UniProtKB - Q9ULV0 (MYO5B_HUMAN)

>sp|Q9ULV0|MYO5B_HUMAN Unconventional myosin-Vb OS=Homo sapiens OX=9606 GN=MYO5B PE=1 SV=3
MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLP
FLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYG
QDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYF
ATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMR
TYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVD
DAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSN
FCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHI
NKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMK
EQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQK
PRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVP
ATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKP
NDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTD
KKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQ
KVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAV
VIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKAR
RELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVE
RLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADL
EQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQR
YDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAA
MDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSL
KRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEE
VLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDW
GYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFC
QTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAA
QALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCL
PAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCL
KQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSA
MLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQ
VFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPL
IQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQ
LQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV

Entry version 194 (02 Jun 2021)
Sequence version 3 (18 May 2010)
Previous versions | rss

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Protein

Unconventional myosin-Vb

Gene

MYO5B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.

2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	163 – 170	ATPSequence analysis		8

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding, Motor protein, Myosin
Biological process	Protein transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q9ULV0
Reactomeⁱ	R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Unconventional myosin-Vb
Gene namesⁱ	Name:MYO5B Synonyms:KIAA1119
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7603, MYO5B
MIMⁱ	606540, gene
neXtProtⁱ	NX_Q9ULV0
VEuPathDBⁱ	HostDB:ENSG00000167306.18

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diarrhea 2, with microvillus atrophy (DIAR2)6 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA disease characterized by onset of intractable life-threatening watery diarrhea during infancy. Two forms are recognized: early-onset microvillus inclusion disease with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054993	108	V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar.	1
Natural variantⁱVAR_071649	143	A → E in DIAR2. 1 Publication	1
Natural variantⁱVAR_071650	168	G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1324907355Ensembl.	1
Natural variantⁱVAR_054994	219	R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532EnsemblClinVar.	1
Natural variantⁱVAR_071651	316	G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar.	1
Natural variantⁱVAR_071652	401	R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1555648414EnsemblClinVar.	1
Natural variantⁱVAR_071653	435	G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1283622290Ensembl.	1
Natural variantⁱVAR_071654	456	N → S in DIAR2. 1 Publication	1
Natural variantⁱVAR_071655	514	C → R in DIAR2. 1 Publication	1
Natural variantⁱVAR_072814	538	F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication	1
Natural variantⁱVAR_072815	550	I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication	1
Natural variantⁱVAR_054995	656	R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar.	1
Natural variantⁱVAR_071656	660	P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar.	1
Natural variantⁱVAR_071657	1556	L → R in DIAR2. 1 Publication	1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1300	Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication	1
Mutagenesisⁱ	1307	Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication	1
Mutagenesisⁱ	1714	Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication	1
Mutagenesisⁱ	1748	Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication	1

Keywords - Diseaseⁱ

Disease variant

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4645
MalaCards human disease database More...MalaCardsⁱ	MYO5B
MIMⁱ	251850, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000167306
Orphanetⁱ	2290, Microvillus inclusion disease 480491, MYO5B-related progressive familial intrahepatic cholestasis 79306, Progressive familial intrahepatic cholestasis type 1
PharmGKBⁱ	PA31408

Miscellaneous databases

Pharosⁱ	Q9ULV0, Tbio

Pharosⁱ

Q9ULV0, Tbio

Genetic variation databases

BioMutaⁱ	MYO5B
DMDMⁱ	296439293

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000123460	1 – 1848	Unconventional myosin-VbAdd BLAST		1848

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1446	PhosphoserineCombined sources	1
Isoform 3 (identifier: Q9ULV0-3)
Modified residueⁱ	1	N-acetylmethionineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9ULV0
jPOSTⁱ	Q9ULV0
MassIVEⁱ	Q9ULV0
PaxDbⁱ	Q9ULV0
PeptideAtlas More...PeptideAtlasⁱ	Q9ULV0
PRIDEⁱ	Q9ULV0
ProteomicsDBⁱ	81062 85128 [Q9ULV0-1]

PTM databases

iPTMnetⁱ	Q9ULV0
PhosphoSitePlusⁱ	Q9ULV0
SwissPalmⁱ	Q9ULV0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167306, Expressed in lower esophagus mucosa and 179 other tissues
ExpressionAtlasⁱ	Q9ULV0, baseline and differential
Genevisibleⁱ	Q9ULV0, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000167306, Tissue enriched (intestine)

HPAⁱ

ENSG00000167306, Tissue enriched (intestine)

Interactionⁱ

Subunit structureⁱ

Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3.

Interacts with RAB11FIP2, RAB11A, and RAB8A.

Found in a complex with CFTR and RAB11A.

Interacts with NPC1L1; (PubMed:19542231).

Interacts with LIMA1 (PubMed:29880681).

6 Publications

Binary interactionsⁱ

Hide details

Q9ULV0

With	#Exp.	IntAct
AMOTL2 - isoform 4 [Q9Y2J4-4]	3	EBI-311356,EBI-10187270
BNIP2 [Q12982]	5	EBI-311356,EBI-752094
TCF4 [P15884]	3	EBI-311356,EBI-533224
TRIM54 [Q9BYV2]	3	EBI-311356,EBI-2130429

Isoform 2 [Q9ULV0-2]

With	#Exp.	IntAct
AMOTL2 [Q9Y2J4]	3	EBI-14093244,EBI-746752
BNIP2 [Q12982]	3	EBI-14093244,EBI-752094
EFHC2 [Q5JST6]	3	EBI-14093244,EBI-2349927
FAM214B [Q7L5A3]	3	EBI-14093244,EBI-745689
GMCL1 [Q96IK5]	3	EBI-14093244,EBI-2548508
MEI4 [A8MW99]	3	EBI-14093244,EBI-19944212
MEOX2 [Q6FHY5]	3	EBI-14093244,EBI-16439278
RAB11A [P62491]	3	EBI-14093244,EBI-745098
RAB11B [Q15907]	3	EBI-14093244,EBI-722234
RAB25 [P57735]	3	EBI-14093244,EBI-1050500
TCF4 - isoform SEF2-1D [P15884-3]	3	EBI-14093244,EBI-13636688
TRIM3 [O75382]	3	EBI-14093244,EBI-2129889
TRIM54 [Q9BYV2]	3	EBI-14093244,EBI-2130429
ZNHIT1 [O43257]	3	EBI-14093244,EBI-347522

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	110729, 74 interactors
CORUMⁱ	Q9ULV0
IntActⁱ	Q9ULV0, 53 interactors
Molecular INTeraction database More...MINTⁱ	Q9ULV0
STRINGⁱ	9606.ENSP00000285039

Miscellaneous databases

RNActⁱ	Q9ULV0, protein

RNActⁱ

Q9ULV0, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	1468 – 1471	Combined sources	4
Helixⁱ	1474 – 1476	Combined sources	3
Helixⁱ	1477 – 1484	Combined sources	8
Turnⁱ	1485 – 1487	Combined sources	3
Helixⁱ	1490 – 1493	Combined sources	4
Helixⁱ	1500 – 1514	Combined sources	15
Helixⁱ	1518 – 1538	Combined sources	21
Turnⁱ	1539 – 1541	Combined sources	3
Helixⁱ	1543 – 1562	Combined sources	20
Helixⁱ	1567 – 1569	Combined sources	3
Helixⁱ	1575 – 1578	Combined sources	4
Helixⁱ	1588 – 1613	Combined sources	26
Helixⁱ	1614 – 1616	Combined sources	3
Helixⁱ	1617 – 1622	Combined sources	6
Helixⁱ	1654 – 1670	Combined sources	17
Helixⁱ	1675 – 1699	Combined sources	25
Helixⁱ	1701 – 1703	Combined sources	3
Helixⁱ	1706 – 1725	Combined sources	20
Helixⁱ	1729 – 1731	Combined sources	3
Helixⁱ	1733 – 1736	Combined sources	4
Helixⁱ	1738 – 1746	Combined sources	9
Helixⁱ	1754 – 1763	Combined sources	10
Helixⁱ	1769 – 1778	Combined sources	10
Helixⁱ	1791 – 1800	Combined sources	10
Turnⁱ	1801 – 1803	Combined sources	3
Helixⁱ	1831 – 1833	Combined sources	3
Helixⁱ	1838 – 1840	Combined sources	3
Beta strandⁱ	1845 – 1848	Combined sources	4

Show more details

3D structure databases

SMRⁱ	Q9ULV0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	8 – 60	Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	69 – 761	Myosin motorPROSITE-ProRule annotationAdd BLAST	693
Domainⁱ	769 – 798	IQ 1PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	792 – 821	IQ 2PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	817 – 848	IQ 3PROSITE-ProRule annotationAdd BLAST	32
Domainⁱ	840 – 869	IQ 4PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	865 – 896	IQ 5PROSITE-ProRule annotationAdd BLAST	32
Domainⁱ	888 – 917	IQ 6PROSITE-ProRule annotationAdd BLAST	30
Domainⁱ	1526 – 1803	DilutePROSITE-ProRule annotationAdd BLAST	278

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	21 – 40	Requires for interaction with LIMA11 PublicationAdd BLAST	20
Regionⁱ	596 – 630	DisorderedSequence analysisAdd BLAST	35
Regionⁱ	640 – 662	Actin-bindingSequence analysisAdd BLAST	23
Regionⁱ	1093 – 1123	DisorderedSequence analysisAdd BLAST	31
Regionⁱ	1166 – 1192	DisorderedSequence analysisAdd BLAST	27

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	899 – 1266	Sequence analysisAdd BLAST		368
Coiled coilⁱ	1341 – 1471	Sequence analysisAdd BLAST		131

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1095 – 1123	Polar residuesSequence analysisAdd BLAST		29
Compositional biasⁱ	1166 – 1183	Basic and acidic residuesSequence analysisAdd BLAST		18

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0160, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000155402
HOGENOMⁱ	CLU_000192_9_1_1
InParanoidⁱ	Q9ULV0
OMAⁱ	ISFIIIH
PhylomeDBⁱ	Q9ULV0
TreeFamⁱ	TF328771

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15477, Myo5b_CBD, 1 hit cd01380, MYSc_Myo5, 1 hit
Gene3Dⁱ	2.30.30.360, 1 hit 3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR002710, Dilute_dom IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR037990, Myo5b_CBD IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR036103, MYSc_Myo5 IPR027417, P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01843, DIL, 1 hit PF00612, IQ, 6 hits PF00063, Myosin_head, 1 hit
PRINTSⁱ	PR00193, MYOSINHEAVY
SMARTⁱ	View protein in SMART SM01132, DIL, 1 hit SM00015, IQ, 6 hits SM00242, MYSc, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS51126, DILUTE, 1 hit PS50096, IQ, 6 hits PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9ULV0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY 
        60         70         80         90        100
PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY 
       110        120        130        140        150
TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM 
       160        170        180        190        200
ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS 
       210        220        230        240        250
PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV 
       260        270        280        290        300
FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD 
       310        320        330        340        350
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS 
       360        370        380        390        400
ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA 
       410        420        430        440        450
RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF 
       460        470        480        490        500
EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI 
       510        520        530        540        550
EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII 
       560        570        580        590        600
VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP 
       610        620        630        640        650
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT 
       660        670        680        690        700
TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY 
       710        720        730        740        750
HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA 
       760        770        780        790        800
GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG 
       810        820        830        840        850
HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF 
       860        870        880        890        900
VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR 
       910        920        930        940        950
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV 
       960        970        980        990       1000
TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK 
      1010       1020       1030       1040       1050
ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS 
      1060       1070       1080       1090       1100
VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN 
      1110       1120       1130       1140       1150
PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ 
      1160       1170       1180       1190       1200
KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL 
      1210       1220       1230       1240       1250
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA 
      1260       1270       1280       1290       1300
HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ 
      1310       1320       1330       1340       1350
EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ 
      1360       1370       1380       1390       1400
SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS 
      1410       1420       1430       1440       1450
RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR 
      1460       1470       1480       1490       1500
HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL 
      1510       1520       1530       1540       1550
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL 
      1560       1570       1580       1590       1600
SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ 
      1610       1620       1630       1640       1650
IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN 
      1660       1670       1680       1690       1700
SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR 
      1710       1720       1730       1740       1750
KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK 
      1760       1770       1780       1790       1800
KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ 
      1810       1820       1830       1840 
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV

Length:1,848

Mass (Da):213,672

Last modified:May 18, 2010 - v3

Checksum:ⁱ4EB8FA02F6B38707

Isoform 2 (identifier: Q9ULV0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-859: Missing.
1315-1340: Missing.

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        10         20         30         40         50
MEHKATTIQK HVRGWMARRH FQRLRDAAIV IQCAFRMLKA RRELKALRIE 
        60         70         80         90        100
ARSAEHLKRL NVGMENKVVQ LQRKIDEQNK EFKTLSEQLS VTTSTYTMEV 
       110        120        130        140        150
ERLKKELVHY QQSPGEDTSL RLQEEVESLR TELQRAHSER KILEDAHSRE 
       160        170        180        190        200
KDELRKRVAD LEQENALLKD EKEQLNNQIL CQSKDEFAQN SVKENLMKKE 
       210        220        230        240        250
LEEERSRYQN LVKEYSQLEQ RYDNLRDEMT IIKQTPGHRR NPSNQSSLES 
       260        270        280        290        300
DSNYPSISTS EIGDTEDALQ QVEEIGLEKA AMDMTVFLKL QKRVRELEQE 
       310        320        330        340        350
RKKLQVQLEK REQQDSKKVQ AEPPQTDIDL DPNADLAYNS LKRQELESEN 
       360        370        380        390        400
KKLKNDLNEL RKAVADQATQ NNSSHGSPDS YSLLLNQLKL AHEELEVRKE 
       410        420        430        440        450
EVLILRTQIV SADQRRLAGR NAEPNINARS SWPNSEKHVD QEDAIEAYHG 
       460        470        480        490        500
VCQTNRLLEA QLQAQSLEHE EEVEHLKAQL EALKEEMDKQ QQTFCQTLLL 
       510        520        530        540        550
SPEAQVEFGV QQEISRLTNE NLDLKELVEK LEKNERKLKK QLKIYMKKAQ 
       560        570        580        590        600
DLEAAQALAQ SERKRHELNR QVTVQRKEKD FQGMLEYHKE DEALLIRNLV 
       610        620        630        640        650
TDLKPQMLSG TVPCLPAYIL YMCIRHADYT NDDLKVHSLL TSTINGIKKV 
       660        670        680        690        700
LKKHNDDFEM TSFWLSNTCR LLHCLKQYSG DEGFMTQNTA KQNEHCLKNF 
       710        720        730        740        750
DLTEYRQVLS DLSIQIYQQL IKIAEGVLQP MIVSAMLENE SIQGLSGVKP 
       760        770        780        790        800
TGYRKRSSSM ADGDNSYCLE AIIRQMNAFH TVMCDQGLDP EIILQVFKQL 
       810        820        830        840        850
FYMINAVTLN NLLLRKDVCS WSTGMQLRYN ISQLEEWLRG RNLHQSGAVQ 
       860        870        880        890        900
TMEPLIQAAQ LLQLKKKTQE DAEAICSLCT SLSTQQIVKI LNLYTPLNEF 
       910        920        930        940        950
EERVTVAFIR TIQAQLQERN DPQQLLLDAK HMFPVLFPFN PSSLTMDSIH 
       960 
IPACLNLEFL NEV

Show »

Length:963

Mass (Da):111,759

Checksum:ⁱ14C45F254C2AFAB5

Isoform 3 (identifier: Q9ULV0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1430: Missing.

« Hide

        10         20         30         40         50
MKKAQDLEAA QALAQSERKR HELNRQVTVQ RKEKDFQGML EYHKEDEALL 
        60         70         80         90        100
IRNLVTDLKP QMLSGTVPCL PAYILYMCIR HADYTNDDLK VHSLLTSTIN 
       110        120        130        140        150
GIKKVLKKHN DDFEMTSFWL SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH 
       160        170        180        190        200
CLKNFDLTEY RQVLSDLSIQ IYQQLIKIAE GVLQPMIVSA MLENESIQGL 
       210        220        230        240        250
SGVKPTGYRK RSSSMADGDN SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ 
       260        270        280        290        300
VFKQLFYMIN AVTLNNLLLR KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ 
       310        320        330        340        350
SGAVQTMEPL IQAAQLLQLK KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT 
       360        370        380        390        400
PLNEFEERVT VAFIRTIQAQ LQERNDPQQL LLDAKHMFPV LFPFNPSSLT 
       410 
MDSIHIPACL NLEFLNEV

Show »

Length:418

Mass (Da):47,983

Checksum:ⁱE2A61014E7DFFF90

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A0MR36	A0A0A0MR36_HUMAN		Unconventional myosin-Vb Unconventional myosin-Vb	MYO5B	965	Annotation score:

Sequence cautionⁱ

The sequence BAA86433 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_056182	10	C → G. Corresponds to variant dbSNP:rs16951438EnsemblClinVar.	1
Natural variantⁱVAR_054993	108	V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar.	1
Natural variantⁱVAR_063141	126	T → A2 PublicationsCorresponds to variant dbSNP:rs1815930EnsemblClinVar.	1
Natural variantⁱVAR_071649	143	A → E in DIAR2. 1 Publication	1
Natural variantⁱVAR_071650	168	G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1324907355Ensembl.	1
Natural variantⁱVAR_054994	219	R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532EnsemblClinVar.	1
Natural variantⁱVAR_056183	307	K → N. Corresponds to variant dbSNP:rs17659179EnsemblClinVar.	1
Natural variantⁱVAR_071651	316	G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar.	1
Natural variantⁱVAR_071652	401	R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1555648414EnsemblClinVar.	1
Natural variantⁱVAR_071653	435	G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1283622290Ensembl.	1
Natural variantⁱVAR_071654	456	N → S in DIAR2. 1 Publication	1
Natural variantⁱVAR_071655	514	C → R in DIAR2. 1 Publication	1
Natural variantⁱVAR_072814	538	F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication	1
Natural variantⁱVAR_072815	550	I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication	1
Natural variantⁱVAR_054995	656	R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar.	1
Natural variantⁱVAR_071656	660	P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar.	1
Natural variantⁱVAR_056184	918	R → H. Corresponds to variant dbSNP:rs2298624EnsemblClinVar.	1
Natural variantⁱVAR_056185	942	K → R. Corresponds to variant dbSNP:rs2277716Ensembl.	1
Natural variantⁱVAR_063142	1055	L → LL2 PublicationsCorresponds to variant dbSNP:rs72530399Ensembl.	1
Natural variantⁱVAR_071657	1556	L → R in DIAR2. 1 Publication	1
Natural variantⁱVAR_071658	1688	M → V1 PublicationCorresponds to variant dbSNP:rs112417235EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056198	1 – 1430	Missing in isoform 3. 1 PublicationAdd BLAST	1430
Alternative sequenceⁱVSP_056199	1 – 859	Missing in isoform 2. 1 PublicationAdd BLAST	859
Alternative sequenceⁱVSP_056200	1315 – 1340	Missing in isoform 2. 1 PublicationAdd BLAST	26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032945 mRNA Translation: BAA86433.2 Different initiation. AK025336 mRNA Translation: BAB15114.1 AB290160 mRNA Translation: BAG06714.1 AC090227 Genomic DNA No translation available. AC091044 Genomic DNA No translation available. AC092705 Genomic DNA No translation available. AC105224 Genomic DNA No translation available. BC033527 mRNA Translation: AAH33527.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42436.1 [Q9ULV0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073936.1, NM_001080467.2 [Q9ULV0-1]

Genome annotation databases

Ensemblⁱ	ENST00000285039; ENSP00000285039; ENSG00000167306 [Q9ULV0-1] ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3]
GeneIDⁱ	4645
KEGGⁱ	hsa:4645
UCSC genome browser More...UCSCⁱ	uc002ldz.4, human [Q9ULV0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV0	Isoform 3 of Unconventional myosin-Vb		HUMAN		418	UniRef100_Q9ULV0
Acetyl-Coenzyme A acyltransferase 2 (Mitochondrial 3-oxoacyl-Coenzyme A thiolase), isoform CRA_d		HUMAN		1228
Q9ULV0-2	Unconventional myosin-Vb (Fragment)		HUMAN		965	UniRef100_Q9ULV0-2

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV0	Isoform 3 of Unconventional myosin-Vb		HUMAN		418	UniRef90_Q9ULV0
unconventional myosin-Vb		PUMCO		1929
unconventional myosin-Vb-like		LEPWE		106
Myosin VB		CANLF		1873
Myosin-vb-partial		LYNPA		1863
+100
Q9ULV0-2	Unconventional myosin-Vb (Fragment)		HUMAN		965	UniRef90_Q9ULV0-2
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9ULV0	Isoform 3 of Unconventional myosin-Vb		HUMAN		418	UniRef50_Q9ULV0
unconventional myosin-Vb		PUMCO		1929
unconventional myosin-Vb-like		LEPWE		106
Myosin VB		CANLF		1873
Myosin-vb-partial		LYNPA		1863
+587
Q9ULV0-2	Unconventional myosin-Vb (Fragment)		HUMAN		965	UniRef50_Q9ULV0-2
Dilute domain-containing protein (Fragment)		NEOVI		878
Uncharacterized protein (Fragment)		CHIPU		1148
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032945 mRNA Translation: BAA86433.2 Different initiation. AK025336 mRNA Translation: BAB15114.1 AB290160 mRNA Translation: BAG06714.1 AC090227 Genomic DNA No translation available. AC091044 Genomic DNA No translation available. AC092705 Genomic DNA No translation available. AC105224 Genomic DNA No translation available. BC033527 mRNA Translation: AAH33527.1
CCDSⁱ	CCDS42436.1 [Q9ULV0-1]
RefSeqⁱ	NP_001073936.1, NM_001080467.2 [Q9ULV0-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4J5M	X-ray	2.07	A	1453-1848	[»]
	4LNZ	X-ray	3.11	A	1460-1848	[»]
	4LWZ	X-ray	2.55	B/D	1456-1848	[»]
	4LX0	X-ray	2.19	B/D	1456-1848	[»]
SMRⁱ	Q9ULV0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	110729, 74 interactors
CORUMⁱ	Q9ULV0
IntActⁱ	Q9ULV0, 53 interactors
MINTⁱ	Q9ULV0
STRINGⁱ	9606.ENSP00000285039

PTM databases

iPTMnetⁱ	Q9ULV0
PhosphoSitePlusⁱ	Q9ULV0
SwissPalmⁱ	Q9ULV0

Genetic variation databases

BioMutaⁱ	MYO5B
DMDMⁱ	296439293

Proteomic databases

EPDⁱ	Q9ULV0
jPOSTⁱ	Q9ULV0
MassIVEⁱ	Q9ULV0
PaxDbⁱ	Q9ULV0
PeptideAtlasⁱ	Q9ULV0
PRIDEⁱ	Q9ULV0
ProteomicsDBⁱ	81062 85128 [Q9ULV0-1]

Protocols and materials databases

Antibodypediaⁱ	49571, 90 antibodies
The DNASU plasmid repository More...DNASUⁱ	4645

Genome annotation databases

Ensemblⁱ	ENST00000285039; ENSP00000285039; ENSG00000167306 [Q9ULV0-1] ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3]
GeneIDⁱ	4645
KEGGⁱ	hsa:4645
UCSCⁱ	uc002ldz.4, human [Q9ULV0-1]

Organism-specific databases

CTDⁱ	4645
DisGeNETⁱ	4645
GeneCardsⁱ	MYO5B
HGNCⁱ	HGNC:7603, MYO5B
HPAⁱ	ENSG00000167306, Tissue enriched (intestine)
MalaCardsⁱ	MYO5B
MIMⁱ	251850, phenotype 606540, gene
neXtProtⁱ	NX_Q9ULV0
OpenTargetsⁱ	ENSG00000167306
Orphanetⁱ	2290, Microvillus inclusion disease 480491, MYO5B-related progressive familial intrahepatic cholestasis 79306, Progressive familial intrahepatic cholestasis type 1
PharmGKBⁱ	PA31408
VEuPathDBⁱ	HostDB:ENSG00000167306.18
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0160, Eukaryota
GeneTreeⁱ	ENSGT00940000155402
HOGENOMⁱ	CLU_000192_9_1_1
InParanoidⁱ	Q9ULV0
OMAⁱ	ISFIIIH
PhylomeDBⁱ	Q9ULV0
TreeFamⁱ	TF328771

Enzyme and pathway databases

PathwayCommonsⁱ	Q9ULV0
Reactomeⁱ	R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins

Miscellaneous databases

BioGRID-ORCSⁱ	4645, 3 hits in 987 CRISPR screens
ChiTaRSⁱ	MYO5B, human
GeneWikiⁱ	MYO5B
GenomeRNAiⁱ	4645
Pharosⁱ	Q9ULV0, Tbio
Protein Ontology More...PROⁱ	PR:Q9ULV0
RNActⁱ	Q9ULV0, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000167306, Expressed in lower esophagus mucosa and 179 other tissues
ExpressionAtlasⁱ	Q9ULV0, baseline and differential
Genevisibleⁱ	Q9ULV0, HS

Family and domain databases

CDDⁱ	cd15477, Myo5b_CBD, 1 hit cd01380, MYSc_Myo5, 1 hit
Gene3Dⁱ	2.30.30.360, 1 hit 3.40.850.10, 1 hit
InterProⁱ	View protein in InterPro IPR002710, Dilute_dom IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR037990, Myo5b_CBD IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR036103, MYSc_Myo5 IPR027417, P-loop_NTPase
Pfamⁱ	View protein in Pfam PF01843, DIL, 1 hit PF00612, IQ, 6 hits PF00063, Myosin_head, 1 hit
PRINTSⁱ	PR00193, MYOSINHEAVY
SMARTⁱ	View protein in SMART SM01132, DIL, 1 hit SM00015, IQ, 6 hits SM00242, MYSc, 1 hit
SUPFAMⁱ	SSF52540, SSF52540, 2 hits
PROSITEⁱ	View protein in PROSITE PS51126, DILUTE, 1 hit PS50096, IQ, 6 hits PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYO5B_HUMAN
Accessionⁱ	Q9ULV0Primary (citable) accession number: Q9ULV0 Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	May 18, 2010
	Last modified:	June 2, 2021
	This is version 194 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9ULV0 (MYO5B_HUMAN)

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Unconventional myosin-Vb

MYO5B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Cytoskeleton

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9ULV0

Isoform 2 [Q9ULV0-2]

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ