UniProtKB - Q9ULV0 (MYO5B_HUMAN)
Unconventional myosin-Vb
MYO5B
Functioni
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 163 – 170 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- microfilament motor activity Source: GO_Central
- small GTPase binding Source: UniProtKB
GO - Biological processi
- actin filament organization Source: GO_Central
- endosomal transport Source: UniProtKB
- protein transport Source: UniProtKB-KW
- renal water homeostasis Source: Reactome
- vesicle-mediated transport Source: UniProtKB
- vesicle transport along actin filament Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | Protein transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9ULV0 |
Reactomei | R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins |
SignaLinki | Q9ULV0 |
Names & Taxonomyi
Protein namesi | Recommended name: Unconventional myosin-Vb |
Gene namesi | Name:MYO5B Synonyms:KIAA1119 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7603, MYO5B |
MIMi | 606540, gene |
neXtProti | NX_Q9ULV0 |
VEuPathDBi | HostDB:ENSG00000167306 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- myosin complex Source: UniProtKB-KW
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- apical cortex Source: UniProtKB
- cytoplasm Source: GO_Central
- cytoplasmic vesicle membrane Source: Reactome
- protein-containing complex Source: UniProtKB
- vesicle Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Diarrhea 2, with microvillus atrophy (DIAR2)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054993 | 108 | V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar. | 1 | |
Natural variantiVAR_071649 | 143 | A → E in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_071650 | 168 | G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1324907355Ensembl. | 1 | |
Natural variantiVAR_054994 | 219 | R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532EnsemblClinVar. | 1 | |
Natural variantiVAR_071651 | 316 | G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar. | 1 | |
Natural variantiVAR_071652 | 401 | R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1555648414EnsemblClinVar. | 1 | |
Natural variantiVAR_071653 | 435 | G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1283622290EnsemblClinVar. | 1 | |
Natural variantiVAR_071654 | 456 | N → S in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_071655 | 514 | C → R in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_072814 | 538 | F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication | 1 | |
Natural variantiVAR_072815 | 550 | I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication | 1 | |
Natural variantiVAR_054995 | 656 | R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar. | 1 | |
Natural variantiVAR_071656 | 660 | P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar. | 1 | |
Natural variantiVAR_071657 | 1556 | L → R in DIAR2. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1300 | Q → L: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with C-1307. 1 Publication | 1 | |
Mutagenesisi | 1307 | Y → C: Abolishes interaction with RAB8A and has no effect on RAB11A interaction; when associated with L-1300. 1 Publication | 1 | |
Mutagenesisi | 1714 | Y → E: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication | 1 | |
Mutagenesisi | 1748 | Q → R: Abolishes interaction with RAB11A; has no effect on RAB8A interaction. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4645 |
MalaCardsi | MYO5B |
MIMi | 251850, phenotype |
OpenTargetsi | ENSG00000167306 |
Orphaneti | 2290, Microvillus inclusion disease 480491, MYO5B-related progressive familial intrahepatic cholestasis 79306, Progressive familial intrahepatic cholestasis type 1 |
PharmGKBi | PA31408 |
Miscellaneous databases
Pharosi | Q9ULV0, Tbio |
Genetic variation databases
BioMutai | MYO5B |
DMDMi | 296439293 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123460 | 1 – 1848 | Unconventional myosin-VbAdd BLAST | 1848 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 1446 | PhosphoserineCombined sources | 1 | ||
Isoform 3 (identifier: Q9ULV0-3) | |||||
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9ULV0 |
jPOSTi | Q9ULV0 |
MassIVEi | Q9ULV0 |
MaxQBi | Q9ULV0 |
PaxDbi | Q9ULV0 |
PeptideAtlasi | Q9ULV0 |
PRIDEi | Q9ULV0 |
ProteomicsDBi | 81062 85128 [Q9ULV0-1] |
PTM databases
iPTMneti | Q9ULV0 |
PhosphoSitePlusi | Q9ULV0 |
SwissPalmi | Q9ULV0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167306, Expressed in lower esophagus mucosa and 179 other tissues |
ExpressionAtlasi | Q9ULV0, baseline and differential |
Genevisiblei | Q9ULV0, HS |
Organism-specific databases
HPAi | ENSG00000167306, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Binary interactionsi
Q9ULV0
With | #Exp. | IntAct |
---|---|---|
AMOTL2 - isoform 4 [Q9Y2J4-4] | 3 | EBI-311356,EBI-10187270 |
BNIP2 [Q12982] | 5 | EBI-311356,EBI-752094 |
TCF4 [P15884] | 3 | EBI-311356,EBI-533224 |
TRIM54 [Q9BYV2] | 3 | EBI-311356,EBI-2130429 |
Isoform 2 [Q9ULV0-2]
GO - Molecular functioni
- actin filament binding Source: GO_Central
- calmodulin binding Source: UniProtKB-KW
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110729, 93 interactors |
CORUMi | Q9ULV0 |
IntActi | Q9ULV0, 54 interactors |
MINTi | Q9ULV0 |
STRINGi | 9606.ENSP00000285039 |
Miscellaneous databases
RNActi | Q9ULV0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9ULV0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 60 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 69 – 761 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 693 | |
Domaini | 769 – 798 | IQ 1PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 792 – 821 | IQ 2PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 817 – 848 | IQ 3PROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 840 – 869 | IQ 4PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 865 – 896 | IQ 5PROSITE-ProRule annotationAdd BLAST | 32 | |
Domaini | 888 – 917 | IQ 6PROSITE-ProRule annotationAdd BLAST | 30 | |
Domaini | 1526 – 1803 | DilutePROSITE-ProRule annotationAdd BLAST | 278 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 40 | Requires for interaction with LIMA11 PublicationAdd BLAST | 20 | |
Regioni | 596 – 630 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 640 – 662 | Actin-bindingSequence analysisAdd BLAST | 23 | |
Regioni | 1093 – 1123 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1166 – 1192 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 899 – 1266 | Sequence analysisAdd BLAST | 368 | |
Coiled coili | 1341 – 1471 | Sequence analysisAdd BLAST | 131 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1095 – 1123 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1166 – 1183 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0160, Eukaryota |
GeneTreei | ENSGT00940000155402 |
HOGENOMi | CLU_000192_9_1_1 |
InParanoidi | Q9ULV0 |
OMAi | KGMFTRR |
PhylomeDBi | Q9ULV0 |
TreeFami | TF328771 |
Family and domain databases
CDDi | cd15477, Myo5b_CBD, 1 hit cd01380, MYSc_Myo5, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR002710, Dilute_dom IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR037990, Myo5b_CBD IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR036103, MYSc_Myo5 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00612, IQ, 6 hits PF00063, Myosin_head, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00015, IQ, 6 hits SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50096, IQ, 6 hits PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVGELYSQC TRVWIPDPDE VWRSAELTKD YKEGDKSLQL RLEDETILEY
60 70 80 90 100
PIDVQRNQLP FLRNPDILVG ENDLTALSYL HEPAVLHNLK VRFLESNHIY
110 120 130 140 150
TYCGIVLVAI NPYEQLPIYG QDVIYTYSGQ NMGDMDPHIF AVAEEAYKQM
160 170 180 190 200
ARDEKNQSII VSGESGAGKT VSAKYAMRYF ATVGGSASET NIEEKVLASS
210 220 230 240 250
PIMEAIGNAK TTRNDNSSRF GKYIQIGFDK RYHIIGANMR TYLLEKSRVV
260 270 280 290 300
FQADDERNYH IFYQLCAAAG LPEFKELALT SAEDFFYTSQ GGDTSIEGVD
310 320 330 340 350
DAEDFEKTRQ AFTLLGVKES HQMSIFKIIA SILHLGSVAI QAERDGDSCS
360 370 380 390 400
ISPQDVYLSN FCRLLGVEHS QMEHWLCHRK LVTTSETYVK TMSLQQVINA
410 420 430 440 450
RNALAKHIYA QLFGWIVEHI NKALHTSLKQ HSFIGVLDIY GFETFEVNSF
460 470 480 490 500
EQFCINYANE KLQQQFNSHV FKLEQEEYMK EQIPWTLIDF YDNQPCIDLI
510 520 530 540 550
EAKLGILDLL DEECKVPKGT DQNWAQKLYD RHSSSQHFQK PRMSNTAFII
560 570 580 590 600
VHFADKVEYL SDGFLEKNRD TVYEEQINIL KASKFPLVAD LFHDDKDPVP
610 620 630 640 650
ATTPGKGSSS KISVRSARPP MKVSNKEHKK TVGHQFRTSL HLLMETLNAT
660 670 680 690 700
TPHYVRCIKP NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY
710 720 730 740 750
HDFFNRYRVL VKKRELANTD KKAICRSVLE NLIKDPDKFQ FGRTKIFFRA
760 770 780 790 800
GQVAYLEKLR ADKFRTATIM IQKTVRGWLQ KVKYHRLKGA TLTLQRYCRG
810 820 830 840 850
HLARRLAEHL RRIRAAVVLQ KHYRMQRARQ AYQRVRRAAV VIQAFTRAMF
860 870 880 890 900
VRRTYRQVLM EHKATTIQKH VRGWMARRHF QRLRDAAIVI QCAFRMLKAR
910 920 930 940 950
RELKALRIEA RSAEHLKRLN VGMENKVVQL QRKIDEQNKE FKTLSEQLSV
960 970 980 990 1000
TTSTYTMEVE RLKKELVHYQ QSPGEDTSLR LQEEVESLRT ELQRAHSERK
1010 1020 1030 1040 1050
ILEDAHSREK DELRKRVADL EQENALLKDE KEQLNNQILC QSKDEFAQNS
1060 1070 1080 1090 1100
VKENLMKKEL EEERSRYQNL VKEYSQLEQR YDNLRDEMTI IKQTPGHRRN
1110 1120 1130 1140 1150
PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEIGLEKAA MDMTVFLKLQ
1160 1170 1180 1190 1200
KRVRELEQER KKLQVQLEKR EQQDSKKVQA EPPQTDIDLD PNADLAYNSL
1210 1220 1230 1240 1250
KRQELESENK KLKNDLNELR KAVADQATQN NSSHGSPDSY SLLLNQLKLA
1260 1270 1280 1290 1300
HEELEVRKEE VLILRTQIVS ADQRRLAGRN AEPNINARSS WPNSEKHVDQ
1310 1320 1330 1340 1350
EDAIEAYHGV CQTNSKTEDW GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ
1360 1370 1380 1390 1400
SLEHEEEVEH LKAQLEALKE EMDKQQQTFC QTLLLSPEAQ VEFGVQQEIS
1410 1420 1430 1440 1450
RLTNENLDLK ELVEKLEKNE RKLKKQLKIY MKKAQDLEAA QALAQSERKR
1460 1470 1480 1490 1500
HELNRQVTVQ RKEKDFQGML EYHKEDEALL IRNLVTDLKP QMLSGTVPCL
1510 1520 1530 1540 1550
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTSFWL
1560 1570 1580 1590 1600
SNTCRLLHCL KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ
1610 1620 1630 1640 1650
IYQQLIKIAE GVLQPMIVSA MLENESIQGL SGVKPTGYRK RSSSMADGDN
1660 1670 1680 1690 1700
SYCLEAIIRQ MNAFHTVMCD QGLDPEIILQ VFKQLFYMIN AVTLNNLLLR
1710 1720 1730 1740 1750
KDVCSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL IQAAQLLQLK
1760 1770 1780 1790 1800
KKTQEDAEAI CSLCTSLSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ
1810 1820 1830 1840
LQERNDPQQL LLDAKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MR36 | A0A0A0MR36_HUMAN | Unconventional myosin-Vb | MYO5B | 965 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056182 | 10 | C → G. Corresponds to variant dbSNP:rs16951438EnsemblClinVar. | 1 | |
Natural variantiVAR_054993 | 108 | V → G in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908103EnsemblClinVar. | 1 | |
Natural variantiVAR_063141 | 126 | T → A2 PublicationsCorresponds to variant dbSNP:rs1815930EnsemblClinVar. | 1 | |
Natural variantiVAR_071649 | 143 | A → E in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_071650 | 168 | G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1324907355Ensembl. | 1 | |
Natural variantiVAR_054994 | 219 | R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1053713532EnsemblClinVar. | 1 | |
Natural variantiVAR_056183 | 307 | K → N. Corresponds to variant dbSNP:rs17659179EnsemblClinVar. | 1 | |
Natural variantiVAR_071651 | 316 | G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs753558336EnsemblClinVar. | 1 | |
Natural variantiVAR_071652 | 401 | R → H in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1555648414EnsemblClinVar. | 1 | |
Natural variantiVAR_071653 | 435 | G → R in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs1283622290EnsemblClinVar. | 1 | |
Natural variantiVAR_071654 | 456 | N → S in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_071655 | 514 | C → R in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_072814 | 538 | F → S in DIAR2; found in a compound heterozygote also carrying F-550; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication | 1 | |
Natural variantiVAR_072815 | 550 | I → F in DIAR2; found in a compound heterozygote also carrying S-538; enterocytes carrying S-538 and F-550 display disruption of cell polarity, mislocalized apical and basolateral transporter proteins and altered distribution of endosomal/lysosomal constituents including Rab GTPases. 1 Publication | 1 | |
Natural variantiVAR_054995 | 656 | R → C in DIAR2. 1 PublicationCorresponds to variant dbSNP:rs121908105EnsemblClinVar. | 1 | |
Natural variantiVAR_071656 | 660 | P → L in DIAR2; patient enterocytes show alterations in junctional composition, loss of polarity in basolateral and apical compartments, loss of apical brush border and formation of microvillus inclusions in cells at the villus tips; the mutation causes the motor to move slowly along F-actin. 3 PublicationsCorresponds to variant dbSNP:rs121908106EnsemblClinVar. | 1 | |
Natural variantiVAR_056184 | 918 | R → H. Corresponds to variant dbSNP:rs2298624EnsemblClinVar. | 1 | |
Natural variantiVAR_056185 | 942 | K → R. Corresponds to variant dbSNP:rs2277716Ensembl. | 1 | |
Natural variantiVAR_063142 | 1055 | L → LL2 PublicationsCorresponds to variant dbSNP:rs72530399Ensembl. | 1 | |
Natural variantiVAR_071657 | 1556 | L → R in DIAR2. 1 Publication | 1 | |
Natural variantiVAR_071658 | 1688 | M → V1 PublicationCorresponds to variant dbSNP:rs112417235EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056198 | 1 – 1430 | Missing in isoform 3. 1 PublicationAdd BLAST | 1430 | |
Alternative sequenceiVSP_056199 | 1 – 859 | Missing in isoform 2. 1 PublicationAdd BLAST | 859 | |
Alternative sequenceiVSP_056200 | 1315 – 1340 | Missing in isoform 2. 1 PublicationAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032945 mRNA Translation: BAA86433.2 Different initiation. AK025336 mRNA Translation: BAB15114.1 AB290160 mRNA Translation: BAG06714.1 AC090227 Genomic DNA No translation available. AC091044 Genomic DNA No translation available. AC092705 Genomic DNA No translation available. AC105224 Genomic DNA No translation available. BC033527 mRNA Translation: AAH33527.1 |
CCDSi | CCDS42436.1 [Q9ULV0-1] |
RefSeqi | NP_001073936.1, NM_001080467.2 [Q9ULV0-1] |
Genome annotation databases
Ensembli | ENST00000285039; ENSP00000285039; ENSG00000167306 ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3] |
GeneIDi | 4645 |
KEGGi | hsa:4645 |
MANE-Selecti | ENST00000285039.12; ENSP00000285039.6; NM_001080467.3; NP_001073936.1 |
UCSCi | uc002ldz.4, human [Q9ULV0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB032945 mRNA Translation: BAA86433.2 Different initiation. AK025336 mRNA Translation: BAB15114.1 AB290160 mRNA Translation: BAG06714.1 AC090227 Genomic DNA No translation available. AC091044 Genomic DNA No translation available. AC092705 Genomic DNA No translation available. AC105224 Genomic DNA No translation available. BC033527 mRNA Translation: AAH33527.1 |
CCDSi | CCDS42436.1 [Q9ULV0-1] |
RefSeqi | NP_001073936.1, NM_001080467.2 [Q9ULV0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4J5M | X-ray | 2.07 | A | 1453-1848 | [»] | |
4LNZ | X-ray | 3.11 | A | 1460-1848 | [»] | |
4LWZ | X-ray | 2.55 | B/D | 1456-1848 | [»] | |
4LX0 | X-ray | 2.19 | B/D | 1456-1848 | [»] | |
SMRi | Q9ULV0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110729, 93 interactors |
CORUMi | Q9ULV0 |
IntActi | Q9ULV0, 54 interactors |
MINTi | Q9ULV0 |
STRINGi | 9606.ENSP00000285039 |
PTM databases
iPTMneti | Q9ULV0 |
PhosphoSitePlusi | Q9ULV0 |
SwissPalmi | Q9ULV0 |
Genetic variation databases
BioMutai | MYO5B |
DMDMi | 296439293 |
Proteomic databases
EPDi | Q9ULV0 |
jPOSTi | Q9ULV0 |
MassIVEi | Q9ULV0 |
MaxQBi | Q9ULV0 |
PaxDbi | Q9ULV0 |
PeptideAtlasi | Q9ULV0 |
PRIDEi | Q9ULV0 |
ProteomicsDBi | 81062 85128 [Q9ULV0-1] |
Protocols and materials databases
Antibodypediai | 49571, 95 antibodies from 24 providers |
DNASUi | 4645 |
Genome annotation databases
Ensembli | ENST00000285039; ENSP00000285039; ENSG00000167306 ENST00000592688; ENSP00000466368; ENSG00000167306 [Q9ULV0-3] |
GeneIDi | 4645 |
KEGGi | hsa:4645 |
MANE-Selecti | ENST00000285039.12; ENSP00000285039.6; NM_001080467.3; NP_001073936.1 |
UCSCi | uc002ldz.4, human [Q9ULV0-1] |
Organism-specific databases
CTDi | 4645 |
DisGeNETi | 4645 |
GeneCardsi | MYO5B |
HGNCi | HGNC:7603, MYO5B |
HPAi | ENSG00000167306, Tissue enhanced (intestine) |
MalaCardsi | MYO5B |
MIMi | 251850, phenotype 606540, gene |
neXtProti | NX_Q9ULV0 |
OpenTargetsi | ENSG00000167306 |
Orphaneti | 2290, Microvillus inclusion disease 480491, MYO5B-related progressive familial intrahepatic cholestasis 79306, Progressive familial intrahepatic cholestasis type 1 |
PharmGKBi | PA31408 |
VEuPathDBi | HostDB:ENSG00000167306 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0160, Eukaryota |
GeneTreei | ENSGT00940000155402 |
HOGENOMi | CLU_000192_9_1_1 |
InParanoidi | Q9ULV0 |
OMAi | KGMFTRR |
PhylomeDBi | Q9ULV0 |
TreeFami | TF328771 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULV0 |
Reactomei | R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins |
SignaLinki | Q9ULV0 |
Miscellaneous databases
BioGRID-ORCSi | 4645, 3 hits in 1038 CRISPR screens |
ChiTaRSi | MYO5B, human |
GeneWikii | MYO5B |
GenomeRNAii | 4645 |
Pharosi | Q9ULV0, Tbio |
PROi | PR:Q9ULV0 |
RNActi | Q9ULV0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167306, Expressed in lower esophagus mucosa and 179 other tissues |
ExpressionAtlasi | Q9ULV0, baseline and differential |
Genevisiblei | Q9ULV0, HS |
Family and domain databases
CDDi | cd15477, Myo5b_CBD, 1 hit cd01380, MYSc_Myo5, 1 hit |
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR002710, Dilute_dom IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR037990, Myo5b_CBD IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR036103, MYSc_Myo5 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01843, DIL, 1 hit PF00612, IQ, 6 hits PF00063, Myosin_head, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM01132, DIL, 1 hit SM00015, IQ, 6 hits SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51126, DILUTE, 1 hit PS50096, IQ, 6 hits PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYO5B_HUMAN | |
Accessioni | Q9ULV0Primary (citable) accession number: Q9ULV0 Secondary accession number(s): B0I1R3, Q0P656, Q9H6Y6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 196 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families