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UniProtKB - Q9ULM3 (YETS2_HUMAN)

Protein

YEATS domain-containing protein 2

Gene

YEATS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 2Curated
Gene namesi
Name:YEATS2Imported
Synonyms:KIAA11971 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163872.15
HGNCiHGNC:25489 YEATS2
MIMi613373 gene
neXtProtiNX_Q9ULM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi259H → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi261S → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi262Y → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi282W → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi283G → A: Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi284E → A: Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi285F → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi313Y → A: Reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1

Organism-specific databases

DisGeNETi55689
OpenTargetsiENSG00000163872
PharmGKBiPA134922615

Polymorphism and mutation databases

BioMutaiYEATS2
DMDMi85542165

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763661 – 1422YEATS domain-containing protein 2Add BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineBy similarity1
Modified residuei157PhosphoserineCombined sources1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki370Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei407PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei536PhosphoserineCombined sources1
Cross-linki552Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei575PhosphoserineCombined sources1
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei627PhosphoserineCombined sources1
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki773Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki923Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1219PhosphothreonineCombined sources1
Cross-linki1222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ULM3
MaxQBiQ9ULM3
PaxDbiQ9ULM3
PeptideAtlasiQ9ULM3
PRIDEiQ9ULM3
ProteomicsDBi85078

PTM databases

iPTMnetiQ9ULM3
PhosphoSitePlusiQ9ULM3

Expressioni

Gene expression databases

BgeeiENSG00000163872 Expressed in 220 organ(s), highest expression level in amniotic fluid
CleanExiHS_YEATS2
ExpressionAtlasiQ9ULM3 baseline and differential
GenevisibleiQ9ULM3 HS

Organism-specific databases

HPAiHPA045891

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120815, 51 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ9ULM3
IntActiQ9ULM3, 11 interactors
MINTiQ9ULM3
STRINGi9606.ENSP00000306983

Structurei

Secondary structure

11422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ULM3
SMRiQ9ULM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 317YEATSPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 261Histone H3K27cr bindingCombined sources1 Publication3
Regioni282 – 284Histone H3K27cr bindingCombined sources1 Publication3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 80Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi794 – 842Gly-richAdd BLAST49

Domaini

The YEATS domain specifically recognizes and binds crotonylated histones.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3149 Eukaryota
COG5033 LUCA
GeneTreeiENSGT00530000063543
HOGENOMiHOG000155538
HOVERGENiHBG062745
InParanoidiQ9ULM3
OMAiPIPKIHG
OrthoDBiEOG091G0EXM
PhylomeDBiQ9ULM3
TreeFamiTF314586

Family and domain databases

Gene3Di2.60.40.1970, 1 hit
InterProiView protein in InterPro
IPR038704 YEAST_sf
IPR005033 YEATS
PANTHERiPTHR23195 PTHR23195, 1 hit
PfamiView protein in Pfam
PF03366 YEATS, 1 hit
PROSITEiView protein in PROSITE
PS51037 YEATS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ULM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF 
        60         70         80         90        100
ALEMKNKEHE IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK 
       110        120        130        140        150
TCDTMVFNHP AIKKFLESPS RSSSPANQRA ETPSANHSES DSLSQHNDFL 
       160        170        180        190        200
SDKDNNSNMD IEERLSNNME QRPSRNTGRD TSRITGSHKT EQRNADLTDE 
       210        220        230        240        250
TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG SRREPSINHF 
       260        270        280        290        300
VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR 
       310        320        330        340        350
IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD 
       360        370        380        390        400
APPSLPLTIP APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL 
       410        420        430        440        450
PSSLERTPTK MTTSQKVTFC SHGNSAFQPI ASSCKIVPQS QVPNPESPGK 
       460        470        480        490        500
SFQPITMSCK IVSGSPISTP SPSPLPRTPT STPVHVKQGT AGSVINNPYV 
       510        520        530        540        550
IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK IHGSSFVTST 
       560        570        580        590        600
VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH 
       610        620        630        640        650
VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV 
       660        670        680        690        700
VGVPVGSALP STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA 
       710        720        730        740        750
IVSGGGGTIV AQPVQTLTKA QVTAAGPQKS GSQGSVMATL QLPATNLANL 
       760        770        780        790        800
ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG AILRATNNAN LQSGSAASGG 
       810        820        830        840        850
SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP GGISQHLTYT 
       860        870        880        890        900
SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK 
       910        920        930        940        950
VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG 
       960        970        980        990       1000
GVITTATSPA VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA 
      1010       1020       1030       1040       1050
TVGTCKAATP TVVSATSLVP TPNPISGKAT VSGLLKIHSS QSSPQQAVLT 
      1060       1070       1080       1090       1100
IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF STSKPPAILP VAAPTPVVPS 
      1110       1120       1130       1140       1150
SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY VIKIDHLETI 
      1160       1170       1180       1190       1200
QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT 
      1210       1220       1230       1240       1250
MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI 
      1260       1270       1280       1290       1300
EDVLTQIDSE PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS 
      1310       1320       1330       1340       1350
EPVKINIKKE QEEKQEEVKF YLPPTPGSEF IGDVTQKIGI TLQPVALHRN 
      1360       1370       1380       1390       1400
VYASVVEDMI LKATEQLVND ILRQALAVGY QTASHNRIPK EITVSNIHQA 
      1410       1420 
ICNIPFLDFL TNKHMGILNE DQ
Length:1,422
Mass (Da):150,782
Last modified:January 10, 2006 - v2
Checksum:i7800718C08B634B3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6M6H0Y6M6_HUMAN
YEATS domain-containing protein 2
YEATS2
219Annotation score:

Sequence cautioni

The sequence BAA86511 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051494184I → V. Corresponds to variant dbSNP:rs16858033Ensembl.1
Natural variantiVAR_051495530V → I. Corresponds to variant dbSNP:rs262993Ensembl.1
Natural variantiVAR_051496993Q → H. Corresponds to variant dbSNP:rs3211095Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033023 mRNA Translation: BAA86511.1 Different initiation.
AC068769 Genomic DNA No translation available.
AC131160 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78316.1
CH471052 Genomic DNA Translation: EAW78317.1
BC082270 mRNA Translation: AAH82270.1
BC150273 mRNA Translation: AAI50274.1
CCDSiCCDS43175.1
RefSeqiNP_060493.3, NM_018023.4
XP_016862298.1, XM_017006809.1
XP_016862299.1, XM_017006810.1
UniGeneiHs.632575

Genome annotation databases

EnsembliENST00000305135; ENSP00000306983; ENSG00000163872
GeneIDi55689
KEGGihsa:55689
UCSCiuc003fly.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033023 mRNA Translation: BAA86511.1 Different initiation.
AC068769 Genomic DNA No translation available.
AC131160 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78316.1
CH471052 Genomic DNA Translation: EAW78317.1
BC082270 mRNA Translation: AAH82270.1
BC150273 mRNA Translation: AAI50274.1
CCDSiCCDS43175.1
RefSeqiNP_060493.3, NM_018023.4
XP_016862298.1, XM_017006809.1
XP_016862299.1, XM_017006810.1
UniGeneiHs.632575

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IQLX-ray2.10A201-332[»]
5XNVX-ray2.70A201-332[»]
ProteinModelPortaliQ9ULM3
SMRiQ9ULM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120815, 51 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ9ULM3
IntActiQ9ULM3, 11 interactors
MINTiQ9ULM3
STRINGi9606.ENSP00000306983

PTM databases

iPTMnetiQ9ULM3
PhosphoSitePlusiQ9ULM3

Polymorphism and mutation databases

BioMutaiYEATS2
DMDMi85542165

Proteomic databases

EPDiQ9ULM3
MaxQBiQ9ULM3
PaxDbiQ9ULM3
PeptideAtlasiQ9ULM3
PRIDEiQ9ULM3
ProteomicsDBi85078

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305135; ENSP00000306983; ENSG00000163872
GeneIDi55689
KEGGihsa:55689
UCSCiuc003fly.2 human

Organism-specific databases

CTDi55689
DisGeNETi55689
EuPathDBiHostDB:ENSG00000163872.15
GeneCardsiYEATS2
H-InvDBiHIX0119993
HGNCiHGNC:25489 YEATS2
HPAiHPA045891
MIMi613373 gene
neXtProtiNX_Q9ULM3
OpenTargetsiENSG00000163872
PharmGKBiPA134922615
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3149 Eukaryota
COG5033 LUCA
GeneTreeiENSGT00530000063543
HOGENOMiHOG000155538
HOVERGENiHBG062745
InParanoidiQ9ULM3
OMAiPIPKIHG
OrthoDBiEOG091G0EXM
PhylomeDBiQ9ULM3
TreeFamiTF314586

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

ChiTaRSiYEATS2 human
GenomeRNAii55689
PROiPR:Q9ULM3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163872 Expressed in 220 organ(s), highest expression level in amniotic fluid
CleanExiHS_YEATS2
ExpressionAtlasiQ9ULM3 baseline and differential
GenevisibleiQ9ULM3 HS

Family and domain databases

Gene3Di2.60.40.1970, 1 hit
InterProiView protein in InterPro
IPR038704 YEAST_sf
IPR005033 YEATS
PANTHERiPTHR23195 PTHR23195, 1 hit
PfamiView protein in Pfam
PF03366 YEATS, 1 hit
PROSITEiView protein in PROSITE
PS51037 YEATS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYETS2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULM3
Secondary accession number(s): A7E2B9
, D3DNS9, Q641P6, Q9NW96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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