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Entry version 154 (16 Oct 2019)
Sequence version 2 (25 Oct 2002)
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Protein

Potassium voltage-gated channel subfamily S member 2

Gene

KCNS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296072 Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.2.16 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNS2
Synonyms:KIAA1144
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6301 KCNS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602906 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULS6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 184CytoplasmicBy similarityAdd BLAST184
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 206Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini207 – 225ExtracellularBy similarityAdd BLAST19
Transmembranei226 – 248Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini249 – 259CytoplasmicBy similarityAdd BLAST11
Transmembranei260 – 280Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini281 – 290ExtracellularBy similarity10
Transmembranei291 – 311Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini312 – 326CytoplasmicBy similarityAdd BLAST15
Transmembranei327 – 348Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini349 – 361ExtracellularBy similarityAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei362 – 373Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei374 – 381By similarity8
Topological domaini382 – 388ExtracellularBy similarity7
Transmembranei389 – 417Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini418 – 477CytoplasmicBy similarityAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000156486

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30079

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULS6

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2362996

DrugCentral

More...
DrugCentrali
Q9ULS6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24418481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540841 – 477Potassium voltage-gated channel subfamily S member 2Add BLAST477

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULS6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULS6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULS6

PeptideAtlas

More...
PeptideAtlasi
Q9ULS6

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULS6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85103

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156486 Expressed in 81 organ(s), highest expression level in endothelial cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULS6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051417

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F05EBI-10323864,EBI-743099

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109989, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULS6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000287042

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi374 – 379Selectivity filterBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3713 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231016

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULS6

KEGG Orthology (KO)

More...
KOi
K04932

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLMLDNP

Database of Orthologous Groups

More...
OrthoDBi
818306at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULS6

TreeFam database of animal gene trees

More...
TreeFami
TF313103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11537 PTHR11537, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01494 KV9CHANNEL
PR01491 KVCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ULS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH
60 70 80 90 100
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS
110 120 130 140 150
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE
160 170 180 190 200
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS ILSILVVMGS
210 220 230 240 250
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP
260 270 280 290 300
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM
310 320 330 340 350
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI
360 370 380 390 400
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL
410 420 430 440 450
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH
460 470
KVKSLMASLT NMSRSSPSEL SLNDSLR
Length:477
Mass (Da):54,237
Last modified:October 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF231AD99EC02EB46
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86458 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB032970 mRNA Translation: BAA86458.1 Different initiation.
AK293096 mRNA Translation: BAF85785.1
CH471060 Genomic DNA Translation: EAW91780.1
BC027932 mRNA Translation: AAH27932.1
BC034778 mRNA Translation: AAH34778.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6279.1

NCBI Reference Sequences

More...
RefSeqi
NP_065748.1, NM_020697.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287042; ENSP00000287042; ENSG00000156486
ENST00000521839; ENSP00000430712; ENSG00000156486

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3788

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3788

UCSC genome browser

More...
UCSCi
uc003yin.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032970 mRNA Translation: BAA86458.1 Different initiation.
AK293096 mRNA Translation: BAF85785.1
CH471060 Genomic DNA Translation: EAW91780.1
BC027932 mRNA Translation: AAH27932.1
BC034778 mRNA Translation: AAH34778.1
CCDSiCCDS6279.1
RefSeqiNP_065748.1, NM_020697.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi109989, 2 interactors
IntActiQ9ULS6, 3 interactors
STRINGi9606.ENSP00000287042

Chemistry databases

ChEMBLiCHEMBL2362996
DrugCentraliQ9ULS6

Protein family/group databases

TCDBi1.A.1.2.16 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ9ULS6
PhosphoSitePlusiQ9ULS6

Polymorphism and mutation databases

BioMutaiKCNS2
DMDMi24418481

Proteomic databases

jPOSTiQ9ULS6
MassIVEiQ9ULS6
PaxDbiQ9ULS6
PeptideAtlasiQ9ULS6
PRIDEiQ9ULS6
ProteomicsDBi85103

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3788

Genome annotation databases

EnsembliENST00000287042; ENSP00000287042; ENSG00000156486
ENST00000521839; ENSP00000430712; ENSG00000156486
GeneIDi3788
KEGGihsa:3788
UCSCiuc003yin.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3788

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNS2
HGNCiHGNC:6301 KCNS2
HPAiHPA051417
MIMi602906 gene
neXtProtiNX_Q9ULS6
OpenTargetsiENSG00000156486
PharmGKBiPA30079

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000160344
HOGENOMiHOG000231016
InParanoidiQ9ULS6
KOiK04932
OMAiWLMLDNP
OrthoDBi818306at2759
PhylomeDBiQ9ULS6
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3788
PharosiQ9ULS6

Protein Ontology

More...
PROi
PR:Q9ULS6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156486 Expressed in 81 organ(s), highest expression level in endothelial cell
GenevisibleiQ9ULS6 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULS6
Secondary accession number(s): A8KAN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: October 16, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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