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UniProtKB - Q9ULQ1 (TPC1_HUMAN)

Entry version 159 (29 Sep 2021)
Sequence version 3 (06 Feb 2007)
Previous versions | rss
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Protein

Two pore channel protein 1

Gene

TPCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intracellular channel initially characterized as a non-selective Ca2+-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na+ channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:24776928, PubMed:23394946).

Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (PubMed:23394946) (Probable).

Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (PubMed:23394946) (Probable).

1 Publication4 Publications

(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Na+ current is inhibited by ATP in a MTORC-dependent manner. ATP sensitivity is independent of PI(3,5)P2 (PubMed:23394946). Probably regulated by Mg2+ ions, cytosolic Mg2+ selectively inhibits outward current while lysosomal Mg2+ modestly inhibits both the outward and inward currents. In the absence of Mg2+, NAADP readily activates TPCN2, with properties similar to PI(3,5)P2 (By similarity). Both current elicited by PI(3,5)P2 as well as NAADP are inhibited by tetrandrine.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULQ1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2672351, Stimuli-sensing channels

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.11.25, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Two pore channel protein 1Curated
Alternative name(s):
Two pore calcium channel protein 1
Voltage-dependent calcium channel protein TPC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPCN1Imported
Synonyms:KIAA1169, TPC12 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18182, TPCN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609666, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULQ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186815

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 112CytoplasmicSequence analysisAdd BLAST112
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei113 – 133Helical; Name=S1 of repeat ISequence analysisAdd BLAST21
Topological domaini134ExtracellularSequence analysis1
Transmembranei135 – 155Helical; Name=S2 of repeat ISequence analysisAdd BLAST21
Topological domaini156 – 177CytoplasmicSequence analysisAdd BLAST22
Transmembranei178 – 198Helical; Name=S3 of repeat ISequence analysisAdd BLAST21
Topological domaini199 – 200ExtracellularSequence analysis2
Transmembranei201 – 220Helical; Name=S4 of repeat ISequence analysisAdd BLAST20
Topological domaini221 – 234CytoplasmicSequence analysisAdd BLAST14
Transmembranei235 – 255Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini256 – 262ExtracellularSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei263 – 286Helical; Pore-formingSequence analysisAdd BLAST24
Topological domaini287 – 294ExtracellularSequence analysis8
Transmembranei295 – 315Helical; Name=S6 of repeat ISequence analysisAdd BLAST21
Topological domaini316 – 444CytoplasmicSequence analysisAdd BLAST129
Transmembranei445 – 465Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini466 – 479ExtracellularSequence analysisAdd BLAST14
Transmembranei480 – 500Helical; Name=S2 of repeat IISequence analysisAdd BLAST21
Topological domaini501 – 503CytoplasmicSequence analysis3
Transmembranei504 – 526Helical; Name=S3 of repeat IISequence analysisAdd BLAST23
Topological domaini527 – 534ExtracellularSequence analysis8
Transmembranei535 – 549Helical; Name=S4 of repeat IISequence analysisAdd BLAST15
Topological domaini550 – 573CytoplasmicSequence analysisAdd BLAST24
Transmembranei574 – 594Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini595 – 629ExtracellularSequence analysisAdd BLAST35
Intramembranei630 – 653Helical; Pore-formingSequence analysisAdd BLAST24
Topological domaini654 – 670ExtracellularSequence analysisAdd BLAST17
Transmembranei671 – 691Helical; Name=S6 of repeat IISequence analysisAdd BLAST21
Topological domaini692 – 816CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi219 – 223RRNLR → QQNLQ: Loss of voltage sensitivity. 1 Publication5
Mutagenesisi273L → P: Loss of NAADP-mediated cytoplasmic calcium release. 1 Publication1
Mutagenesisi539R → I: Loss of voltage sensitivity. 1 Publication1
Mutagenesisi740 – 741LL → AA: No effect on subcellular location. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		53373

Open Targets

More...OpenTargetsi		ENSG00000186815

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134922711

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULQ1, Tchem

Chemistry databases

DrugCentral

More...DrugCentrali		Q9ULQ1

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		392

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TPCN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		125991219

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002768531 – 816Two pore channel protein 1Add BLAST816

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi599N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi611N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULQ1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULQ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULQ1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULQ1

PeptideAtlas

More...PeptideAtlasi		Q9ULQ1

PRoteomics IDEntifications database

More...PRIDEi		Q9ULQ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85094 [Q9ULQ1-1]
85095 [Q9ULQ1-2]
85096 [Q9ULQ1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9ULQ1, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULQ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULQ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression found in the heart and kidney, and lowest expression found in the spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186815, Expressed in right hemisphere of cerebellum and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULQ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULQ1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186815, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer.

Interacts with MTOR; the interaction is required for TPCN1 ATP sensitivity (PubMed:23394946).

Interacts with STX7, STX8 and STX12 (By similarity).

By similarityCurated1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119760, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q9ULQ1, 8 interactors

Molecular INTeraction database

More...MINTi		Q9ULQ1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000448083

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULQ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULQ1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 64DisorderedSequence analysisAdd BLAST48
Regioni782 – 816DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili769 – 796Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 64Polar residuesSequence analysisAdd BLAST24
Compositional biasi791 – 816Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2301, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158958

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULQ1

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULQ1

TreeFam database of animal gene trees

More...TreeFami		TF328550

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821, Ion_trans_dom
IPR028801, TPC1_animal
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR46474, PTHR46474, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00520, Ion_trans, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP 
        60         70         80         90        100
SLSSGGESSP SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY 
       110        120        130        140        150
LFAHNHLFYL MELATALLLL LLSLCEAPAV PALRLGIYVH ATLELFALMV 
       160        170        180        190        200
VVFELCMKLR WLGLHTFIRH KRTMVKTSVL VVQFVEAIVV LVRQMSHVRV 
       210        220        230        240        250
TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL FFMIIFAILG 
       260        270        280        290        300
FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF 
       310        320        330        340        350
IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLI 
       360        370        380        390        400
SQRRPAGISY RQFEGLMRFY KPRMSARERY LTFKALNQNN TPLLSLKDFY 
       410        420        430        440        450
DIYEVAALKW KAKKNREHWF DELPRTALLI FKGINILVKS KAFQYFMYLV 
       460        470        480        490        500
VAVNGVWILV ETFMLKGGNF FSKHVPWSYL VFLTIYGVEL FLKVAGLGPV 
       510        520        530        540        550
EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP LQLLRLFKLK 
       560        570        580        590        600
ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT 
       610        620        630        640        650
STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY 
       660        670        680        690        700
IIMEGVTSQT SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN 
       710        720        730        740        750
QDSEVDGGIT LEKEISKEEL VAVLELYREA RGASSDVTRL LETLSQMERY 
       760        770        780        790        800
QQHSMVFLGR RSRTKSDLSL KMYQEEIQEW YEEHAREQEQ QRQLSSSAAP 
       810 
AAQQPPGSRQ RSQTVT
Length:816
Mass (Da):94,147
Last modified:February 6, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6D26BFAF33E1463
GO
Isoform 2 (identifier: Q9ULQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.
     569-618: SLGLTLLIFY...WRNHTVGNRT → RYCQPPPWPA...PDGAPRSLES
     619-816: Missing.

Show »
Length:252
Mass (Da):29,136
Checksum:iBDD06287A468FA93
GO
Isoform 3 (identifier: Q9ULQ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPGYHILRATGEENM

Show »
Length:888
Mass (Da):101,796
Checksum:iD3267C511D4C6BC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z3R2B7Z3R2_HUMAN
Two pore calcium channel protein 1
TPCN1
748Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VR74F8VR74_HUMAN
Two pore calcium channel protein 1
TPCN1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIK4H0YIK4_HUMAN
Two pore calcium channel protein 1
TPCN1
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0P9F8W0P9_HUMAN
Two pore calcium channel protein 1
TPCN1
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1L6F8W1L6_HUMAN
Two pore calcium channel protein 1
TPCN1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS97F8VS97_HUMAN
Two pore calcium channel protein 1
TPCN1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VV93F8VV93_HUMAN
Two pore calcium channel protein 1
TPCN1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHX1H0YHX1_HUMAN
Two pore calcium channel protein 1
TPCN1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVY9F8VVY9_HUMAN
Two pore calcium channel protein 1
TPCN1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZZ6F8VZZ6_HUMAN
Two pore calcium channel protein 1
TPCN1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK057414 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86483 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti621E → G in AK057414 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0230031 – 366Missing in isoform 2. 1 PublicationAdd BLAST366
Alternative sequenceiVSP_0413461M → MESCYIAQAGLELLGSSSSP TLTSQSAEITEDASNGGVSE QHPWPSGFERELKPETISSP GYHILRATGEENM in isoform 3. 1 Publication1
Alternative sequenceiVSP_023004569 – 618SLGLT…VGNRT → RYCQPPPWPAGPGAVWQCPV GAGAEWQSGERSSTKDCNRG PDGAPRSLES in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_023005619 – 816Missing in isoform 2. 1 PublicationAdd BLAST198

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY083666 mRNA Translation: AAM01199.1
AB032995 mRNA Translation: BAA86483.2 Different initiation.
AK057414 mRNA No translation available.
AK075071 mRNA Translation: BAC11385.1
AC010178 Genomic DNA No translation available.
AC089999 Genomic DNA No translation available.
AC127004 Genomic DNA No translation available.
BC136795 mRNA Translation: AAI36796.1
BC136796 mRNA Translation: AAI36797.1
BC150203 mRNA Translation: AAI50204.1
BC152423 mRNA Translation: AAI52424.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31908.1 [Q9ULQ1-1]
CCDS44985.1 [Q9ULQ1-3]

NCBI Reference Sequences

More...RefSeqi		NP_001137291.1, NM_001143819.2 [Q9ULQ1-3]
NP_001288143.1, NM_001301214.1
NP_060371.2, NM_017901.5 [Q9ULQ1-1]
XP_011536792.1, XM_011538490.2 [Q9ULQ1-3]
XP_011536794.1, XM_011538492.2 [Q9ULQ1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335509; ENSP00000335300; ENSG00000186815 [Q9ULQ1-1]
ENST00000541517; ENSP00000438125; ENSG00000186815 [Q9ULQ1-3]
ENST00000550785; ENSP00000448083; ENSG00000186815 [Q9ULQ1-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		53373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:53373

UCSC genome browser

More...UCSCi		uc001tuw.4, human [Q9ULQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083666 mRNA Translation: AAM01199.1
AB032995 mRNA Translation: BAA86483.2 Different initiation.
AK057414 mRNA No translation available.
AK075071 mRNA Translation: BAC11385.1
AC010178 Genomic DNA No translation available.
AC089999 Genomic DNA No translation available.
AC127004 Genomic DNA No translation available.
BC136795 mRNA Translation: AAI36796.1
BC136796 mRNA Translation: AAI36797.1
BC150203 mRNA Translation: AAI50204.1
BC152423 mRNA Translation: AAI52424.1
CCDSiCCDS31908.1 [Q9ULQ1-1]
CCDS44985.1 [Q9ULQ1-3]
RefSeqiNP_001137291.1, NM_001143819.2 [Q9ULQ1-3]
NP_001288143.1, NM_001301214.1
NP_060371.2, NM_017901.5 [Q9ULQ1-1]
XP_011536792.1, XM_011538490.2 [Q9ULQ1-3]
XP_011536794.1, XM_011538492.2 [Q9ULQ1-1]

3D structure databases

SMRiQ9ULQ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119760, 12 interactors
IntActiQ9ULQ1, 8 interactors
MINTiQ9ULQ1
STRINGi9606.ENSP00000448083

Chemistry databases

DrugCentraliQ9ULQ1
GuidetoPHARMACOLOGYi392

Protein family/group databases

TCDBi1.A.1.11.25, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniQ9ULQ1, 3 sites
iPTMnetiQ9ULQ1
PhosphoSitePlusiQ9ULQ1

Genetic variation databases

BioMutaiTPCN1
DMDMi125991219

Proteomic databases

EPDiQ9ULQ1
jPOSTiQ9ULQ1
MassIVEiQ9ULQ1
PaxDbiQ9ULQ1
PeptideAtlasiQ9ULQ1
PRIDEiQ9ULQ1
ProteomicsDBi85094 [Q9ULQ1-1]
85095 [Q9ULQ1-2]
85096 [Q9ULQ1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31242, 58 antibodies

The DNASU plasmid repository

More...DNASUi		53373

Genome annotation databases

EnsembliENST00000335509; ENSP00000335300; ENSG00000186815 [Q9ULQ1-1]
ENST00000541517; ENSP00000438125; ENSG00000186815 [Q9ULQ1-3]
ENST00000550785; ENSP00000448083; ENSG00000186815 [Q9ULQ1-3]
GeneIDi53373
KEGGihsa:53373
UCSCiuc001tuw.4, human [Q9ULQ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		53373
DisGeNETi53373

GeneCards: human genes, protein and diseases

More...GeneCardsi		TPCN1
HGNCiHGNC:18182, TPCN1
HPAiENSG00000186815, Low tissue specificity
MIMi609666, gene
neXtProtiNX_Q9ULQ1
OpenTargetsiENSG00000186815
PharmGKBiPA134922711
VEuPathDBiHostDB:ENSG00000186815

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
GeneTreeiENSGT00940000158958
InParanoidiQ9ULQ1
PhylomeDBiQ9ULQ1
TreeFamiTF328550

Enzyme and pathway databases

PathwayCommonsiQ9ULQ1
ReactomeiR-HSA-2672351, Stimuli-sensing channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		53373, 7 hits in 1019 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TPCN1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TPCN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		53373
PharosiQ9ULQ1, Tchem

Protein Ontology

More...PROi		PR:Q9ULQ1
RNActiQ9ULQ1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186815, Expressed in right hemisphere of cerebellum and 244 other tissues
ExpressionAtlasiQ9ULQ1, baseline and differential
GenevisibleiQ9ULQ1, HS

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR028801, TPC1_animal
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR46474, PTHR46474, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULQ1
Secondary accession number(s): A7E258, Q86XS9, Q8NC20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 29, 2021
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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