UniProtKB - Q9ULM3 (YETS2_HUMAN)
YEATS domain-containing protein 2
YEATS2
Functioni
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431).
YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431).
Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).
3 PublicationsGO - Molecular functioni
- histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- TBP-class protein binding Source: BHF-UCL
GO - Biological processi
- histone H3 acetylation Source: BHF-UCL
- histone H3-K14 acetylation Source: ComplexPortal
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of cell cycle Source: ComplexPortal
- regulation of cell division Source: ComplexPortal
- regulation of embryonic development Source: Ensembl
- regulation of histone deacetylation Source: ComplexPortal
- regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of transcription by RNA polymerase II Source: ComplexPortal
- regulation of tubulin deacetylation Source: ComplexPortal
Enzyme and pathway databases
PathwayCommonsi | Q9ULM3 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q9ULM3 |
Names & Taxonomyi
Protein namesi | Recommended name: YEATS domain-containing protein 2Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25489, YEATS2 |
MIMi | 613373, gene |
neXtProti | NX_Q9ULM3 |
VEuPathDBi | HostDB:ENSG00000163872 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoskeleton
- mitotic spindle Source: Ensembl
Nucleus
- ATAC complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Epilepsy, familial adult myoclonic, 4 (FAME4)2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 259 | H → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 261 | S → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 262 | Y → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 282 | W → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 283 | G → A: Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 284 | E → A: Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 285 | F → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 | |
Mutagenesisi | 313 | Y → A: Reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication | 1 |
Keywords - Diseasei
EpilepsyOrganism-specific databases
DisGeNETi | 55689 |
MalaCardsi | YEATS2 |
MIMi | 615127, phenotype |
OpenTargetsi | ENSG00000163872 |
Orphaneti | 86814, Benign adult familial myoclonic epilepsy |
PharmGKBi | PA134922615 |
Miscellaneous databases
Pharosi | Q9ULM3, Tbio |
Genetic variation databases
BioMutai | YEATS2 |
DMDMi | 85542165 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076366 | 1 – 1422 | YEATS domain-containing protein 2Add BLAST | 1422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 9 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 113 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 118 | PhosphoserineCombined sources | 1 | |
Modified residuei | 120 | PhosphoserineBy similarity | 1 | |
Modified residuei | 157 | PhosphoserineCombined sources | 1 | |
Cross-linki | 189 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 370 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 407 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 447 | PhosphoserineCombined sources | 1 | |
Modified residuei | 463 | PhosphoserineCombined sources | 1 | |
Modified residuei | 465 | PhosphoserineCombined sources | 1 | |
Modified residuei | 471 | PhosphoserineCombined sources | 1 | |
Modified residuei | 473 | PhosphoserineCombined sources | 1 | |
Modified residuei | 478 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 487 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 536 | PhosphoserineCombined sources | 1 | |
Cross-linki | 552 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 575 | PhosphoserineCombined sources | 1 | |
Cross-linki | 592 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 627 | PhosphoserineCombined sources | 1 | |
Cross-linki | 649 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 773 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 923 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 1110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 1130 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1219 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 1222 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1285 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9ULM3 |
jPOSTi | Q9ULM3 |
MassIVEi | Q9ULM3 |
MaxQBi | Q9ULM3 |
PaxDbi | Q9ULM3 |
PeptideAtlasi | Q9ULM3 |
PRIDEi | Q9ULM3 |
ProteomicsDBi | 85078 |
PTM databases
GlyGeni | Q9ULM3, 5 sites, 2 O-linked glycans (5 sites) |
iPTMneti | Q9ULM3 |
PhosphoSitePlusi | Q9ULM3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163872, Expressed in amniotic fluid and 231 other tissues |
ExpressionAtlasi | Q9ULM3, baseline and differential |
Genevisiblei | Q9ULM3, HS |
Organism-specific databases
HPAi | ENSG00000163872, Low tissue specificity |
Interactioni
Subunit structurei
Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.
2 PublicationsGO - Molecular functioni
- histone binding Source: UniProtKB
- modification-dependent protein binding Source: UniProtKB
- TBP-class protein binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 120815, 131 interactors |
ComplexPortali | CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex |
CORUMi | Q9ULM3 |
IntActi | Q9ULM3, 31 interactors |
MINTi | Q9ULM3 |
STRINGi | 9606.ENSP00000306983 |
Miscellaneous databases
RNActi | Q9ULM3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9ULM3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 200 – 345 | YEATSPROSITE-ProRule annotationAdd BLAST | 146 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 117 – 198 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 259 – 261 | Histone H3K27cr bindingCombined sources1 Publication | 3 | |
Regioni | 282 – 284 | Histone H3K27cr bindingCombined sources1 Publication | 3 | |
Regioni | 465 – 486 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 513 – 540 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 794 – 842 | DisorderedSequence analysisAdd BLAST | 49 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 47 – 80 | Sequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 117 – 152 | Polar residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 153 – 169 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 182 – 198 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 828 – 842 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000156789 |
HOGENOMi | CLU_258270_0_0_1 |
InParanoidi | Q9ULM3 |
OMAi | HKNTYAS |
OrthoDBi | 1482359at2759 |
PhylomeDBi | Q9ULM3 |
TreeFami | TF314586 |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
PANTHERi | PTHR23195, PTHR23195, 1 hit |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF
60 70 80 90 100
ALEMKNKEHE IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK
110 120 130 140 150
TCDTMVFNHP AIKKFLESPS RSSSPANQRA ETPSANHSES DSLSQHNDFL
160 170 180 190 200
SDKDNNSNMD IEERLSNNME QRPSRNTGRD TSRITGSHKT EQRNADLTDE
210 220 230 240 250
TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG SRREPSINHF
260 270 280 290 300
VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR
310 320 330 340 350
IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD
360 370 380 390 400
APPSLPLTIP APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL
410 420 430 440 450
PSSLERTPTK MTTSQKVTFC SHGNSAFQPI ASSCKIVPQS QVPNPESPGK
460 470 480 490 500
SFQPITMSCK IVSGSPISTP SPSPLPRTPT STPVHVKQGT AGSVINNPYV
510 520 530 540 550
IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK IHGSSFVTST
560 570 580 590 600
VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH
610 620 630 640 650
VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV
660 670 680 690 700
VGVPVGSALP STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA
710 720 730 740 750
IVSGGGGTIV AQPVQTLTKA QVTAAGPQKS GSQGSVMATL QLPATNLANL
760 770 780 790 800
ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG AILRATNNAN LQSGSAASGG
810 820 830 840 850
SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP GGISQHLTYT
860 870 880 890 900
SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK
910 920 930 940 950
VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG
960 970 980 990 1000
GVITTATSPA VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA
1010 1020 1030 1040 1050
TVGTCKAATP TVVSATSLVP TPNPISGKAT VSGLLKIHSS QSSPQQAVLT
1060 1070 1080 1090 1100
IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF STSKPPAILP VAAPTPVVPS
1110 1120 1130 1140 1150
SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY VIKIDHLETI
1160 1170 1180 1190 1200
QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT
1210 1220 1230 1240 1250
MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI
1260 1270 1280 1290 1300
EDVLTQIDSE PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS
1310 1320 1330 1340 1350
EPVKINIKKE QEEKQEEVKF YLPPTPGSEF IGDVTQKIGI TLQPVALHRN
1360 1370 1380 1390 1400
VYASVVEDMI LKATEQLVND ILRQALAVGY QTASHNRIPK EITVSNIHQA
1410 1420
ICNIPFLDFL TNKHMGILNE DQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y6M6 | H0Y6M6_HUMAN | YEATS domain-containing protein 2 | YEATS2 | 219 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051494 | 184 | I → V. Corresponds to variant dbSNP:rs16858033Ensembl. | 1 | |
Natural variantiVAR_051495 | 530 | V → I. Corresponds to variant dbSNP:rs262993Ensembl. | 1 | |
Natural variantiVAR_051496 | 993 | Q → H. Corresponds to variant dbSNP:rs3211095Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033023 mRNA Translation: BAA86511.1 Different initiation. AC068769 Genomic DNA No translation available. AC131160 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78316.1 CH471052 Genomic DNA Translation: EAW78317.1 BC082270 mRNA Translation: AAH82270.1 BC150273 mRNA Translation: AAI50274.1 |
CCDSi | CCDS43175.1 |
RefSeqi | NP_060493.3, NM_018023.4 XP_016862298.1, XM_017006809.1 XP_016862299.1, XM_017006810.1 |
Genome annotation databases
Ensembli | ENST00000305135; ENSP00000306983; ENSG00000163872 |
GeneIDi | 55689 |
KEGGi | hsa:55689 |
MANE-Selecti | ENST00000305135.10; ENSP00000306983.5; NM_018023.5; NP_060493.3 |
UCSCi | uc003fly.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033023 mRNA Translation: BAA86511.1 Different initiation. AC068769 Genomic DNA No translation available. AC131160 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW78316.1 CH471052 Genomic DNA Translation: EAW78317.1 BC082270 mRNA Translation: AAH82270.1 BC150273 mRNA Translation: AAI50274.1 |
CCDSi | CCDS43175.1 |
RefSeqi | NP_060493.3, NM_018023.4 XP_016862298.1, XM_017006809.1 XP_016862299.1, XM_017006810.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5IQL | X-ray | 2.10 | A | 201-332 | [»] | |
5XNV | X-ray | 2.70 | A | 201-332 | [»] | |
6LSD | X-ray | 2.05 | A/B | 201-332 | [»] | |
SMRi | Q9ULM3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120815, 131 interactors |
ComplexPortali | CPX-1004, PCAF-containing ATAC complex CPX-997, GCN5-containing ATAC complex |
CORUMi | Q9ULM3 |
IntActi | Q9ULM3, 31 interactors |
MINTi | Q9ULM3 |
STRINGi | 9606.ENSP00000306983 |
PTM databases
GlyGeni | Q9ULM3, 5 sites, 2 O-linked glycans (5 sites) |
iPTMneti | Q9ULM3 |
PhosphoSitePlusi | Q9ULM3 |
Genetic variation databases
BioMutai | YEATS2 |
DMDMi | 85542165 |
Proteomic databases
EPDi | Q9ULM3 |
jPOSTi | Q9ULM3 |
MassIVEi | Q9ULM3 |
MaxQBi | Q9ULM3 |
PaxDbi | Q9ULM3 |
PeptideAtlasi | Q9ULM3 |
PRIDEi | Q9ULM3 |
ProteomicsDBi | 85078 |
Protocols and materials databases
Antibodypediai | 50874, 88 antibodies from 26 providers |
DNASUi | 55689 |
Genome annotation databases
Ensembli | ENST00000305135; ENSP00000306983; ENSG00000163872 |
GeneIDi | 55689 |
KEGGi | hsa:55689 |
MANE-Selecti | ENST00000305135.10; ENSP00000306983.5; NM_018023.5; NP_060493.3 |
UCSCi | uc003fly.2, human |
Organism-specific databases
CTDi | 55689 |
DisGeNETi | 55689 |
GeneCardsi | YEATS2 |
HGNCi | HGNC:25489, YEATS2 |
HPAi | ENSG00000163872, Low tissue specificity |
MalaCardsi | YEATS2 |
MIMi | 613373, gene 615127, phenotype |
neXtProti | NX_Q9ULM3 |
OpenTargetsi | ENSG00000163872 |
Orphaneti | 86814, Benign adult familial myoclonic epilepsy |
PharmGKBi | PA134922615 |
VEuPathDBi | HostDB:ENSG00000163872 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3149, Eukaryota |
GeneTreei | ENSGT00940000156789 |
HOGENOMi | CLU_258270_0_0_1 |
InParanoidi | Q9ULM3 |
OMAi | HKNTYAS |
OrthoDBi | 1482359at2759 |
PhylomeDBi | Q9ULM3 |
TreeFami | TF314586 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULM3 |
Reactomei | R-HSA-3214847, HATs acetylate histones |
SignaLinki | Q9ULM3 |
Miscellaneous databases
BioGRID-ORCSi | 55689, 359 hits in 1063 CRISPR screens |
ChiTaRSi | YEATS2, human |
GenomeRNAii | 55689 |
Pharosi | Q9ULM3, Tbio |
PROi | PR:Q9ULM3 |
RNActi | Q9ULM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163872, Expressed in amniotic fluid and 231 other tissues |
ExpressionAtlasi | Q9ULM3, baseline and differential |
Genevisiblei | Q9ULM3, HS |
Family and domain databases
Gene3Di | 2.60.40.1970, 1 hit |
InterProi | View protein in InterPro IPR038704, YEAST_sf IPR005033, YEATS |
PANTHERi | PTHR23195, PTHR23195, 1 hit |
Pfami | View protein in Pfam PF03366, YEATS, 1 hit |
PROSITEi | View protein in PROSITE PS51037, YEATS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YETS2_HUMAN | |
Accessioni | Q9ULM3Primary (citable) accession number: Q9ULM3 Secondary accession number(s): A7E2B9 Q9NW96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references