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UniProtKB - Q9ULM3 (YETS2_HUMAN)

Entry version 148 (17 Jun 2020)
Sequence version 2 (10 Jan 2006)
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Protein

YEATS domain-containing protein 2

Gene

YEATS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214847 HATs acetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
YEATS domain-containing protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YEATS2Imported
Synonyms:KIAA11971 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163872.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:25489 YEATS2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613373 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULM3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epilepsy, familial adult myoclonic, 4 (FAME4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME4 inheritance is autosomal dominant.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi259H → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi261S → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi262Y → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi282W → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi283G → A: Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi284E → A: Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi285F → A: Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1
Mutagenesisi313Y → A: Reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). 1 Publication1

Keywords - Diseasei

Epilepsy

Organism-specific databases

DisGeNET

More...DisGeNETi		55689

MalaCards human disease database

More...MalaCardsi		YEATS2
MIMi615127 phenotype

Open Targets

More...OpenTargetsi		ENSG00000163872

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		86814 Benign adult familial myoclonic epilepsy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134922615

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULM3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YEATS2

Domain mapping of disease mutations (DMDM)

More...DMDMi		85542165

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763661 – 1422YEATS domain-containing protein 2Add BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineBy similarity1
Modified residuei157PhosphoserineCombined sources1
Cross-linki189Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki370Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei407PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei536PhosphoserineCombined sources1
Cross-linki552Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei575PhosphoserineCombined sources1
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei627PhosphoserineCombined sources1
Cross-linki649Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki773Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki923Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1219PhosphothreonineCombined sources1
Cross-linki1222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULM3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULM3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULM3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9ULM3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULM3

PeptideAtlas

More...PeptideAtlasi		Q9ULM3

PRoteomics IDEntifications database

More...PRIDEi		Q9ULM3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85078

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULM3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163872 Expressed in amniotic fluid and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULM3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULM3 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163872 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, SGF29 and DR1.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120815, 64 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9ULM3

Protein interaction database and analysis system

More...IntActi		Q9ULM3, 31 interactors

Molecular INTeraction database

More...MINTi		Q9ULM3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306983

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULM3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULM3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini207 – 317YEATSPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni259 – 261Histone H3K27cr bindingCombined sources1 Publication3
Regioni282 – 284Histone H3K27cr bindingCombined sources1 Publication3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili47 – 80Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi794 – 842Gly-richAdd BLAST49

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The YEATS domain specifically recognizes and binds crotonylated histones.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3149 Eukaryota
COG5033 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156789

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_258270_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULM3

Identification of Orthologs from Complete Genome Data

More...OMAi		YVIMDKP

Database of Orthologous Groups

More...OrthoDBi		1482359at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULM3

TreeFam database of animal gene trees

More...TreeFami		TF314586

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1970, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038704 YEAST_sf
IPR005033 YEATS

The PANTHER Classification System

More...PANTHERi		PTHR23195 PTHR23195, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03366 YEATS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51037 YEATS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ULM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF 
        60         70         80         90        100
ALEMKNKEHE IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK 
       110        120        130        140        150
TCDTMVFNHP AIKKFLESPS RSSSPANQRA ETPSANHSES DSLSQHNDFL 
       160        170        180        190        200
SDKDNNSNMD IEERLSNNME QRPSRNTGRD TSRITGSHKT EQRNADLTDE 
       210        220        230        240        250
TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG SRREPSINHF 
       260        270        280        290        300
VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR 
       310        320        330        340        350
IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD 
       360        370        380        390        400
APPSLPLTIP APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL 
       410        420        430        440        450
PSSLERTPTK MTTSQKVTFC SHGNSAFQPI ASSCKIVPQS QVPNPESPGK 
       460        470        480        490        500
SFQPITMSCK IVSGSPISTP SPSPLPRTPT STPVHVKQGT AGSVINNPYV 
       510        520        530        540        550
IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK IHGSSFVTST 
       560        570        580        590        600
VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH 
       610        620        630        640        650
VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV 
       660        670        680        690        700
VGVPVGSALP STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA 
       710        720        730        740        750
IVSGGGGTIV AQPVQTLTKA QVTAAGPQKS GSQGSVMATL QLPATNLANL 
       760        770        780        790        800
ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG AILRATNNAN LQSGSAASGG 
       810        820        830        840        850
SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP GGISQHLTYT 
       860        870        880        890        900
SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK 
       910        920        930        940        950
VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG 
       960        970        980        990       1000
GVITTATSPA VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA 
      1010       1020       1030       1040       1050
TVGTCKAATP TVVSATSLVP TPNPISGKAT VSGLLKIHSS QSSPQQAVLT 
      1060       1070       1080       1090       1100
IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF STSKPPAILP VAAPTPVVPS 
      1110       1120       1130       1140       1150
SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY VIKIDHLETI 
      1160       1170       1180       1190       1200
QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT 
      1210       1220       1230       1240       1250
MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI 
      1260       1270       1280       1290       1300
EDVLTQIDSE PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS 
      1310       1320       1330       1340       1350
EPVKINIKKE QEEKQEEVKF YLPPTPGSEF IGDVTQKIGI TLQPVALHRN 
      1360       1370       1380       1390       1400
VYASVVEDMI LKATEQLVND ILRQALAVGY QTASHNRIPK EITVSNIHQA 
      1410       1420 
ICNIPFLDFL TNKHMGILNE DQ
Length:1,422
Mass (Da):150,782
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7800718C08B634B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6M6H0Y6M6_HUMAN
YEATS domain-containing protein 2
YEATS2
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86511 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051494184I → V. Corresponds to variant dbSNP:rs16858033Ensembl.1
Natural variantiVAR_051495530V → I. Corresponds to variant dbSNP:rs262993Ensembl.1
Natural variantiVAR_051496993Q → H. Corresponds to variant dbSNP:rs3211095Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB033023 mRNA Translation: BAA86511.1 Different initiation.
AC068769 Genomic DNA No translation available.
AC131160 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78316.1
CH471052 Genomic DNA Translation: EAW78317.1
BC082270 mRNA Translation: AAH82270.1
BC150273 mRNA Translation: AAI50274.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43175.1

NCBI Reference Sequences

More...RefSeqi		NP_060493.3, NM_018023.4
XP_016862298.1, XM_017006809.1
XP_016862299.1, XM_017006810.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305135; ENSP00000306983; ENSG00000163872

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55689

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55689

UCSC genome browser

More...UCSCi		uc003fly.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033023 mRNA Translation: BAA86511.1 Different initiation.
AC068769 Genomic DNA No translation available.
AC131160 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78316.1
CH471052 Genomic DNA Translation: EAW78317.1
BC082270 mRNA Translation: AAH82270.1
BC150273 mRNA Translation: AAI50274.1
CCDSiCCDS43175.1
RefSeqiNP_060493.3, NM_018023.4
XP_016862298.1, XM_017006809.1
XP_016862299.1, XM_017006810.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IQLX-ray2.10A201-332[»]
5XNVX-ray2.70A201-332[»]
SMRiQ9ULM3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120815, 64 interactors
ComplexPortaliCPX-1004 PCAF-containing ATAC complex
CPX-997 GCN5-containing ATAC complex
CORUMiQ9ULM3
IntActiQ9ULM3, 31 interactors
MINTiQ9ULM3
STRINGi9606.ENSP00000306983

PTM databases

iPTMnetiQ9ULM3
PhosphoSitePlusiQ9ULM3

Polymorphism and mutation databases

BioMutaiYEATS2
DMDMi85542165

Proteomic databases

EPDiQ9ULM3
jPOSTiQ9ULM3
MassIVEiQ9ULM3
MaxQBiQ9ULM3
PaxDbiQ9ULM3
PeptideAtlasiQ9ULM3
PRIDEiQ9ULM3
ProteomicsDBi85078

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50874 79 antibodies

Genome annotation databases

EnsembliENST00000305135; ENSP00000306983; ENSG00000163872
GeneIDi55689
KEGGihsa:55689
UCSCiuc003fly.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55689
DisGeNETi55689
EuPathDBiHostDB:ENSG00000163872.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		YEATS2
HGNCiHGNC:25489 YEATS2
HPAiENSG00000163872 Low tissue specificity
MalaCardsiYEATS2
MIMi613373 gene
615127 phenotype
neXtProtiNX_Q9ULM3
OpenTargetsiENSG00000163872
Orphaneti86814 Benign adult familial myoclonic epilepsy
PharmGKBiPA134922615

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3149 Eukaryota
COG5033 LUCA
GeneTreeiENSGT00940000156789
HOGENOMiCLU_258270_0_0_1
InParanoidiQ9ULM3
OMAiYVIMDKP
OrthoDBi1482359at2759
PhylomeDBiQ9ULM3
TreeFamiTF314586

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55689 346 hits in 799 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YEATS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55689
PharosiQ9ULM3 Tbio

Protein Ontology

More...PROi		PR:Q9ULM3
RNActiQ9ULM3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163872 Expressed in amniotic fluid and 219 other tissues
ExpressionAtlasiQ9ULM3 baseline and differential
GenevisibleiQ9ULM3 HS

Family and domain databases

Gene3Di2.60.40.1970, 1 hit
InterProiView protein in InterPro
IPR038704 YEAST_sf
IPR005033 YEATS
PANTHERiPTHR23195 PTHR23195, 1 hit
PfamiView protein in Pfam
PF03366 YEATS, 1 hit
PROSITEiView protein in PROSITE
PS51037 YEATS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYETS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULM3
Secondary accession number(s): A7E2B9
, D3DNS9, Q641P6, Q9NW96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: June 17, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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