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Protein

Striatin-interacting protein 2

Gene

STRIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

GO - Biological processi

  • cell migration Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-interacting protein 2
Alternative name(s):
Protein FAM40B
Gene namesi
Name:STRIP2
Synonyms:FAM40B, KIAA1170
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128578.9
HGNCiHGNC:22209 STRIP2
MIMi617919 gene
neXtProtiNX_Q9ULQ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128578
PharmGKBiPA134923427

Polymorphism and mutation databases

BioMutaiSTRIP2
DMDMi71151881

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870221 – 834Striatin-interacting protein 2Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULQ0
PaxDbiQ9ULQ0
PeptideAtlasiQ9ULQ0
PRIDEiQ9ULQ0
ProteomicsDBi85092
85093 [Q9ULQ0-2]

PTM databases

iPTMnetiQ9ULQ0
PhosphoSitePlusiQ9ULQ0

Expressioni

Gene expression databases

BgeeiENSG00000128578
CleanExiHS_FAM40B
GenevisibleiQ9ULQ0 HS

Organism-specific databases

HPAiHPA019657

Interactioni

Subunit structurei

Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.By similarity1 Publication

Protein-protein interaction databases

BioGridi121534, 28 interactors
DIPiDIP-51635N
IntActiQ9ULQ0, 20 interactors
STRINGi9606.ENSP00000249344

Structurei

3D structure databases

ProteinModelPortaliQ9ULQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi577 – 582Poly-Leu6

Sequence similaritiesi

Belongs to the STRIP family.Curated

Phylogenomic databases

eggNOGiKOG3680 Eukaryota
ENOG410XRAB LUCA
GeneTreeiENSGT00400000022095
HOGENOMiHOG000252963
HOVERGENiHBG081506
InParanoidiQ9ULQ0
OMAiRRYDKPQ
OrthoDBiEOG091G02GC
PhylomeDBiQ9ULQ0
TreeFamiTF314205

Family and domain databases

InterProiView protein in InterPro
IPR021819 Far11/STRP_C
IPR012486 Far11/STRP_N
PfamiView protein in Pfam
PF11882 DUF3402, 2 hits
PF07923 N1221, 1 hit
SMARTiView protein in SMART
SM01293 DUF3402, 1 hit
SM01292 N1221, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDPAAPGTG GPPANGNGNG GGKGKQAAPK GREAFRSQRR ESEGSVDCPT
60 70 80 90 100
LEFEYGDADG HAAELSELYS YTENLEFTNN RRCFEEDFKT QVQGKEWLEL
110 120 130 140 150
EEDAQKAYIM GLLDRLEVVS RERRLKVARA VLYLAQGTFG ECDSEVDVLH
160 170 180 190 200
WSRYNCFLLY QMGTFSTFLE LLHMEIDNSQ ACSSALRKPA VSIADSTELR
210 220 230 240 250
VLLSVMYLMV ENIRLERETD PCGWRTARET FRTELSFSMH NEEPFALLLF
260 270 280 290 300
SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQTL KVQKRAELGL
310 320 330 340 350
PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG RRGSRRQLLT
360 370 380 390 400
KQDSLDIYNE RDLFKTEEPA TEEEEESAGD GERTLDGELD LLEQDPLVPP
410 420 430 440 450
PPSQAPLSAE RVAFPKGLPW APKVRQKDIE HFLEMSRNKF IGFTLGQDTD
460 470 480 490 500
TLVGLPRPIH ESVKTLKQHK YISIADVQIK NEEELEKCPM SLGEEVVPET
510 520 530 540 550
PCEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI LADVLPEEMP
560 570 580 590 600
ITVLQSMKLG IDVNRHKEII VKSISTLLLL LLKHFKLNHI YQFEYVSQHL
610 620 630 640 650
VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL PELTTESLEA
660 670 680 690 700
GDNSQFCWRN LFSCINLLRL LNKLTKWKHS RTMMLVVFKS APILKRALKV
710 720 730 740 750
KQAMLQLYVL KLLKLQTKYL GRQWRKSNMK TMSAIYQKVR HRMNDDWAYG
760 770 780 790 800
NDIDARPWDF QAEECTLRAN IEAFNSRRYD RPQDSEFSPV DNCLQSVLGQ
810 820 830
RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH
Length:834
Mass (Da):95,360
Last modified:July 19, 2005 - v2
Checksum:i3DAF1DA8FD6E4C4D
GO
Isoform 2 (identifier: Q9ULQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     752-758: DIDARPW → GESSQSS
     759-834: Missing.

Show »
Length:758
Mass (Da):86,018
Checksum:iC70233AEEB0C6690
GO

Sequence cautioni

The sequence BAA86484 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049021383R → Q. Corresponds to variant dbSNP:rs2242030Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014867752 – 758DIDARPW → GESSQSS in isoform 2. 1 Publication7
Alternative sequenceiVSP_014868759 – 834Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032996 mRNA Translation: BAA86484.1 Different initiation.
AC009244 Genomic DNA No translation available.
BC019064 mRNA Translation: AAH19064.1
CCDSiCCDS34752.1 [Q9ULQ0-1]
CCDS47709.1 [Q9ULQ0-2]
RefSeqiNP_001127808.1, NM_001134336.1 [Q9ULQ0-2]
NP_065755.1, NM_020704.2 [Q9ULQ0-1]
UniGeneiHs.489988

Genome annotation databases

EnsembliENST00000249344; ENSP00000249344; ENSG00000128578 [Q9ULQ0-1]
ENST00000435494; ENSP00000392393; ENSG00000128578 [Q9ULQ0-2]
GeneIDi57464
KEGGihsa:57464
UCSCiuc003vow.5 human [Q9ULQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTRP2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULQ0
Secondary accession number(s): Q8WUZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 20, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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