CIZ1

Functionⁱ

May regulate the subcellular localization of CIP/WAF1.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	799 – 830	Matrin-typePROSITE-ProRule annotationAdd BLAST		32

GO - Molecular functionⁱ

nucleic acid binding Source: InterPro
zinc ion binding
Source: ProtInc
Traceable author statementⁱ
- 10529385

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cip1-interacting zinc finger protein Alternative name(s): CDKN1A-interacting zinc finger protein 1 Nuclear protein NP94 Zinc finger protein 356
Gene namesⁱ	Name:CIZ1 Synonyms:LSFR1, NP94, ZNF356
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148337.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16744 CIZ1
MIMⁱ	611420 gene
neXtProtⁱ	NX_Q9ULV3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.

Keywords - Diseaseⁱ

Disease mutation, Dystonia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25792
MalaCards human disease database More...MalaCardsⁱ	CIZ1
Open Targets More...OpenTargetsⁱ	ENSG00000148337
PharmGKBⁱ	PA134883336

Polymorphism and mutation databases

BioMutaⁱ	CIZ1
DMDMⁱ	296434448

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089776	1 – 898	Cip1-interacting zinc finger proteinAdd BLAST		898

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	209	PhosphoserineCombined sources	1
Modified residueⁱ	244	PhosphothreonineCombined sources	1
Cross-linkⁱ	280	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	340	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	350	PhosphoserineCombined sources	1
Cross-linkⁱ	401	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	547	PhosphoserineCombined sources	1
Cross-linkⁱ	549	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	567	PhosphothreonineCombined sources	1
Cross-linkⁱ	588	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	680	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	705	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	821	PhosphoserineCombined sources	1
Cross-linkⁱ	830	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	838	PhosphoserineCombined sources	1
Cross-linkⁱ	879	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9ULV3
PaxDbⁱ	Q9ULV3
PeptideAtlas More...PeptideAtlasⁱ	Q9ULV3
PRIDEⁱ	Q9ULV3
ProteomicsDBⁱ	85130 85131 [Q9ULV3-2] 85132 [Q9ULV3-3] 85133 [Q9ULV3-4]

PTM databases

CarbonylDBⁱ	Q9ULV3
iPTMnetⁱ	Q9ULV3
PhosphoSitePlusⁱ	Q9ULV3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148337 Expressed in 229 organ(s), highest expression level in testis
CleanExⁱ	HS_CIZ1
ExpressionAtlasⁱ	Q9ULV3 baseline and differential
Genevisibleⁱ	Q9ULV3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020380 HPA020387

HPAⁱ

HPA020380
HPA020387

Interactionⁱ

Subunit structureⁱ

Interacts with CIP/WAF1.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SH3BP4	Q9P0V3	2	EBI-2652948,EBI-1049513

With

Entry

#Exp.

IntAct

Notes

SH3BP4

Q9P0V3

2

EBI-2652948,EBI-1049513

Protein-protein interaction databases

BioGridⁱ	117325, 27 interactors
IntActⁱ	Q9ULV3, 11 interactors
STRINGⁱ	9606.ENSP00000362029

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULV3
SMRⁱ	Q9ULV3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	4 – 44	Gln-richAdd BLAST	41
Compositional biasⁱ	276 – 470	Gln-richAdd BLAST	195
Compositional biasⁱ	741 – 761	Glu-richAdd BLAST	21

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	799 – 830	Matrin-typePROSITE-ProRule annotationAdd BLAST		32

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410II97 Eukaryota ENOG4111HAM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039084
HOVERGENⁱ	HBG002558
InParanoidⁱ	Q9ULV3
PhylomeDBⁱ	Q9ULV3
TreeFamⁱ	TF332388

Family and domain databases

InterProⁱ	View protein in InterPro IPR026811 CIZ1 IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR022755 Znf_C2H2_jaz IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR15491 PTHR15491, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12171 zf-C2H2_jaz, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits SM00451 ZnF_U1, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9ULV3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP 
        60         70         80         90        100
LPMAVSRGLP PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGLDQF 
       110        120        130        140        150
AMPPATYDTA GLTMPTATLG NLRGYGMASP GLAAPSLTPP QLATPNLQQF 
       160        170        180        190        200
FPQATRQSLL GPPPVGVPMN PSQFNLSGRN PQKQARTSSS TTPNRKDSSS 
       210        220        230        240        250
QTMPVEDKSD PPEGSEEAAE PRMDTPEDQD LPPCPEDIAK EKRTPAPEPE 
       260        270        280        290        300
PCEASELPAK RLRSSEEPTE KEPPGQLQVK AQPQARMTVP KQTQTPDLLP 
       310        320        330        340        350
EALEAQVLPR FQPRVLQVQA QVQSQTQPRI PSTDTQVQPK LQKQAQTQTS 
       360        370        380        390        400
PEHLVLQQKQ VQPQLQQEAE PQKQVQPQVQ PQAHSQGPRQ VQLQQEAEPL 
       410        420        430        440        450
KQVQPQVQPQ AHSQPPRQVQ LQLQKQVQTQ TYPQVHTQAQ PSVQPQEHPP 
       460        470        480        490        500
AQVSVQPPEQ THEQPHTQPQ VSLLAPEQTP VVVHVCGLEM PPDAVEAGGG 
       510        520        530        540        550
MEKTLPEPVG TQVSMEEIQN ESACGLDVGE CENRAREMPG VWGAGGSLKV 
       560        570        580        590        600
TILQSSDSRA FSTVPLTPVP RPSDSVSSTP AATSTPSKQA LQFFCYICKA 
       610        620        630        640        650
SCSSQQEFQD HMSEPQHQQR LGEIQHMSQA CLLSLLPVPR DVLETEDEEP 
       660        670        680        690        700
PPRRWCNTCQ LYYMGDLIQH RRTQDHKIAK QSLRPFCTVC NRYFKTPRKF 
       710        720        730        740        750
VEHVKSQGHK DKAKELKSLE KEIAGQDEDH FITVDAVGCF EGDEEEEEDD 
       760        770        780        790        800
EDEEEIEVEE ELCKQVRSRD ISREEWKGSE TYSPNTAYGV DFLVPVMGYI 
       810        820        830        840        850
CRICHKFYHS NSGAQLSHCK SLGHFENLQK YKAAKNPSPT TRPVSRRCAI 
       860        870        880        890 
NARNALTALF TSSGRPPSQP NTQDKTPSKV TARPSQPPLP RRSTRLKT

Length:898

Mass (Da):100,045

Last modified:May 18, 2010 - v2

Checksum:ⁱ5E14389E81A146F1

GO

Isoform 2 (identifier: Q9ULV3-2) [UniParc]FASTA Add to basket

Also known as: NP94B

The sequence of this isoform differs from the canonical sequence as follows:
97-120: Missing.
197-201: Missing.

« Hide

        10         20         30         40         50
MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP 
        60         70         80         90        100
LPMAVSRGLP PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGNLRG 
       110        120        130        140        150
YGMASPGLAA PSLTPPQLAT PNLQQFFPQA TRQSLLGPPP VGVPMNPSQF 
       160        170        180        190        200
NLSGRNPQKQ ARTSSSTTPN RKTMPVEDKS DPPEGSEEAA EPRMDTPEDQ 
       210        220        230        240        250
DLPPCPEDIA KEKRTPAPEP EPCEASELPA KRLRSSEEPT EKEPPGQLQV 
       260        270        280        290        300
KAQPQARMTV PKQTQTPDLL PEALEAQVLP RFQPRVLQVQ AQVQSQTQPR 
       310        320        330        340        350
IPSTDTQVQP KLQKQAQTQT SPEHLVLQQK QVQPQLQQEA EPQKQVQPQV 
       360        370        380        390        400
QPQAHSQGPR QVQLQQEAEP LKQVQPQVQP QAHSQPPRQV QLQLQKQVQT 
       410        420        430        440        450
QTYPQVHTQA QPSVQPQEHP PAQVSVQPPE QTHEQPHTQP QVSLLAPEQT 
       460        470        480        490        500
PVVVHVCGLE MPPDAVEAGG GMEKTLPEPV GTQVSMEEIQ NESACGLDVG 
       510        520        530        540        550
ECENRAREMP GVWGAGGSLK VTILQSSDSR AFSTVPLTPV PRPSDSVSST 
       560        570        580        590        600
PAATSTPSKQ ALQFFCYICK ASCSSQQEFQ DHMSEPQHQQ RLGEIQHMSQ 
       610        620        630        640        650
ACLLSLLPVP RDVLETEDEE PPPRRWCNTC QLYYMGDLIQ HRRTQDHKIA 
       660        670        680        690        700
KQSLRPFCTV CNRYFKTPRK FVEHVKSQGH KDKAKELKSL EKEIAGQDED 
       710        720        730        740        750
HFITVDAVGC FEGDEEEEED DEDEEEIEVE EELCKQVRSR DISREEWKGS 
       760        770        780        790        800
ETYSPNTAYG VDFLVPVMGY ICRICHKFYH SNSGAQLSHC KSLGHFENLQ 
       810        820        830        840        850
KYKAAKNPSP TTRPVSRRCA INARNALTAL FTSSGRPPSQ PNTQDKTPSK 
       860 
VTARPSQPPL PRRSTRLKT

Show »

Length:869

Mass (Da):97,075

Checksum:ⁱACCB3ABBE6A91F03

GO

Isoform 3 (identifier: Q9ULV3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
97-120: Missing.
377-432: Missing.

« Hide

        10         20         30         40         50
MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP 
        60         70         80         90        100
LPMAVSRGLP PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGNLRG 
       110        120        130        140        150
YGMASPGLAA PSLTPPQLAT PNLQQFFPQA TRQSLLGPPP VGVPMNPSQF 
       160        170        180        190        200
NLSGRNPQKQ ARTSSSTTPN RKDSSSQTMP VEDKSDPPEG SEEAAEPRMD 
       210        220        230        240        250
TPEDQDLPPC PEDIAKEKRT PAPEPEPCEA SELPAKRLRS SEEPTEKEPP 
       260        270        280        290        300
GQLQVKAQPQ ARMTVPKQTQ TPDLLPEALE AQVLPRFQPR VLQVQAQVQS 
       310        320        330        340        350
QTQPRIPSTD TQVQPKLQKQ AQTQTSPEHL VLQQKQVQPQ LQQEAEPQKQ 
       360        370        380        390        400
VQPQVHTQAQ PSVQPQEHPP AQVSVQPPEQ THEQPHTQPQ VSLLAPEQTP 
       410        420        430        440        450
VVVHVCGLEM PPDAVEAGGG MEKTLPEPVG TQVSMEEIQN ESACGLDVGE 
       460        470        480        490        500
CENRAREMPG VWGAGGSLKV TILQSSDSRA FSTVPLTPVP RPSDSVSSTP 
       510        520        530        540        550
AATSTPSKQA LQFFCYICKA SCSSQQEFQD HMSEPQHQQR LGEIQHMSQA 
       560        570        580        590        600
CLLSLLPVPR DVLETEDEEP PPRRWCNTCQ LYYMGDLIQH RRTQDHKIAK 
       610        620        630        640        650
QSLRPFCTVC NRYFKTPRKF VEHVKSQGHK DKAKELKSLE KEIAGQDEDH 
       660        670        680        690        700
FITVDAVGCF EGDEEEEEDD EDEEEIEVEE ELCKQVRSRD ISREEWKGSE 
       710        720        730        740        750
TYSPNTAYGV DFLVPVMGYI CRICHKFYHS NSGAQLSHCK SLGHFENLQK 
       760        770        780        790        800
YKAAKNPSPT TRPVSRRCAI NARNALTALF TSSGRPPSQP NTQDKTPSKV 
       810 
TARPSQPPLP RRSTRLKT

Show »

Length:818

Mass (Da):91,153

Checksum:ⁱ28DBDF0FB222820E

GO

Isoform 4 (identifier: Q9ULV3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
377-432: Missing.

« Hide

        10         20         30         40         50
MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP 
        60         70         80         90        100
LPMAVSRGLP PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGLDQF 
       110        120        130        140        150
AMPPATYDTA GLTMPTATLG NLRGYGMASP GLAAPSLTPP QLATPNLQQF 
       160        170        180        190        200
FPQATRQSLL GPPPVGVPMN PSQFNLSGRN PQKQARTSSS TTPNRKDSSS 
       210        220        230        240        250
QTMPVEDKSD PPEGSEEAAE PRMDTPEDQD LPPCPEDIAK EKRTPAPEPE 
       260        270        280        290        300
PCEASELPAK RLRSSEEPTE KEPPGQLQVK AQPQARMTVP KQTQTPDLLP 
       310        320        330        340        350
EALEAQVLPR FQPRVLQVQA QVQSQTQPRI PSTDTQVQPK LQKQAQTQTS 
       360        370        380        390        400
PEHLVLQQKQ VQPQLQQEAE PQKQVQPQVH TQAQPSVQPQ EHPPAQVSVQ 
       410        420        430        440        450
PPEQTHEQPH TQPQVSLLAP EQTPVVVHVC GLEMPPDAVE AGGGMEKTLP 
       460        470        480        490        500
EPVGTQVSME EIQNESACGL DVGECENRAR EMPGVWGAGG SLKVTILQSS 
       510        520        530        540        550
DSRAFSTVPL TPVPRPSDSV SSTPAATSTP SKQALQFFCY ICKASCSSQQ 
       560        570        580        590        600
EFQDHMSEPQ HQQRLGEIQH MSQACLLSLL PVPRDVLETE DEEPPPRRWC 
       610        620        630        640        650
NTCQLYYMGD LIQHRRTQDH KIAKQSLRPF CTVCNRYFKT PRKFVEHVKS 
       660        670        680        690        700
QGHKDKAKEL KSLEKEIAGQ DEDHFITVDA VGCFEGDEEE EEDDEDEEEI 
       710        720        730        740        750
EVEEELCKQV RSRDISREEW KGSETYSPNT AYGVDFLVPV MGYICRICHK 
       760        770        780        790        800
FYHSNSGAQL SHCKSLGHFE NLQKYKAAKN PSPTTRPVSR RCAINARNAL 
       810        820        830        840 
TALFTSSGRP PSQPNTQDKT PSKVTARPSQ PPLPRRSTRL KT

Show »

Length:842

Mass (Da):93,619

Checksum:ⁱC799C715E082C006

GO

Isoform 5 (identifier: Q9ULV3-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-101: Missing.

« Hide

        10         20         30         40         50
MPPATYDTAG LTMPTATLGN LRGYGMASPG LAAPSLTPPQ LATPNLQQFF 
        60         70         80         90        100
PQATRQSLLG PPPVGVPMNP SQFNLSGRNP QKQARTSSST TPNRKDSSSQ 
       110        120        130        140        150
TMPVEDKSDP PEGSEEAAEP RMDTPEDQDL PPCPEDIAKE KRTPAPEPEP 
       160        170        180        190        200
CEASELPAKR LRSSEEPTEK EPPGQLQVKA QPQARMTVPK QTQTPDLLPE 
       210        220        230        240        250
ALEAQVLPRF QPRVLQVQAQ VQSQTQPRIP STDTQVQPKL QKQAQTQTSP 
       260        270        280        290        300
EHLVLQQKQV QPQLQQEAEP QKQVQPQVQP QAHSQGPRQV QLQQEAEPLK 
       310        320        330        340        350
QVQPQVQPQA HSQPPRQVQL QLQKQVQTQT YPQVHTQAQP SVQPQEHPPA 
       360        370        380        390        400
QVSVQPPEQT HEQPHTQPQV SLLAPEQTPV VVHVCGLEMP PDAVEAGGGM 
       410        420        430        440        450
EKTLPEPVGT QVSMEEIQNE SACGLDVGEC ENRAREMPGV WGAGGSLKVT 
       460        470        480        490        500
ILQSSDSRAF STVPLTPVPR PSDSVSSTPA ATSTPSKQAL QFFCYICKAS 
       510        520        530        540        550
CSSQQEFQDH MSEPQHQQRL GEIQHMSQAC LLSLLPVPRD VLETEDEEPP 
       560        570        580        590        600
PRRWCNTCQL YYMGDLIQHR RTQDHKIAKQ SLRPFCTVCN RYFKTPRKFV 
       610        620        630        640        650
EHVKSQGHKD KAKELKSLEK EIAGQDEDHF ITVDAVGCFE GDEEEEEDDE 
       660        670        680        690        700
DEEEIEVEEE LCKQVRSRDI SREEWKGSET YSPNTAYGVD FLVPVMGYIC 
       710        720        730        740        750
RICHKFYHSN SGAQLSHCKS LGHFENLQKY KAAKNPSPTT RPVSRRCAIN 
       760        770        780        790 
ARNALTALFT SSGRPPSQPN TQDKTPSKVT ARPSQPPLPR RSTRLKT

Note: No experimental confirmation available.

Show »

Length:797

Mass (Da):88,520

Checksum:ⁱ1C3805A4CFAC8864

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H2X7	F5H2X7_HUMAN	Cip1-interacting zinc finger protei... Cip1-interacting zinc finger protein	CIZ1	954	Annotation score:
Q9BTG3	Q9BTG3_HUMAN	CIZ1 protein CIZ1 protein (Cip1-interacting zinc finger protein)	CIZ1	837	Annotation score:
Q5SYW2	Q5SYW2_HUMAN	Cip1-interacting zinc finger protei... Cip1-interacting zinc finger protein	CIZ1	870	Annotation score:
H0Y5D5	H0Y5D5_HUMAN	Cip1-interacting zinc finger protei... Cip1-interacting zinc finger protein	CIZ1	820	Annotation score:
A0A0U1RQR2	A0A0U1RQR2_HUMAN	Cip1-interacting zinc finger protei... Cip1-interacting zinc finger protein	CIZ1	310	Annotation score:
F6VD24	F6VD24_HUMAN	Cip1-interacting zinc finger protei... Cip1-interacting zinc finger protein	CIZ1	252	Annotation score:
F6WSM2	F6WSM2_HUMAN	Cip1-interacting zinc finger protei... Cip1-interacting zinc finger protein	CIZ1	168	Annotation score:

Sequence cautionⁱ

The sequence AAF23231 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAF37882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	9	Missing in AAF23231 (PubMed:12824700).Curated	1
Sequence conflictⁱ	35	L → S in AAF23231 (PubMed:12824700).Curated	1
Sequence conflictⁱ	101	A → V in BAB14750 (PubMed:14702039).Curated	1
Sequence conflictⁱ	232	P → L in BAA85783 (PubMed:10529385).Curated	1
Sequence conflictⁱ	500	G → S in AAF37882 (PubMed:12824700).Curated	1
Sequence conflictⁱ	549	K → E in BAG64643 (PubMed:14702039).Curated	1
Sequence conflictⁱ	555	S → G in BAA85783 (PubMed:10529385).Curated	1
Sequence conflictⁱ	568	P → L in AAF23231 (PubMed:12824700).Curated	1
Sequence conflictⁱ	634	S → P in AAF23231 (PubMed:12824700).Curated	1
Sequence conflictⁱ	677	K → R in AAF37882 (PubMed:12824700).Curated	1
Sequence conflictⁱ	678	I → V in BAB14750 (PubMed:14702039).Curated	1
Sequence conflictⁱ	682	S → P in BAB14750 (PubMed:14702039).Curated	1
Sequence conflictⁱ	698	R → L in CAB44346 (PubMed:10369878).Curated	1
Sequence conflictⁱ	735	D → G in AAF23231 (PubMed:12824700).Curated	1
Sequence conflictⁱ	757	E → K in BAB14750 (PubMed:14702039).Curated	1
Sequence conflictⁱ	810	S → N in AAF37882 (PubMed:12824700).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_067971	47	P → S Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. 1 Publication	1
Natural variantⁱVAR_067972	50	P → L1 PublicationCorresponds to variant dbSNP:rs747696276Ensembl.	1
Natural variantⁱVAR_056820	219	A → T1 PublicationCorresponds to variant dbSNP:rs45588035EnsemblClinVar.	1
Natural variantⁱVAR_067973	264	S → G Probable disease-associated mutation found in a family with adult onset primary cervical dystonia; exonic splicing enhancer mutation resulting in altered CIZ1 splicing pattern. 1 PublicationCorresponds to variant dbSNP:rs397514566EnsemblClinVar.	1
Natural variantⁱVAR_063105	370	E → G1 PublicationCorresponds to variant dbSNP:rs45554035EnsemblClinVar.	1
Natural variantⁱVAR_067974	394	Q → E1 PublicationCorresponds to variant dbSNP:rs200010931Ensembl.	1
Natural variantⁱVAR_067975	577	S → F1 PublicationCorresponds to variant dbSNP:rs780188256Ensembl.	1
Natural variantⁱVAR_056821	578	S → F1 PublicationCorresponds to variant dbSNP:rs12334EnsemblClinVar.	1
Natural variantⁱVAR_056822	638	V → M2 PublicationsCorresponds to variant dbSNP:rs11549266Ensembl.	1
Natural variantⁱVAR_067976	672	R → M Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. 1 Publication	1
Natural variantⁱVAR_063106	847	R → Q1 PublicationCorresponds to variant dbSNP:rs11549260EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044729	1 – 101	Missing in isoform 5. 1 PublicationAdd BLAST	101
Alternative sequenceⁱVSP_004164	97 – 120	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	24
Alternative sequenceⁱVSP_004165	197 – 201	Missing in isoform 2. 1 Publication	5
Alternative sequenceⁱVSP_039894	377 – 432	Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST	56

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB030835 mRNA Translation: BAA85783.1 EF467915 Genomic DNA Translation: ABO43037.1 AK023978 mRNA Translation: BAB14750.1 AK292713 mRNA Translation: BAF85402.1 AK303636 mRNA Translation: BAG64643.1 AK316393 mRNA Translation: BAH14764.1 AL590708 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87752.1 CH471090 Genomic DNA Translation: EAW87753.1 CH471090 Genomic DNA Translation: EAW87754.1 BC021163 mRNA Translation: AAH21163.1 AF159027 mRNA Translation: AAF23231.1 Different initiation. AF234161 mRNA Translation: AAF37882.1 Different initiation. Y17453 Genomic DNA Translation: CAB44346.1 Y17454 Genomic DNA Translation: CAB44347.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS48033.1 [Q9ULV3-3] CCDS48034.1 [Q9ULV3-4] CCDS59147.1 [Q9ULV3-5] CCDS6894.1 [Q9ULV3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124487.1, NM_001131015.1 [Q9ULV3-4] NP_001124488.1, NM_001131016.1 [Q9ULV3-1] NP_001124489.1, NM_001131017.1 NP_001124490.1, NM_001131018.1 [Q9ULV3-3] NP_001244904.1, NM_001257975.1 NP_001244905.1, NM_001257976.1 [Q9ULV3-5] NP_036259.2, NM_012127.2 [Q9ULV3-1] XP_005251945.2, XM_005251888.3 XP_005251948.2, XM_005251891.3 XP_005251950.4, XM_005251893.4 [Q9ULV3-3] XP_006717102.2, XM_006717039.3 [Q9ULV3-2] XP_016870085.1, XM_017014596.1 [Q9ULV3-4]
UniGeneⁱ	Hs.212395

Genome annotation databases

Ensemblⁱ	ENST00000372938; ENSP00000362029; ENSG00000148337 [Q9ULV3-1] ENST00000372948; ENSP00000362039; ENSG00000148337 [Q9ULV3-4] ENST00000372954; ENSP00000362045; ENSG00000148337 [Q9ULV3-3] ENST00000629610; ENSP00000486816; ENSG00000148337 [Q9ULV3-5] ENST00000634901; ENSP00000489425; ENSG00000148337 [Q9ULV3-1]
GeneIDⁱ	25792
KEGGⁱ	hsa:25792
UCSC genome browser More...UCSCⁱ	uc004btt.4 human [Q9ULV3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV3	CDKN1A interacting zinc finger protein 1, isoform CRA_b		HUMAN		898	UniRef100_Q9ULV3
Ciz1 (Fragment)		HUMAN		454
Isoform 5 of Cip1-interacting zinc finger protein		HUMAN		797
UPI000D0C8541		HUMAN		930
Q9ULV3-2	Cip1-interacting zinc finger protein (Fragment)		HUMAN		820	UniRef100_Q9ULV3-2

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV3	CDKN1A interacting zinc finger protein 1, isoform CRA_b		HUMAN		898	UniRef90_Q9ULV3
CIZ1 isoform 13		PANTR		903
CDKN1A interacting zinc finger protein 1		GORGO		900
Uncharacterized protein		RHIRO		898
Uncharacterized protein		RHIBE		898
+92
Q9ULV3-2	Cip1-interacting zinc finger protein (Fragment)		HUMAN		820	UniRef90_Q9ULV3-2
Uncharacterized protein		PANTR		879
Uncharacterized protein		Cebus capucinus imitator		873
CDKN1A interacting zinc finger protein 1		SAIBB		867
CIZ1 isoform 18 (Fragment)		PONAB		807
+16
Q9ULV3-3	Isoform 4 of Cip1-interacting zinc finger protein		HUMAN		842	UniRef90_Q9ULV3-4
CIZ1 isoform 1		PANTR		847
Uncharacterized protein		RHIBE		847
Uncharacterized protein		CERAT		847
Uncharacterized protein		RHIRO		847
+62
Q9ULV3-4	CIZ1 isoform 1		PANTR		847	UniRef90_Q9ULV3-4
Uncharacterized protein		RHIBE		847
Uncharacterized protein		CERAT		847
Uncharacterized protein		RHIRO		847
Uncharacterized protein		MACFA		847
+62

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV3	CDKN1A interacting zinc finger protein 1, isoform CRA_b		HUMAN		898	UniRef50_Q9ULV3
CIZ1 isoform 13		PANTR		903
CDKN1A interacting zinc finger protein 1		GORGO		900
Uncharacterized protein		RHIRO		898
Uncharacterized protein		RHIBE		898
+512
Q9ULV3-3	Isoform 4 of Cip1-interacting zinc finger protein		HUMAN		842	UniRef50_Q9ULV3-4
CDKN1A interacting zinc finger protein 1		PANTR		847
Uncharacterized protein		MACFA		847
Uncharacterized protein		MACNE		847
Uncharacterized protein		CERAT		847
+163
Q9ULV3-4	CDKN1A interacting zinc finger protein 1		PANTR		847	UniRef50_Q9ULV3-4
Uncharacterized protein		MACFA		847
Uncharacterized protein		MACNE		847
Uncharacterized protein		CERAT		847
Uncharacterized protein		RHIRO		847
+163

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB030835 mRNA Translation: BAA85783.1 EF467915 Genomic DNA Translation: ABO43037.1 AK023978 mRNA Translation: BAB14750.1 AK292713 mRNA Translation: BAF85402.1 AK303636 mRNA Translation: BAG64643.1 AK316393 mRNA Translation: BAH14764.1 AL590708 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87752.1 CH471090 Genomic DNA Translation: EAW87753.1 CH471090 Genomic DNA Translation: EAW87754.1 BC021163 mRNA Translation: AAH21163.1 AF159027 mRNA Translation: AAF23231.1 Different initiation. AF234161 mRNA Translation: AAF37882.1 Different initiation. Y17453 Genomic DNA Translation: CAB44346.1 Y17454 Genomic DNA Translation: CAB44347.1
CCDSⁱ	CCDS48033.1 [Q9ULV3-3] CCDS48034.1 [Q9ULV3-4] CCDS59147.1 [Q9ULV3-5] CCDS6894.1 [Q9ULV3-1]
RefSeqⁱ	NP_001124487.1, NM_001131015.1 [Q9ULV3-4] NP_001124488.1, NM_001131016.1 [Q9ULV3-1] NP_001124489.1, NM_001131017.1 NP_001124490.1, NM_001131018.1 [Q9ULV3-3] NP_001244904.1, NM_001257975.1 NP_001244905.1, NM_001257976.1 [Q9ULV3-5] NP_036259.2, NM_012127.2 [Q9ULV3-1] XP_005251945.2, XM_005251888.3 XP_005251948.2, XM_005251891.3 XP_005251950.4, XM_005251893.4 [Q9ULV3-3] XP_006717102.2, XM_006717039.3 [Q9ULV3-2] XP_016870085.1, XM_017014596.1 [Q9ULV3-4]
UniGeneⁱ	Hs.212395

3D structure databases

ProteinModelPortalⁱ	Q9ULV3
SMRⁱ	Q9ULV3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117325, 27 interactors
IntActⁱ	Q9ULV3, 11 interactors
STRINGⁱ	9606.ENSP00000362029

PTM databases

CarbonylDBⁱ	Q9ULV3
iPTMnetⁱ	Q9ULV3
PhosphoSitePlusⁱ	Q9ULV3

Polymorphism and mutation databases

BioMutaⁱ	CIZ1
DMDMⁱ	296434448

Proteomic databases

EPDⁱ	Q9ULV3
PaxDbⁱ	Q9ULV3
PeptideAtlasⁱ	Q9ULV3
PRIDEⁱ	Q9ULV3
ProteomicsDBⁱ	85130 85131 [Q9ULV3-2] 85132 [Q9ULV3-3] 85133 [Q9ULV3-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000372938; ENSP00000362029; ENSG00000148337 [Q9ULV3-1] ENST00000372948; ENSP00000362039; ENSG00000148337 [Q9ULV3-4] ENST00000372954; ENSP00000362045; ENSG00000148337 [Q9ULV3-3] ENST00000629610; ENSP00000486816; ENSG00000148337 [Q9ULV3-5] ENST00000634901; ENSP00000489425; ENSG00000148337 [Q9ULV3-1]
GeneIDⁱ	25792
KEGGⁱ	hsa:25792
UCSCⁱ	uc004btt.4 human [Q9ULV3-1]

Organism-specific databases

CTDⁱ	25792
DisGeNETⁱ	25792
EuPathDBⁱ	HostDB:ENSG00000148337.20
GeneCardsⁱ	CIZ1
HGNCⁱ	HGNC:16744 CIZ1
HPAⁱ	HPA020380 HPA020387
MalaCardsⁱ	CIZ1
MIMⁱ	611420 gene
neXtProtⁱ	NX_Q9ULV3
OpenTargetsⁱ	ENSG00000148337
PharmGKBⁱ	PA134883336
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410II97 Eukaryota ENOG4111HAM LUCA
GeneTreeⁱ	ENSGT00440000039084
HOVERGENⁱ	HBG002558
InParanoidⁱ	Q9ULV3
PhylomeDBⁱ	Q9ULV3
TreeFamⁱ	TF332388

Miscellaneous databases

ChiTaRSⁱ	CIZ1 human
GeneWikiⁱ	CIZ1
GenomeRNAiⁱ	25792
Protein Ontology More...PROⁱ	PR:Q9ULV3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148337 Expressed in 229 organ(s), highest expression level in testis
CleanExⁱ	HS_CIZ1
ExpressionAtlasⁱ	Q9ULV3 baseline and differential
Genevisibleⁱ	Q9ULV3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026811 CIZ1 IPR000690 Matrin/U1-C_Znf_C2H2 IPR003604 Matrin/U1-like-C_Znf_C2H2 IPR022755 Znf_C2H2_jaz IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR15491 PTHR15491, 2 hits
Pfamⁱ	View protein in Pfam PF12171 zf-C2H2_jaz, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits SM00451 ZnF_U1, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50171 ZF_MATRIN, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CIZ1_HUMAN
Accessionⁱ	Q9ULV3Primary (citable) accession number: Q9ULV3 Secondary accession number(s): A8K9J8 Q9Y3G0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9ULV3 (CIZ1_HUMAN)

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Cip1-interacting zinc finger protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ