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Protein

Potassium voltage-gated channel subfamily S member 2

Gene

KCNS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Protein family/group databases

TCDBi1.A.1.2.16 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene namesi
Name:KCNS2
Synonyms:KIAA1144
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156486.7
HGNCiHGNC:6301 KCNS2
MIMi602906 gene
neXtProtiNX_Q9ULS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 184CytoplasmicBy similarityAdd BLAST184
Transmembranei185 – 206Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini207 – 225ExtracellularBy similarityAdd BLAST19
Transmembranei226 – 248Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini249 – 259CytoplasmicBy similarityAdd BLAST11
Transmembranei260 – 280Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini281 – 290ExtracellularBy similarity10
Transmembranei291 – 311Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini312 – 326CytoplasmicBy similarityAdd BLAST15
Transmembranei327 – 348Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini349 – 361ExtracellularBy similarityAdd BLAST13
Intramembranei362 – 373Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei374 – 381By similarity8
Topological domaini382 – 388ExtracellularBy similarity7
Transmembranei389 – 417Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini418 – 477CytoplasmicBy similarityAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000156486
PharmGKBiPA30079

Chemistry databases

ChEMBLiCHEMBL2362996

Polymorphism and mutation databases

BioMutaiKCNS2
DMDMi24418481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540841 – 477Potassium voltage-gated channel subfamily S member 2Add BLAST477

Proteomic databases

PaxDbiQ9ULS6
PeptideAtlasiQ9ULS6
PRIDEiQ9ULS6
ProteomicsDBi85103

PTM databases

iPTMnetiQ9ULS6
PhosphoSitePlusiQ9ULS6

Expressioni

Gene expression databases

BgeeiENSG00000156486 Expressed in 81 organ(s), highest expression level in endothelial cell
CleanExiHS_KCNS2
GenevisibleiQ9ULS6 HS

Organism-specific databases

HPAiHPA051417

Interactioni

Subunit structurei

Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F05EBI-10323864,EBI-743099

Protein-protein interaction databases

BioGridi109989, 1 interactor
IntActiQ9ULS6, 3 interactors
STRINGi9606.ENSP00000287042

Structurei

3D structure databases

ProteinModelPortaliQ9ULS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi374 – 379Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiQ9ULS6
KOiK04932
OMAiVGGFKKK
OrthoDBiEOG091G0FP3
PhylomeDBiQ9ULS6
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ULS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH
60 70 80 90 100
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS
110 120 130 140 150
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE
160 170 180 190 200
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS ILSILVVMGS
210 220 230 240 250
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP
260 270 280 290 300
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM
310 320 330 340 350
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI
360 370 380 390 400
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL
410 420 430 440 450
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH
460 470
KVKSLMASLT NMSRSSPSEL SLNDSLR
Length:477
Mass (Da):54,237
Last modified:October 25, 2002 - v2
Checksum:iF231AD99EC02EB46
GO

Sequence cautioni

The sequence BAA86458 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032970 mRNA Translation: BAA86458.1 Different initiation.
AK293096 mRNA Translation: BAF85785.1
CH471060 Genomic DNA Translation: EAW91780.1
BC027932 mRNA Translation: AAH27932.1
BC034778 mRNA Translation: AAH34778.1
CCDSiCCDS6279.1
RefSeqiNP_065748.1, NM_020697.3
UniGeneiHs.388045

Genome annotation databases

EnsembliENST00000287042; ENSP00000287042; ENSG00000156486
ENST00000521839; ENSP00000430712; ENSG00000156486
GeneIDi3788
KEGGihsa:3788
UCSCiuc003yin.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032970 mRNA Translation: BAA86458.1 Different initiation.
AK293096 mRNA Translation: BAF85785.1
CH471060 Genomic DNA Translation: EAW91780.1
BC027932 mRNA Translation: AAH27932.1
BC034778 mRNA Translation: AAH34778.1
CCDSiCCDS6279.1
RefSeqiNP_065748.1, NM_020697.3
UniGeneiHs.388045

3D structure databases

ProteinModelPortaliQ9ULS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109989, 1 interactor
IntActiQ9ULS6, 3 interactors
STRINGi9606.ENSP00000287042

Chemistry databases

ChEMBLiCHEMBL2362996

Protein family/group databases

TCDBi1.A.1.2.16 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ9ULS6
PhosphoSitePlusiQ9ULS6

Polymorphism and mutation databases

BioMutaiKCNS2
DMDMi24418481

Proteomic databases

PaxDbiQ9ULS6
PeptideAtlasiQ9ULS6
PRIDEiQ9ULS6
ProteomicsDBi85103

Protocols and materials databases

DNASUi3788
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287042; ENSP00000287042; ENSG00000156486
ENST00000521839; ENSP00000430712; ENSG00000156486
GeneIDi3788
KEGGihsa:3788
UCSCiuc003yin.4 human

Organism-specific databases

CTDi3788
EuPathDBiHostDB:ENSG00000156486.7
GeneCardsiKCNS2
HGNCiHGNC:6301 KCNS2
HPAiHPA051417
MIMi602906 gene
neXtProtiNX_Q9ULS6
OpenTargetsiENSG00000156486
PharmGKBiPA30079
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231016
HOVERGENiHBG052230
InParanoidiQ9ULS6
KOiK04932
OMAiVGGFKKK
OrthoDBiEOG091G0FP3
PhylomeDBiQ9ULS6
TreeFamiTF313103

Enzyme and pathway databases

ReactomeiR-HSA-1296072 Voltage gated Potassium channels

Miscellaneous databases

GeneWikiiKCNS2
GenomeRNAii3788
PROiPR:Q9ULS6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156486 Expressed in 81 organ(s), highest expression level in endothelial cell
CleanExiHS_KCNS2
GenevisibleiQ9ULS6 HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003971 K_chnl_volt-dep_Kv9
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01494 KV9CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNS2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULS6
Secondary accession number(s): A8KAN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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