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UniProtKB - Q9ULW2 (FZD10_HUMAN)

Entry version 179 (25 May 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Frizzled-10

Gene

FZD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).

The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

By similarityCurated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULW2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-373080, Class B/2 (Secretin family receptors)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9ULW2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9ULW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Short name:
hFz10
Alternative name(s):
FzE7
CD_antigen: CD350
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FZD10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4039, FZD10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606147, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULW2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111432

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 225ExtracellularSequence analysisAdd BLAST205
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei226 – 246Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini247 – 262CytoplasmicSequence analysisAdd BLAST16
Transmembranei263 – 283Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini284 – 311ExtracellularSequence analysisAdd BLAST28
Transmembranei312 – 332Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini333 – 351CytoplasmicSequence analysisAdd BLAST19
Transmembranei352 – 372Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini373 – 393ExtracellularSequence analysisAdd BLAST21
Transmembranei394 – 414Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini415 – 443CytoplasmicSequence analysisAdd BLAST29
Transmembranei444 – 464Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini465 – 502ExtracellularSequence analysisAdd BLAST38
Transmembranei503 – 523Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini524 – 581CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11211

Open Targets

More...OpenTargetsi		ENSG00000111432

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28456

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULW2, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523492

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FZD10

Domain mapping of disease mutations (DMDM)

More...DMDMi		17433091

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001300521 – 581Frizzled-10Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 95PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 117PROSITE-ProRule annotation
Disulfide bondi106 ↔ 147PROSITE-ProRule annotation
Disulfide bondi110 ↔ 134PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULW2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULW2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9ULW2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULW2

PeptideAtlas

More...PeptideAtlasi		Q9ULW2

PRoteomics IDEntifications database

More...PRIDEi		Q9ULW2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85140

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9ULW2, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111432, Expressed in vagina and 145 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULW2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111432, Tissue enhanced (esophagus, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WNT7B (By similarity).

Interacts with MYOC (PubMed:19188438).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116380, 70 interactors

Protein interaction database and analysis system

More...IntActi		Q9ULW2, 55 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000229030

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULW2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9ULW2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULW2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 150FZPROSITE-ProRule annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni560 – 581DisorderedSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi526 – 531Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi579 – 581PDZ-binding3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor Fz/Smo family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3577, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161861

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007873_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULW2

Identification of Orthologs from Complete Genome Data

More...OMAi		LMGHDDQ

Database of Orthologous Groups

More...OrthoDBi		509772at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULW2

TreeFam database of animal gene trees

More...TreeFami		TF317907

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.2000.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015526, Frizzled/SFRP
IPR000539, Frizzled/Smoothened_TM
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR026549, FZD10
IPR017981, GPCR_2-like

The PANTHER Classification System

More...PANTHERi		PTHR11309, PTHR11309, 1 hit
PTHR11309:SF86, PTHR11309:SF86, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01534, Frizzled, 1 hit
PF01392, Fz, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00489, FRIZZLED

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00063, FRI, 1 hit
SM01330, Frizzled, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF63501, SSF63501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50038, FZ, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ULW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT 
        60         70         80         90        100
RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS 
       110        120        130        140        150
TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA 
       160        170        180        190        200
PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH 
       210        220        230        240        250
VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF SSAFTVLTFL 
       260        270        280        290        300
IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI 
       310        320        330        340        350
QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN 
       360        370        380        390        400
SSYFHLAAWA IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI 
       410        420        430        440        450
PLACYLVIGT SFILSGFVAL FHIRRVMKTG GENTDKLEKL MVRIGLFSVL 
       460        470        480        490        500
YTVPATCVIA CYFYERLNMD YWKILAAQHK CKMNNQTKTL DCLMAASIPA 
       510        520        530        540        550
VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK KKSRRKPASV 
       560        570        580 
ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V
Length:581
Mass (Da):65,336
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9B7E51FA7C87B26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H450F5H450_HUMAN
Frizzled-10
FZD10
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB027464 mRNA Translation: BAA84093.1
BC074997 mRNA Translation: AAH74997.1
BC074998 mRNA Translation: AAH74998.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9267.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC7086

NCBI Reference Sequences

More...RefSeqi		NP_009128.1, NM_007197.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229030.5; ENSP00000229030.4; ENSG00000111432.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11211

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000229030.5; ENSP00000229030.4; NM_007197.4; NP_009128.1

UCSC genome browser

More...UCSCi		uc001uii.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027464 mRNA Translation: BAA84093.1
BC074997 mRNA Translation: AAH74997.1
BC074998 mRNA Translation: AAH74998.1
CCDSiCCDS9267.1
PIRiJC7086
RefSeqiNP_009128.1, NM_007197.3

3D structure databases

AlphaFoldDBiQ9ULW2
SMRiQ9ULW2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116380, 70 interactors
IntActiQ9ULW2, 55 interactors
STRINGi9606.ENSP00000229030

Chemistry databases

ChEMBLiCHEMBL4523492

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ9ULW2, 3 sites
iPTMnetiQ9ULW2
PhosphoSitePlusiQ9ULW2

Genetic variation databases

BioMutaiFZD10
DMDMi17433091

Proteomic databases

jPOSTiQ9ULW2
MassIVEiQ9ULW2
MaxQBiQ9ULW2
PaxDbiQ9ULW2
PeptideAtlasiQ9ULW2
PRIDEiQ9ULW2
ProteomicsDBi85140

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9ULW2, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2928, 275 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		11211

Genome annotation databases

EnsembliENST00000229030.5; ENSP00000229030.4; ENSG00000111432.5
GeneIDi11211
KEGGihsa:11211
MANE-SelectiENST00000229030.5; ENSP00000229030.4; NM_007197.4; NP_009128.1
UCSCiuc001uii.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11211
DisGeNETi11211

GeneCards: human genes, protein and diseases

More...GeneCardsi		FZD10
HGNCiHGNC:4039, FZD10
HPAiENSG00000111432, Tissue enhanced (esophagus, skin)
MIMi606147, gene
neXtProtiNX_Q9ULW2
OpenTargetsiENSG00000111432
PharmGKBiPA28456
VEuPathDBiHostDB:ENSG00000111432

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3577, Eukaryota
GeneTreeiENSGT00940000161861
HOGENOMiCLU_007873_2_1_1
InParanoidiQ9ULW2
OMAiLMGHDDQ
OrthoDBi509772at2759
PhylomeDBiQ9ULW2
TreeFamiTF317907

Enzyme and pathway databases

PathwayCommonsiQ9ULW2
ReactomeiR-HSA-373080, Class B/2 (Secretin family receptors)
SignaLinkiQ9ULW2
SIGNORiQ9ULW2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11211, 8 hits in 1031 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FZD10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11211
PharosiQ9ULW2, Tbio

Protein Ontology

More...PROi		PR:Q9ULW2
RNActiQ9ULW2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111432, Expressed in vagina and 145 other tissues
ExpressionAtlasiQ9ULW2, baseline and differential
GenevisibleiQ9ULW2, HS

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526, Frizzled/SFRP
IPR000539, Frizzled/Smoothened_TM
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR026549, FZD10
IPR017981, GPCR_2-like
PANTHERiPTHR11309, PTHR11309, 1 hit
PTHR11309:SF86, PTHR11309:SF86, 1 hit
PfamiView protein in Pfam
PF01534, Frizzled, 1 hit
PF01392, Fz, 1 hit
PRINTSiPR00489, FRIZZLED
SMARTiView protein in SMART
SM00063, FRI, 1 hit
SM01330, Frizzled, 1 hit
SUPFAMiSSF63501, SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038, FZ, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFZD10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: May 25, 2022
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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