNETi26993
EuPathDBiHostDB:ENSG00000011243.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		AKAP8L
HGNCiHGNC:29857, AKAP8L
HPAiENSG00000011243, Low tissue specificity
MIMi609475, gene
neXtProtiNX_Q9ULX6
OpenTargetsiENSG00000011243
PharmGKBiPA134867364

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSFC, Eukaryota
GeneTreeiENSGT00530000063777
HOGENOMiCLU_024193_0_0_1
InParanoidiQ9ULX6
KOiK15978
OMAiNWKMWDA
OrthoDBi902224at2759
PhylomeDBiQ9ULX6
TreeFamiTF105407

Enzyme and pathway databases

PathwayCommonsiQ9ULX6
SIGNORiQ9ULX6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26993, 7 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AKAP8L, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AKAP8L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26993
PharosiQ9ULX6, Tbio

Protein Ontology

More...PROi		PR:Q9ULX6
RNActiQ9ULX6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000011243, Expressed in left lobe of thyroid gland and 229 other tissues
ExpressionAtlasiQ9ULX6, baseline and differential
GenevisibleiQ9ULX6, HS

Family and domain databases

InterProiView protein in InterPro
IPR007071, AKAP95
IPR034736, ZF_C2H2_AKAP95
PANTHERiPTHR12190, PTHR12190, 1 hit
PfamiView protein in Pfam
PF04988, AKAP95, 1 hit
PROSITEiView protein in PROSITE
PS51799, ZF_C2H2_AKAP95, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKP8L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULX6
Secondary accession number(s): B4DJ74
, B5BU90, O94792, Q96J58, Q9NRQ0, Q9UGM0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: September 12, 2018
Last modified: October 7, 2020
This is version 191 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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