Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9ULU4 (PKCB1_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein kinase C-binding protein 1

Gene

ZMYND8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 133PHD-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1028 – 1062MYND-typePROSITE-ProRule annotationAdd BLAST35

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein 1
Alternative name(s):
Cutaneous T-cell lymphoma-associated antigen se14-3
Short name:
CTCL-associated antigen se14-3
Rack7
Zinc finger MYND domain-containing protein 8
Gene namesi
Name:ZMYND8
Synonyms:KIAA1125, PRKCBP1, RACK7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101040.19
HGNCiHGNC:9397 ZMYND8
neXtProtiNX_Q9ULU4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi76D → A: Decreases interaction with histone H3K4me0. 1 Publication1
Mutagenesisi79D → A: Decreases interaction with histone H3K4me0. 1 Publication1
Mutagenesisi84D → A: Decreases interaction with histone H3K4me0. 1 Publication1
Mutagenesisi88D → A: Decreases interaction with histone H3K4me0. 1 Publication1
Mutagenesisi89F → D: Increases interaction with histone H3K4me0. 1 Publication1
Mutagenesisi104E → A: Decreases interaction with histone H3K4me0. 1 Publication1
Mutagenesisi227 – 228YN → AA: Decreases interaction with histone H3K4me0. 1 Publication2

Organism-specific databases

DisGeNETi23613
OpenTargetsiENSG00000101040
PharmGKBiPA162409890

Chemistry databases

ChEMBLiCHEMBL3627580

Polymorphism and mutation databases

BioMutaiZMYND8
DMDMi25453223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112091 – 1186Protein kinase C-binding protein 1Add BLAST1186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki390Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei404PhosphothreonineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei413N6-acetyllysine; alternateCombined sources1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei417PhosphoserineCombined sources1
Modified residuei425PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Cross-linki453Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei460PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei490PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Cross-linki505Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei514PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Cross-linki530Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei541PhosphothreonineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Cross-linki549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei563PhosphothreonineCombined sources1
Cross-linki611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki645Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei652PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Cross-linki657Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei668PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei737PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei756PhosphoserineCombined sources1
Cross-linki1115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1119PhosphoserineCombined sources1
Modified residuei1141PhosphoserineCombined sources1
Isoform 5 (identifier: Q9ULU4-5)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 7 (identifier: Q9ULU4-7)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 8 (identifier: Q9ULU4-8)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 10 (identifier: Q9ULU4-10)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 12 (identifier: Q9ULU4-12)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 13 (identifier: Q9ULU4-13)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 14 (identifier: Q9ULU4-14)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 15 (identifier: Q9ULU4-15)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 16 (identifier: Q9ULU4-16)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 17 (identifier: Q9ULU4-17)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 18 (identifier: Q9ULU4-18)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Isoform 22 (identifier: Q9ULU4-22)
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ULU4
PeptideAtlasiQ9ULU4
PRIDEiQ9ULU4
ProteomicsDBi85109
85110 [Q9ULU4-10]
85111 [Q9ULU4-11]
85112 [Q9ULU4-12]
85113 [Q9ULU4-13]
85114 [Q9ULU4-14]
85115 [Q9ULU4-2]
85116 [Q9ULU4-3]
85117 [Q9ULU4-4]
85118 [Q9ULU4-5]
85119 [Q9ULU4-6]
85120 [Q9ULU4-7]
85121 [Q9ULU4-8]
85122 [Q9ULU4-9]

PTM databases

iPTMnetiQ9ULU4
PhosphoSitePlusiQ9ULU4

Expressioni

Tissue specificityi

Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).

Gene expression databases

BgeeiENSG00000101040
CleanExiHS_ZMYND8
ExpressionAtlasiQ9ULU4 baseline and differential
GenevisibleiQ9ULU4 HS

Organism-specific databases

HPAiHPA020949

Interactioni

Subunit structurei

Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A. Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL6P411823EBI-765834,EBI-765407

GO - Molecular functioni

  • lysine-acetylated histone binding Source: UniProtKB
  • methylated histone binding Source: UniProtKB
  • protein N-terminus binding Source: Ensembl
  • repressing transcription factor binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi117146, 59 interactors
IntActiQ9ULU4, 46 interactors
MINTiQ9ULU4

Chemistry databases

BindingDBiQ9ULU4

Structurei

Secondary structure

11186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi89 – 91Combined sources3
Turni92 – 94Combined sources3
Beta strandi104 – 107Combined sources4
Helixi112 – 115Combined sources4
Helixi128 – 137Combined sources10
Helixi139 – 141Combined sources3
Helixi144 – 147Combined sources4
Helixi151 – 165Combined sources15
Helixi171 – 173Combined sources3
Turni179 – 181Combined sources3
Helixi185 – 188Combined sources4
Helixi195 – 203Combined sources9
Helixi210 – 228Combined sources19
Helixi233 – 254Combined sources22
Helixi256 – 264Combined sources9
Helixi269 – 271Combined sources3
Beta strandi280 – 283Combined sources4
Beta strandi291 – 299Combined sources9
Beta strandi302 – 307Combined sources6
Turni308 – 310Combined sources3
Beta strandi313 – 317Combined sources5
Helixi318 – 320Combined sources3
Beta strandi321 – 323Combined sources3
Beta strandi325 – 327Combined sources3
Helixi336 – 357Combined sources22
Helixi375 – 377Combined sources3
Helixi384 – 386Combined sources3
Helixi953 – 972Combined sources20
Helixi975 – 1023Combined sources49
Turni1029 – 1031Combined sources3
Beta strandi1037 – 1040Combined sources4
Beta strandi1043 – 1047Combined sources5
Helixi1048 – 1058Combined sources11
Helixi1059 – 1061Combined sources3

3D structure databases

ProteinModelPortaliQ9ULU4
SMRiQ9ULU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 235BromoPROSITE-ProRule annotationAdd BLAST71
Domaini277 – 327PWWPPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni75 – 406Interaction with histone H3K14ac1 PublicationAdd BLAST332
Regioni75 – 268Interaction with histone H3K4me01 PublicationAdd BLAST194
Regioni1147 – 1186Interaction with PRKCB1Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 47Poly-Lys5
Compositional biasi838 – 854Poly-GlnAdd BLAST17
Compositional biasi1089 – 1092Poly-Ser4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 133PHD-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri1028 – 1062MYND-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Bromodomain, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00910000144099
HOGENOMiHOG000230951
HOVERGENiHBG031823
InParanoidiQ9ULU4
OMAiSSKSSCW
OrthoDBiEOG091G0B2W
PhylomeDBiQ9ULU4
TreeFamiTF317221

Family and domain databases

CDDicd05508 Bromo_RACK7, 1 hit
cd05841 BS69_related, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR000313 PWWP_dom
IPR037967 RACK7_Bromo_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR021931 ZMYND8
IPR035505 ZMYND8/11_PWWP
IPR011011 Znf_FYVE_PHD
IPR002893 Znf_MYND
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF12064 DUF3544, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 1 hit
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS50812 PWWP, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (23)i

Sequence statusi: Complete.

This entry describes 23 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDISTRSKDP GSAERTAQKR KFPSPPHSSN GHSPQDTSTS PIKKKKKPGL 
        60         70         80         90        100
LNSNNKEQSE LRHGPFYYMK QPLTTDPVDV VPQDGRNDFY CWVCHREGQV 
       110        120        130        140        150
LCCELCPRVY HAKCLRLTSE PEGDWFCPEC EKITVAECIE TQSKAMTMLT 
       160        170        180        190        200
IEQLSYLLKF AIQKMKQPGT DAFQKPVPLE QHPDYAEYIF HPMDLCTLEK 
       210        220        230        240        250
NAKKKMYGCT EAFLADAKWI LHNCIIYNGG NHKLTQIAKV VIKICEHEMN 
       260        270        280        290        300
EIEVCPECYL AACQKRDNWF CEPCSNPHPL VWAKLKGFPF WPAKALRDKD 
       310        320        330        340        350
GQVDARFFGQ HDRAWVPINN CYLMSKEIPF SVKKTKSIFN SAMQEMEVYV 
       360        370        380        390        400
ENIRRKFGVF NYSPFRTPYT PNSQYQMLLD PTNPSAGTAK IDKQEKVKLN 
       410        420        430        440        450
FDMTASPKIL MSKPVLSGGT GRRISLSDMP RSPMSTNSSV HTGSDVEQDA 
       460        470        480        490        500
EKKATSSHFS ASEESMDFLD KSTASPASTK TGQAGSLSGS PKPFSPQLSA 
       510        520        530        540        550
PITTKTDKTS TTGSILNLNL DRSKAEMDLK ELSESVQQQS TPVPLISPKR 
       560        570        580        590        600
QIRSRFQLNL DKTIESCKAQ LGINEISEDV YTAVEHSDSE DSEKSDSSDS 
       610        620        630        640        650
EYISDDEQKS KNEPEDTEDK EGCQMDKEPS AVKKKPKPTN PVEIKEELKS 
       660        670        680        690        700
TSPASEKADP GAVKDKASPE PEKDFSEKAK PSPHPIKDKL KGKDETDSPT 
       710        720        730        740        750
VHLGLDSDSE SELVIDLGED HSGREGRKNK KEPKEPSPKQ DVVGKTPPST 
       760        770        780        790        800
TVGSHSPPET PVLTRSSAQT SAAGATATTS TSSTVTVTAP APAATGSPVK 
       810        820        830        840        850
KQRPLLPKET APAVQRVVWN SSSKFQTSSQ KWHMQKMQRQ QQQQQQQNQQ 
       860        870        880        890        900
QQPQSSQGTR YQTRQAVKAV QQKEITQSPS TSTITLVTST QSSPLVTSSG 
       910        920        930        940        950
SMSTLVSSVN ADLPIATASA DVAADIAKYT SKMMDAIKGT MTEIYNDLSK 
       960        970        980        990       1000
NTTGSTIAEI RRLRIEIEKL QWLHQQELSE MKHNLELTMA EMRQSLEQER 
      1010       1020       1030       1040       1050
DRLIAEVKKQ LELEKQQAVD ETKKKQWCAN CKKEAIFYCC WNTSYCDYPC 
      1060       1070       1080       1090       1100
QQAHWPEHMK SCTQSATAPQ QEADAEVNTE TLNKSSQGSS SSTQSAPSET 
      1110       1120       1130       1140       1150
ASASKEKETS AEKSKESGST LDLSGSRETP SSILLGSNQG SDHSRSNKSS 
      1160       1170       1180 
WSSSDEKRGS TRSDHNTSTS TKSLLPKESR LDTFWD
Note: No experimental confirmation available.
Length:1,186
Mass (Da):131,692
Last modified:November 25, 2002 - v2
Checksum:iBAE8CDEF240E647A
GO
Isoform 2 (identifier: Q9ULU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-526: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Show »
Length:614
Mass (Da):66,961
Checksum:i8E6EF67059803EF7
GO
Isoform 3 (identifier: Q9ULU4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Show »
Length:995
Mass (Da):109,683
Checksum:i9FE7BB1FB8105F83
GO
Isoform 4 (identifier: Q9ULU4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-376: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Show »
Length:764
Mass (Da):82,691
Checksum:iC403C40DE69E8BB3
GO
Isoform 5 (identifier: Q9ULU4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     58-82: Missing.

Show »
Length:1,181
Mass (Da):131,058
Checksum:i03A6396E9A94AD94
GO
Isoform 6 (identifier: Q9ULU4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Note: No experimental confirmation available.
Show »
Length:1,023
Mass (Da):112,892
Checksum:i37EB9CAA51A856E3
GO
Isoform 7 (identifier: Q9ULU4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Show »
Length:1,234
Mass (Da):137,168
Checksum:i10471430CE043C09
GO
Isoform 8 (identifier: Q9ULU4-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     742-868: Missing.
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Show »
Length:1,107
Mass (Da):123,518
Checksum:i3EF5E50B6BAA5800
GO
Isoform 9 (identifier: Q9ULU4-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Note: No experimental confirmation available.
Show »
Length:1,168
Mass (Da):129,315
Checksum:i871DE79731D3654E
GO
Isoform 10 (identifier: Q9ULU4-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM

Show »
Length:1,206
Mass (Da):133,958
Checksum:i3CB6DF728E65DE2E
GO
Isoform 11 (identifier: Q9ULU4-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Show »
Length:1,214
Mass (Da):134,902
Checksum:i6BCD191178126950
GO
Isoform 12 (identifier: Q9ULU4-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Show »
Length:1,160
Mass (Da):128,371
Checksum:i9780CF6CACFCCC9A
GO
Isoform 13 (identifier: Q9ULU4-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Show »
Length:1,188
Mass (Da):131,580
Checksum:iC10B9CA76DB23389
GO
Isoform 14 (identifier: Q9ULU4-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     58-82: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Show »
Length:1,135
Mass (Da):125,471
Checksum:i0CAAD0AFD252C3A2
GO
Isoform 15 (identifier: Q9ULU4-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     58-82: Missing.
     474-520: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Show »
Length:1,088
Mass (Da):120,828
Checksum:i89769DB84068AE00
GO
Isoform 16 (identifier: Q9ULU4-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     58-82: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Show »
Length:1,163
Mass (Da):128,680
Checksum:i1BBBE722ED85361C
GO
Isoform 17 (identifier: Q9ULU4-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     58-82: Missing.
     742-868: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,054
Mass (Da):117,408
Checksum:iC01B7C094F9C970C
GO
Isoform 18 (identifier: Q9ULU4-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     58-82: Missing.
     474-520: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:1,134
Mass (Da):126,415
Checksum:i64F9746E9458BB1B
GO
Isoform 19 (identifier: Q9ULU4-19) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVFLEEFEARSCLAEEEIKTEQEVVEGM
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Note: No experimental confirmation available.
Show »
Length:1,241
Mass (Da):138,030
Checksum:i20A285CF0B00832B
GO
Isoform 20 (identifier: Q9ULU4-20) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSSLQKSFNLAEEEIKTEQEVVEGM
     58-82: Missing.

Note: No experimental confirmation available.
Show »
Length:1,186
Mass (Da):131,647
Checksum:iD94974DC1C82F30B
GO
Isoform 21 (identifier: Q9ULU4-21) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-82: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T

Note: No experimental confirmation available.
Show »
Length:1,115
Mass (Da):123,205
Checksum:i521DADD47EDA30FA
GO
Isoform 22 (identifier: Q9ULU4-22) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHPQSLAEEEIKTEQEVVEGM
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
     933-959: Missing.
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Note: Gene prediction based on EST data.Combined sources
Show »
Length:1,161
Mass (Da):128,662
Checksum:iDF2932354478AD04
GO
Isoform 23 (identifier: Q9ULU4-23) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-82: Missing.
     132-169: Missing.
     823-869: SKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKA → T
     1142-1142: D → VSKRCDKQPAYAPTTTDHQPHPNYPAQKY

Note: No experimental confirmation available.
Show »
Length:1,105
Mass (Da):122,116
Checksum:i1FC56CEF2DEDD752
GO

Sequence cautioni

The sequence AAC72244 differs from that shown. Reason: Frameshift at position 816.Curated
The sequence BAA86439 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119S → P in BAH11794 (PubMed:14702039).Curated1
Sequence conflicti202A → T in BAH12176 (PubMed:14702039).Curated1
Sequence conflicti325S → F in BAH12176 (PubMed:14702039).Curated1
Sequence conflicti391I → V in AAL50790 (PubMed:11149944).Curated1
Sequence conflicti399L → P in BAH11794 (PubMed:14702039).Curated1
Sequence conflicti470D → G in BAH11794 (PubMed:14702039).Curated1
Sequence conflicti874E → G in BAG53824 (PubMed:14702039).Curated1
Sequence conflicti894P → A in AAG34905 (PubMed:11149944).Curated1
Sequence conflicti894P → A in AAL50790 (PubMed:11149944).Curated1
Sequence conflicti967I → T in CAE46008 (PubMed:17974005).Curated1
Isoform 2 (identifier: Q9ULU4-2)
Sequence conflicti297T → S in AAF71262 (PubMed:11003709).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055559752V → A1 PublicationCorresponds to variant dbSNP:rs2275801Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0005661 – 526Missing in isoform 2. 1 PublicationAdd BLAST526
Alternative sequenceiVSP_0005651 – 376Missing in isoform 4. 1 PublicationAdd BLAST376
Alternative sequenceiVSP_0005641 – 145Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST145
Alternative sequenceiVSP_0548101M → MVFLEEFEARSCLAEEEIKT EQEVVEGM in isoform 19. 1 Publication1
Alternative sequenceiVSP_0548111M → MFSSLQKSFNLAEEEIKTEQ EVVEGM in isoform 20. 1 Publication1
Alternative sequenceiVSP_0005631M → MHPQSLAEEEIKTEQEVVEG M in isoform 5, isoform 7, isoform 8, isoform 10, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 17, isoform 18 and isoform 22. 3 Publications1
Alternative sequenceiVSP_00056758 – 82Missing in isoform 5, isoform 14, isoform 15, isoform 16, isoform 17, isoform 18, isoform 20, isoform 21 and isoform 23. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_054812132 – 169Missing in isoform 23. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_053400474 – 520Missing in isoform 15 and isoform 18. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_017096742 – 868Missing in isoform 8 and isoform 17. 2 PublicationsAdd BLAST127
Alternative sequenceiVSP_000568823 – 869SKFQT…QAVKA → T in isoform 2, isoform 3, isoform 4, isoform 6, isoform 9, isoform 12, isoform 13, isoform 14, isoform 15, isoform 16, isoform 21, isoform 22 and isoform 23. 6 PublicationsAdd BLAST47
Alternative sequenceiVSP_054814933 – 959Missing in isoform 22. CuratedAdd BLAST27
Alternative sequenceiVSP_0005701142D → VSKRCDKQPAYAPTTTDHQP HPNYPAQKY in isoform 6, isoform 7, isoform 8, isoform 9, isoform 11, isoform 13, isoform 16, isoform 19, isoform 22 and isoform 23. 5 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233453 mRNA Translation: AAF71262.1
U48251 mRNA Translation: AAC72244.1 Frameshift.
AF454056 mRNA Translation: AAL50790.1
AF273045 mRNA Translation: AAG34905.1
DQ082998 mRNA Translation: AAY85630.1
DQ082999 mRNA Translation: AAY85631.1
DQ368669 mRNA Translation: ABC86680.1
DQ368670 mRNA Translation: ABC86681.1
DQ368671 mRNA Translation: ABC86682.1
DQ368672 mRNA Translation: ABC86683.1
DQ368673 mRNA Translation: ABC86684.1
DQ368674 mRNA Translation: ABC86685.1
DQ368677 mRNA Translation: ABC86688.1
DQ368678 mRNA Translation: ABC86689.1
DQ368679 mRNA Translation: ABC86690.1
DQ368680 mRNA Translation: ABC86691.1
AB032951 mRNA Translation: BAA86439.1 Different initiation.
AK122966 mRNA Translation: BAG53824.1
AK294511 mRNA Translation: BAH11794.1
AK295747 mRNA Translation: BAH12176.1
AK299899 mRNA Translation: BAH13166.1
BX641005 mRNA Translation: CAE46008.1
AL031666, AL049540, AL022342 Genomic DNA Translation: CAI21842.1
AL049540, AL031666, AL022342 Genomic DNA Translation: CAI23169.1
AL049540, AL031666, AL390212 Genomic DNA Translation: CAI23168.1
CH471077 Genomic DNA Translation: EAW75703.1
CH471077 Genomic DNA Translation: EAW75706.1
CH471077 Genomic DNA Translation: EAW75709.1
CH471077 Genomic DNA Translation: EAW75711.1
CH471077 Genomic DNA Translation: EAW75712.1
CH471077 Genomic DNA Translation: EAW75715.1
BC030721 mRNA Translation: AAH30721.2
BC136608 mRNA Translation: AAI36609.1
BC144289 mRNA Translation: AAI44290.1
CCDSiCCDS13404.1 [Q9ULU4-12]
CCDS13405.1 [Q9ULU4-13]
CCDS46613.1 [Q9ULU4-14]
CCDS63300.1 [Q9ULU4-11]
CCDS63301.1 [Q9ULU4-9]
CCDS63303.1 [Q9ULU4-18]
CCDS63304.1 [Q9ULU4-17]
CCDS63306.1 [Q9ULU4-7]
CCDS74738.1 [Q9ULU4-20]
RefSeqiNP_001268700.1, NM_001281771.2 [Q9ULU4-17]
NP_001268701.1, NM_001281772.2 [Q9ULU4-20]
NP_001268702.1, NM_001281773.2 [Q9ULU4-11]
NP_001268703.1, NM_001281774.2 [Q9ULU4-9]
NP_001268704.1, NM_001281775.2 [Q9ULU4-7]
NP_001268705.1, NM_001281776.2 [Q9ULU4-8]
NP_001268706.1, NM_001281777.2 [Q9ULU4-16]
NP_001268707.1, NM_001281778.2 [Q9ULU4-5]
NP_001268710.1, NM_001281781.2 [Q9ULU4-15]
NP_001268711.1, NM_001281782.2
NP_001268712.1, NM_001281783.2 [Q9ULU4-10]
NP_001268713.1, NM_001281784.2 [Q9ULU4-18]
NP_036540.3, NM_012408.5 [Q9ULU4-12]
NP_898868.1, NM_183047.3 [Q9ULU4-13]
NP_898869.1, NM_183048.3 [Q9ULU4-14]
XP_005260413.1, XM_005260356.4 [Q9ULU4-19]
XP_005260417.1, XM_005260360.4 [Q9ULU4-11]
XP_005260423.1, XM_005260366.2 [Q9ULU4-1]
XP_006723825.1, XM_006723762.3 [Q9ULU4-11]
XP_011527053.1, XM_011528751.1 [Q9ULU4-11]
XP_016883250.1, XM_017027761.1 [Q9ULU4-11]
XP_016883256.1, XM_017027767.1 [Q9ULU4-1]
XP_016883257.1, XM_017027768.1 [Q9ULU4-1]
UniGeneiHs.446240
Hs.658553
Hs.668465

Genome annotation databases

EnsembliENST00000262975; ENSP00000262975; ENSG00000101040 [Q9ULU4-9]
ENST00000311275; ENSP00000312237; ENSG00000101040 [Q9ULU4-1]
ENST00000352431; ENSP00000335537; ENSG00000101040 [Q9ULU4-12]
ENST00000355972; ENSP00000348246; ENSG00000101040 [Q9ULU4-11]
ENST00000360911; ENSP00000354166; ENSG00000101040 [Q9ULU4-14]
ENST00000372023; ENSP00000361093; ENSG00000101040 [Q9ULU4-23]
ENST00000396281; ENSP00000379577; ENSG00000101040 [Q9ULU4-20]
ENST00000446994; ENSP00000396725; ENSG00000101040 [Q9ULU4-11]
ENST00000458360; ENSP00000392964; ENSG00000101040 [Q9ULU4-17]
ENST00000461685; ENSP00000418210; ENSG00000101040 [Q9ULU4-13]
ENST00000471951; ENSP00000420095; ENSG00000101040 [Q9ULU4-7]
ENST00000536340; ENSP00000439800; ENSG00000101040 [Q9ULU4-19]
ENST00000540497; ENSP00000443086; ENSG00000101040 [Q9ULU4-18]
GeneIDi23613
KEGGihsa:23613
UCSCiuc002xss.3 human [Q9ULU4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPKCB1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULU4
Secondary accession number(s): B3KVL2
, B7Z2A8, B7Z3E0, B7Z680, B7ZM62, E1P5U5, F5H0X3, H7C0U2, J3KPU3, Q13517, Q2HXV1, Q2HXV2, Q2HXV3, Q2HXV4, Q2HXV7, Q2HXV8, Q2HXV9, Q2HXW0, Q2HXW1, Q2HXW2, Q4JJ94, Q4JJ95, Q5TH09, Q5TH11, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: July 18, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notic