UniProtKB - Q9ULU4 (PKCB1_HUMAN)
Protein kinase C-binding protein 1
ZMYND8
Functioni
May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 91 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 94 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 103 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 106 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 111 | Zinc 1; via pros nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 114 | Zinc 1Combined sources1 Publication | 1 | |
Metal bindingi | 127 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 130 | Zinc 2Combined sources1 Publication | 1 | |
Metal bindingi | 255 | Zinc 3Combined sources1 Publication | 1 | |
Metal bindingi | 258 | Zinc 3Combined sources1 Publication | 1 | |
Metal bindingi | 274 | Zinc 3Combined sources1 Publication | 1 | |
Metal bindingi | 1028 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1031 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1039 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1040 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1046 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1050 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1058 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1062 | Zinc 4PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 133 | PHD-typePROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 1028 – 1062 | MYND-typePROSITE-ProRule annotationAdd BLAST | 35 |
GO - Molecular functioni
- DNA-binding transcription factor binding Source: BHF-UCL
- lysine-acetylated histone binding Source: UniProtKB
- methylated histone binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- negative regulation of cell migration Source: UniProtKB
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9ULU4 |
SignaLinki | Q9ULU4 |
SIGNORi | Q9ULU4 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase C-binding protein 1Alternative name(s): Cutaneous T-cell lymphoma-associated antigen se14-3 Short name: CTCL-associated antigen se14-3 Rack7 Zinc finger MYND domain-containing protein 8 |
Gene namesi | Name:ZMYND8 Synonyms:KIAA1125, PRKCBP1, RACK7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9397, ZMYND8 |
neXtProti | NX_Q9ULU4 |
VEuPathDBi | HostDB:ENSG00000101040 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 76 | D → A: Decreases interaction with histone H3K4me0. 1 Publication | 1 | |
Mutagenesisi | 79 | D → A: Decreases interaction with histone H3K4me0. 1 Publication | 1 | |
Mutagenesisi | 84 | D → A: Decreases interaction with histone H3K4me0. 1 Publication | 1 | |
Mutagenesisi | 88 | D → A: Decreases interaction with histone H3K4me0. 1 Publication | 1 | |
Mutagenesisi | 89 | F → D: Increases interaction with histone H3K4me0. 1 Publication | 1 | |
Mutagenesisi | 104 | E → A: Decreases interaction with histone H3K4me0. 1 Publication | 1 | |
Mutagenesisi | 227 – 228 | YN → AA: Decreases interaction with histone H3K4me0. 1 Publication | 2 | |
Mutagenesisi | 240 | V → Q: Decreases binding to DBN1. 1 Publication | 1 | |
Mutagenesisi | 311 | H → A: Loss of binding to DBN1. Loss of cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 312 | D → R: Loss of binding to DBN1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23613 |
OpenTargetsi | ENSG00000101040 |
PharmGKBi | PA162409890 |
Miscellaneous databases
Pharosi | Q9ULU4, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3627580 |
Genetic variation databases
BioMutai | ZMYND8 |
DMDMi | 25453223 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211209 | 1 – 1186 | Protein kinase C-binding protein 1Add BLAST | 1186 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 24 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 56 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 70 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 390 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 404 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 406 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 413 | N6-acetyllysine; alternateCombined sources | 1 | ||
Cross-linki | 413 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | |||
Modified residuei | 417 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 425 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 432 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 444 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 453 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 460 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 462 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 465 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 486 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 490 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 495 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 505 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 514 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 523 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 530 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 541 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 547 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 549 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 563 | PhosphothreonineCombined sources | 1 | ||
Cross-linki | 611 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 645 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 652 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 655 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 657 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 668 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 682 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 707 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 709 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 737 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 746 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 754 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 756 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 1115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 1119 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1141 | PhosphoserineCombined sources | 1 | ||
Isoform 5 (identifier: Q9ULU4-5) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 7 (identifier: Q9ULU4-7) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 8 (identifier: Q9ULU4-8) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 10 (identifier: Q9ULU4-10) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 12 (identifier: Q9ULU4-12) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 13 (identifier: Q9ULU4-13) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 14 (identifier: Q9ULU4-14) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 15 (identifier: Q9ULU4-15) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 16 (identifier: Q9ULU4-16) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 17 (identifier: Q9ULU4-17) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 18 (identifier: Q9ULU4-18) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Isoform 22 (identifier: Q9ULU4-22) | |||||
Cross-linki | 12 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9ULU4 |
jPOSTi | Q9ULU4 |
MassIVEi | Q9ULU4 |
MaxQBi | Q9ULU4 |
PeptideAtlasi | Q9ULU4 |
PRIDEi | Q9ULU4 |
ProteomicsDBi | 25473 44416 61294 61295 7246 85109 [Q9ULU4-1] 85110 [Q9ULU4-10] 85111 [Q9ULU4-11] 85112 [Q9ULU4-12] 85113 [Q9ULU4-13] 85114 [Q9ULU4-14] 85115 [Q9ULU4-2] 85116 [Q9ULU4-3] 85117 [Q9ULU4-4] 85118 [Q9ULU4-5] 85119 [Q9ULU4-6] 85120 [Q9ULU4-7] 85121 [Q9ULU4-8] 85122 [Q9ULU4-9] |
PTM databases
GlyGeni | Q9ULU4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9ULU4 |
PhosphoSitePlusi | Q9ULU4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000101040, Expressed in caput epididymis and 259 other tissues |
ExpressionAtlasi | Q9ULU4, baseline and differential |
Genevisiblei | Q9ULU4, HS |
Organism-specific databases
HPAi | ENSG00000101040, Low tissue specificity |
Interactioni
Subunit structurei
Interacts in vitro with PRKCB1 (PubMed:11003709).
Interacts with KDM5D and KDM1A (PubMed:27477906).
Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac) (PubMed:27477906).
Interacts (via PHD-type Zinc finger, Bromo and PWWP domains) with DBN1 (via ADF-H domain); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017).
3 PublicationsBinary interactionsi
Q9ULU4
With | #Exp. | IntAct |
---|---|---|
BCL6 [P41182] | 3 | EBI-765834,EBI-765407 |
DBN1 [Q16643] | 4 | EBI-765834,EBI-351394 |
USP7 [Q93009] | 2 | EBI-765834,EBI-302474 |
Isoform 14 [Q9ULU4-14]
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-12169985,EBI-16439278 |
GO - Molecular functioni
- DNA-binding transcription factor binding Source: BHF-UCL
- lysine-acetylated histone binding Source: UniProtKB
- methylated histone binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117146, 152 interactors |
IntActi | Q9ULU4, 61 interactors |
MINTi | Q9ULU4 |
STRINGi | 9606.ENSP00000420095 |
Chemistry databases
BindingDBi | Q9ULU4 |
Miscellaneous databases
RNActi | Q9ULU4, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9ULU4 |
SMRi | Q9ULU4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 165 – 235 | BromoPROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 277 – 327 | PWWPPROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 75 – 406 | Interaction with histone H3K14ac1 PublicationAdd BLAST | 332 | |
Regioni | 75 – 268 | Interaction with histone H3K4me01 PublicationAdd BLAST | 194 | |
Regioni | 412 – 512 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 582 – 884 | DisorderedSequence analysisAdd BLAST | 303 | |
Regioni | 1071 – 1186 | DisorderedSequence analysisAdd BLAST | 116 | |
Regioni | 1147 – 1186 | Interaction with PRKCB1Add BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 22 – 38 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 429 – 444 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 459 – 512 | Polar residuesSequence analysisAdd BLAST | 54 | |
Compositional biasi | 582 – 701 | Basic and acidic residuesSequence analysisAdd BLAST | 120 | |
Compositional biasi | 714 – 739 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 743 – 791 | Polar residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 815 – 884 | Polar residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 1071 – 1104 | Polar residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 1116 – 1148 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 1149 – 1163 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 133 | PHD-typePROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 1028 – 1062 | MYND-typePROSITE-ProRule annotationAdd BLAST | 35 |
Keywords - Domaini
Bromodomain, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3612, Eukaryota |
GeneTreei | ENSGT00940000154897 |
InParanoidi | Q9ULU4 |
OMAi | MPVQRFN |
OrthoDBi | 369818at2759 |
PhylomeDBi | Q9ULU4 |
TreeFami | TF317221 |
Family and domain databases
CDDi | cd05508, Bromo_RACK7, 1 hit cd05841, BS69_related, 1 hit cd15538, PHD_PRKCBP1, 1 hit |
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR044075, PRKCBP1_PHD IPR000313, PWWP_dom IPR037967, RACK7_Bromo_dom IPR019786, Zinc_finger_PHD-type_CS IPR021931, ZMYND8 IPR035505, ZMYND8/11_PWWP IPR011011, Znf_FYVE_PHD IPR002893, Znf_MYND IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF12064, DUF3544, 1 hit PF00855, PWWP, 1 hit |
SMARTi | View protein in SMART SM00297, BROMO, 1 hit SM00249, PHD, 1 hit SM00293, PWWP, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50014, BROMODOMAIN_2, 1 hit PS50812, PWWP, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (23+)i Sequence
Sequence statusi: Complete.
This entry describes 23 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 23 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDISTRSKDP GSAERTAQKR KFPSPPHSSN GHSPQDTSTS PIKKKKKPGL
60 70 80 90 100
LNSNNKEQSE LRHGPFYYMK QPLTTDPVDV VPQDGRNDFY CWVCHREGQV
110 120 130 140 150
LCCELCPRVY HAKCLRLTSE PEGDWFCPEC EKITVAECIE TQSKAMTMLT
160 170 180 190 200
IEQLSYLLKF AIQKMKQPGT DAFQKPVPLE QHPDYAEYIF HPMDLCTLEK
210 220 230 240 250
NAKKKMYGCT EAFLADAKWI LHNCIIYNGG NHKLTQIAKV VIKICEHEMN
260 270 280 290 300
EIEVCPECYL AACQKRDNWF CEPCSNPHPL VWAKLKGFPF WPAKALRDKD
310 320 330 340 350
GQVDARFFGQ HDRAWVPINN CYLMSKEIPF SVKKTKSIFN SAMQEMEVYV
360 370 380 390 400
ENIRRKFGVF NYSPFRTPYT PNSQYQMLLD PTNPSAGTAK IDKQEKVKLN
410 420 430 440 450
FDMTASPKIL MSKPVLSGGT GRRISLSDMP RSPMSTNSSV HTGSDVEQDA
460 470 480 490 500
EKKATSSHFS ASEESMDFLD KSTASPASTK TGQAGSLSGS PKPFSPQLSA
510 520 530 540 550
PITTKTDKTS TTGSILNLNL DRSKAEMDLK ELSESVQQQS TPVPLISPKR
560 570 580 590 600
QIRSRFQLNL DKTIESCKAQ LGINEISEDV YTAVEHSDSE DSEKSDSSDS
610 620 630 640 650
EYISDDEQKS KNEPEDTEDK EGCQMDKEPS AVKKKPKPTN PVEIKEELKS
660 670 680 690 700
TSPASEKADP GAVKDKASPE PEKDFSEKAK PSPHPIKDKL KGKDETDSPT
710 720 730 740 750
VHLGLDSDSE SELVIDLGED HSGREGRKNK KEPKEPSPKQ DVVGKTPPST
760 770 780 790 800
TVGSHSPPET PVLTRSSAQT SAAGATATTS TSSTVTVTAP APAATGSPVK
810 820 830 840 850
KQRPLLPKET APAVQRVVWN SSSKFQTSSQ KWHMQKMQRQ QQQQQQQNQQ
860 870 880 890 900
QQPQSSQGTR YQTRQAVKAV QQKEITQSPS TSTITLVTST QSSPLVTSSG
910 920 930 940 950
SMSTLVSSVN ADLPIATASA DVAADIAKYT SKMMDAIKGT MTEIYNDLSK
960 970 980 990 1000
NTTGSTIAEI RRLRIEIEKL QWLHQQELSE MKHNLELTMA EMRQSLEQER
1010 1020 1030 1040 1050
DRLIAEVKKQ LELEKQQAVD ETKKKQWCAN CKKEAIFYCC WNTSYCDYPC
1060 1070 1080 1090 1100
QQAHWPEHMK SCTQSATAPQ QEADAEVNTE TLNKSSQGSS SSTQSAPSET
1110 1120 1130 1140 1150
ASASKEKETS AEKSKESGST LDLSGSRETP SSILLGSNQG SDHSRSNKSS
1160 1170 1180
WSSSDEKRGS TRSDHNTSTS TKSLLPKESR LDTFWD
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
The sequence of this isoform differs from the canonical sequence as follows:
1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
58-82: Missing.
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
58-82: Missing.
474-520: Missing.
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
58-82: Missing.
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
58-82: Missing.
742-868: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
58-82: Missing.
474-520: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MVFLEEFEARSCLAEEEIKTEQEVVEGM
1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MFSSLQKSFNLAEEEIKTEQEVVEGM
58-82: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
58-82: Missing.
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHPQSLAEEEIKTEQEVVEGM
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
933-959: Missing.
1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY
The sequence of this isoform differs from the canonical sequence as follows:
58-82: Missing.
132-169: Missing.
823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVZ6 | A0A087WVZ6_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 1,136 | Annotation score: | ||
H7C4X9 | H7C4X9_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 1,095 | Annotation score: | ||
A0A087WYS3 | A0A087WYS3_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 1,087 | Annotation score: | ||
A0A087WV57 | A0A087WV57_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 767 | Annotation score: | ||
Q5TH12 | Q5TH12_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 175 | Annotation score: | ||
Q5TH07 | Q5TH07_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 24 | Annotation score: | ||
Q5TH08 | Q5TH08_HUMAN | Protein kinase C-binding protein 1 | ZMYND8 | 42 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 119 | S → P in BAH11794 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 202 | A → T in BAH12176 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 325 | S → F in BAH12176 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 391 | I → V in AAL50790 (PubMed:11149944).Curated | 1 | ||
Sequence conflicti | 399 | L → P in BAH11794 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 470 | D → G in BAH11794 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 874 | E → G in BAG53824 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 894 | P → A in AAG34905 (PubMed:11149944).Curated | 1 | ||
Sequence conflicti | 894 | P → A in AAL50790 (PubMed:11149944).Curated | 1 | ||
Sequence conflicti | 967 | I → T in CAE46008 (PubMed:17974005).Curated | 1 | ||
Isoform 2 (identifier: Q9ULU4-2) | |||||
Sequence conflicti | 297 | T → S in AAF71262 (PubMed:11003709).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055559 | 752 | V → A1 PublicationCorresponds to variant dbSNP:rs2275801Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000566 | 1 – 526 | Missing in isoform 2. 1 PublicationAdd BLAST | 526 | |
Alternative sequenceiVSP_000565 | 1 – 376 | Missing in isoform 4. 1 PublicationAdd BLAST | 376 | |
Alternative sequenceiVSP_000564 | 1 – 145 | Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST | 145 | |
Alternative sequenceiVSP_054810 | 1 | M → MVFLEEFEARSCLAEEEIKT EQEVVEGM in isoform 19. 1 Publication | 1 | |
Alternative sequenceiVSP_054811 | 1 | M → MFSSLQKSFNLAEEEIKTEQ EVVEGM in isoform 20. 1 Publication | 1 | |
Alternative sequenceiVSP_000563 | 1 | M → MHPQSLAEEEIKTEQEVVEG M in isoform 5, isoform 7, isoform 8, isoform 10, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 17, isoform 18 and isoform 22. 3 Publications | 1 | |
Alternative sequenceiVSP_000567 | 58 – 82 | Missing in isoform 5, isoform 14, isoform 15, isoform 16, isoform 17, isoform 18, isoform 20, isoform 21 and isoform 23. 3 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_054812 | 132 – 169 | Missing in isoform 23. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_053400 | 474 – 520 | Missing in isoform 15 and isoform 18. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_017096 | 742 – 868 | Missing in isoform 8 and isoform 17. 2 PublicationsAdd BLAST | 127 | |
Alternative sequenceiVSP_000568 | 823 – 869 | SKFQT…QAVKA → T in isoform 2, isoform 3, isoform 4, isoform 6, isoform 9, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 21, isoform 22 and isoform 23. 6 PublicationsAdd BLAST | 47 | |
Alternative sequenceiVSP_054814 | 933 – 959 | Missing in isoform 22. CuratedAdd BLAST | 27 | |
Alternative sequenceiVSP_000570 | 1142 | D → VSKRCDKQPAYAPTTTDHQP HPNYPAQKY in isoform 6, isoform 7, isoform 8, isoform 9, isoform 11, isoform 13, isoform 16, isoform 19, isoform 22 and isoform 23. 5 Publications | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4COS | X-ray | 1.67 | A | 83-406 | [»] | |
5B73 | X-ray | 1.80 | A | 73-406 | [»] | |
5MQ4 | X-ray | 2.70 | A/B/C/D/E/F | 949-1073 | [»] | |
5Y1Z | X-ray | 2.68 | C/D | 83-406 | [»] | |
7CWH | NMR | - | B | 83-143 | [»] | |
AlphaFoldDBi | Q9ULU4 | |||||
SMRi | Q9ULU4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117146, 152 interactors |
IntActi | Q9ULU4, 61 interactors |
MINTi | Q9ULU4 |
STRINGi | 9606.ENSP00000420095 |
Chemistry databases
BindingDBi | Q9ULU4 |
ChEMBLi | CHEMBL3627580 |
PTM databases
GlyGeni | Q9ULU4, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9ULU4 |
PhosphoSitePlusi | Q9ULU4 |
Genetic variation databases
BioMutai | ZMYND8 |
DMDMi | 25453223 |
Proteomic databases
EPDi | Q9ULU4 |
jPOSTi | Q9ULU4 |
MassIVEi | Q9ULU4 |
MaxQBi | Q9ULU4 |
PeptideAtlasi | Q9ULU4 |
PRIDEi | Q9ULU4 |
ProteomicsDBi | 25473 44416 61294 61295 7246 85109 [Q9ULU4-1] 85110 [Q9ULU4-10] 85111 [Q9ULU4-11] 85112 [Q9ULU4-12] 85113 [Q9ULU4-13] 85114 [Q9ULU4-14] 85115 [Q9ULU4-2] 85116 [Q9ULU4-3] 85117 [Q9ULU4-4] 85118 [Q9ULU4-5] 85119 [Q9ULU4-6] 85120 [Q9ULU4-7] 85121 [Q9ULU4-8] 85122 [Q9ULU4-9] |
Protocols and materials databases
Antibodypediai | 13294, 190 antibodies from 30 providers |
DNASUi | 23613 |
Genome annotation databases
Organism-specific databases
CTDi | 23613 |
DisGeNETi | 23613 |
GeneCardsi | ZMYND8 |
HGNCi | HGNC:9397, ZMYND8 |
HPAi | ENSG00000101040, Low tissue specificity |
neXtProti | NX_Q9ULU4 |
OpenTargetsi | ENSG00000101040 |
PharmGKBi | PA162409890 |
VEuPathDBi | HostDB:ENSG00000101040 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3612, Eukaryota |
GeneTreei | ENSGT00940000154897 |
InParanoidi | Q9ULU4 |
OMAi | MPVQRFN |
OrthoDBi | 369818at2759 |
PhylomeDBi | Q9ULU4 |
TreeFami | TF317221 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULU4 |
SignaLinki | Q9ULU4 |
SIGNORi | Q9ULU4 |
Miscellaneous databases
BioGRID-ORCSi | 23613, 210 hits in 1103 CRISPR screens |
ChiTaRSi | ZMYND8, human |
GeneWikii | ZMYND8 |
GenomeRNAii | 23613 |
Pharosi | Q9ULU4, Tbio |
PROi | PR:Q9ULU4 |
RNActi | Q9ULU4, protein |
Gene expression databases
Bgeei | ENSG00000101040, Expressed in caput epididymis and 259 other tissues |
ExpressionAtlasi | Q9ULU4, baseline and differential |
Genevisiblei | Q9ULU4, HS |
Family and domain databases
CDDi | cd05508, Bromo_RACK7, 1 hit cd05841, BS69_related, 1 hit cd15538, PHD_PRKCBP1, 1 hit |
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR044075, PRKCBP1_PHD IPR000313, PWWP_dom IPR037967, RACK7_Bromo_dom IPR019786, Zinc_finger_PHD-type_CS IPR021931, ZMYND8 IPR035505, ZMYND8/11_PWWP IPR011011, Znf_FYVE_PHD IPR002893, Znf_MYND IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF12064, DUF3544, 1 hit PF00855, PWWP, 1 hit |
SMARTi | View protein in SMART SM00297, BROMO, 1 hit SM00249, PHD, 1 hit SM00293, PWWP, 1 hit |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50014, BROMODOMAIN_2, 1 hit PS50812, PWWP, 1 hit PS01360, ZF_MYND_1, 1 hit PS50865, ZF_MYND_2, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKCB1_HUMAN | |
Accessioni | Q9ULU4Primary (citable) accession number: Q9ULU4 Secondary accession number(s): B3KVL2 Q9UIX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 25, 2002 |
Last sequence update: | November 25, 2002 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references