FZD4

Functionⁱ

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functionⁱ

amyloid-beta binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 18234671
cytokine binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17955262
G protein-coupled receptor activity Source: UniProtKB-KW
PDZ domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20802536
protein-containing complex binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 18234671
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14688793
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14688793
signaling receptor activity Source: ARUK-UCL
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22575959
Wnt-activated receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17955262
Wnt-protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 20802536
cellular response to leukemia inhibitory factor Source: Ensembl
cellular response to retinoic acid Source: UniProtKB
cerebellum vasculature morphogenesis Source: Ensembl
extracellular matrix-cell signaling Source: Ensembl
locomotion involved in locomotory behavior Source: Ensembl
membrane organization Source: Reactome
negative regulation of cell-substrate adhesion
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18156211
neuron differentiation Source: UniProtKB
non-canonical Wnt signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 14688793
positive regulation of JUN kinase activity Source: Ensembl
positive regulation of neuron projection arborization Source: ARUK-UCL
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 15035989
- 17955262
progesterone secretion Source: Ensembl
regulation of vascular endothelial growth factor receptor signaling pathway Source: Ensembl
retinal blood vessel morphogenesis Source: Ensembl
retina vasculature morphogenesis in camera-type eye
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12172548
- 15024691
sensory perception of sound Source: Ensembl
substrate adhesion-dependent cell spreading Source: Ensembl
vasculogenesis Source: Ensembl
Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 17955262
Wnt signaling pathway, calcium modulating pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12172548
Wnt signaling pathway, planar cell polarity pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, G-protein coupled receptor, Receptor, Transducer
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-4086398 Ca2+ pathway R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641263 Regulation of FZD by ubiquitination R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-5340588 RNF mutants show enhanced WNT signaling and proliferation R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	Q9ULV1
SIGNORⁱ	Q9ULV1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Frizzled-4 Short name: Fz-4 Short name: hFz4 Alternative name(s): FzE4 CD_antigen: CD344
Gene namesⁱ	Name:FZD4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174804.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4042 FZD4
MIMⁱ	604579 gene
neXtProtⁱ	NX_Q9ULV1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	37 – 222	ExtracellularSequence analysisAdd BLAST	186
Transmembraneⁱ	223 – 243	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	244 – 254	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	255 – 275	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	276 – 302	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	303 – 323	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	324 – 344	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	345 – 365	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	366 – 389	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	390 – 410	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	411 – 436	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	437 – 457	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	458 – 477	ExtracellularSequence analysisAdd BLAST	20
Transmembraneⁱ	478 – 498	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	499 – 537	CytoplasmicSequence analysisAdd BLAST	39

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Vitreoretinopathy, exudative 1 (EVR1)13 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. In many ways the disease resembles retinopathy of prematurity but there is no evidence of prematurity or small birth weight in the patient history.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8322
GeneReviewsⁱ	FZD4
MalaCards human disease database More...MalaCardsⁱ	FZD4
MIMⁱ	133780 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000174804
Orphanetⁱ	891 Familial exudative vitreoretinopathy 91495 Persistent hyperplastic primary vitreous 90050 Retinopathy of prematurity
PharmGKBⁱ	PA28459

Polymorphism and mutation databases

BioMutaⁱ	FZD4
DMDMⁱ	62298045

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 36	Sequence analysisAdd BLAST		36
ChainⁱPRO_0000012985	37 – 537	Frizzled-4Add BLAST		501

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	45 ↔ 106	PROSITE-ProRule annotation
Disulfide bondⁱ	53 ↔ 99	PROSITE-ProRule annotation
Glycosylationⁱ	59	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	90 ↔ 128	PROSITE-ProRule annotation
Disulfide bondⁱ	117 ↔ 158	PROSITE-ProRule annotation
Disulfide bondⁱ	121 ↔ 145	PROSITE-ProRule annotation
Glycosylationⁱ	144	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9ULV1
PaxDbⁱ	Q9ULV1
PeptideAtlas More...PeptideAtlasⁱ	Q9ULV1
PRIDEⁱ	Q9ULV1
ProteomicsDBⁱ	85129

PTM databases

iPTMnetⁱ	Q9ULV1
PhosphoSitePlusⁱ	Q9ULV1

Expressionⁱ

Tissue specificityⁱ

Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.

Gene expression databases

Bgeeⁱ	ENSG00000174804 Expressed in 213 organ(s), highest expression level in adipose tissue of abdominal region
CleanExⁱ	HS_FZD4
Genevisibleⁱ	Q9ULV1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042328 HPA074833

HPAⁱ

HPA042328
HPA074833

Interactionⁱ

Subunit structureⁱ

Interacts with MAGI3 and NDP. Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP). Interacts (via FZ domain) with TSKU. Interacts with glypican GPC3 (PubMed:24496449).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
I79_000956	G3GTH2	2	EBI-2466380,EBI-3504975	From Cricetulus griseus.
NDP	Q00604	4	EBI-2466380,EBI-2466352

GO - Molecular functionⁱ

cytokine binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17955262
PDZ domain binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20802536
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14688793
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 14688793
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22575959
Wnt-protein binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113918, 12 interactors
IntActⁱ	Q9ULV1, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q9ULV1
STRINGⁱ	9606.ENSP00000434034

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	45 – 47	Combined sources	3
Helixⁱ	51 – 53	Combined sources	3
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	59 – 61	Combined sources	3
Helixⁱ	72 – 79	Combined sources	8
Helixⁱ	80 – 82	Combined sources	3
Helixⁱ	83 – 88	Combined sources	6
Helixⁱ	94 – 102	Combined sources	9
Beta strandⁱ	105 – 107	Combined sources	3
Beta strandⁱ	110 – 114	Combined sources	5
Helixⁱ	118 – 134	Combined sources	17
Helixⁱ	141 – 143	Combined sources	3
Helixⁱ	145 – 147	Combined sources	3
Beta strandⁱ	153 – 155	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9ULV1
SMRⁱ	Q9ULV1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	40 – 161	FZPROSITE-ProRule annotationAdd BLAST		122

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	499 – 504	Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity		6
Motifⁱ	535 – 537	PDZ-binding		3

Domainⁱ

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor Fz/Smo family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3577 Eukaryota ENOG410XRC8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118864
HOGENOMⁱ	HOG000233236
HOVERGENⁱ	HBG006977
InParanoidⁱ	Q9ULV1
KEGG Orthology (KO) More...KOⁱ	K02354
OMAⁱ	SMCLSVK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N5M
PhylomeDBⁱ	Q9ULV1
TreeFamⁱ	TF317907

Family and domain databases

Gene3Dⁱ	1.10.2000.10, 1 hit
InterProⁱ	View protein in InterPro IPR015526 Frizzled/SFRP IPR000539 Frizzled/Smoothened_TM IPR020067 Frizzled_dom IPR036790 Frizzled_dom_sf IPR026551 FZD4 IPR017981 GPCR_2-like
PANTHERⁱ	PTHR11309 PTHR11309, 1 hit PTHR11309:SF23 PTHR11309:SF23, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01534 Frizzled, 1 hit PF01392 Fz, 1 hit
PRINTSⁱ	PR00489 FRIZZLED
SMARTⁱ	View protein in SMART SM00063 FRI, 1 hit SM01330 Frizzled, 1 hit
SUPFAMⁱ	SSF63501 SSF63501, 1 hit
PROSITEⁱ	View protein in PROSITE PS50038 FZ, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9ULV1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAWRGAGPSV PGAPGGVGLS LGLLLQLLLL LGPARGFGDE EERRCDPIRI 
        60         70         80         90        100
SMCQNLGYNV TKMPNLVGHE LQTDAELQLT TFTPLIQYGC SSQLQFFLCS 
       110        120        130        140        150
VYVPMCTEKI NIPIGPCGGM CLSVKRRCEP VLKEFGFAWP ESLNCSKFPP 
       160        170        180        190        200
QNDHNHMCME GPGDEEVPLP HKTPIQPGEE CHSVGTNSDQ YIWVKRSLNC 
       210        220        230        240        250
VLKCGYDAGL YSRSAKEFTD IWMAVWASLC FISTAFTVLT FLIDSSRFSY 
       260        270        280        290        300
PERPIIFLSM CYNIYSIAYI VRLTVGRERI SCDFEEAAEP VLIQEGLKNT 
       310        320        330        340        350
GCAIIFLLMY FFGMASSIWW VILTLTWFLA AGLKWGHEAI EMHSSYFHIA 
       360        370        380        390        400
AWAIPAVKTI VILIMRLVDA DELTGLCYVG NQNLDALTGF VVAPLFTYLV 
       410        420        430        440        450
IGTLFIAAGL VALFKIRSNL QKDGTKTDKL ERLMVKIGVF SVLYTVPATC 
       460        470        480        490        500
VIACYFYEIS NWALFRYSAD DSNMAVEMLK IFMSLLVGIT SGMWIWSAKT 
       510        520        530 
LHTWQKCSNR LVNSGKVKRE KRGNGWVKPG KGSETVV

Length:537

Mass (Da):59,881

Last modified:March 29, 2005 - v2

Checksum:ⁱE0A83ECEC560A381

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	481	I → T in BAA86286 (PubMed:10544037).Curated		1
Sequence conflictⁱ	500	T → S in BAA86286 (PubMed:10544037).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063920	33	P → S in EVR1; unknown pathological significance. 3 PublicationsCorresponds to variant dbSNP:rs61735304EnsemblClinVar.	1
Natural variantⁱVAR_063921	36	G → D in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358281Ensembl.	1
Natural variantⁱVAR_063922	40	E → Q in EVR1. 1 PublicationCorresponds to variant dbSNP:rs139401671EnsemblClinVar.	1
Natural variantⁱVAR_063923	69	H → Y in EVR1; minor reduction of its wild-type activity. 4 PublicationsCorresponds to variant dbSNP:rs80358282EnsemblClinVar.	1
Natural variantⁱVAR_063924	105	M → T in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358285Ensembl.	1
Natural variantⁱVAR_038947	105	M → V in EVR1; loss of function. 4 PublicationsCorresponds to variant dbSNP:rs80358284EnsemblClinVar.	1
Natural variantⁱVAR_063925	114	I → T in EVR1. 1 Publication	1
Natural variantⁱVAR_038948	157	M → V in EVR1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs80358286Ensembl.	1
Natural variantⁱVAR_063926	168	P → S3 PublicationsCorresponds to variant dbSNP:rs61735303EnsemblClinVar.	1
Natural variantⁱVAR_063927	181	C → R in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358287Ensembl.	1
Natural variantⁱVAR_063928	203	K → N in retinopathy of prematurity. 1 PublicationCorresponds to variant dbSNP:rs1476724511Ensembl.	1
Natural variantⁱVAR_063929	204	C → R in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358288Ensembl.	1
Natural variantⁱVAR_063930	204	C → Y in EVR1. 1 PublicationCorresponds to variant dbSNP:rs1064794064Ensembl.	1
Natural variantⁱVAR_063931	223	M → K in EVR1. 1 Publication	1
Natural variantⁱVAR_063932	256	I → V in EVR1. 1 PublicationCorresponds to variant dbSNP:rs104894223EnsemblClinVar.	1
Natural variantⁱVAR_063933	335	W → C in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358292EnsemblClinVar.	1
Natural variantⁱVAR_063934	342	M → V in EVR1. 2 PublicationsCorresponds to variant dbSNP:rs80358293EnsemblClinVar.	1
Natural variantⁱVAR_063935	370	A → G in retinopathy of prematurity. 1 Publication	1
Natural variantⁱVAR_063936	417	R → Q in EVR1; 48% loss of its wild-type activity; associated in a EVR4 patient with mutation CYS-444 in LPR5. 3 PublicationsCorresponds to variant dbSNP:rs80358294EnsemblClinVar.	1
Natural variantⁱVAR_036413	436	K → T in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_063937	445	T → P in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358297Ensembl.	1
Natural variantⁱVAR_063938	488	G → D in EVR1. 2 PublicationsCorresponds to variant dbSNP:rs80358298Ensembl.	1
Natural variantⁱVAR_017777	493 – 494	Missing in EVR1; loss of function. 3 Publications	2
Natural variantⁱVAR_063939	497	S → F in EVR1. 1 PublicationCorresponds to variant dbSNP:rs80358300Ensembl.	1
Natural variantⁱVAR_063940	525	G → R in EVR1. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032417 mRNA Translation: BAA86286.1 AY462097 mRNA Translation: AAR23924.1 AK292768 mRNA Translation: BAF85457.1 AP001528 Genomic DNA No translation available. BC114527 mRNA Translation: AAI14528.1 BC114622 mRNA Translation: AAI14623.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8279.1
PIRⁱ	JC7127
NCBI Reference Sequences More...RefSeqⁱ	NP_036325.2, NM_012193.3
UniGeneⁱ	Hs.591968

Genome annotation databases

Ensemblⁱ	ENST00000531380; ENSP00000434034; ENSG00000174804
GeneIDⁱ	8322
KEGGⁱ	hsa:8322
UCSC genome browser More...UCSCⁱ	uc001pce.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV1	Frizzled-4		RAT		538	UniRef90_Q9ULV1
Frizzled-4		MOUSE		537
Uncharacterized protein		AOTNA		543
Uncharacterized protein		Cebus capucinus imitator		543
Frizzled class receptor 4		SARHA		542
+125

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV1	Frizzled-4		RAT		538	UniRef50_Q9ULV1
Frizzled-4		MOUSE		537
Frizzled-4		CHICK		525
Frizzled-4		XENLA		523
Uncharacterized protein		AOTNA		543
+247

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032417 mRNA Translation: BAA86286.1 AY462097 mRNA Translation: AAR23924.1 AK292768 mRNA Translation: BAF85457.1 AP001528 Genomic DNA No translation available. BC114527 mRNA Translation: AAI14528.1 BC114622 mRNA Translation: AAI14623.1
CCDSⁱ	CCDS8279.1
PIRⁱ	JC7127
RefSeqⁱ	NP_036325.2, NM_012193.3
UniGeneⁱ	Hs.591968

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5BPB	X-ray	2.20	A/B/C/D	42-179	[»]
	5BPQ	X-ray	2.40	A/B/C/D	42-179	[»]
	5BQC	X-ray	3.00	B	42-179	[»]
	5BQE	X-ray	2.30	C	42-179	[»]
	5CL1	X-ray	3.80	C/D	38-160	[»]
	5CM4	X-ray	2.40	A/B	40-164	[»]
	5UWG	X-ray	2.56	A/B	40-164	[»]
ProteinModelPortalⁱ	Q9ULV1
SMRⁱ	Q9ULV1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113918, 12 interactors
IntActⁱ	Q9ULV1, 7 interactors
MINTⁱ	Q9ULV1
STRINGⁱ	9606.ENSP00000434034

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q9ULV1
PhosphoSitePlusⁱ	Q9ULV1

Polymorphism and mutation databases

BioMutaⁱ	FZD4
DMDMⁱ	62298045

Proteomic databases

MaxQBⁱ	Q9ULV1
PaxDbⁱ	Q9ULV1
PeptideAtlasⁱ	Q9ULV1
PRIDEⁱ	Q9ULV1
ProteomicsDBⁱ	85129

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000531380; ENSP00000434034; ENSG00000174804
GeneIDⁱ	8322
KEGGⁱ	hsa:8322
UCSCⁱ	uc001pce.4 human

Organism-specific databases

CTDⁱ	8322
DisGeNETⁱ	8322
EuPathDBⁱ	HostDB:ENSG00000174804.3
GeneCardsⁱ	FZD4
GeneReviewsⁱ	FZD4
HGNCⁱ	HGNC:4042 FZD4
HPAⁱ	HPA042328 HPA074833
MalaCardsⁱ	FZD4
MIMⁱ	133780 phenotype 604579 gene
neXtProtⁱ	NX_Q9ULV1
OpenTargetsⁱ	ENSG00000174804
Orphanetⁱ	891 Familial exudative vitreoretinopathy 91495 Persistent hyperplastic primary vitreous 90050 Retinopathy of prematurity
PharmGKBⁱ	PA28459
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3577 Eukaryota ENOG410XRC8 LUCA
GeneTreeⁱ	ENSGT00760000118864
HOGENOMⁱ	HOG000233236
HOVERGENⁱ	HBG006977
InParanoidⁱ	Q9ULV1
KOⁱ	K02354
OMAⁱ	SMCLSVK
OrthoDBⁱ	EOG091G0N5M
PhylomeDBⁱ	Q9ULV1
TreeFamⁱ	TF317907

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-4086398 Ca2+ pathway R-HSA-4608870 Asymmetric localization of PCP proteins R-HSA-4641263 Regulation of FZD by ubiquitination R-HSA-5099900 WNT5A-dependent internalization of FZD4 R-HSA-5340588 RNF mutants show enhanced WNT signaling and proliferation R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	Q9ULV1
SIGNORⁱ	Q9ULV1

Miscellaneous databases

GeneWikiⁱ	FZD4
GenomeRNAiⁱ	8322
Protein Ontology More...PROⁱ	PR:Q9ULV1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174804 Expressed in 213 organ(s), highest expression level in adipose tissue of abdominal region
CleanExⁱ	HS_FZD4
Genevisibleⁱ	Q9ULV1 HS

Family and domain databases

Gene3Dⁱ	1.10.2000.10, 1 hit
InterProⁱ	View protein in InterPro IPR015526 Frizzled/SFRP IPR000539 Frizzled/Smoothened_TM IPR020067 Frizzled_dom IPR036790 Frizzled_dom_sf IPR026551 FZD4 IPR017981 GPCR_2-like
PANTHERⁱ	PTHR11309 PTHR11309, 1 hit PTHR11309:SF23 PTHR11309:SF23, 1 hit
Pfamⁱ	View protein in Pfam PF01534 Frizzled, 1 hit PF01392 Fz, 1 hit
PRINTSⁱ	PR00489 FRIZZLED
SMARTⁱ	View protein in SMART SM00063 FRI, 1 hit SM01330 Frizzled, 1 hit
SUPFAMⁱ	SSF63501 SSF63501, 1 hit
PROSITEⁱ	View protein in PROSITE PS50038 FZ, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FZD4_HUMAN
Accessionⁱ	Q9ULV1Primary (citable) accession number: Q9ULV1 Secondary accession number(s): A8K9Q3, Q14C97, Q6S9E4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
	Last sequence update:	March 29, 2005
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - Q9ULV1 (FZD4_HUMAN)

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Frizzled-4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

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Plasma Membrane

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Gene expression databases

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Secondary structure

3D structure databases

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Keywords - Coding sequence diversityi

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ