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Protein

Ras-related protein Rab-26

Gene

RAB26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi70 – 78GTP1 Publication9
Nucleotide bindingi119 – 123GTP1 Publication5
Nucleotide bindingi177 – 180GTP1 Publication4
Nucleotide bindingi207 – 209GTP1 Publication3

GO - Molecular functioni

  • GMP binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:RAB26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000167964.12
HGNCiHGNC:14259 RAB26
MIMi605455 gene
neXtProtiNX_Q9ULW5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77T → N: Inactive, constitutively GDP-bound. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 2 Publications1
Mutagenesisi123Q → L: Constitutively activated. 1 Publication1
Mutagenesisi177N → I: Inactive, due to loss of GNP binding. Abolishes location at Golgi membranes. Impairs transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000167964
PharmGKBiPA34116

Polymorphism and mutation databases

BioMutaiRAB26
DMDMi134044256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212181 – 256Ras-related protein Rab-26Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi253S-geranylgeranyl cysteineBy similarity1
Lipidationi254S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiQ9ULW5
PeptideAtlasiQ9ULW5
PRIDEiQ9ULW5
ProteomicsDBi85142

PTM databases

iPTMnetiQ9ULW5
PhosphoSitePlusiQ9ULW5

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Gene expression databases

BgeeiENSG00000167964 Expressed in 151 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_RAB26
ExpressionAtlasiQ9ULW5 baseline and differential
GenevisibleiQ9ULW5 HS

Organism-specific databases

HPAiHPA075624

Interactioni

Subunit structurei

Interacts with RIMS1 (By similarity). Interacts with ADRA2B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRA2BP180894EBI-958239,EBI-9077302

Protein-protein interaction databases

BioGridi117364, 10 interactors
IntActiQ9ULW5, 8 interactors
STRINGi9606.ENSP00000210187

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ULW5
SMRiQ9ULW5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULW5

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi93 – 101Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9ULW5
KOiK07913
OMAiVRGSGCC
OrthoDBiEOG091G0JXU
PhylomeDBiQ9ULW5
TreeFamiTF323428

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRKKTPKSK GASTPAASTL PTANGARPAR SGTALSGPDA PPNGPLQPGR
60 70 80 90 100
PSLGGGVDFY DVAFKVMLVG DSGVGKTCLL VRFKDGAFLA GTFISTVGID
110 120 130 140 150
FRNKVLDVDG VKVKLQMWDT AGQERFRSVT HAYYRDAHAL LLLYDVTNKA
160 170 180 190 200
SFDNIQAWLT EIHEYAQHDV ALMLLGNKVD SAHERVVKRE DGEKLAKEYG
210 220 230 240 250
LPFMETSAKT GLNVDLAFTA IAKELKQRSM KAPSEPRFRL HDYVKREGRG

ASCCRP
Length:256
Mass (Da):27,900
Last modified:March 6, 2007 - v3
Checksum:i575232F4B9E7FA7E
GO
Isoform 2 (identifier: Q9ULW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,355
Checksum:i517387B7C0B3291C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMG6H3BMG6_HUMAN
Ras-related protein Rab-26
RAB26
64Annotation score:
H3BQ97H3BQ97_HUMAN
Ras-related protein Rab-26
RAB26
136Annotation score:

Sequence cautioni

The sequence BAA84707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227Q → R in AAH66913 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568791 – 66Missing in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646153 mRNA Translation: AAU88191.1
AK314110 mRNA Translation: BAG36803.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85552.1
BC066913 mRNA Translation: AAH66913.1
AB027137 mRNA Translation: BAA84707.1 Different initiation.
AF498952 mRNA Translation: AAM21100.1
CCDSiCCDS10460.1 [Q9ULW5-1]
CCDS76806.1 [Q9ULW5-2]
RefSeqiNP_001294982.1, NM_001308053.1 [Q9ULW5-2]
NP_055168.2, NM_014353.4 [Q9ULW5-1]
UniGeneiHs.3797

Genome annotation databases

EnsembliENST00000210187; ENSP00000210187; ENSG00000167964 [Q9ULW5-1]
ENST00000541451; ENSP00000441580; ENSG00000167964 [Q9ULW5-2]
GeneIDi25837
KEGGihsa:25837
UCSCiuc002cou.4 human [Q9ULW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY646153 mRNA Translation: AAU88191.1
AK314110 mRNA Translation: BAG36803.1
AC009065 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85552.1
BC066913 mRNA Translation: AAH66913.1
AB027137 mRNA Translation: BAA84707.1 Different initiation.
AF498952 mRNA Translation: AAM21100.1
CCDSiCCDS10460.1 [Q9ULW5-1]
CCDS76806.1 [Q9ULW5-2]
RefSeqiNP_001294982.1, NM_001308053.1 [Q9ULW5-2]
NP_055168.2, NM_014353.4 [Q9ULW5-1]
UniGeneiHs.3797

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6BX-ray2.00A56-233[»]
ProteinModelPortaliQ9ULW5
SMRiQ9ULW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117364, 10 interactors
IntActiQ9ULW5, 8 interactors
STRINGi9606.ENSP00000210187

PTM databases

iPTMnetiQ9ULW5
PhosphoSitePlusiQ9ULW5

Polymorphism and mutation databases

BioMutaiRAB26
DMDMi134044256

Proteomic databases

PaxDbiQ9ULW5
PeptideAtlasiQ9ULW5
PRIDEiQ9ULW5
ProteomicsDBi85142

Protocols and materials databases

DNASUi25837
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000210187; ENSP00000210187; ENSG00000167964 [Q9ULW5-1]
ENST00000541451; ENSP00000441580; ENSG00000167964 [Q9ULW5-2]
GeneIDi25837
KEGGihsa:25837
UCSCiuc002cou.4 human [Q9ULW5-1]

Organism-specific databases

CTDi25837
EuPathDBiHostDB:ENSG00000167964.12
GeneCardsiRAB26
HGNCiHGNC:14259 RAB26
HPAiHPA075624
MIMi605455 gene
neXtProtiNX_Q9ULW5
OpenTargetsiENSG00000167964
PharmGKBiPA34116
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9ULW5
KOiK07913
OMAiVRGSGCC
OrthoDBiEOG091G0JXU
PhylomeDBiQ9ULW5
TreeFamiTF323428

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

EvolutionaryTraceiQ9ULW5
GeneWikiiRAB26
GenomeRNAii25837
PROiPR:Q9ULW5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167964 Expressed in 151 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_RAB26
ExpressionAtlasiQ9ULW5 baseline and differential
GenevisibleiQ9ULW5 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB26_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW5
Secondary accession number(s): B2RAA6, Q3L6K5, Q6NXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 6, 2007
Last modified: November 7, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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