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Entry version 166 (22 Apr 2020)
Sequence version 2 (22 Feb 2003)
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Protein

Mediator of RNA polymerase II transcription subunit 23

Gene

MED23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coactivator activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 23
Alternative name(s):
Activator-recruited cofactor 130 kDa component
Short name:
ARC130
Cofactor required for Sp1 transcriptional activation subunit 3
Short name:
CRSP complex subunit 3
Mediator complex subunit 23
Protein sur-2 homolog
Short name:
hSur-2
Transcriptional coactivator CRSP130
Vitamin D3 receptor-interacting protein complex 130 kDa component
Short name:
DRIP130
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED23
Synonyms:ARC130, CRSP3, DRIP130, KIAA1216, SUR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2372 MED23

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605042 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULK4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 18 (MRT18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082644611R → Q in MRT18; specifically impairs the response of JUN and FOS immediate early genes to serum mitogens by altering the interaction between enhancer-bound transcription factors TCF7L2 and ELK1 and the Mediator complex. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9439

MalaCards human disease database

More...
MalaCardsi
MED23
MIMi614249 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000112282

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616 Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162395499

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULK4 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4146

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MED23

Domain mapping of disease mutations (DMDM)

More...
DMDMi
28558074

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793581 – 1368Mediator of RNA polymerase II transcription subunit 23Add BLAST1368

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULK4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULK4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULK4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULK4

PeptideAtlas

More...
PeptideAtlasi
Q9ULK4

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULK4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
7541
85057 [Q9ULK4-1]
85058 [Q9ULK4-2]
85059 [Q9ULK4-3]
85060 [Q9ULK4-4]
85061 [Q9ULK4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULK4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9ULK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112282 Expressed in forebrain and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULK4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULK4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112282 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ELK1 (By similarity).

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Interacts with CEBPB (when not methylated), CTNNB1, and GLI3.

Interacts with the adenovirus E1A protein.

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114829, 212 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3227 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9ULK4

Database of interacting proteins

More...
DIPi
DIP-31461N

Protein interaction database and analysis system

More...
IntActi
Q9ULK4, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9ULK4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357047

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9ULK4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULK4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULK4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 23 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1883 Eukaryota
ENOG410ZH5R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010380

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002773_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULK4

KEGG Orthology (KO)

More...
KOi
K15166

Database of Orthologous Groups

More...
OrthoDBi
94121at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULK4

TreeFam database of animal gene trees

More...
TreeFami
TF324163

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021629 Mediator_Med23

The PANTHER Classification System

More...
PANTHERi
PTHR12691 PTHR12691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11573 Med23, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG
60 70 80 90 100
LSQESHEQCI QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES
110 120 130 140 150
LINSDTLEWE RTQLWALTFK LVRKIIGGVD YKGVRDLLKV ILEKILTIPN
160 170 180 190 200
TVSSAVVQQL LAAREVIAYI LERNACLLPA YFAVTEIRKL YPEGKLPHWL
210 220 230 240 250
LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS WKLDPATLRF
260 270 280 290 300
PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL
310 320 330 340 350
EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP
360 370 380 390 400
HMVLSLHQKL AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD
410 420 430 440 450
LLYPEKEYIP VPDINKPQST HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS
460 470 480 490 500
LRLHHEFLQQ SLRNKSLQMN DYKIALLCNA YSTNSECFTL PMGALVETIY
510 520 530 540 550
GNGIMRIPLP GTNCMASGSI TPLPMNLLDS LTVHAKMSLI HSIATRVIKL
560 570 580 590 600
AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI
610 620 630 640 650
LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL
660 670 680 690 700
RLITALGSSE VQPQFTRFLS DPKTVLSAES EELNRALILT LARATHVTDF
710 720 730 740 750
FTGSDSIQGT WCKDILQTIM SFTPHNWASH TLSCFPGPLQ AFFKQNNVPQ
760 770 780 790 800
ESRFNLKKNV EEEYRKWKSM SNENDIITHF SMQGSPPLFL CLLWKMLLET
810 820 830 840 850
DHINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG QQLNKCIEIL
860 870 880 890 900
NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV
910 920 930 940 950
SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VDPPVQIQSP
960 970 980 990 1000
YLPIYFGNVC LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR
1010 1020 1030 1040 1050
PVTYLYNTLH YYEMHLRDRA FLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK
1060 1070 1080 1090 1100
CAMNAREENP WVPDDTYYCR LIGRLVDTMA GKSPGPFPNC DWRFNEFPNP
1110 1120 1130 1140 1150
AAHALHVTCV ELMALAVSGK EVGNALLNVV LKSQPLVPRE NITAWMNAIG
1160 1170 1180 1190 1200
LIITALPEPY WIVLHDRIVS VISSPSLTSE TEWVGYPFRL FDFTACHQSY
1210 1220 1230 1240 1250
SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPIVK TEFQLLYVYH
1260 1270 1280 1290 1300
LVGPFLQRFQ QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH
1310 1320 1330 1340 1350
MKYMFTGDSV KEQVEKIICN LKPALKLRLR FITHISKMEP AAVPPQAMNS
1360
GSPAPQSNQV PVSLPVTQ
Length:1,368
Mass (Da):156,474
Last modified:February 22, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BEE9FF5E328477D
GO
Isoform 2 (identifier: Q9ULK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     292-292: Q → QTLNIAQ
     870-880: AMRSHEGNEAQ → VRINTFLSLFS
     881-1368: Missing.

Show »
Length:886
Mass (Da):100,834
Checksum:iF1461C27AF9D7817
GO
Isoform 3 (identifier: Q9ULK4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     292-292: Q → QTLNIAQ
     1360-1368: Missing.

Show »
Length:1,365
Mass (Da):156,194
Checksum:i8F401B9FF90878C3
GO
Isoform 4 (identifier: Q9ULK4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1360-1368: Missing.

Show »
Length:1,359
Mass (Da):155,553
Checksum:iE6EB563FEBC111DE
GO
Isoform 5 (identifier: Q9ULK4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1361-1368: PVSLPVTQ → DTLT

Show »
Length:1,364
Mass (Da):156,082
Checksum:i55BAD400A566EB56
GO
Isoform 6 (identifier: Q9ULK4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-475: FLQQSLRNKSLQMNDYKIA → SAFANCFQITCMGDLTHTP
     476-1368: Missing.

Show »
Length:475
Mass (Da):54,314
Checksum:i3621AC3036B0F0B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JWT2Q5JWT2_HUMAN
Mediator of RNA polymerase II trans...
MED23
1,374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD12724 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAD31729 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86530 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti59C → W in AAH60759 (PubMed:15489334).Curated1
Sequence conflicti131Y → N in AAD31729 (PubMed:10235266).Curated1
Sequence conflicti208F → V in AAD30202 (PubMed:10353252).Curated1
Sequence conflicti230V → E in AAD30202 (PubMed:10353252).Curated1
Sequence conflicti464N → H in AAD30202 (PubMed:10353252).Curated1
Sequence conflicti488F → V in AAD30202 (PubMed:10353252).Curated1
Sequence conflicti507I → L in AAD30202 (PubMed:10353252).Curated1
Sequence conflicti518G → A in AAD30202 (PubMed:10353252).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082644611R → Q in MRT18; specifically impairs the response of JUN and FOS immediate early genes to serum mitogens by altering the interaction between enhancer-bound transcription factors TCF7L2 and ELK1 and the Mediator complex. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004034292Q → QTLNIAQ in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_047860457 – 475FLQQS…DYKIA → SAFANCFQITCMGDLTHTP in isoform 6. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_047861476 – 1368Missing in isoform 6. 1 PublicationAdd BLAST893
Alternative sequenceiVSP_004036870 – 880AMRSHEGNEAQ → VRINTFLSLFS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_004037881 – 1368Missing in isoform 2. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_0040351360 – 1368Missing in isoform 3 and isoform 4. 2 Publications9
Alternative sequenceiVSP_0283801361 – 1368PVSLPVTQ → DTLT in isoform 5. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF105332 mRNA Translation: AAD31729.1 Frameshift.
AF135022 mRNA Translation: AAD30202.1
AF104255 mRNA Translation: AAD12724.1 Different initiation.
EU392526 mRNA Translation: ACB88854.1
AB033042 mRNA Translation: BAA86530.1 Different initiation.
AL136776 mRNA Translation: CAB66710.1
AL121575 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48052.1
BC060759 mRNA Translation: AAH60759.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5146.1 [Q9ULK4-3]
CCDS5147.1 [Q9ULK4-1]
CCDS59039.1 [Q9ULK4-5]

NCBI Reference Sequences

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RefSeqi
NP_001257450.1, NM_001270521.1 [Q9ULK4-4]
NP_001257451.1, NM_001270522.1 [Q9ULK4-5]
NP_004821.2, NM_004830.3 [Q9ULK4-1]
NP_057063.2, NM_015979.3 [Q9ULK4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354577; ENSP00000346588; ENSG00000112282 [Q9ULK4-3]
ENST00000368053; ENSP00000357032; ENSG00000112282 [Q9ULK4-2]
ENST00000368060; ENSP00000357039; ENSG00000112282 [Q9ULK4-5]
ENST00000368068; ENSP00000357047; ENSG00000112282 [Q9ULK4-1]
ENST00000539158; ENSP00000445072; ENSG00000112282 [Q9ULK4-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9439

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9439

UCSC genome browser

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UCSCi
uc003qcq.5 human [Q9ULK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105332 mRNA Translation: AAD31729.1 Frameshift.
AF135022 mRNA Translation: AAD30202.1
AF104255 mRNA Translation: AAD12724.1 Different initiation.
EU392526 mRNA Translation: ACB88854.1
AB033042 mRNA Translation: BAA86530.1 Different initiation.
AL136776 mRNA Translation: CAB66710.1
AL121575 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48052.1
BC060759 mRNA Translation: AAH60759.1
CCDSiCCDS5146.1 [Q9ULK4-3]
CCDS5147.1 [Q9ULK4-1]
CCDS59039.1 [Q9ULK4-5]
RefSeqiNP_001257450.1, NM_001270521.1 [Q9ULK4-4]
NP_001257451.1, NM_001270522.1 [Q9ULK4-5]
NP_004821.2, NM_004830.3 [Q9ULK4-1]
NP_057063.2, NM_015979.3 [Q9ULK4-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6H02X-ray2.80A1-1368[»]
SMRiQ9ULK4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114829, 212 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ9ULK4
DIPiDIP-31461N
IntActiQ9ULK4, 37 interactors
MINTiQ9ULK4
STRINGi9606.ENSP00000357047

Chemistry databases

BindingDBiQ9ULK4
ChEMBLiCHEMBL4146

PTM databases

iPTMnetiQ9ULK4
PhosphoSitePlusiQ9ULK4
SwissPalmiQ9ULK4

Polymorphism and mutation databases

BioMutaiMED23
DMDMi28558074

Proteomic databases

EPDiQ9ULK4
jPOSTiQ9ULK4
MassIVEiQ9ULK4
PaxDbiQ9ULK4
PeptideAtlasiQ9ULK4
PRIDEiQ9ULK4
ProteomicsDBi7541
85057 [Q9ULK4-1]
85058 [Q9ULK4-2]
85059 [Q9ULK4-3]
85060 [Q9ULK4-4]
85061 [Q9ULK4-5]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9ULK4

Antibodypedia a portal for validated antibodies

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Antibodypediai
19677 223 antibodies

The DNASU plasmid repository

More...
DNASUi
9439

Genome annotation databases

EnsembliENST00000354577; ENSP00000346588; ENSG00000112282 [Q9ULK4-3]
ENST00000368053; ENSP00000357032; ENSG00000112282 [Q9ULK4-2]
ENST00000368060; ENSP00000357039; ENSG00000112282 [Q9ULK4-5]
ENST00000368068; ENSP00000357047; ENSG00000112282 [Q9ULK4-1]
ENST00000539158; ENSP00000445072; ENSG00000112282 [Q9ULK4-6]
GeneIDi9439
KEGGihsa:9439
UCSCiuc003qcq.5 human [Q9ULK4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9439
DisGeNETi9439

GeneCards: human genes, protein and diseases

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GeneCardsi
MED23
HGNCiHGNC:2372 MED23
HPAiENSG00000112282 Low tissue specificity
MalaCardsiMED23
MIMi605042 gene
614249 phenotype
neXtProtiNX_Q9ULK4
OpenTargetsiENSG00000112282
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA162395499

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1883 Eukaryota
ENOG410ZH5R LUCA
GeneTreeiENSGT00390000010380
HOGENOMiCLU_002773_0_0_1
InParanoidiQ9ULK4
KOiK15166
OrthoDBi94121at2759
PhylomeDBiQ9ULK4
TreeFamiTF324163

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MED23 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CRSP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9439
PharosiQ9ULK4 Tbio

Protein Ontology

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PROi
PR:Q9ULK4
RNActiQ9ULK4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112282 Expressed in forebrain and 222 other tissues
ExpressionAtlasiQ9ULK4 baseline and differential
GenevisibleiQ9ULK4 HS

Family and domain databases

InterProiView protein in InterPro
IPR021629 Mediator_Med23
PANTHERiPTHR12691 PTHR12691, 1 hit
PfamiView protein in Pfam
PF11573 Med23, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED23_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULK4
Secondary accession number(s): B9TX55
, O95403, Q5JWT3, Q5JWT4, Q6P9H6, Q9H0J2, Q9NTT9, Q9NTU0, Q9Y5P7, Q9Y667
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: February 22, 2003
Last modified: April 22, 2020
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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