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Protein

Pleckstrin homology domain-containing family G member 1

Gene

PLEKHG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

SIGNORiQ9ULL1

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 1
Gene namesi
Name:PLEKHG1
Synonyms:KIAA1209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120278.14
HGNCiHGNC:20884 PLEKHG1
neXtProtiNX_Q9ULL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi57480
OpenTargetsiENSG00000120278
PharmGKBiPA134922441

Polymorphism and mutation databases

BioMutaiPLEKHG1
DMDMi62288848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809641 – 1385Pleckstrin homology domain-containing family G member 1Add BLAST1385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1192PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULL1
MaxQBiQ9ULL1
PaxDbiQ9ULL1
PeptideAtlasiQ9ULL1
PRIDEiQ9ULL1
ProteomicsDBi85068

PTM databases

iPTMnetiQ9ULL1
PhosphoSitePlusiQ9ULL1

Expressioni

Gene expression databases

BgeeiENSG00000120278 Expressed in 164 organ(s), highest expression level in heart left ventricle
CleanExiHS_PLEKHG1
ExpressionAtlasiQ9ULL1 baseline and differential
GenevisibleiQ9ULL1 HS

Organism-specific databases

HPAiHPA027128
HPA027319
HPA028270

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121550, 15 interactors
IntActiQ9ULL1, 17 interactors
STRINGi9606.ENSP00000351318

Structurei

3D structure databases

ProteinModelPortaliQ9ULL1
SMRiQ9ULL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 293DHPROSITE-ProRule annotationAdd BLAST181
Domaini317 – 416PHPROSITE-ProRule annotationAdd BLAST100

Phylogenomic databases

eggNOGiKOG3518 Eukaryota
ENOG410XR81 LUCA
GeneTreeiENSGT00920000148975
HOGENOMiHOG000115556
HOVERGENiHBG053605
InParanoidiQ9ULL1
OMAiNCENDPV
OrthoDBiEOG091G00JV
PhylomeDBiQ9ULL1
TreeFamiTF328565

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9ULL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSDSDRPV SFGSTSSSAS SRDSHGSFGS RMTLVSNSHM GLFNQDKEVG
60 70 80 90 100
AIKLELIPAR PFSSSELQRD NPATGQQNAD EGSERPPRAQ WRVDSNGAPK
110 120 130 140 150
TIADSATSPK LLYVDRVVQE ILETERTYVQ DLKSIVEDYL DCIRDQTKLP
160 170 180 190 200
LGTEERSALF GNIQDIYHFN SELLQDLENC ENDPVAIAEC FVSKSEEFHI
210 220 230 240 250
YTQYCTNYPR SVAVLTECMR NKILAKFFRE RQETLKHSLP LGSYLLKPVQ
260 270 280 290 300
RILKYHLLLH EIENHLDKDT EGYDVVLDAI DTMQRVAWHI NDMKRKHEHA
310 320 330 340 350
VRLQEIQSLL TNWKGPDLTS YGELVLEGTF RIQRAKNERT LFLFDKLLLI
360 370 380 390 400
TKKRDDTFTY KAHILCGNLM LVEVIPKEPL SFSVFHYKNP KLQHTVQAKS
410 420 430 440 450
QQDKRLWVLH LKRLILENHA AKIPAKAKQA ILEMDAIHHP GFCYSPEGGT
460 470 480 490 500
KALFGSKEGS APYRLRRKSE PSSRSHKVLK TSETAQDIQK VSREEGSPQL
510 520 530 540 550
SSARPSPAQR NSQPSSSTMI SVLRAGGALR NIWTDHQIRQ ALFPSRRSPQ
560 570 580 590 600
ENEDDEDDYQ MFVPSFSSSD LNSTRLCEDS TSSRPCSWHM GQMESTETSS
610 620 630 640 650
SGHRIVRRAS SAGESNTCPP EIGTSDRTRE LQNSPKTEGQ EEMTPFGSSI
660 670 680 690 700
ELTIDDIDHV YDNISYEDLK LMVAKREEAE STPSKSARDS VRPKSTPELA
710 720 730 740 750
FTKRQAGHSK GSLYAQTDGT LSGGEASSQS THELQAVEEN IYDTIGLPDP
760 770 780 790 800
PSLGFKCSSL KRAKRSTFLG LEADFVCCDS LRPFVSQDSL QLSEDEAPYH
810 820 830 840 850
QATPDHGYLS LLYDSPSGNL SMPHKPVSDK LSEEVDEIWN DLENYIKKNE
860 870 880 890 900
DKARDRLLAA FPVSKDDVPD RLHAESTPEL SRDVGRSVST LSLPESQALL
910 920 930 940 950
TPVKSRAGRA SRANCPFEED LISKEGSFMS LNRLSLASEM PLMDNPYDLA
960 970 980 990 1000
NSGLSQTDPE NPDLGMEATD KTKSRVFMMA RQYSQKIKKA NQLLKVKSLE
1010 1020 1030 1040 1050
LEQPPASQHQ KSMHKDLAAI LEEKKQGGPA IGARIAEYSQ LYDQIVFRES
1060 1070 1080 1090 1100
PLKIQKDGWA SPQESSLLRS VSPSQVHHGS GDWLLHSTYS NGELADFCLP
1110 1120 1130 1140 1150
PEQDLRSRYP TFEINTKSTP RQLSAACSVP SLQTSDPLPG SVQRCSVVVS
1160 1170 1180 1190 1200
QPNKENWCQD HLYNSLGRKG ISAKSQPYHR SQSSSSVLIN KSMDSINYPS
1210 1220 1230 1240 1250
DVGKQQLLSL HRSSRCESHQ DLLPDIADSH QQGTEKLSDL TLQDSQKVVV
1260 1270 1280 1290 1300
VNRNLPLNAQ IATQNYFSNF KETDGDEDDY VEIKSEEDES ELELSHNRRR
1310 1320 1330 1340 1350
KSDSKFVDAD FSDNVCSGNT LHSLNSPRTP KKPVNSKLGL SPYLTPYNDS
1360 1370 1380
DKLNDYLWRG PSPNQQNIVQ SLREKFQCLS SSSFA
Length:1,385
Mass (Da):155,439
Last modified:February 1, 2005 - v2
Checksum:i1174A1AC7A9EB913
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YD71H0YD71_HUMAN
Pleckstrin homology domain-containi...
PLEKHG1
392Annotation score:
A0A2R8Y2B1A0A2R8Y2B1_HUMAN
Pleckstrin homology domain-containi...
PLEKHG1
209Annotation score:
Q5T1F3Q5T1F3_HUMAN
Pleckstrin homology domain-containi...
PLEKHG1
46Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051988787Q → R. Corresponds to variant dbSNP:rs17080381Ensembl.1
Natural variantiVAR_0519891071V → A. Corresponds to variant dbSNP:rs17080410Ensembl.1
Natural variantiVAR_0519901321L → S. Corresponds to variant dbSNP:rs17054318Ensembl.1
Natural variantiVAR_0617971377Q → P. Corresponds to variant dbSNP:rs58786678Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035086 Genomic DNA No translation available.
AL450339 Genomic DNA No translation available.
AB033035 mRNA Translation: BAA86523.1
CCDSiCCDS34552.1
RefSeqiNP_001025055.1, NM_001029884.2
NP_001316729.1, NM_001329800.1
NP_001316730.1, NM_001329801.1
XP_005267122.1, XM_005267065.3
XP_006715584.1, XM_006715521.1
XP_011534285.1, XM_011535983.2
UniGeneiHs.189781

Genome annotation databases

EnsembliENST00000358517; ENSP00000351318; ENSG00000120278
ENST00000644968; ENSP00000496254; ENSG00000120278
GeneIDi57480
KEGGihsa:57480
UCSCiuc003qny.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035086 Genomic DNA No translation available.
AL450339 Genomic DNA No translation available.
AB033035 mRNA Translation: BAA86523.1
CCDSiCCDS34552.1
RefSeqiNP_001025055.1, NM_001029884.2
NP_001316729.1, NM_001329800.1
NP_001316730.1, NM_001329801.1
XP_005267122.1, XM_005267065.3
XP_006715584.1, XM_006715521.1
XP_011534285.1, XM_011535983.2
UniGeneiHs.189781

3D structure databases

ProteinModelPortaliQ9ULL1
SMRiQ9ULL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121550, 15 interactors
IntActiQ9ULL1, 17 interactors
STRINGi9606.ENSP00000351318

PTM databases

iPTMnetiQ9ULL1
PhosphoSitePlusiQ9ULL1

Polymorphism and mutation databases

BioMutaiPLEKHG1
DMDMi62288848

Proteomic databases

EPDiQ9ULL1
MaxQBiQ9ULL1
PaxDbiQ9ULL1
PeptideAtlasiQ9ULL1
PRIDEiQ9ULL1
ProteomicsDBi85068

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358517; ENSP00000351318; ENSG00000120278
ENST00000644968; ENSP00000496254; ENSG00000120278
GeneIDi57480
KEGGihsa:57480
UCSCiuc003qny.1 human

Organism-specific databases

CTDi57480
DisGeNETi57480
EuPathDBiHostDB:ENSG00000120278.14
GeneCardsiPLEKHG1
H-InvDBiHIX0006294
HGNCiHGNC:20884 PLEKHG1
HPAiHPA027128
HPA027319
HPA028270
neXtProtiNX_Q9ULL1
OpenTargetsiENSG00000120278
PharmGKBiPA134922441
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3518 Eukaryota
ENOG410XR81 LUCA
GeneTreeiENSGT00920000148975
HOGENOMiHOG000115556
HOVERGENiHBG053605
InParanoidiQ9ULL1
OMAiNCENDPV
OrthoDBiEOG091G00JV
PhylomeDBiQ9ULL1
TreeFamiTF328565

Enzyme and pathway databases

SIGNORiQ9ULL1

Miscellaneous databases

ChiTaRSiPLEKHG1 human
GenomeRNAii57480
PROiPR:Q9ULL1

Gene expression databases

BgeeiENSG00000120278 Expressed in 164 organ(s), highest expression level in heart left ventricle
CleanExiHS_PLEKHG1
ExpressionAtlasiQ9ULL1 baseline and differential
GenevisibleiQ9ULL1 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKHG1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULL1
Secondary accession number(s): Q5T1F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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