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Protein

Unconventional myosin-Vb

Gene

MYO5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi163 – 170ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • endosomal transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • renal water homeostasis Source: Reactome
  • vesicle-mediated transport Source: UniProtKB

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Vb
Gene namesi
Name:MYO5B
Synonyms:KIAA1119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000167306.18
HGNCiHGNC:7603 MYO5B
MIMi606540 gene
neXtProtiNX_Q9ULV0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Diarrhea 2, with microvillus atrophy (DIAR2)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
See also OMIM:251850
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054993108V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar.1
Natural variantiVAR_071649143A → E in DIAR2. 1 Publication1
Natural variantiVAR_071650168G → R in DIAR2. 1 Publication1
Natural variantiVAR_054994219R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532Ensembl.1
Natural variantiVAR_071651316G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar.1
Natural variantiVAR_071652401R → H in DIAR2. 1 Publication1
Natural variantiVAR_071653435G → R in DIAR2. 1 Publication1
Natural variantiVAR_071654456N → S in DIAR2. 1 Publication1
Natural variantiVAR_071655514C → R in DIAR2. 1 Publication1
Natural variantiVAR_072814538F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_072815550I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_054995656R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar.1
Natural variantiVAR_071656660P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar.1
Natural variantiVAR_0716571556L → R in DIAR2. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1300Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication1
Mutagenesisi1307Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication1
Mutagenesisi1714Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication1
Mutagenesisi1748Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4645
MalaCardsiMYO5B
MIMi251850 phenotype
OpenTargetsiENSG00000167306
Orphaneti2290 Microvillus inclusion disease
PharmGKBiPA31408

Polymorphism and mutation databases

BioMutaiMYO5B
DMDMi296439293

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234601 – 1848Unconventional myosin-VbAdd BLAST1848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1446PhosphoserineCombined sources1
Isoform 3 (identifier: Q9ULV0-3)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ULV0
PaxDbiQ9ULV0
PeptideAtlasiQ9ULV0
PRIDEiQ9ULV0
ProteomicsDBi85128

PTM databases

iPTMnetiQ9ULV0
PhosphoSitePlusiQ9ULV0
SwissPalmiQ9ULV0

Expressioni

Gene expression databases

BgeeiENSG00000167306 Expressed in 165 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_MYO5B
ExpressionAtlasiQ9ULV0 baseline and differential
GenevisibleiQ9ULV0 HS

Organism-specific databases

HPAiHPA040593
HPA040902
HPA069773

Interactioni

Subunit structurei

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1; (PubMed:19542231). Interacts with LIMA1 (PubMed:29880681).6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110729, 54 interactors
CORUMiQ9ULV0
IntActiQ9ULV0, 36 interactors
MINTiQ9ULV0
STRINGi9606.ENSP00000285039

Structurei

Secondary structure

11848
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ULV0
SMRiQ9ULV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 60Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST53
Domaini69 – 761Myosin motorPROSITE-ProRule annotationAdd BLAST693
Domaini769 – 798IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini792 – 821IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini817 – 848IQ 3PROSITE-ProRule annotationAdd BLAST32
Domaini840 – 869IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini865 – 896IQ 5PROSITE-ProRule annotationAdd BLAST32
Domaini888 – 917IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini1526 – 1803DilutePROSITE-ProRule annotationAdd BLAST278

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 40Requires for interaction with LIMA11 PublicationAdd BLAST20
Regioni640 – 662Actin-bindingSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili899 – 1266Sequence analysisAdd BLAST368
Coiled coili1341 – 1471Sequence analysisAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi801 – 916Arg-richAdd BLAST116

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000171839
HOVERGENiHBG052556
InParanoidiQ9ULV0
KOiK10357
OMAiYMINAVT
OrthoDBiEOG091G0G93
PhylomeDBiQ9ULV0
TreeFamiTF328771

Family and domain databases

CDDicd15477 Myo5b_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037990 Myo5b_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 6 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY
60 70 80 90 100
PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS
210 220 230 240 250
PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV
260 270 280 290 300
FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD
310 320 330 340 350
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS
360 370 380 390 400
ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA
410 420 430 440 450
RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF
460 470 480 490 500
EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI
510 520 530 540 550
EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII
560 570 580 590 600
VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP
610 620 630 640 650
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT
660 670 680 690 700
TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY
710 720 730 740 750
HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA
760 770 780 790 800
GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG
810 820 830 840 850
HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF
860 870 880 890 900
VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR
910 920 930 940 950
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV
960 970 980 990 1000
TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK
1010 1020 1030 1040 1050
ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS
1060 1070 1080 1090 1100
VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN
1110 1120 1130 1140 1150
PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ
1160 1170 1180 1190 1200
KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL
1210 1220 1230 1240 1250
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA
1260 1270 1280 1290 1300
HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ
1310 1320 1330 1340 1350
EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ
1360 1370 1380 1390 1400
SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS
1410 1420 1430 1440 1450
RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR
1460 1470 1480 1490 1500
HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL
1510 1520 1530 1540 1550
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL
1560 1570 1580 1590 1600
SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ
1610 1620 1630 1640 1650
IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN
1660 1670 1680 1690 1700
SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR
1710 1720 1730 1740 1750
KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK
1760 1770 1780 1790 1800
KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ
1810 1820 1830 1840
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV
Length:1,848
Mass (Da):213,672
Last modified:May 18, 2010 - v3
Checksum:i4EB8FA02F6B38707
GO
Isoform 2 (identifier: Q9ULV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-859: Missing.
     1315-1340: Missing.

Note: No experimental confirmation available.
Show »
Length:963
Mass (Da):111,759
Checksum:i14C45F254C2AFAB5
GO
Isoform 3 (identifier: Q9ULV0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1430: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:418
Mass (Da):47,983
Checksum:iE2A61014E7DFFF90
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR36A0A0A0MR36_HUMAN
Unconventional myosin-Vb
MYO5B
965Annotation score:

Sequence cautioni

The sequence BAA86433 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05618210C → G. Corresponds to variant dbSNP:rs16951438EnsemblClinVar.1
Natural variantiVAR_054993108V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar.1
Natural variantiVAR_063141126T → A2 PublicationsCorresponds to variant dbSNP:rs1815930EnsemblClinVar.1
Natural variantiVAR_071649143A → E in DIAR2. 1 Publication1
Natural variantiVAR_071650168G → R in DIAR2. 1 Publication1
Natural variantiVAR_054994219R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532Ensembl.1
Natural variantiVAR_056183307K → N. Corresponds to variant dbSNP:rs17659179EnsemblClinVar.1
Natural variantiVAR_071651316G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar.1
Natural variantiVAR_071652401R → H in DIAR2. 1 Publication1
Natural variantiVAR_071653435G → R in DIAR2. 1 Publication1
Natural variantiVAR_071654456N → S in DIAR2. 1 Publication1
Natural variantiVAR_071655514C → R in DIAR2. 1 Publication1
Natural variantiVAR_072814538F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_072815550I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication1
Natural variantiVAR_054995656R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar.1
Natural variantiVAR_071656660P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar.1
Natural variantiVAR_056184918R → H. Corresponds to variant dbSNP:rs2298624EnsemblClinVar.1
Natural variantiVAR_056185942K → R. Corresponds to variant dbSNP:rs2277716Ensembl.1
Natural variantiVAR_0631421055L → LL2 PublicationsCorresponds to variant dbSNP:rs72530399Ensembl.1
Natural variantiVAR_0716571556L → R in DIAR2. 1 Publication1
Natural variantiVAR_0716581688M → V1 PublicationCorresponds to variant dbSNP:rs112417235EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561981 – 1430Missing in isoform 3. 1 PublicationAdd BLAST1430
Alternative sequenceiVSP_0561991 – 859Missing in isoform 2. 1 PublicationAdd BLAST859
Alternative sequenceiVSP_0562001315 – 1340Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA Translation: BAA86433.2 Different initiation.
AK025336 mRNA Translation: BAB15114.1
AB290160 mRNA Translation: BAG06714.1
AC090227 Genomic DNA No translation available.
AC091044 Genomic DNA No translation available.
AC092705 Genomic DNA No translation available.
AC105224 Genomic DNA No translation available.
BC033527 mRNA Translation: AAH33527.1
CCDSiCCDS42436.1 [Q9ULV0-1]
RefSeqiNP_001073936.1, NM_001080467.2 [Q9ULV0-1]
UniGeneiHs.720076

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306 [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3]
GeneIDi4645
KEGGihsa:4645
UCSCiuc002ldz.4 human [Q9ULV0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032945 mRNA Translation: BAA86433.2 Different initiation.
AK025336 mRNA Translation: BAB15114.1
AB290160 mRNA Translation: BAG06714.1
AC090227 Genomic DNA No translation available.
AC091044 Genomic DNA No translation available.
AC092705 Genomic DNA No translation available.
AC105224 Genomic DNA No translation available.
BC033527 mRNA Translation: AAH33527.1
CCDSiCCDS42436.1 [Q9ULV0-1]
RefSeqiNP_001073936.1, NM_001080467.2 [Q9ULV0-1]
UniGeneiHs.720076

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J5MX-ray2.07A1453-1848[»]
4LNZX-ray3.11A1460-1848[»]
4LWZX-ray2.55B/D1456-1848[»]
4LX0X-ray2.19B/D1456-1848[»]
ProteinModelPortaliQ9ULV0
SMRiQ9ULV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110729, 54 interactors
CORUMiQ9ULV0
IntActiQ9ULV0, 36 interactors
MINTiQ9ULV0
STRINGi9606.ENSP00000285039

PTM databases

iPTMnetiQ9ULV0
PhosphoSitePlusiQ9ULV0
SwissPalmiQ9ULV0

Polymorphism and mutation databases

BioMutaiMYO5B
DMDMi296439293

Proteomic databases

EPDiQ9ULV0
PaxDbiQ9ULV0
PeptideAtlasiQ9ULV0
PRIDEiQ9ULV0
ProteomicsDBi85128

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285039; ENSP00000285039; ENSG00000167306 [Q9ULV0-1]
ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3]
GeneIDi4645
KEGGihsa:4645
UCSCiuc002ldz.4 human [Q9ULV0-1]

Organism-specific databases

CTDi4645
DisGeNETi4645
EuPathDBiHostDB:ENSG00000167306.18
GeneCardsiMYO5B
H-InvDBiHIX0014446
HGNCiHGNC:7603 MYO5B
HPAiHPA040593
HPA040902
HPA069773
MalaCardsiMYO5B
MIMi251850 phenotype
606540 gene
neXtProtiNX_Q9ULV0
OpenTargetsiENSG00000167306
Orphaneti2290 Microvillus inclusion disease
PharmGKBiPA31408
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0160 Eukaryota
KOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000171839
HOVERGENiHBG052556
InParanoidiQ9ULV0
KOiK10357
OMAiYMINAVT
OrthoDBiEOG091G0G93
PhylomeDBiQ9ULV0
TreeFamiTF328771

Enzyme and pathway databases

ReactomeiR-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins

Miscellaneous databases

ChiTaRSiMYO5B human
GeneWikiiMYO5B
GenomeRNAii4645
PROiPR:Q9ULV0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167306 Expressed in 165 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_MYO5B
ExpressionAtlasiQ9ULV0 baseline and differential
GenevisibleiQ9ULV0 HS

Family and domain databases

CDDicd15477 Myo5b_CBD, 1 hit
cd01380 MYSc_Myo5, 1 hit
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR002710 Dilute_dom
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR037990 Myo5b_CBD
IPR001609 Myosin_head_motor_dom
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR036103 MYSc_Myo5
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01843 DIL, 1 hit
PF00612 IQ, 6 hits
PF00063 Myosin_head, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM01132 DIL, 1 hit
SM00015 IQ, 6 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51126 DILUTE, 1 hit
PS50096 IQ, 6 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO5B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULV0
Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 18, 2010
Last modified: October 10, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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