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Entry version 159 (07 Oct 2020)
Sequence version 4 (28 Jul 2009)
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Protein

Ankyrin repeat domain-containing protein 50

Gene

ANKRD50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9ULJ7

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.3.1.1, the sorting nexin27 (snx27)-retromer assembly apparatus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD50
Synonyms:KIAA1223
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000151458.11

Human Gene Nomenclature Database

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HGNCi
HGNC:29223, ANKRD50

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULJ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57182

Open Targets

More...
OpenTargetsi
ENSG00000151458

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394695

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9ULJ7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD50

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669201 – 1429Ankyrin repeat domain-containing protein 50Add BLAST1429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1165PhosphoserineCombined sources1
Modified residuei1167PhosphoserineCombined sources1
Modified residuei1222PhosphoserineCombined sources1
Modified residuei1400PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9ULJ7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9ULJ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9ULJ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULJ7

PeptideAtlas

More...
PeptideAtlasi
Q9ULJ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULJ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19759
85050 [Q9ULJ7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULJ7

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9ULJ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULJ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151458, Expressed in sperm and 208 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9ULJ7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000151458, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VPS35 (PubMed:25278552).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121431, 20 interactors

Database of interacting proteins

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DIPi
DIP-47302N

Protein interaction database and analysis system

More...
IntActi
Q9ULJ7, 14 interactors

Molecular INTeraction database

More...
MINTi
Q9ULJ7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000425658

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULJ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULJ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati477 – 509ANK 1Add BLAST33
Repeati511 – 540ANK 2Add BLAST30
Repeati544 – 573ANK 3Add BLAST30
Repeati577 – 606ANK 4Add BLAST30
Repeati610 – 639ANK 5Add BLAST30
Repeati643 – 672ANK 6Add BLAST30
Repeati676 – 705ANK 7Add BLAST30
Repeati709 – 743ANK 8Add BLAST35
Repeati747 – 776ANK 9Add BLAST30
Repeati780 – 809ANK 10Add BLAST30
Repeati813 – 842ANK 11Add BLAST30
Repeati846 – 875ANK 12Add BLAST30
Repeati879 – 908ANK 13Add BLAST30
Repeati912 – 941ANK 14Add BLAST30
Repeati945 – 974ANK 15Add BLAST30
Repeati978 – 1007ANK 16Add BLAST30
Repeati1011 – 1040ANK 17Add BLAST30
Repeati1044 – 1073ANK 18Add BLAST30
Repeati1077 – 1107ANK 19Add BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1123 – 1292Ser-richAdd BLAST170

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0504, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155116

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002138_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ULJ7

KEGG Orthology (KO)

More...
KOi
K21440

Identification of Orthologs from Complete Genome Data

More...
OMAi
LVDHTCN

Database of Orthologous Groups

More...
OrthoDBi
1073736at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULJ7

TreeFam database of animal gene trees

More...
TreeFami
TF323159

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248, ANK, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ULJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTNPWEEKVC KMAQTSLLQG KQFYCREWVF HKLQHCLQEK SNCCNSAVNA
60 70 80 90 100
PSLVMNSGNN ASGVSGKGAA WGVLLVGGPG SGKTALCTEL LWPSSPASLQ
110 120 130 140 150
RGLHRQALAF HFCKAQDSDT LCVGGFIRGL VAQICRSGLL QGYEDKLRDP
160 170 180 190 200
AVQSLLQPGE CERNPAEAFK RCVLLPLLGM KPPQQSLYLL VDSVDEGCNI
210 220 230 240 250
TEGEQTSTSL SGTVAALLAG HHEFFPPWLL LLCSARKQSK AVTKMFTGFR
260 270 280 290 300
KISLDDLRKA YIVKDVQQYI LHRLDQEEAL RQHLTKETAE MLNQLHIKSS
310 320 330 340 350
GCFLYLERVL DGVVENFIML REIRDIPGTL NGLYLWLCQR LFVRKQFAKV
360 370 380 390 400
QPILNVILAA CRPLTITELY HAVWTKNMSL TLEDFQRKLD ILSKLLVDGL
410 420 430 440 450
GNTKILFHYS FAEWLLDVKH CTQKYLCNAA EGHRMLAMSY TCQAKNLTPL
460 470 480 490 500
EAQEFALHLI NSNLQLETAE LALWMIWNGT PVRDSLSTLI PKEQEVLQLL
510 520 530 540 550
VKAGAHVNSE DDRTSCIVRQ ALEREDSIRT LLDNGASVNQ CDSNGRTLLA
560 570 580 590 600
NAAYSGSLDV VNLLVSRGAD LEIEDAHGHT PLTLAARQGH TKVVNCLIGC
610 620 630 640 650
GANINHTDQD GWTALRSAAW GGHTEVVSAL LYAGVKVDCA DADSRTALRA
660 670 680 690 700
AAWGGHEDIV LNLLQHGAEV NKADNEGRTA LIAAAYMGHR EIVEHLLDHG
710 720 730 740 750
AEVNHEDVDG RTALSVAALC VPASKGHASV VSLLIDRGAE VDHCDKDGMT
760 770 780 790 800
PLLVAAYEGH VDVVDLLLEG GADVDHTDNN GRTPLLAAAS MGHASVVNTL
810 820 830 840 850
LFWGAAVDSI DSEGRTVLSI ASAQGNVEVV RTLLDRGLDE NHRDDAGWTP
860 870 880 890 900
LHMAAFEGHR LICEALIEQG ARTNEIDNDG RIPFILASQE GHYDCVQILL
910 920 930 940 950
ENKSNIDQRG YDGRNALRVA ALEGHRDIVE LLFSHGADVN CKDADGRPTL
960 970 980 990 1000
YILALENQLT MAEYFLENGA NVEASDAEGR TALHVSCWQG HMEMVQVLIA
1010 1020 1030 1040 1050
YHADVNAADN EKRSALQSAA WQGHVKVVQL LIEHGAVVDH TCNQGATALC
1060 1070 1080 1090 1100
IAAQEGHIDV VQVLLEHGAD PNHADQFGRT AMRVAAKNGH SQIIKLLEKY
1110 1120 1130 1140 1150
GASSLNGCSP SPVHTMEQKP LQSLSSKVQS LTIKSNSSGS TGGGDMQPSL
1160 1170 1180 1190 1200
RGLPNGPTHA FSSPSESPDS TVDRQKSSLS NNSLKSSKNS SLRTTSSTAT
1210 1220 1230 1240 1250
AQTVPIDSFH NLSFTEQIQQ HSLPRSRSRQ SIVSPSSTTQ SLGQSHNSPS
1260 1270 1280 1290 1300
SEFEWSQVKP SLKSTKASKG GKSENSAKSG SAGKKAKQSN SSQPKVLEYE
1310 1320 1330 1340 1350
MTQFDRRGPI AKSGTAAPPK QMPAESQCKI MIPSAQQEIG RSQQQFLIHQ
1360 1370 1380 1390 1400
QSGEQKKRNG IMTNPNYHLQ SNQVFLGRVS VPRTMQDRGH QEVLEGYPSS
1410 1420
ETELSLKQAL KLQIEGSDPS FNYKKETPL
Length:1,429
Mass (Da):155,859
Last modified:July 28, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B5403A8433147C2
GO
Isoform 2 (identifier: Q9ULJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Show »
Length:1,250
Mass (Da):136,500
Checksum:iF547918C279FCE96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45N → D in BAF83757 (PubMed:14702039).Curated1
Sequence conflicti281R → Q in CAE45806 (PubMed:17974005).Curated1
Sequence conflicti647A → V in BAA86537 (PubMed:10574462).Curated1
Sequence conflicti656H → R in BAC87007 (PubMed:14702039).Curated1
Sequence conflicti1043N → D in BAG58158 (PubMed:14702039).Curated1
Sequence conflicti1111S → P in BAF83757 (PubMed:14702039).Curated1
Sequence conflicti1362M → I in BAF83757 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454591 – 179Missing in isoform 2. 1 PublicationAdd BLAST179

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK127496 mRNA Translation: BAC87007.1
AK291068 mRNA Translation: BAF83757.1
AK295135 mRNA Translation: BAG58158.1
AC105421 Genomic DNA No translation available.
BX640674 mRNA Translation: CAE45806.1
AB033049 mRNA Translation: BAA86537.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS34060.1 [Q9ULJ7-1]
CCDS54802.1 [Q9ULJ7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161354.1, NM_001167882.1 [Q9ULJ7-2]
NP_065070.1, NM_020337.2 [Q9ULJ7-1]
XP_016863960.1, XM_017008471.1 [Q9ULJ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000504087; ENSP00000425658; ENSG00000151458 [Q9ULJ7-1]
ENST00000515641; ENSP00000425355; ENSG00000151458 [Q9ULJ7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57182

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57182

UCSC genome browser

More...
UCSCi
uc010inw.4, human [Q9ULJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127496 mRNA Translation: BAC87007.1
AK291068 mRNA Translation: BAF83757.1
AK295135 mRNA Translation: BAG58158.1
AC105421 Genomic DNA No translation available.
BX640674 mRNA Translation: CAE45806.1
AB033049 mRNA Translation: BAA86537.2
CCDSiCCDS34060.1 [Q9ULJ7-1]
CCDS54802.1 [Q9ULJ7-2]
RefSeqiNP_001161354.1, NM_001167882.1 [Q9ULJ7-2]
NP_065070.1, NM_020337.2 [Q9ULJ7-1]
XP_016863960.1, XM_017008471.1 [Q9ULJ7-1]

3D structure databases

SMRiQ9ULJ7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121431, 20 interactors
DIPiDIP-47302N
IntActiQ9ULJ7, 14 interactors
MINTiQ9ULJ7
STRINGi9606.ENSP00000425658

Protein family/group databases

TCDBi9.A.3.1.1, the sorting nexin27 (snx27)-retromer assembly apparatus

PTM databases

iPTMnetiQ9ULJ7
MetOSiteiQ9ULJ7
PhosphoSitePlusiQ9ULJ7

Polymorphism and mutation databases

BioMutaiANKRD50
DMDMi254763437

Proteomic databases

EPDiQ9ULJ7
jPOSTiQ9ULJ7
MassIVEiQ9ULJ7
PaxDbiQ9ULJ7
PeptideAtlasiQ9ULJ7
PRIDEiQ9ULJ7
ProteomicsDBi19759
85050 [Q9ULJ7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48522, 72 antibodies

The DNASU plasmid repository

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DNASUi
57182

Genome annotation databases

EnsembliENST00000504087; ENSP00000425658; ENSG00000151458 [Q9ULJ7-1]
ENST00000515641; ENSP00000425355; ENSG00000151458 [Q9ULJ7-2]
GeneIDi57182
KEGGihsa:57182
UCSCiuc010inw.4, human [Q9ULJ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57182
DisGeNETi57182
EuPathDBiHostDB:ENSG00000151458.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD50
HGNCiHGNC:29223, ANKRD50
HPAiENSG00000151458, Low tissue specificity
neXtProtiNX_Q9ULJ7
OpenTargetsiENSG00000151458
PharmGKBiPA128394695

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0504, Eukaryota
GeneTreeiENSGT00940000155116
HOGENOMiCLU_002138_0_0_1
InParanoidiQ9ULJ7
KOiK21440
OMAiLVDHTCN
OrthoDBi1073736at2759
PhylomeDBiQ9ULJ7
TreeFamiTF323159

Enzyme and pathway databases

PathwayCommonsiQ9ULJ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57182, 5 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD50, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57182
PharosiQ9ULJ7, Tdark

Protein Ontology

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PROi
PR:Q9ULJ7
RNActiQ9ULJ7, protein

Gene expression databases

BgeeiENSG00000151458, Expressed in sperm and 208 other tissues
GenevisibleiQ9ULJ7, HS

Family and domain databases

Gene3Di1.25.40.20, 5 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 4 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 17 hits
SUPFAMiSSF48403, SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR50_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULJ7
Secondary accession number(s): A8K4V3
, B4DHJ6, E9PDW0, Q6N064, Q6ZSE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 28, 2009
Last modified: October 7, 2020
This is version 159 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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