Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 176 (13 Feb 2019)
Sequence version 2 (19 Jul 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Neurabin-1

Gene

PPP1R9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurabin-1
Alternative name(s):
Neurabin-I
Neural tissue-specific F-actin-binding protein I
Protein phosphatase 1 regulatory subunit 9A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R9A
Synonyms:KIAA1222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158528.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14946 PPP1R9A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602468 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULJ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55607

Open Targets

More...
OpenTargetsi
ENSG00000158528

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33661

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R9A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000715071 – 1098Neurabin-1Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei192PhosphoserineBy similarity1
Modified residuei312PhosphothreonineBy similarity1
Modified residuei338PhosphoserineCombined sources1
Modified residuei371PhosphoserineBy similarity1
Modified residuei460Phosphoserine; by PKABy similarity1
Modified residuei840PhosphoserineCombined sources1
Modified residuei915PhosphoserineBy similarity1
Modified residuei928PhosphoserineBy similarity1
Modified residuei956PhosphoserineBy similarity1
Modified residuei957PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei974PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULJ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULJ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULJ8

PeptideAtlas

More...
PeptideAtlasi
Q9ULJ8

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULJ8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85051
85052 [Q9ULJ8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULJ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158528 Expressed in 203 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULJ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULJ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027726
HPA075591

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2 and p70-S6K (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RGS2P412203EBI-2515561,EBI-712388

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120747, 35 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULJ8, 18 interactors

Molecular INTeraction database

More...
MINTi
Q9ULJ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405514

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF8NMR-A500-593[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9ULJ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULJ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9ULJ8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini504 – 592PDZPROSITE-ProRule annotationAdd BLAST89
Domaini988 – 1051SAMPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 144Actin-bindingAdd BLAST144
Regioni425 – 502Interaction with protein phosphatase 1By similarityAdd BLAST78
Regioni597 – 1090Interaction with TGN38By similarityAdd BLAST494

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili597 – 627Sequence analysisAdd BLAST31
Coiled coili670 – 824Sequence analysisAdd BLAST155
Coiled coili1033 – 1090Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi447 – 450Poly-Glu4
Compositional biasi829 – 833Poly-Asn5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Interacts with p70-S6K via its PDZ domain.By similarity
The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1945 Eukaryota
ENOG410Y7F2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155538

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252962

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005213

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULJ8

KEGG Orthology (KO)

More...
KOi
K17551

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPQNEPL

Database of Orthologous Groups

More...
OrthoDBi
128743at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULJ8

TreeFam database of animal gene trees

More...
TreeFami
TF105540

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029994 Neurabin-1
IPR040645 Neurabin-1/2_PDZ
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16154:SF22 PTHR16154:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit
PF17817 PDZ_5, 1 hit
PF07647 SAM_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULJ8-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG
60 70 80 90 100
SQQSRGRKYG SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM
110 120 130 140 150
KPKEFLEKTD GSVVKLESSV SERISRFDTM YDGPSYSKFT ETRKMFERSV
160 170 180 190 200
HESGQNNRYS PKKEKAGGSE PQDEWGGSKS NRGSTDSLDS LSSRTEAVSP
210 220 230 240 250
TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS VTVTNLDTFG
260 270 280 290 300
HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS
310 320 330 340 350
KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN
360 370 380 390 400
LVGREAAKQQ RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD
410 420 430 440 450
YNVYRVRSRY NSDWGETGTE QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE
460 470 480 490 500
IPANRKIKFS SAPIKVFNTY SNEDYDRRND EVDPVAASAE YELEKRVEKL
510 520 530 540 550
ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT EGGAAQRDGR
560 570 580 590 600
IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA
610 620 630 640 650
QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS
660 670 680 690 700
DMAIEVFELP ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK
710 720 730 740 750
LQAAENEKVR WELEKTQLQQ NIEENKERML KLESYWIEAQ TLCHTVNEHL
760 770 780 790 800
KETQSQYQAL EKKYNKAKKL IKDFQQKELD FIKRQEAERK KIEDLEKAHL
810 820 830 840 850
VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS LGEVSKGDTM
860 870 880 890 900
ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR
910 920 930 940 950
TRLYDSVSST DGEDSLERKN FTFNDDFSPS STSSADLSGL GAEPKTPGLS
960 970 980 990 1000
QSLALSSDES LDMIDDEILD DGQSPKHSQC QNRAVQEWSV QQVSHWLMSL
1010 1020 1030 1040 1050
NLEQYVSEFS AQNITGEQLL QLDGNKLKAL GMTASQDRAV VKKKLKEMKM
1060 1070 1080 1090
SLEKARKAQE KMEKQREKLR RKEQEQMQRK SKKTEKMTST TAEGAGEQ
Length:1,098
Mass (Da):123,342
Last modified:July 19, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i998FD9821C422891
GO
Isoform 2 (identifier: Q9ULJ8-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-918: MLKTESSGER...STDGEDSLER → MHITKLLPPK...ETLISDKKGS
     960-967: Missing.

Note: No experimental confirmation available.
Show »
Length:387
Mass (Da):43,095
Checksum:i766E2172EC14E378
GO
Isoform 3 (identifier: Q9ULJ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     630-630: E → ENTVAELQGMSGNCNNNNNYFLK
     919-919: K → KPSNSFYNHM...MSVVWIQETN
     960-967: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,374
Mass (Da):154,050
Checksum:i032653B6F678A491
GO
Isoform 4 (identifier: Q9ULJ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     920-1028: NFTFNDDFSP...LLQLDGNKLK → PSNSFYNHMH...SQSLALSSDE

Note: No experimental confirmation available.Curated
Show »
Length:1,253
Mass (Da):140,302
Checksum:i297ABA81A72D3FA5
GO
Isoform 5 (identifier: Q9ULJ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     919-919: K → KGLRTSSPES...TLISDKKGSK
     960-967: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,296
Mass (Da):145,176
Checksum:iE757C7C0B46A2EC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J730C9J730_HUMAN
Neurabin-1
PPP1R9A
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3G5C9J3G5_HUMAN
Neurabin-1
PPP1R9A
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti379C → S in AAI50637 (PubMed:15489334).Curated1
Sequence conflicti952S → P in BAA90928 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q9ULJ8-4)
Sequence conflicti1017R → Q in AAI30450 (PubMed:15489334).Curated1
Sequence conflicti1057S → N in AAI30450 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q9ULJ8-3)
Sequence conflicti1039R → Q in AAI50637 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051746331M → V1 PublicationCorresponds to variant dbSNP:rs10230714Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0111391 – 918MLKTE…DSLER → MHITKLLPPKGLRTSSPESD SGVPPLTPVDSNVPFSSDHI AEFQEEPLDPEMGPLSSMWG DTSLFSTSKSDHDVEESPCH HQTTNKKILREKDDAKDPKS LRASSSLAVQGGKIKRKFVD LGAPLRRNSSKGKKWKEKEK EASRFSAGSRIFRGRLENWT PKPCSTAQTSTRSPCMPFSW FNDSRKGSYSFRNLPAPTSS LQPSPETLISDKKGS in isoform 2. 1 PublicationAdd BLAST918
Alternative sequenceiVSP_044469630E → ENTVAELQGMSGNCNNNNNY FLK in isoform 3. 1 Publication1
Alternative sequenceiVSP_044470919K → KPSNSFYNHMHITKLLPPKG LRTSSPESDSGVPPLTPVDS NVPFSSDHIAEFQEEPLDPE MGPLSSMWGDTSLFSTSKSD HDVEESPCHHQTTNKKILRE KDDAKDPKSLRASSSLAVQG GKIKRKFVDLGAPLRRNSSK GKKWKEKEKEASRFSAGSRI FRGRLENWTPKPCSTAQTST RSPCMPFSWFNDSRKGSYSF RNLPAPTSSLQPSPETLISD KKGSKVENTWITKANKRNPN PSSSSIFGRHSQLMSVVWIQ ETN in isoform 3. 1 Publication1
Alternative sequenceiVSP_053808919K → KGLRTSSPESDSGVPPLTPV DSNVPFSSDHIAEFQEEPLD PEMGPLSSMWGDTSLFSTSK SDHDVEESPCHHQTTNKKIL REKDDAKDPKSLRASSSLAV QGGKIKRKFVDLGAPLRRNS SKGKKWKEKEKEASRFSAGS RIFRGRLENWTPKPCSTAQT STRSPCMPFSWFNDSRKGSY SFRNLPAPTSSLQPSPETLI SDKKGSK in isoform 5. Curated1
Alternative sequenceiVSP_044471920 – 1028NFTFN…GNKLK → PSNSFYNHMHITKLLPPKGL RTSSPESDSGVPPLTPVDSN VPFSSDHIAEFQEEPLDPEM GPLSSMWGDTSLFSTSKSDH DVEESPCHHQTTNKKILREK DDAKDPKSLRASSSLAVQGG KIKRKFVDLGAPLRRNSSKG KKWKEKEKEASRFSAGSRIF RGRLENWTPKPCSTAQTSTR SPCMPFSWFNDSRKGSYSFR NLPAPTSSLQPSPETLISDK KGSKNFTFNDDFSPSSTSSA DLSGLGAEPKTPGLSQSLAL SSDE in isoform 4. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_005121960 – 967Missing in isoform 2, isoform 3 and isoform 5. 2 Publications8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000075 mRNA Translation: BAA90928.1
AC002429 Genomic DNA No translation available.
AC004022 Genomic DNA Translation: AAC35294.2
AC073886 Genomic DNA No translation available.
AC073890 Genomic DNA No translation available.
BC130449 mRNA Translation: AAI30450.1
BC150636 mRNA Translation: AAI50637.1
AB033048 mRNA Translation: BAA86536.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34683.1 [Q9ULJ8-1]
CCDS55127.1 [Q9ULJ8-3]
CCDS55128.1 [Q9ULJ8-4]
CCDS55129.1 [Q9ULJ8-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001159632.1, NM_001166160.1 [Q9ULJ8-3]
NP_001159633.1, NM_001166161.1 [Q9ULJ8-5]
NP_001159634.1, NM_001166162.1 [Q9ULJ8-4]
NP_001159635.1, NM_001166163.1
NP_060120.2, NM_017650.2 [Q9ULJ8-1]
XP_016867892.1, XM_017012403.1 [Q9ULJ8-5]
XP_016867894.1, XM_017012405.1 [Q9ULJ8-1]
XP_016867895.1, XM_017012406.1 [Q9ULJ8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.21816

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000289495; ENSP00000289495; ENSG00000158528 [Q9ULJ8-5]
ENST00000340694; ENSP00000344524; ENSG00000158528 [Q9ULJ8-1]
ENST00000424654; ENSP00000411342; ENSG00000158528 [Q9ULJ8-4]
ENST00000433360; ENSP00000405514; ENSG00000158528 [Q9ULJ8-3]
ENST00000433881; ENSP00000398870; ENSG00000158528 [Q9ULJ8-1]
ENST00000456331; ENSP00000402893; ENSG00000158528 [Q9ULJ8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55607

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55607

UCSC genome browser

More...
UCSCi
uc003unp.5 human [Q9ULJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000075 mRNA Translation: BAA90928.1
AC002429 Genomic DNA No translation available.
AC004022 Genomic DNA Translation: AAC35294.2
AC073886 Genomic DNA No translation available.
AC073890 Genomic DNA No translation available.
BC130449 mRNA Translation: AAI30450.1
BC150636 mRNA Translation: AAI50637.1
AB033048 mRNA Translation: BAA86536.1
CCDSiCCDS34683.1 [Q9ULJ8-1]
CCDS55127.1 [Q9ULJ8-3]
CCDS55128.1 [Q9ULJ8-4]
CCDS55129.1 [Q9ULJ8-5]
RefSeqiNP_001159632.1, NM_001166160.1 [Q9ULJ8-3]
NP_001159633.1, NM_001166161.1 [Q9ULJ8-5]
NP_001159634.1, NM_001166162.1 [Q9ULJ8-4]
NP_001159635.1, NM_001166163.1
NP_060120.2, NM_017650.2 [Q9ULJ8-1]
XP_016867892.1, XM_017012403.1 [Q9ULJ8-5]
XP_016867894.1, XM_017012405.1 [Q9ULJ8-1]
XP_016867895.1, XM_017012406.1 [Q9ULJ8-1]
UniGeneiHs.21816

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF8NMR-A500-593[»]
ProteinModelPortaliQ9ULJ8
SMRiQ9ULJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120747, 35 interactors
IntActiQ9ULJ8, 18 interactors
MINTiQ9ULJ8
STRINGi9606.ENSP00000405514

PTM databases

iPTMnetiQ9ULJ8
PhosphoSitePlusiQ9ULJ8

Polymorphism and mutation databases

BioMutaiPPP1R9A
DMDMi50403806

Proteomic databases

EPDiQ9ULJ8
jPOSTiQ9ULJ8
PaxDbiQ9ULJ8
PeptideAtlasiQ9ULJ8
PRIDEiQ9ULJ8
ProteomicsDBi85051
85052 [Q9ULJ8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289495; ENSP00000289495; ENSG00000158528 [Q9ULJ8-5]
ENST00000340694; ENSP00000344524; ENSG00000158528 [Q9ULJ8-1]
ENST00000424654; ENSP00000411342; ENSG00000158528 [Q9ULJ8-4]
ENST00000433360; ENSP00000405514; ENSG00000158528 [Q9ULJ8-3]
ENST00000433881; ENSP00000398870; ENSG00000158528 [Q9ULJ8-1]
ENST00000456331; ENSP00000402893; ENSG00000158528 [Q9ULJ8-4]
GeneIDi55607
KEGGihsa:55607
UCSCiuc003unp.5 human [Q9ULJ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55607
DisGeNETi55607
EuPathDBiHostDB:ENSG00000158528.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP1R9A
HGNCiHGNC:14946 PPP1R9A
HPAiHPA027726
HPA075591
MIMi602468 gene
neXtProtiNX_Q9ULJ8
OpenTargetsiENSG00000158528
PharmGKBiPA33661

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1945 Eukaryota
ENOG410Y7F2 LUCA
GeneTreeiENSGT00940000155538
HOGENOMiHOG000252962
HOVERGENiHBG005213
InParanoidiQ9ULJ8
KOiK17551
OMAiSPQNEPL
OrthoDBi128743at2759
PhylomeDBiQ9ULJ8
TreeFamiTF105540

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP1R9A human
EvolutionaryTraceiQ9ULJ8

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP1R9A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55607

Protein Ontology

More...
PROi
PR:Q9ULJ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158528 Expressed in 203 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9ULJ8 baseline and differential
GenevisibleiQ9ULJ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029994 Neurabin-1
IPR040645 Neurabin-1/2_PDZ
IPR001478 PDZ
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR16154:SF22 PTHR16154:SF22, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF17817 PDZ_5, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULJ8
Secondary accession number(s): A1L494
, B2RWQ1, E9PCA0, E9PCK6, E9PDX1, F8W7J9, O76059, Q9NXT2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 19, 2004
Last modified: February 13, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again