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Protein

Activator of basal transcription 1

Gene

ABT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of basal transcription 1
Short name:
hABT1
Alternative name(s):
Basal transcriptional activator
Gene namesi
Name:ABT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146109.4
HGNCiHGNC:17369 ABT1
neXtProtiNX_Q9ULW3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29777
OpenTargetsiENSG00000146109
PharmGKBiPA38451

Polymorphism and mutation databases

BioMutaiABT1
DMDMi74753396

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331681 – 272Activator of basal transcription 1Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9ULW3
MaxQBiQ9ULW3
PaxDbiQ9ULW3
PeptideAtlasiQ9ULW3
PRIDEiQ9ULW3
ProteomicsDBi85141

PTM databases

iPTMnetiQ9ULW3
PhosphoSitePlusiQ9ULW3

Expressioni

Gene expression databases

BgeeiENSG00000146109 Expressed in 189 organ(s), highest expression level in leukocyte
CleanExiHS_ABT1
ExpressionAtlasiQ9ULW3 baseline and differential
GenevisibleiQ9ULW3 HS

Organism-specific databases

HPAiHPA077039

Interactioni

Subunit structurei

Interacts with ESF1/ABTAP (By similarity). Interacts with IGHMBP2.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi118909, 34 interactors
IntActiQ9ULW3, 22 interactors
STRINGi9606.ENSP00000274849

Structurei

3D structure databases

ProteinModelPortaliQ9ULW3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 142RRMAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili161 – 191Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 94Poly-Ala5

Sequence similaritiesi

Belongs to the ESF2/ABP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3152 Eukaryota
ENOG4111JJV LUCA
GeneTreeiENSGT00390000002062
HOGENOMiHOG000242500
HOVERGENiHBG057308
InParanoidiQ9ULW3
KOiK14785
OMAiLSGFKWV
OrthoDBiEOG091G0G6C
PhylomeDBiQ9ULW3
TreeFamiTF314506

Family and domain databases

CDDicd12263 RRM_ABT1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR039119 ABT1/Esf2
IPR034353 ABT1/ESF2_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
PANTHERiPTHR12311 PTHR12311, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ULW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEESEKAA TEQEPLEGTE QTLDAEEEQE ESEEAACGSK KRVVPGIVYL
60 70 80 90 100
GHIPPRFRPL HVRNLLSAYG EVGRVFFQAE DRFVRRKKKA AAAAGGKKRS
110 120 130 140 150
YTKDYTEGWV EFRDKRIAKR VAASLHNTPM GARRRSPFRY DLWNLKYLHR
160 170 180 190 200
FTWSHLSEHL AFERQVRRQR LRAEVAQAKR ETDFYLQSVE RGQRFLAADG
210 220 230 240 250
DPARPDGSWT FAQRPTEQEL RARKAARPGG RERARLATAQ DKARSNKGLL
260 270
ARIFGAPPPS ESMEGPSLVR DS
Length:272
Mass (Da):31,079
Last modified:May 1, 2000 - v1
Checksum:iFB9B44192C16BD8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027258 mRNA Translation: BAA86886.1
AL513548 Genomic DNA No translation available.
BC048812 mRNA Translation: AAH48812.1
BC066313 mRNA Translation: AAH66313.1
CCDSiCCDS4616.1
RefSeqiNP_037507.1, NM_013375.3
UniGeneiHs.254406

Genome annotation databases

EnsembliENST00000274849; ENSP00000274849; ENSG00000146109
GeneIDi29777
KEGGihsa:29777
UCSCiuc003nii.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027258 mRNA Translation: BAA86886.1
AL513548 Genomic DNA No translation available.
BC048812 mRNA Translation: AAH48812.1
BC066313 mRNA Translation: AAH66313.1
CCDSiCCDS4616.1
RefSeqiNP_037507.1, NM_013375.3
UniGeneiHs.254406

3D structure databases

ProteinModelPortaliQ9ULW3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118909, 34 interactors
IntActiQ9ULW3, 22 interactors
STRINGi9606.ENSP00000274849

PTM databases

iPTMnetiQ9ULW3
PhosphoSitePlusiQ9ULW3

Polymorphism and mutation databases

BioMutaiABT1
DMDMi74753396

Proteomic databases

EPDiQ9ULW3
MaxQBiQ9ULW3
PaxDbiQ9ULW3
PeptideAtlasiQ9ULW3
PRIDEiQ9ULW3
ProteomicsDBi85141

Protocols and materials databases

DNASUi29777
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274849; ENSP00000274849; ENSG00000146109
GeneIDi29777
KEGGihsa:29777
UCSCiuc003nii.4 human

Organism-specific databases

CTDi29777
DisGeNETi29777
EuPathDBiHostDB:ENSG00000146109.4
GeneCardsiABT1
HGNCiHGNC:17369 ABT1
HPAiHPA077039
neXtProtiNX_Q9ULW3
OpenTargetsiENSG00000146109
PharmGKBiPA38451
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3152 Eukaryota
ENOG4111JJV LUCA
GeneTreeiENSGT00390000002062
HOGENOMiHOG000242500
HOVERGENiHBG057308
InParanoidiQ9ULW3
KOiK14785
OMAiLSGFKWV
OrthoDBiEOG091G0G6C
PhylomeDBiQ9ULW3
TreeFamiTF314506

Miscellaneous databases

ChiTaRSiABT1 human
GenomeRNAii29777
PROiPR:Q9ULW3

Gene expression databases

BgeeiENSG00000146109 Expressed in 189 organ(s), highest expression level in leukocyte
CleanExiHS_ABT1
ExpressionAtlasiQ9ULW3 baseline and differential
GenevisibleiQ9ULW3 HS

Family and domain databases

CDDicd12263 RRM_ABT1_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR039119 ABT1/Esf2
IPR034353 ABT1/ESF2_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
PANTHERiPTHR12311 PTHR12311, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABT1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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