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Entry version 183 (18 Sep 2019)
Sequence version 3 (18 May 2010)
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Protein

Unconventional myosin-Vb

Gene

MYO5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi163 – 170ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Unconventional myosin-Vb
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYO5B
Synonyms:KIAA1119
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7603 MYO5B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606540 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULV0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diarrhea 2, with microvillus atrophy (DIAR2)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054993108V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar.1
Natural variantiVAR_071649143A → E in DIAR2. 1 Publication1
Natural variantiVAR_071650168G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1324907355Ensembl.1
Natural variantiVAR_054994219R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532Ensembl.1
Natural variantiVAR_071651316G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar.1
Natural variantiVAR_071652401R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1555648414EnsemblClinVar.1
Natural variantiVAR_071653435G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1283622290Ensembl.1
Natural variantiVAR_071654456N → S in DIAR2. 1 Publication1
Natural variantiVAR_071655514C → R in DIAR2. 1 Publication1
Natural variantiVAR_072814538F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_072815550I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_054995656R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar.1
Natural variantiVAR_071656660P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar.1
Natural variantiVAR_0716571556L → R in DIAR2. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1300Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication1
Mutagenesisi1307Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication1
Mutagenesisi1714Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication1
Mutagenesisi1748Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4645

MalaCards human disease database

More...
MalaCardsi
MYO5B
MIMi251850 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167306

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2290 Microvillus inclusion disease
480491 MYO5B-related progressive familial intrahepatic cholestasis
79306 Progressive familial intrahepatic cholestasis type 1

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31408

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYO5B

Domain mapping of disease mutations (DMDM)

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DMDMi
296439293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234601 – 1848Unconventional myosin-VbAdd BLAST1848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1446PhosphoserineCombined sources1
Isoform 3 (identifier: Q9ULV0-3)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9ULV0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9ULV0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9ULV0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9ULV0

PeptideAtlas

More...
PeptideAtlasi
Q9ULV0

PRoteomics IDEntifications database

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PRIDEi
Q9ULV0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81062
85128 [Q9ULV0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULV0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULV0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9ULV0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000167306 Expressed in 165 organ(s), highest expression level in lower esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9ULV0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9ULV0 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA040593
HPA040902
HPA069773

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3.

Interacts with RAB11FIP2, RAB11A, and RAB8A.

Found in a complex with CFTR and RAB11A.

Interacts with NPC1L1; (PubMed:19542231).

Interacts with LIMA1 (PubMed:29880681).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110729, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9ULV0

Protein interaction database and analysis system

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IntActi
Q9ULV0, 43 interactors

Molecular INTeraction database

More...
MINTi
Q9ULV0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285039

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11848
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9ULV0

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 60Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST53
Domaini69 – 761Myosin motorPROSITE-ProRule annotationAdd BLAST693
Domaini769 – 798IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini792 – 821IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini817 – 848IQ 3PROSITE-ProRule annotationAdd BLAST32
Domaini840 – 869IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini865 – 896IQ 5PROSITE-ProRule annotationAdd BLAST32
Domaini888 – 917IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1526 – 1803DilutePROSITE-ProRule annotationAdd BLAST278

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni21 – 40Requires for interaction with LIMA11 PublicationAdd BLAST20
Regioni640 – 662Actin-bindingSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili899 – 1266Sequence analysisAdd BLAST368
Coiled coili1341 – 1471Sequence analysisAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi801 – 916Arg-richAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155402

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000171839

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ULV0

KEGG Orthology (KO)

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KOi
K10357

Identification of Orthologs from Complete Genome Data

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OMAi
QCTRVWI

Database of Orthologous Groups

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OrthoDBi
1270467at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9ULV0

TreeFam database of animal gene trees

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TreeFami
TF328771

Family and domain databases

Conserved Domains Database

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CDDi
cd15477 Myo5b_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037990 Myo5b_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 6 hits
PF00063 Myosin_head, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY
60 70 80 90 100
PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS
210 220 230 240 250
PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV
260 270 280 290 300
FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD
310 320 330 340 350
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS
360 370 380 390 400
ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA
410 420 430 440 450
RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF
460 470 480 490 500
EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI
510 520 530 540 550
EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII
560 570 580 590 600
VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP
610 620 630 640 650
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT
660 670 680 690 700
TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY
710 720 730 740 750
HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA
760 770 780 790 800
GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG
810 820 830 840 850
HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF
860 870 880 890 900
VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR
910 920 930 940 950
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV
960 970 980 990 1000
TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK
1010 1020 1030 1040 1050
ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS
1060 1070 1080 1090 1100
VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN
1110 1120 1130 1140 1150
PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ
1160 1170 1180 1190 1200
KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL
1210 1220 1230 1240 1250
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA
1260 1270 1280 1290 1300
HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ
1310 1320 1330 1340 1350
EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ
1360 1370 1380 1390 1400
SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS
1410 1420 1430 1440 1450
RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR
1460 1470 1480 1490 1500
HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL
1510 1520 1530 1540 1550
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL
1560 1570 1580 1590 1600
SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ
1610 1620 1630 1640 1650
IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN
1660 1670 1680 1690 1700
SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR
1710 1720 1730 1740 1750
KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK
1760 1770 1780 1790 1800
KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ
1810 1820 1830 1840
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV
Length:1,848
Mass (Da):213,672
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EB8FA02F6B38707
GO
Isoform 2 (identifier: Q9ULV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-859: Missing.
     1315-1340: Missing.

Note: No experimental confirmation available.
Show »
Length:963
Mass (Da):111,759
Checksum:i14C45F254C2AFAB5
GO
Isoform 3 (identifier: Q9ULV0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:418
Mass (Da):47,983
Checksum:iE2A61014E7DFFF90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR36A0A0A0MR36_HUMAN
Unconventional myosin-Vb
MYO5B
965Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86433 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05618210C → G. Corresponds to variant dbSNP:rs16951438EnsemblClinVar.1
Natural variantiVAR_054993108V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar.1
Natural variantiVAR_063141126T → A2 PublicationsCorresponds to variant dbSNP:rs1815930EnsemblClinVar.1
Natural variantiVAR_071649143A → E in DIAR2. 1 Publication1
Natural variantiVAR_071650168G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1324907355Ensembl.1
Natural variantiVAR_054994219R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532Ensembl.1
Natural variantiVAR_056183307K → N. Corresponds to variant dbSNP:rs17659179EnsemblClinVar.1
Natural variantiVAR_071651316G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar.1
Natural variantiVAR_071652401R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1555648414EnsemblClinVar.1
Natural variantiVAR_071653435G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1283622290Ensembl.1
Natural variantiVAR_071654456N → S in DIAR2. 1 Publication1
Natural variantiVAR_071655514C → R in DIAR2. 1 Publication1
Natural variantiVAR_072814538F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_072815550I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_054995656R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar.1
Natural variantiVAR_071656660P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar.1
Natural variantiVAR_056184918R → H. Corresponds to variant dbSNP:rs2298624EnsemblClinVar.1
Natural variantiVAR_056185942K → R. Corresponds to variant dbSNP:rs2277716Ensembl.1
Natural variantiVAR_0631421055L → LL2 PublicationsCorresponds to variant dbSNP:rs72530399Ensembl.1
Natural variantiVAR_0716571556L → R in DIAR2. 1 Publication1
Natural variantiVAR_0716581688M → V1 PublicationCorresponds to variant dbSNP:rs112417235EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0561981 – 1430Missing in isoform 3. 1 PublicationAdd BLAST1430
Alternative sequenceiVSP_0561991 – 859Missing in isoform 2. 1 PublicationAdd BLAST859
Alternative sequenceiVSP_0562001315 – 1340Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032945 mRNA Translation: BAA86433.2 Different initiation.
AK025336 mRNA Translation: BAB15114.1
AB290160 mRNA Translation: BAG06714.1
AC090227 Genomic DNA No translation available.
AC091044 Genomic DNA No translation available.
AC092705 Genomic DNA No translation available.
AC105224 Genomic DNA No translation available.
BC033527 mRNA Translation: AAH33527.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42436.1 [Q9ULV0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001073936.1, NM_001080467.2 [Q9ULV0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285039; ENSP00000285039; ENSG00000167306 [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4645

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4645

UCSC genome browser

More...
UCSCi
uc002ldz.4 human [Q9ULV0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA Translation: BAA86433.2 Different initiation.
AK025336 mRNA Translation: BAB15114.1
AB290160 mRNA Translation: BAG06714.1
AC090227 Genomic DNA No translation available.
AC091044 Genomic DNA No translation available.
AC092705 Genomic DNA No translation available.
AC105224 Genomic DNA No translation available.
BC033527 mRNA Translation: AAH33527.1
CCDSiCCDS42436.1 [Q9ULV0-1]
RefSeqiNP_001073936.1, NM_001080467.2 [Q9ULV0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J5MX-ray2.07A1453-1848[»]
4LNZX-ray3.11A1460-1848[»]
4LWZX-ray2.55B/D1456-1848[»]
4LX0X-ray2.19B/D1456-1848[»]
SMRiQ9ULV0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110729, 58 interactors
CORUMiQ9ULV0
IntActiQ9ULV0, 43 interactors
MINTiQ9ULV0
STRINGi9606.ENSP00000285039

PTM databases

iPTMnetiQ9ULV0
PhosphoSitePlusiQ9ULV0
SwissPalmiQ9ULV0

Polymorphism and mutation databases

BioMutaiMYO5B
DMDMi296439293

Proteomic databases

EPDiQ9ULV0
jPOSTiQ9ULV0
MassIVEiQ9ULV0
PaxDbiQ9ULV0
PeptideAtlasiQ9ULV0
PRIDEiQ9ULV0
ProteomicsDBi81062
85128 [Q9ULV0-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306 [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3]
GeneIDi4645
KEGGihsa:4645
UCSCiuc002ldz.4 human [Q9ULV0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4645
DisGeNETi4645

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYO5B
HGNCiHGNC:7603 MYO5B
HPAiHPA040593
HPA040902
HPA069773
MalaCardsiMYO5B
MIMi251850 phenotype
606540 gene
neXtProtiNX_Q9ULV0
OpenTargetsiENSG00000167306
Orphaneti2290 Microvillus inclusion disease
480491 MYO5B-related progressive familial intrahepatic cholestasis
79306 Progressive familial intrahepatic cholestasis type 1
PharmGKBiPA31408

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155402
HOGENOMiHOG000171839
InParanoidiQ9ULV0
KOiK10357
OMAiQCTRVWI
OrthoDBi1270467at2759
PhylomeDBiQ9ULV0
TreeFamiTF328771

Enzyme and pathway databases

ReactomeiR-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYO5B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYO5B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4645

Pharos

More...
Pharosi
Q9ULV0

Protein Ontology

More...
PROi
PR:Q9ULV0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167306 Expressed in 165 organ(s), highest expression level in lower esophagus mucosa
ExpressionAtlasiQ9ULV0 baseline and differential
GenevisibleiQ9ULV0 HS

Family and domain databases

CDDicd15477 Myo5b_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037990 Myo5b_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 6 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO5B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULV0
Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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