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Entry version 175 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

Frizzled-10

Gene

FZD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).By similarityCurated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9ULW2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373080, Class B/2 (Secretin family receptors)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9ULW2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Frizzled-10
Short name:
Fz-10
Short name:
hFz10
Alternative name(s):
FzE7
CD_antigen: CD350
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FZD10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4039, FZD10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606147, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULW2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111432.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 225ExtracellularSequence analysisAdd BLAST205
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei226 – 246Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini247 – 262CytoplasmicSequence analysisAdd BLAST16
Transmembranei263 – 283Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini284 – 311ExtracellularSequence analysisAdd BLAST28
Transmembranei312 – 332Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini333 – 351CytoplasmicSequence analysisAdd BLAST19
Transmembranei352 – 372Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini373 – 393ExtracellularSequence analysisAdd BLAST21
Transmembranei394 – 414Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini415 – 443CytoplasmicSequence analysisAdd BLAST29
Transmembranei444 – 464Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini465 – 502ExtracellularSequence analysisAdd BLAST38
Transmembranei503 – 523Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini524 – 581CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11211

Open Targets

More...
OpenTargetsi
ENSG00000111432

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28456

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULW2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FZD10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17433091

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001300521 – 581Frizzled-10Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 95PROSITE-ProRule annotation
Disulfide bondi42 ↔ 88PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 117PROSITE-ProRule annotation
Disulfide bondi106 ↔ 147PROSITE-ProRule annotation
Disulfide bondi110 ↔ 134PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULW2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9ULW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULW2

PeptideAtlas

More...
PeptideAtlasi
Q9ULW2

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULW2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85140

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9ULW2, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111432, Expressed in vagina and 145 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULW2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULW2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111432, Tissue enhanced (esophagus, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WNT7B (By similarity).

Interacts with MYOC (PubMed:19188438).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116380, 63 interactors

Protein interaction database and analysis system

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IntActi
Q9ULW2, 55 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229030

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULW2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 150FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi526 – 531Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi579 – 581PDZ-binding3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3577, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161861

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007873_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSYCVYS

Database of Orthologous Groups

More...
OrthoDBi
509772at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULW2

TreeFam database of animal gene trees

More...
TreeFami
TF317907

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015526, Frizzled/SFRP
IPR000539, Frizzled/Smoothened_TM
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR026549, FZD10
IPR017981, GPCR_2-like

The PANTHER Classification System

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PANTHERi
PTHR11309, PTHR11309, 1 hit
PTHR11309:SF86, PTHR11309:SF86, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01534, Frizzled, 1 hit
PF01392, Fz, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00489, FRIZZLED

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063, FRI, 1 hit
SM01330, Frizzled, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63501, SSF63501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038, FZ, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ULW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRPGPRLWL VLQVMGSCAA ISSMDMERPG DGKCQPIEIP MCKDIGYNMT
60 70 80 90 100
RMPNLMGHEN QREAAIQLHE FAPLVEYGCH GHLRFFLCSL YAPMCTEQVS
110 120 130 140 150
TPIPACRVMC EQARLKCSPI MEQFNFKWPD SLDCRKLPNK NDPNYLCMEA
160 170 180 190 200
PNNGSDEPTR GSGLFPPLFR PQRPHSAQEH PLKDGGPGRG GCDNPGKFHH
210 220 230 240 250
VEKSASCAPL CTPGVDVYWS REDKRFAVVW LAIWAVLCFF SSAFTVLTFL
260 270 280 290 300
IDPARFRYPE RPIIFLSMCY CVYSVGYLIR LFAGAESIAC DRDSGQLYVI
310 320 330 340 350
QEGLESTGCT LVFLVLYYFG MASSLWWVVL TLTWFLAAGK KWGHEAIEAN
360 370 380 390 400
SSYFHLAAWA IPAVKTILIL VMRRVAGDEL TGVCYVGSMD VNALTGFVLI
410 420 430 440 450
PLACYLVIGT SFILSGFVAL FHIRRVMKTG GENTDKLEKL MVRIGLFSVL
460 470 480 490 500
YTVPATCVIA CYFYERLNMD YWKILAAQHK CKMNNQTKTL DCLMAASIPA
510 520 530 540 550
VEIFMVKIFM LLVVGITSGM WIWTSKTLQS WQQVCSRRLK KKSRRKPASV
560 570 580
ITSGGIYKKA QHPQKTHHGK YEIPAQSPTC V
Length:581
Mass (Da):65,336
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9B7E51FA7C87B26
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H450F5H450_HUMAN
Frizzled-10
FZD10
454Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB027464 mRNA Translation: BAA84093.1
BC074997 mRNA Translation: AAH74997.1
BC074998 mRNA Translation: AAH74998.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9267.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7086

NCBI Reference Sequences

More...
RefSeqi
NP_009128.1, NM_007197.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229030; ENSP00000229030; ENSG00000111432

Database of genes from NCBI RefSeq genomes

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GeneIDi
11211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11211

UCSC genome browser

More...
UCSCi
uc001uii.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027464 mRNA Translation: BAA84093.1
BC074997 mRNA Translation: AAH74997.1
BC074998 mRNA Translation: AAH74998.1
CCDSiCCDS9267.1
PIRiJC7086
RefSeqiNP_009128.1, NM_007197.3

3D structure databases

SMRiQ9ULW2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116380, 63 interactors
IntActiQ9ULW2, 55 interactors
STRINGi9606.ENSP00000229030

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniQ9ULW2, 3 sites
iPTMnetiQ9ULW2
PhosphoSitePlusiQ9ULW2

Genetic variation databases

BioMutaiFZD10
DMDMi17433091

Proteomic databases

jPOSTiQ9ULW2
MaxQBiQ9ULW2
PaxDbiQ9ULW2
PeptideAtlasiQ9ULW2
PRIDEiQ9ULW2
ProteomicsDBi85140

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9ULW2, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
2928, 266 antibodies

Genome annotation databases

EnsembliENST00000229030; ENSP00000229030; ENSG00000111432
GeneIDi11211
KEGGihsa:11211
UCSCiuc001uii.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11211
DisGeNETi11211

GeneCards: human genes, protein and diseases

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GeneCardsi
FZD10
HGNCiHGNC:4039, FZD10
HPAiENSG00000111432, Tissue enhanced (esophagus, lymphoid tissue)
MIMi606147, gene
neXtProtiNX_Q9ULW2
OpenTargetsiENSG00000111432
PharmGKBiPA28456
VEuPathDBiHostDB:ENSG00000111432.4

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3577, Eukaryota
GeneTreeiENSGT00940000161861
HOGENOMiCLU_007873_2_1_1
InParanoidiQ9ULW2
OMAiMSYCVYS
OrthoDBi509772at2759
PhylomeDBiQ9ULW2
TreeFamiTF317907

Enzyme and pathway databases

PathwayCommonsiQ9ULW2
ReactomeiR-HSA-373080, Class B/2 (Secretin family receptors)
SIGNORiQ9ULW2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
11211, 3 hits in 949 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FZD10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11211
PharosiQ9ULW2, Tbio

Protein Ontology

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PROi
PR:Q9ULW2
RNActiQ9ULW2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000111432, Expressed in vagina and 145 other tissues
ExpressionAtlasiQ9ULW2, baseline and differential
GenevisibleiQ9ULW2, HS

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526, Frizzled/SFRP
IPR000539, Frizzled/Smoothened_TM
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR026549, FZD10
IPR017981, GPCR_2-like
PANTHERiPTHR11309, PTHR11309, 1 hit
PTHR11309:SF86, PTHR11309:SF86, 1 hit
PfamiView protein in Pfam
PF01534, Frizzled, 1 hit
PF01392, Fz, 1 hit
PRINTSiPR00489, FRIZZLED
SMARTiView protein in SMART
SM00063, FRI, 1 hit
SM01330, Frizzled, 1 hit
SUPFAMiSSF63501, SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038, FZ, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFZD10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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