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UniProtKB - Q9ULV3 (CIZ1_HUMAN)

Entry version 164 (31 Jul 2019)
Sequence version 2 (18 May 2010)
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Protein

Cip1-interacting zinc finger protein

Gene

CIZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate the subcellular localization of CIP/WAF1.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri799 – 830Matrin-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cip1-interacting zinc finger protein
Alternative name(s):
CDKN1A-interacting zinc finger protein 1
Nuclear protein NP94
Zinc finger protein 356
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CIZ1
Synonyms:LSFR1, NP94, ZNF356
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16744 CIZ1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611420 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULV3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in CIZ1 may be a cause of adult onset primary cervical dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Cervical dystonia or spasmodic torticollis, the most common form of focal dystonia, is characterized by involuntary contractions of the neck muscles, which produce abnormal posturing of the head upon the trunk.

Keywords - Diseasei

Disease mutation, Dystonia

Organism-specific databases

DisGeNET

More...DisGeNETi		25792

MalaCards human disease database

More...MalaCardsi		CIZ1

Open Targets

More...OpenTargetsi		ENSG00000148337

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		420492 Adult-onset cervical dystonia, DYT23 type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134883336

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CIZ1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434448

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897761 – 898Cip1-interacting zinc finger proteinAdd BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei209PhosphoserineCombined sources1
Modified residuei244PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei350PhosphoserineCombined sources1
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei547PhosphoserineCombined sources1
Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei567PhosphothreonineCombined sources1
Cross-linki588Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki680Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei821PhosphoserineCombined sources1
Cross-linki830Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei838PhosphoserineCombined sources1
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULV3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULV3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULV3

PeptideAtlas

More...PeptideAtlasi		Q9ULV3

PRoteomics IDEntifications database

More...PRIDEi		Q9ULV3

ProteomicsDB human proteome resource

More...ProteomicsDBi		7084
85130 [Q9ULV3-1]
85131 [Q9ULV3-2]
85132 [Q9ULV3-3]
85133 [Q9ULV3-4]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9ULV3

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148337 Expressed in 229 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULV3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULV3 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA020380
HPA020387

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CIP/WAF1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SH3BP4Q9P0V32EBI-2652948,EBI-1049513

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		117325, 29 interactors

Protein interaction database and analysis system

More...IntActi		Q9ULV3, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000439244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULV3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 44Gln-richAdd BLAST41
Compositional biasi276 – 470Gln-richAdd BLAST195
Compositional biasi741 – 761Glu-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri799 – 830Matrin-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410II97 Eukaryota
ENOG4111HAM LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00440000039084

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULV3

Database of Orthologous Groups

More...OrthoDBi		524482at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULV3

TreeFam database of animal gene trees

More...TreeFami		TF332388

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026811 CIZ1
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR15491 PTHR15491, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355 ZnF_C2H2, 3 hits
SM00451 ZnF_U1, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50171 ZF_MATRIN, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSQQQQQQL QQQQQQLQQL QQQQLQQQQL QQQQLLQLQQ LLQQSPPQAP 
        60         70         80         90        100
LPMAVSRGLP PQQPQQPLLN LQGTNSASLL NGSMLQRALL LQQLQGLDQF 
       110        120        130        140        150
AMPPATYDTA GLTMPTATLG NLRGYGMASP GLAAPSLTPP QLATPNLQQF 
       160        170        180        190        200
FPQATRQSLL GPPPVGVPMN PSQFNLSGRN PQKQARTSSS TTPNRKDSSS 
       210        220        230        240        250
QTMPVEDKSD PPEGSEEAAE PRMDTPEDQD LPPCPEDIAK EKRTPAPEPE 
       260        270        280        290        300
PCEASELPAK RLRSSEEPTE KEPPGQLQVK AQPQARMTVP KQTQTPDLLP 
       310        320        330        340        350
EALEAQVLPR FQPRVLQVQA QVQSQTQPRI PSTDTQVQPK LQKQAQTQTS 
       360        370        380        390        400
PEHLVLQQKQ VQPQLQQEAE PQKQVQPQVQ PQAHSQGPRQ VQLQQEAEPL 
       410        420        430        440        450
KQVQPQVQPQ AHSQPPRQVQ LQLQKQVQTQ TYPQVHTQAQ PSVQPQEHPP 
       460        470        480        490        500
AQVSVQPPEQ THEQPHTQPQ VSLLAPEQTP VVVHVCGLEM PPDAVEAGGG 
       510        520        530        540        550
MEKTLPEPVG TQVSMEEIQN ESACGLDVGE CENRAREMPG VWGAGGSLKV 
       560        570        580        590        600
TILQSSDSRA FSTVPLTPVP RPSDSVSSTP AATSTPSKQA LQFFCYICKA 
       610        620        630        640        650
SCSSQQEFQD HMSEPQHQQR LGEIQHMSQA CLLSLLPVPR DVLETEDEEP 
       660        670        680        690        700
PPRRWCNTCQ LYYMGDLIQH RRTQDHKIAK QSLRPFCTVC NRYFKTPRKF 
       710        720        730        740        750
VEHVKSQGHK DKAKELKSLE KEIAGQDEDH FITVDAVGCF EGDEEEEEDD 
       760        770        780        790        800
EDEEEIEVEE ELCKQVRSRD ISREEWKGSE TYSPNTAYGV DFLVPVMGYI 
       810        820        830        840        850
CRICHKFYHS NSGAQLSHCK SLGHFENLQK YKAAKNPSPT TRPVSRRCAI 
       860        870        880        890 
NARNALTALF TSSGRPPSQP NTQDKTPSKV TARPSQPPLP RRSTRLKT
Length:898
Mass (Da):100,045
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E14389E81A146F1
GO
Isoform 2 (identifier: Q9ULV3-2) [UniParc]FASTAAdd to basket
Also known as: NP94B

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     197-201: Missing.

Show »
Length:869
Mass (Da):97,075
Checksum:iACCB3ABBE6A91F03
GO
Isoform 3 (identifier: Q9ULV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-120: Missing.
     377-432: Missing.

Show »
Length:818
Mass (Da):91,153
Checksum:i28DBDF0FB222820E
GO
Isoform 4 (identifier: Q9ULV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-432: Missing.

Show »
Length:842
Mass (Da):93,619
Checksum:iC799C715E082C006
GO
Isoform 5 (identifier: Q9ULV3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Note: No experimental confirmation available.
Show »
Length:797
Mass (Da):88,520
Checksum:i1C3805A4CFAC8864
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2X7F5H2X7_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
954Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9BTG3Q9BTG3_HUMAN
CIZ1 protein
CIZ1
837Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5D5H0Y5D5_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
820Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SYW2Q5SYW2_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
870Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6VD24F6VD24_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0L7A0A494C0L7_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
820Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQR2A0A0U1RQR2_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6WSM2F6WSM2_HUMAN
Cip1-interacting zinc finger protei...
CIZ1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF23231 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF37882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9Missing in AAF23231 (PubMed:12824700).Curated1
Sequence conflicti35L → S in AAF23231 (PubMed:12824700).Curated1
Sequence conflicti101A → V in BAB14750 (PubMed:14702039).Curated1
Sequence conflicti232P → L in BAA85783 (PubMed:10529385).Curated1
Sequence conflicti500G → S in AAF37882 (PubMed:12824700).Curated1
Sequence conflicti549K → E in BAG64643 (PubMed:14702039).Curated1
Sequence conflicti555S → G in BAA85783 (PubMed:10529385).Curated1
Sequence conflicti568P → L in AAF23231 (PubMed:12824700).Curated1
Sequence conflicti634S → P in AAF23231 (PubMed:12824700).Curated1
Sequence conflicti677K → R in AAF37882 (PubMed:12824700).Curated1
Sequence conflicti678I → V in BAB14750 (PubMed:14702039).Curated1
Sequence conflicti682S → P in BAB14750 (PubMed:14702039).Curated1
Sequence conflicti698R → L in CAB44346 (PubMed:10369878).Curated1
Sequence conflicti735D → G in AAF23231 (PubMed:12824700).Curated1
Sequence conflicti757E → K in BAB14750 (PubMed:14702039).Curated1
Sequence conflicti810S → N in AAF37882 (PubMed:12824700).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06797147P → S Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. 1 Publication1
Natural variantiVAR_06797250P → L1 PublicationCorresponds to variant dbSNP:rs747696276Ensembl.1
Natural variantiVAR_056820219A → T1 PublicationCorresponds to variant dbSNP:rs45588035EnsemblClinVar.1
Natural variantiVAR_067973264S → G Probable disease-associated mutation found in a family with adult onset primary cervical dystonia; exonic splicing enhancer mutation resulting in altered CIZ1 splicing pattern. 1 PublicationCorresponds to variant dbSNP:rs397514566EnsemblClinVar.1
Natural variantiVAR_063105370E → G1 PublicationCorresponds to variant dbSNP:rs45554035EnsemblClinVar.1
Natural variantiVAR_067974394Q → E1 PublicationCorresponds to variant dbSNP:rs200010931Ensembl.1
Natural variantiVAR_067975577S → F1 PublicationCorresponds to variant dbSNP:rs780188256Ensembl.1
Natural variantiVAR_056821578S → F1 PublicationCorresponds to variant dbSNP:rs12334EnsemblClinVar.1
Natural variantiVAR_056822638V → M2 PublicationsCorresponds to variant dbSNP:rs11549266Ensembl.1
Natural variantiVAR_067976672R → M Probable disease-associated mutation found in patients with adult onset primary cervical dystonia. 1 Publication1
Natural variantiVAR_063106847R → Q1 PublicationCorresponds to variant dbSNP:rs11549260EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0447291 – 101Missing in isoform 5. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_00416497 – 120Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_004165197 – 201Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_039894377 – 432Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB030835 mRNA Translation: BAA85783.1
EF467915 Genomic DNA Translation: ABO43037.1
AK023978 mRNA Translation: BAB14750.1
AK292713 mRNA Translation: BAF85402.1
AK303636 mRNA Translation: BAG64643.1
AK316393 mRNA Translation: BAH14764.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87752.1
CH471090 Genomic DNA Translation: EAW87753.1
CH471090 Genomic DNA Translation: EAW87754.1
BC021163 mRNA Translation: AAH21163.1
AF159027 mRNA Translation: AAF23231.1 Different initiation.
AF234161 mRNA Translation: AAF37882.1 Different initiation.
Y17453 Genomic DNA Translation: CAB44346.1
Y17454 Genomic DNA Translation: CAB44347.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48033.1 [Q9ULV3-3]
CCDS48034.1 [Q9ULV3-4]
CCDS59147.1 [Q9ULV3-5]
CCDS6894.1 [Q9ULV3-1]

NCBI Reference Sequences

More...RefSeqi		NP_001124487.1, NM_001131015.1 [Q9ULV3-4]
NP_001124488.1, NM_001131016.1 [Q9ULV3-1]
NP_001124489.1, NM_001131017.1
NP_001124490.1, NM_001131018.1 [Q9ULV3-3]
NP_001244904.1, NM_001257975.1
NP_001244905.1, NM_001257976.1 [Q9ULV3-5]
NP_036259.2, NM_012127.2 [Q9ULV3-1]
XP_005251945.2, XM_005251888.3
XP_005251948.2, XM_005251891.3
XP_005251950.4, XM_005251893.4 [Q9ULV3-3]
XP_006717102.2, XM_006717039.3 [Q9ULV3-2]
XP_016870085.1, XM_017014596.1 [Q9ULV3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372938; ENSP00000362029; ENSG00000148337 [Q9ULV3-1]
ENST00000372948; ENSP00000362039; ENSG00000148337 [Q9ULV3-4]
ENST00000372954; ENSP00000362045; ENSG00000148337 [Q9ULV3-3]
ENST00000629610; ENSP00000486816; ENSG00000148337 [Q9ULV3-5]
ENST00000634901; ENSP00000489425; ENSG00000148337 [Q9ULV3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25792

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25792

UCSC genome browser

More...UCSCi		uc004btt.4 human [Q9ULV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030835 mRNA Translation: BAA85783.1
EF467915 Genomic DNA Translation: ABO43037.1
AK023978 mRNA Translation: BAB14750.1
AK292713 mRNA Translation: BAF85402.1
AK303636 mRNA Translation: BAG64643.1
AK316393 mRNA Translation: BAH14764.1
AL590708 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87752.1
CH471090 Genomic DNA Translation: EAW87753.1
CH471090 Genomic DNA Translation: EAW87754.1
BC021163 mRNA Translation: AAH21163.1
AF159027 mRNA Translation: AAF23231.1 Different initiation.
AF234161 mRNA Translation: AAF37882.1 Different initiation.
Y17453 Genomic DNA Translation: CAB44346.1
Y17454 Genomic DNA Translation: CAB44347.1
CCDSiCCDS48033.1 [Q9ULV3-3]
CCDS48034.1 [Q9ULV3-4]
CCDS59147.1 [Q9ULV3-5]
CCDS6894.1 [Q9ULV3-1]
RefSeqiNP_001124487.1, NM_001131015.1 [Q9ULV3-4]
NP_001124488.1, NM_001131016.1 [Q9ULV3-1]
NP_001124489.1, NM_001131017.1
NP_001124490.1, NM_001131018.1 [Q9ULV3-3]
NP_001244904.1, NM_001257975.1
NP_001244905.1, NM_001257976.1 [Q9ULV3-5]
NP_036259.2, NM_012127.2 [Q9ULV3-1]
XP_005251945.2, XM_005251888.3
XP_005251948.2, XM_005251891.3
XP_005251950.4, XM_005251893.4 [Q9ULV3-3]
XP_006717102.2, XM_006717039.3 [Q9ULV3-2]
XP_016870085.1, XM_017014596.1 [Q9ULV3-4]

3D structure databases

SMRiQ9ULV3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117325, 29 interactors
IntActiQ9ULV3, 11 interactors
STRINGi9606.ENSP00000439244

PTM databases

CarbonylDBiQ9ULV3
iPTMnetiQ9ULV3
PhosphoSitePlusiQ9ULV3

Polymorphism and mutation databases

BioMutaiCIZ1
DMDMi296434448

Proteomic databases

EPDiQ9ULV3
jPOSTiQ9ULV3
PaxDbiQ9ULV3
PeptideAtlasiQ9ULV3
PRIDEiQ9ULV3
ProteomicsDBi7084
85130 [Q9ULV3-1]
85131 [Q9ULV3-2]
85132 [Q9ULV3-3]
85133 [Q9ULV3-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372938; ENSP00000362029; ENSG00000148337 [Q9ULV3-1]
ENST00000372948; ENSP00000362039; ENSG00000148337 [Q9ULV3-4]
ENST00000372954; ENSP00000362045; ENSG00000148337 [Q9ULV3-3]
ENST00000629610; ENSP00000486816; ENSG00000148337 [Q9ULV3-5]
ENST00000634901; ENSP00000489425; ENSG00000148337 [Q9ULV3-1]
GeneIDi25792
KEGGihsa:25792
UCSCiuc004btt.4 human [Q9ULV3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25792
DisGeNETi25792

GeneCards: human genes, protein and diseases

More...GeneCardsi		CIZ1
HGNCiHGNC:16744 CIZ1
HPAiHPA020380
HPA020387
MalaCardsiCIZ1
MIMi611420 gene
neXtProtiNX_Q9ULV3
OpenTargetsiENSG00000148337
Orphaneti420492 Adult-onset cervical dystonia, DYT23 type
PharmGKBiPA134883336

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410II97 Eukaryota
ENOG4111HAM LUCA
GeneTreeiENSGT00440000039084
InParanoidiQ9ULV3
OrthoDBi524482at2759
PhylomeDBiQ9ULV3
TreeFamiTF332388

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CIZ1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CIZ1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25792

Protein Ontology

More...PROi		PR:Q9ULV3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148337 Expressed in 229 organ(s), highest expression level in testis
ExpressionAtlasiQ9ULV3 baseline and differential
GenevisibleiQ9ULV3 HS

Family and domain databases

InterProiView protein in InterPro
IPR026811 CIZ1
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR15491 PTHR15491, 2 hits
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SM00451 ZnF_U1, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50171 ZF_MATRIN, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIZ1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULV3
Secondary accession number(s): A8K9J8
, B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 18, 2010
Last modified: July 31, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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