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Entry version 156 (16 Oct 2019)
Sequence version 2 (21 Dec 2004)
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Protein

Protein-arginine deiminase type-3

Gene

PADI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the deimination of arginine residues of proteins.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06944-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.3.15 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3247509 Chromatin modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-arginine deiminase type-3 (EC:3.5.3.151 Publication)
Alternative name(s):
Peptidylarginine deiminase III
Protein-arginine deiminase type III
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PADI3
Synonyms:PAD3, PDI3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18337 PADI3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606755 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Uncombable hair syndrome 1 (UHS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of uncombable hair syndrome, a condition characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair. Most individuals are affected early in childhood and the hair takes on a spun-glass appearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. The hair growth rate can range from slow to normal, and the condition improves with age. UHS1 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078023112L → H in UHS1; forms large aggregates; decreases protein-arginine deiminase activity. 1 PublicationCorresponds to variant dbSNP:rs142129409EnsemblClinVar.1
Natural variantiVAR_078024294A → V in UHS1; forms large aggregates; decreases protein-arginine deiminase activity. 1 PublicationCorresponds to variant dbSNP:rs144080386EnsemblClinVar.1
Natural variantiVAR_078025605P → T in UHS1; forms large aggregates; decreases protein-arginine deiminase activity. 1 PublicationCorresponds to variant dbSNP:rs144944758EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
51702

MalaCards human disease database

More...
MalaCardsi
PADI3
MIMi191480 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000142619

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1410 Uncombable hair syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32901

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULW8

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1909488

Drug and drug target database

More...
DrugBanki
DB00155 L-Citrulline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PADI3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56757696

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002200291 – 664Protein-arginine deiminase type-3Add BLAST664

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9ULW8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULW8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9ULW8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9ULW8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULW8

PeptideAtlas

More...
PeptideAtlasi
Q9ULW8

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULW8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85144

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9ULW8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hair follicles, and epidermis at very low levels.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142619 Expressed in 37 organ(s), highest expression level in lower esophagus mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9ULW8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10488185,EBI-10488185

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119686, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULW8, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364609

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9ULW8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1664
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9ULW8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153217

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220908

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ULW8

KEGG Orthology (KO)

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KOi
K01481

Identification of Orthologs from Complete Genome Data

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OMAi
SPSACYQ

Database of Orthologous Groups

More...
OrthoDBi
787070at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULW8

TreeFam database of animal gene trees

More...
TreeFami
TF331952

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1700, 1 hit
2.60.40.1860, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10837 PTHR10837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001247 Protein-arginine_deiminase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ULW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLQRIVRVS LEHPTSAVCV AGVETLVDIY GSVPEGTEMF EVYGTPGVDI
60 70 80 90 100
YISPNMERGR ERADTRRWRF DATLEIIVVM NSPSNDLNDS HVQISYHSSH
110 120 130 140 150
EPLPLAYAVL YLTCVDISLD CDLNCEGRQD RNFVDKRQWV WGPSGYGGIL
160 170 180 190 200
LVNCDRDDPS CDVQDNCDQH VHCLQDLEDM SVMVLRTQGP AALFDDHKLV
210 220 230 240 250
LHTSSYDAKR AQVFHICGPE DVCEAYRHVL GQDKVSYEVP RLHGDEERFF
260 270 280 290 300
VEGLSFPDAG FTGLISFHVT LLDDSNEDFS ASPIFTDTVV FRVAPWIMTP
310 320 330 340 350
STLPPLEVYV CRVRNNTCFV DAVAELARKA GCKLTICPQA ENRNDRWIQD
360 370 380 390 400
EMELGYVQAP HKTLPVVFDS PRNGELQDFP YKRILGPDFG YVTREPRDRS
410 420 430 440 450
VSGLDSFGNL EVSPPVVANG KEYPLGRILI GGNLPGSSGR RVTQVVRDFL
460 470 480 490 500
HAQKVQPPVE LFVDWLAVGH VDEFLSFVPA PDGKGFRMLL ASPGACFKLF
510 520 530 540 550
QEKQKCGHGR ALLFQGVVDD EQVKTISINQ VLSNKDLINY NKFVQSCIDW
560 570 580 590 600
NREVLKRELG LAECDIIDIP QLFKTERKKA TAFFPDLVNM LVLGKHLGIP
610 620 630 640 650
KPFGPIINGC CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV
660
CRKPFSFKWW NMVP
Length:664
Mass (Da):74,743
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90C22A50BF6FD480
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti480A → V in BAA85974 (PubMed:11069618).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02046252I → V. Corresponds to variant dbSNP:rs3750300Ensembl.1
Natural variantiVAR_078023112L → H in UHS1; forms large aggregates; decreases protein-arginine deiminase activity. 1 PublicationCorresponds to variant dbSNP:rs142129409EnsemblClinVar.1
Natural variantiVAR_020463171V → M. Corresponds to variant dbSNP:rs2272629Ensembl.1
Natural variantiVAR_078024294A → V in UHS1; forms large aggregates; decreases protein-arginine deiminase activity. 1 PublicationCorresponds to variant dbSNP:rs144080386EnsemblClinVar.1
Natural variantiVAR_035502509G → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs781009577Ensembl.1
Natural variantiVAR_053558582A → T. Corresponds to variant dbSNP:rs34097903EnsemblClinVar.1
Natural variantiVAR_078025605P → T in UHS1; forms large aggregates; decreases protein-arginine deiminase activity. 1 PublicationCorresponds to variant dbSNP:rs144944758EnsemblClinVar.1
Natural variantiVAR_053559618R → Q. Corresponds to variant dbSNP:rs35624745Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026831 mRNA Translation: BAA85974.1
AJ549502 Genomic DNA Translation: CAE47742.1
AL590644 Genomic DNA No translation available.
BC041592 mRNA Translation: AAH41592.1
BC109091 mRNA Translation: AAI09092.1
BC109092 mRNA Translation: AAI09093.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS179.1

NCBI Reference Sequences

More...
RefSeqi
NP_057317.2, NM_016233.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375460; ENSP00000364609; ENSG00000142619
ENST00000625769; ENSP00000486702; ENSG00000280549

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51702

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51702

UCSC genome browser

More...
UCSCi
uc001bai.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026831 mRNA Translation: BAA85974.1
AJ549502 Genomic DNA Translation: CAE47742.1
AL590644 Genomic DNA No translation available.
BC041592 mRNA Translation: AAH41592.1
BC109091 mRNA Translation: AAI09092.1
BC109092 mRNA Translation: AAI09093.1
CCDSiCCDS179.1
RefSeqiNP_057317.2, NM_016233.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CE1X-ray2.80A1-664[»]
SMRiQ9ULW8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119686, 20 interactors
IntActiQ9ULW8, 16 interactors
STRINGi9606.ENSP00000364609

Chemistry databases

BindingDBiQ9ULW8
ChEMBLiCHEMBL1909488
DrugBankiDB00155 L-Citrulline

PTM databases

iPTMnetiQ9ULW8
PhosphoSitePlusiQ9ULW8

Polymorphism and mutation databases

BioMutaiPADI3
DMDMi56757696

Proteomic databases

EPDiQ9ULW8
jPOSTiQ9ULW8
MassIVEiQ9ULW8
MaxQBiQ9ULW8
PaxDbiQ9ULW8
PeptideAtlasiQ9ULW8
PRIDEiQ9ULW8
ProteomicsDBi85144
TopDownProteomicsiQ9ULW8

Genome annotation databases

EnsembliENST00000375460; ENSP00000364609; ENSG00000142619
ENST00000625769; ENSP00000486702; ENSG00000280549
GeneIDi51702
KEGGihsa:51702
UCSCiuc001bai.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51702
DisGeNETi51702

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PADI3
HGNCiHGNC:18337 PADI3
HPAiHPA043739
MalaCardsiPADI3
MIMi191480 phenotype
606755 gene
neXtProtiNX_Q9ULW8
OpenTargetsiENSG00000142619
Orphaneti1410 Uncombable hair syndrome
PharmGKBiPA32901

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00940000153217
HOGENOMiHOG000220908
InParanoidiQ9ULW8
KOiK01481
OMAiSPSACYQ
OrthoDBi787070at2759
PhylomeDBiQ9ULW8
TreeFamiTF331952

Enzyme and pathway databases

BioCyciMetaCyc:HS06944-MONOMER
BRENDAi3.5.3.15 2681
ReactomeiR-HSA-3247509 Chromatin modifying enzymes

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PADI3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51702
PharosiQ9ULW8

Protein Ontology

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PROi
PR:Q9ULW8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000142619 Expressed in 37 organ(s), highest expression level in lower esophagus mucosa
GenevisibleiQ9ULW8 HS

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPADI3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULW8
Secondary accession number(s): Q58EY7, Q70SX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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