HSF4

Functionⁱ

DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	17 – 121	By similarityAdd BLAST		105

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16581800
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 8972228

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

camera-type eye development Source: Ensembl
cell development Source: Ensembl
cellular response to heat
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
histone H3-K9 demethylation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of cell differentiation Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter in response to heat stress
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homotrimerization Source: Ensembl
regulation of transcription, DNA-templated
Source: ProtInc
Traceable author statementⁱ
- 8972228
visual perception Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q9ULV5

SIGNORⁱ

Q9ULV5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heat shock factor protein 4 Short name: HSF 4 Short name: hHSF4 Alternative name(s): Heat shock transcription factor 4 Short name: HSTF 4
Gene namesⁱ	Name:HSF4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102878.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5227 HSF4
MIMⁱ	602438 gene
neXtProtⁱ	NX_Q9ULV5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cataract 5, multiple types (CTRCT5)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT5 includes infantile, lamellar, zonular, nuclear, anterior polar, stellate, and Marner-type cataracts, among others. Finger malformation is observed in some kindreds.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	293	K → R: Abolishes sumoylation. 10-fold increased in transactivational activity. 1 Publication		1
Mutagenesisⁱ	298	S → A: Abolishes phosphorylation. Greatly reduced sumoylation. Greatly increased transactivational activity. 1 Publication		1

Keywords - Diseaseⁱ

Cataract, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3299
MalaCards human disease database More...MalaCardsⁱ	HSF4
MIMⁱ	116800 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000102878
Orphanetⁱ	441452 Early-onset lamellar cataract 98994 Total early-onset cataract
PharmGKBⁱ	PA29496

Chemistry databases

ChEMBLⁱ	CHEMBL3988631

ChEMBLⁱ

CHEMBL3988631

Polymorphism and mutation databases

BioMutaⁱ	HSF4
DMDMⁱ	296434534

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124571	1 – 492	Heat shock factor protein 4Add BLAST		492

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	293	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residueⁱ	298	Phosphoserine1 Publication		1

Post-translational modificationⁱ

Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-293.1 Publication

Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-298. HSFA is not sumoylated.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q9ULV5
PeptideAtlas More...PeptideAtlasⁱ	Q9ULV5
PRIDEⁱ	Q9ULV5
ProteomicsDBⁱ	85135 85136 [Q9ULV5-2]

PTM databases

iPTMnetⁱ	Q9ULV5
PhosphoSitePlusⁱ	Q9ULV5

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000102878 Expressed in 155 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_HSF4
ExpressionAtlasⁱ	Q9ULV5 baseline and differential
Genevisibleⁱ	Q9ULV5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048584

HPAⁱ

HPA048584

Interactionⁱ

Subunit structureⁱ

Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with ALKBH4, DUSP26, MAPK1, MAPK2 and MAP kinase p38.2 Publications

GO - Molecular functionⁱ

protein phosphatase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16581800

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109532, 18 interactors
ELMⁱ	Q9ULV5
IntActⁱ	Q9ULV5, 46 interactors
Molecular INTeraction database More...MINTⁱ	Q9ULV5
STRINGⁱ	9606.ENSP00000264009

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULV5
SMRⁱ	Q9ULV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	129 – 203	Hydrophobic repeat HR-A/BAdd BLAST	75
Regionⁱ	245 – 322	Interactions with DUSP26, MAPK1 and MAPK2Add BLAST	78
Regionⁱ	364 – 389	Hydrophobic repeat HR-CAdd BLAST	26

Sequence similaritiesⁱ

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0627 Eukaryota COG5169 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001182
HOGENOMⁱ	HOG000253917
HOVERGENⁱ	HBG005999
InParanoidⁱ	Q9ULV5
KEGG Orthology (KO) More...KOⁱ	K09417
OMAⁱ	MLIKEEP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G087O
PhylomeDBⁱ	Q9ULV5
TreeFamⁱ	TF330401

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000232 HSF_DNA-bd IPR027725 HSF_fam IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10015 PTHR10015, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00447 HSF_DNA-bind, 1 hit
PRINTSⁱ	PR00056 HSFDOMAIN
SMARTⁱ	View protein in SMART SM00415 HSF, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00434 HSF_DOMAIN, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show all Align All

Isoform HSF4B (identifier: Q9ULV5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD 
        60         70         80         90        100
QSRFAKEVLP QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE 
       110        120        130        140        150
FQHPSFVRGR EQLLERVRRK VPALRGDDGR WRPEDLGRLL GEVQALRGVQ 
       160        170        180        190        200
ESTEARLREL RQQNEILWRE VVTLRQSHGQ QHRVIGKLIQ CLFGPLQAGP 
       210        220        230        240        250
SNAGGKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF IQSPLPETNL 
       260        270        280        290        300
GLSPHRARGP IISDIPEDSP SPEGTRLSPS SDGRREKGLA LLKEEPASPG 
       310        320        330        340        350
GDGEAGLALA PNECDFCVTA PPPLPVAVVQ AILEGKGSFS PEGPRNAQQP 
       360        370        380        390        400
EPGDPREIPD RGPLGLESGD RSPESLLPPM LLQPPQESVE PAGPLDVLGP 
       410        420        430        440        450
SLQGREWTLM DLDMELSLMQ PLVPERGEPE LAVKGLNSPS PGKDPTLGAP 
       460        470        480        490 
LLLDVQAALG GPALGLPGAL TIYSTPESRT ASYLGPEASP SP

Length:492

Mass (Da):53,011

Last modified:May 18, 2010 - v2

Checksum:ⁱD5F1C0D68014BC2E

GO

Isoform HSF4A (identifier: Q9ULV5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
245-319: LPETNLGLSP...APNECDFCVT → STYSLSQRQI...PGFLPPVMAG

« Hide

        10         20         30         40         50
MQEAPAALPT EPGPSPVPAF LGKLWALVGD PGTDHLIRWS PSGTSFLVSD 
        60         70         80         90        100
QSRFAKEVLP QYFKHSNMAS FVRQLNMYGF RKVVSIEQGG LLRPERDHVE 
       110        120        130        140        150
FQHPSFVRGR EQLLERVRRK VPALRGDDGR WRPEDLGRLL GEVQALRGVQ 
       160        170        180        190        200
ESTEARLREL RQQNEILWRE VVTLRQSHGQ QHRVIGKLIQ CLFGPLQAGP 
       210        220        230        240        250
SNAGGKRKLS LMLDEGSSCP TPAKFNTCPL PGALLQDPYF IQSPSTYSLS 
       260        270        280        290        300
QRQIWALALT GPGAPSSLTS QKTLHPLRGP GFLPPVMAGA PPPLPVAVVQ 
       310        320        330        340        350
AILEGKGSFS PEGPRNAQQP EPGDPREIPD RGPLGLESGD RSPESLLPPM 
       360        370        380        390        400
LLQPPQESVE PAGPLDVLGP SLQGREWTLM DLDMELSLMQ PLVPERGEPE 
       410        420        430        440        450
LAVKGLNSPS PGKDPTLGAP LLLDVQAALG GPALGLPGAL TIYSTPESRT 
       460 
ASYLGPEASP SP

Show »

Length:462

Mass (Da):49,952

Checksum:ⁱF850CE8843CF4DDB

GO

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E5RK26	E5RK26_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	416	Annotation score:
	E5RJV4	E5RJV4_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	318	Annotation score:
	E7EWW4	E7EWW4_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	315	Annotation score:
	E5RG51	E5RG51_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	194	Annotation score:
	H0YBT7	H0YBT7_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	185	Annotation score:
	H0YC39	H0YC39_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	141	Annotation score:
	H0YAU2	H0YAU2_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	223	Annotation score:
	E5RHY0	E5RHY0_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	47	Annotation score:
	H0YBS6	H0YBS6_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	182	Annotation score:
	H0YBG9	H0YBG9_HUMAN	Heat shock factor protein 4 Heat shock factor protein 4	HSF4	63	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1	M → MV in BAA13433 (PubMed:8972228).Curated		1
Sequence conflictⁱ	1	M → MV in BAA84582 (PubMed:10488131).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_017558	19	A → D in CTRCT5; sporadic. 1 PublicationCorresponds to variant dbSNP:rs121909049EnsemblClinVar.	1
Natural variantⁱVAR_029018	73	R → H in CTRCT5. 1 Publication	1
Natural variantⁱVAR_017559	86	I → V in CTRCT5; sporadic. 1 PublicationCorresponds to variant dbSNP:rs121909050EnsemblClinVar.	1
Natural variantⁱVAR_017560	114	L → P in CTRCT5. 1 PublicationCorresponds to variant dbSNP:rs121909048EnsemblClinVar.	1
Natural variantⁱVAR_017561	119	R → C in CTRCT5. 1 PublicationCorresponds to variant dbSNP:rs28937573EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002418	245 – 319	LPETN…DFCVT → STYSLSQRQIWALALTGPGA PSSLTSQKTLHPLRGPGFLP PVMAG in isoform HSF4A. 1 PublicationAdd BLAST		75

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87673 mRNA Translation: BAA13433.1 AB029347 Genomic DNA Translation: BAA84581.1 AB029348 mRNA Translation: BAA84582.1 AC074143 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42175.1 [Q9ULV5-1] CCDS45510.1 [Q9ULV5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035757.1, NM_001040667.2 [Q9ULV5-1] NP_001529.2, NM_001538.3 [Q9ULV5-2]
UniGeneⁱ	Hs.512156 Hs.710714

Genome annotation databases

Ensemblⁱ	ENST00000521374; ENSP00000430947; ENSG00000102878 [Q9ULV5-1] ENST00000584272; ENSP00000463706; ENSG00000102878 [Q9ULV5-2]
GeneIDⁱ	3299
KEGGⁱ	hsa:3299
UCSC genome browser More...UCSCⁱ	uc002erl.2 human [Q9ULV5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV5	HCG2025835, isoform CRA_a		HUMAN		492	UniRef100_Q9ULV5

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV5	Heat shock factor protein 4		CANLF		492	UniRef90_Q9ULV5
HCG2025835, isoform CRA_a		HUMAN		492
Heat shock transcription factor 4		AILME		497
Heat shock transcription factor 4		CHLSB		494
heat shock factor protein 4 isoform X1		ODORO		493
+83
Q9ULV5-2	heat shock factor protein 4 isoform X2		TARSY		465	UniRef90_Q9ULV5-2
HSF4 isoform 9		PONAB		462
HSF4 isoform 1		PANTR		462
Uncharacterized protein		PANPA		462
UPI0004F22768		PAPAN		481
+22

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV5	Heat shock factor protein 4		CANLF		492	UniRef50_Q9ULV5
Heat shock factor protein 4		MOUSE		492
HCG2025835, isoform CRA_a		HUMAN		492
Heat shock transcription factor 4		AILME		497
Heat shock transcription factor 4		CHLSB		494
+126
Q9ULV5-2	heat shock factor protein 4 isoform X2		TARSY		465	UniRef50_Q9ULV5-2
HSF4 isoform 9		PONAB		462
HSF4 isoform 1		PANTR		462
Uncharacterized protein		PANPA		462
Uncharacterized protein		CAVPO		491
+118

Cross-referencesⁱ

Web resourcesⁱ

Eye disease Heat shock transcription factor 4 (HSF4)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87673 mRNA Translation: BAA13433.1 AB029347 Genomic DNA Translation: BAA84581.1 AB029348 mRNA Translation: BAA84582.1 AC074143 Genomic DNA No translation available.
CCDSⁱ	CCDS42175.1 [Q9ULV5-1] CCDS45510.1 [Q9ULV5-2]
RefSeqⁱ	NP_001035757.1, NM_001040667.2 [Q9ULV5-1] NP_001529.2, NM_001538.3 [Q9ULV5-2]
UniGeneⁱ	Hs.512156 Hs.710714

3D structure databases

ProteinModelPortalⁱ	Q9ULV5
SMRⁱ	Q9ULV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109532, 18 interactors
ELMⁱ	Q9ULV5
IntActⁱ	Q9ULV5, 46 interactors
MINTⁱ	Q9ULV5
STRINGⁱ	9606.ENSP00000264009

Chemistry databases

ChEMBLⁱ	CHEMBL3988631

ChEMBLⁱ

CHEMBL3988631

PTM databases

iPTMnetⁱ	Q9ULV5
PhosphoSitePlusⁱ	Q9ULV5

Polymorphism and mutation databases

BioMutaⁱ	HSF4
DMDMⁱ	296434534

Proteomic databases

PaxDbⁱ	Q9ULV5
PeptideAtlasⁱ	Q9ULV5
PRIDEⁱ	Q9ULV5
ProteomicsDBⁱ	85135 85136 [Q9ULV5-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3299
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000521374; ENSP00000430947; ENSG00000102878 [Q9ULV5-1] ENST00000584272; ENSP00000463706; ENSG00000102878 [Q9ULV5-2]
GeneIDⁱ	3299
KEGGⁱ	hsa:3299
UCSCⁱ	uc002erl.2 human [Q9ULV5-1]

Organism-specific databases

CTDⁱ	3299
DisGeNETⁱ	3299
EuPathDBⁱ	HostDB:ENSG00000102878.16
GeneCardsⁱ	HSF4
HGNCⁱ	HGNC:5227 HSF4
HPAⁱ	HPA048584
MalaCardsⁱ	HSF4
MIMⁱ	116800 phenotype 602438 gene
neXtProtⁱ	NX_Q9ULV5
OpenTargetsⁱ	ENSG00000102878
Orphanetⁱ	441452 Early-onset lamellar cataract 98994 Total early-onset cataract
PharmGKBⁱ	PA29496
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0627 Eukaryota COG5169 LUCA
GeneTreeⁱ	ENSGT00390000001182
HOGENOMⁱ	HOG000253917
HOVERGENⁱ	HBG005999
InParanoidⁱ	Q9ULV5
KOⁱ	K09417
OMAⁱ	MLIKEEP
OrthoDBⁱ	EOG091G087O
PhylomeDBⁱ	Q9ULV5
TreeFamⁱ	TF330401

Enzyme and pathway databases

SIGNORⁱ	Q9ULV5

SIGNORⁱ

Q9ULV5

Miscellaneous databases

GeneWikiⁱ	HSF4
GenomeRNAiⁱ	3299
Protein Ontology More...PROⁱ	PR:Q9ULV5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102878 Expressed in 155 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_HSF4
ExpressionAtlasⁱ	Q9ULV5 baseline and differential
Genevisibleⁱ	Q9ULV5 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000232 HSF_DNA-bd IPR027725 HSF_fam IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR10015 PTHR10015, 1 hit
Pfamⁱ	View protein in Pfam PF00447 HSF_DNA-bind, 1 hit
PRINTSⁱ	PR00056 HSFDOMAIN
SMARTⁱ	View protein in SMART SM00415 HSF, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00434 HSF_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HSF4_HUMAN
Accessionⁱ	Q9ULV5Primary (citable) accession number: Q9ULV5 Secondary accession number(s): Q99472, Q9ULV6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9ULV5 (HSF4_HUMAN)

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Heat shock factor protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ