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Protein

Polyadenylate-binding protein-interacting protein 2B

Gene

PAIP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.1 Publication

GO - Molecular functioni

  • translation repressor activity, mRNA regulatory element binding Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 2B
Short name:
PABP-interacting protein 2B
Short name:
PAIP-2B
Short name:
Poly(A)-binding protein-interacting protein 2B
Gene namesi
Name:PAIP2B
Synonyms:KIAA1155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000124374.8
HGNCiHGNC:29200 PAIP2B
MIMi611018 gene
neXtProtiNX_Q9ULR5

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124374
PharmGKBiPA162398595

Polymorphism and mutation databases

BioMutaiPAIP2B
DMDMi166977703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172941 – 123Polyadenylate-binding protein-interacting protein 2BAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Post-translational modificationi

Ubiquitinated in vitro.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ9ULR5
MaxQBiQ9ULR5
PaxDbiQ9ULR5
PeptideAtlasiQ9ULR5
PRIDEiQ9ULR5
ProteomicsDBi85101

PTM databases

iPTMnetiQ9ULR5
PhosphoSitePlusiQ9ULR5

Expressioni

Tissue specificityi

Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis.1 Publication

Gene expression databases

BgeeiENSG00000124374 Expressed in 227 organ(s), highest expression level in brain
CleanExiHS_PAIP2B
GenevisibleiQ9ULR5 HS

Organism-specific databases

HPAiHPA046784
HPA072371

Interactioni

Subunit structurei

Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus).1 Publication

Protein-protein interaction databases

BioGridi134843, 10 interactors
ELMiQ9ULR5
STRINGi9606.ENSP00000244221

Structurei

3D structure databases

ProteinModelPortaliQ9ULR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAIP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW9I Eukaryota
ENOG4111Z4B LUCA
GeneTreeiENSGT00390000017284
HOGENOMiHOG000008098
HOVERGENiHBG053493
InParanoidiQ9ULR5
OMAiQGLNGHE
OrthoDBiEOG091G1372
PhylomeDBiQ9ULR5
TreeFamiTF326855

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
PfamiView protein in Pfam
PF07145 PAM2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ULR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGSNMANTS PSVKSKEDQG LSGHDEKENP FAEYMWMENE EDFNRQVEEE
60 70 80 90 100
LQEQDFLDRC FQEMLDEEDQ DWFIPSRDLP QAMGQLQQQL NGLSVSEGHD
110 120
SEDILSKSNL NPDAKEFIPG EKY
Length:123
Mass (Da):14,237
Last modified:February 5, 2008 - v2
Checksum:iD1C85F950BD651C3
GO

Sequence cautioni

The sequence BAA86469 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032981 mRNA Translation: BAA86469.1 Different initiation.
CCDSiCCDS46322.1
RefSeqiNP_065192.1, NM_020459.1
XP_005264367.1, XM_005264310.3
XP_005264368.1, XM_005264311.4
XP_011531145.1, XM_011532843.2
UniGeneiHs.416735

Genome annotation databases

EnsembliENST00000244221; ENSP00000244221; ENSG00000124374
GeneIDi400961
KEGGihsa:400961
UCSCiuc002shu.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032981 mRNA Translation: BAA86469.1 Different initiation.
CCDSiCCDS46322.1
RefSeqiNP_065192.1, NM_020459.1
XP_005264367.1, XM_005264310.3
XP_005264368.1, XM_005264311.4
XP_011531145.1, XM_011532843.2
UniGeneiHs.416735

3D structure databases

ProteinModelPortaliQ9ULR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134843, 10 interactors
ELMiQ9ULR5
STRINGi9606.ENSP00000244221

PTM databases

iPTMnetiQ9ULR5
PhosphoSitePlusiQ9ULR5

Polymorphism and mutation databases

BioMutaiPAIP2B
DMDMi166977703

Proteomic databases

EPDiQ9ULR5
MaxQBiQ9ULR5
PaxDbiQ9ULR5
PeptideAtlasiQ9ULR5
PRIDEiQ9ULR5
ProteomicsDBi85101

Protocols and materials databases

DNASUi400961
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244221; ENSP00000244221; ENSG00000124374
GeneIDi400961
KEGGihsa:400961
UCSCiuc002shu.3 human

Organism-specific databases

CTDi400961
EuPathDBiHostDB:ENSG00000124374.8
GeneCardsiPAIP2B
HGNCiHGNC:29200 PAIP2B
HPAiHPA046784
HPA072371
MIMi611018 gene
neXtProtiNX_Q9ULR5
OpenTargetsiENSG00000124374
PharmGKBiPA162398595
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW9I Eukaryota
ENOG4111Z4B LUCA
GeneTreeiENSGT00390000017284
HOGENOMiHOG000008098
HOVERGENiHBG053493
InParanoidiQ9ULR5
OMAiQGLNGHE
OrthoDBiEOG091G1372
PhylomeDBiQ9ULR5
TreeFamiTF326855

Miscellaneous databases

ChiTaRSiPAIP2B human
GenomeRNAii400961
PROiPR:Q9ULR5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124374 Expressed in 227 organ(s), highest expression level in brain
CleanExiHS_PAIP2B
GenevisibleiQ9ULR5 HS

Family and domain databases

InterProiView protein in InterPro
IPR009818 Ataxin-2_C
PfamiView protein in Pfam
PF07145 PAM2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAI2B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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