UniProtKB - Q9ULW2 (FZD10_HUMAN)
Frizzled-10
FZD10
Functioni
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).
The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
By similarityCuratedGO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- Wnt-activated receptor activity Source: WormBase
- Wnt-protein binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: WormBase
- cellular response to retinoic acid Source: UniProtKB
- negative regulation of GTPase activity Source: BHF-UCL
- neuron differentiation Source: UniProtKB
- non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
- positive regulation of GTPase activity Source: BHF-UCL
- positive regulation of JUN kinase activity Source: BHF-UCL
- regulation of actin cytoskeleton organization Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9ULW2 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | Q9ULW2 |
SIGNORi | Q9ULW2 |
Names & Taxonomyi
Protein namesi | Recommended name: Frizzled-10Short name: Fz-10 Short name: hFz10 Alternative name(s): FzE7 CD_antigen: CD350 |
Gene namesi | Name:FZD10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4039, FZD10 |
MIMi | 606147, gene |
neXtProti | NX_Q9ULW2 |
VEuPathDBi | HostDB:ENSG00000111432 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: BHF-UCL
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 225 | ExtracellularSequence analysisAdd BLAST | 205 | |
Transmembranei | 226 – 246 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 247 – 262 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 263 – 283 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 311 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 312 – 332 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 333 – 351 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 352 – 372 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 373 – 393 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 394 – 414 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 415 – 443 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 444 – 464 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 465 – 502 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 503 – 523 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 524 – 581 | CytoplasmicSequence analysisAdd BLAST | 58 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11211 |
OpenTargetsi | ENSG00000111432 |
PharmGKBi | PA28456 |
Miscellaneous databases
Pharosi | Q9ULW2, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523492 |
Genetic variation databases
BioMutai | FZD10 |
DMDMi | 17433091 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000013005 | 21 – 581 | Frizzled-10Add BLAST | 561 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 95 | PROSITE-ProRule annotation | ||
Disulfide bondi | 42 ↔ 88 | PROSITE-ProRule annotation | ||
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 79 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 106 ↔ 147 | PROSITE-ProRule annotation | ||
Disulfide bondi | 110 ↔ 134 | PROSITE-ProRule annotation | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
jPOSTi | Q9ULW2 |
MassIVEi | Q9ULW2 |
MaxQBi | Q9ULW2 |
PaxDbi | Q9ULW2 |
PeptideAtlasi | Q9ULW2 |
PRIDEi | Q9ULW2 |
ProteomicsDBi | 85140 |
PTM databases
GlyGeni | Q9ULW2, 3 sites |
iPTMneti | Q9ULW2 |
PhosphoSitePlusi | Q9ULW2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000111432, Expressed in vagina and 145 other tissues |
ExpressionAtlasi | Q9ULW2, baseline and differential |
Genevisiblei | Q9ULW2, HS |
Organism-specific databases
HPAi | ENSG00000111432, Tissue enhanced (esophagus, skin) |
Interactioni
Subunit structurei
Interacts with WNT7B (By similarity).
Interacts with MYOC (PubMed:19188438).
By similarity1 PublicationBinary interactionsi
Q9ULW2
GO - Molecular functioni
- Wnt-protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116380, 70 interactors |
IntActi | Q9ULW2, 55 interactors |
STRINGi | 9606.ENSP00000229030 |
Miscellaneous databases
RNActi | Q9ULW2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 150 | FZPROSITE-ProRule annotationAdd BLAST | 122 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 560 – 581 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 526 – 531 | Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity | 6 | |
Motifi | 579 – 581 | PDZ-binding | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000161861 |
HOGENOMi | CLU_007873_2_1_1 |
InParanoidi | Q9ULW2 |
OMAi | LMGHDDQ |
OrthoDBi | 509772at2759 |
PhylomeDBi | Q9ULW2 |
TreeFami | TF317907 |
Family and domain databases
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR000539, Frizzled/Smoothened_TM IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR026549, FZD10 IPR017981, GPCR_2-like |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF86, PTHR11309:SF86, 1 hit |
Pfami | View protein in Pfam PF01534, Frizzled, 1 hit PF01392, Fz, 1 hit |
PRINTSi | PR00489, FRIZZLED |
SMARTi | View protein in SMART SM00063, FRI, 1 hit SM01330, Frizzled, 1 hit |
SUPFAMi | SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT
60 70 80 90 100
RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS
110 120 130 140 150
TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA
160 170 180 190 200
PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH
210 220 230 240 250
VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF SSAFTVLTFL
260 270 280 290 300
IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI
310 320 330 340 350
QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN
360 370 380 390 400
SSYFHLAAWA IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI
410 420 430 440 450
PLACYLVIGT SFILSGFVAL FHIRRVMKTG GENTDKLEKL MVRIGLFSVL
460 470 480 490 500
YTVPATCVIA CYFYERLNMD YWKILAAQHK CKMNNQTKTL DCLMAASIPA
510 520 530 540 550
VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK KKSRRKPASV
560 570 580
ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5H450 | F5H450_HUMAN | Frizzled-10 | FZD10 | 454 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB027464 mRNA Translation: BAA84093.1 BC074997 mRNA Translation: AAH74997.1 BC074998 mRNA Translation: AAH74998.1 |
CCDSi | CCDS9267.1 |
PIRi | JC7086 |
RefSeqi | NP_009128.1, NM_007197.3 |
Genome annotation databases
Ensembli | ENST00000229030.5; ENSP00000229030.4; ENSG00000111432.5 |
GeneIDi | 11211 |
KEGGi | hsa:11211 |
MANE-Selecti | ENST00000229030.5; ENSP00000229030.4; NM_007197.4; NP_009128.1 |
UCSCi | uc001uii.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB027464 mRNA Translation: BAA84093.1 BC074997 mRNA Translation: AAH74997.1 BC074998 mRNA Translation: AAH74998.1 |
CCDSi | CCDS9267.1 |
PIRi | JC7086 |
RefSeqi | NP_009128.1, NM_007197.3 |
3D structure databases
AlphaFoldDBi | Q9ULW2 |
SMRi | Q9ULW2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116380, 70 interactors |
IntActi | Q9ULW2, 55 interactors |
STRINGi | 9606.ENSP00000229030 |
Chemistry databases
ChEMBLi | CHEMBL4523492 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9ULW2, 3 sites |
iPTMneti | Q9ULW2 |
PhosphoSitePlusi | Q9ULW2 |
Genetic variation databases
BioMutai | FZD10 |
DMDMi | 17433091 |
Proteomic databases
jPOSTi | Q9ULW2 |
MassIVEi | Q9ULW2 |
MaxQBi | Q9ULW2 |
PaxDbi | Q9ULW2 |
PeptideAtlasi | Q9ULW2 |
PRIDEi | Q9ULW2 |
ProteomicsDBi | 85140 |
Protocols and materials databases
ABCDi | Q9ULW2, 5 sequenced antibodies |
Antibodypediai | 2928, 275 antibodies from 33 providers |
DNASUi | 11211 |
Genome annotation databases
Ensembli | ENST00000229030.5; ENSP00000229030.4; ENSG00000111432.5 |
GeneIDi | 11211 |
KEGGi | hsa:11211 |
MANE-Selecti | ENST00000229030.5; ENSP00000229030.4; NM_007197.4; NP_009128.1 |
UCSCi | uc001uii.4, human |
Organism-specific databases
CTDi | 11211 |
DisGeNETi | 11211 |
GeneCardsi | FZD10 |
HGNCi | HGNC:4039, FZD10 |
HPAi | ENSG00000111432, Tissue enhanced (esophagus, skin) |
MIMi | 606147, gene |
neXtProti | NX_Q9ULW2 |
OpenTargetsi | ENSG00000111432 |
PharmGKBi | PA28456 |
VEuPathDBi | HostDB:ENSG00000111432 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000161861 |
HOGENOMi | CLU_007873_2_1_1 |
InParanoidi | Q9ULW2 |
OMAi | LMGHDDQ |
OrthoDBi | 509772at2759 |
PhylomeDBi | Q9ULW2 |
TreeFami | TF317907 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULW2 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | Q9ULW2 |
SIGNORi | Q9ULW2 |
Miscellaneous databases
BioGRID-ORCSi | 11211, 8 hits in 1031 CRISPR screens |
GeneWikii | FZD10 |
GenomeRNAii | 11211 |
Pharosi | Q9ULW2, Tbio |
PROi | PR:Q9ULW2 |
RNActi | Q9ULW2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111432, Expressed in vagina and 145 other tissues |
ExpressionAtlasi | Q9ULW2, baseline and differential |
Genevisiblei | Q9ULW2, HS |
Family and domain databases
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR000539, Frizzled/Smoothened_TM IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR026549, FZD10 IPR017981, GPCR_2-like |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF86, PTHR11309:SF86, 1 hit |
Pfami | View protein in Pfam PF01534, Frizzled, 1 hit PF01392, Fz, 1 hit |
PRINTSi | PR00489, FRIZZLED |
SMARTi | View protein in SMART SM00063, FRI, 1 hit SM01330, Frizzled, 1 hit |
SUPFAMi | SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FZD10_HUMAN | |
Accessioni | Q9ULW2Primary (citable) accession number: Q9ULW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families