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Entry version 182 (16 Oct 2019)
Sequence version 2 (01 Dec 2000)
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Protein

Zinc finger and BTB domain-containing protein 21

Gene

ZBTB21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcription repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 21
Alternative name(s):
Zinc finger protein 295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB21
Synonyms:KIAA1227, ZNF295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13083 ZBTB21

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616485 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULJ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
49854

Open Targets

More...
OpenTargetsi
ENSG00000173276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37659

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULJ3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBTB21

Domain mapping of disease mutations (DMDM)

More...
DMDMi
9979550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475151 – 1066Zinc finger and BTB domain-containing protein 21Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki312Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei345PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei411PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei431PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei605PhosphoserineCombined sources1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki702Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei714PhosphoserineCombined sources1
Cross-linki763Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki875Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki935Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1003PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULJ3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULJ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULJ3

PeptideAtlas

More...
PeptideAtlasi
Q9ULJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULJ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85046 [Q9ULJ3-1]
85047 [Q9ULJ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULJ3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9ULJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous in fetal and adult tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173276 Expressed in 203 organ(s), highest expression level in cauda epididymis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULJ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULJ3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024655
HPA031757
HPA031758

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ZBTB14.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119066, 112 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULJ3, 21 interactors

Molecular INTeraction database

More...
MINTi
Q9ULJ3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000308759

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9ULJ3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9ULJ3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 96BTBPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 96Mediates homodimerizationAdd BLAST67

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237324

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULJ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
KRQYMCK

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULJ3

TreeFam database of animal gene trees

More...
TreeFami
TF331184

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR041011 Znf_C2H2_6
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
PF18450 zf_C2H2_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULJ3-1) [UniParc]FASTAAdd to basket
Also known as: ZNF295L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA
60 70 80 90 100
SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA
110 120 130 140 150
AVQELGYSLG ISFLTNIVSK TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI
160 170 180 190 200
VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI AVKANTNKPH VPKPIEPLHN
210 220 230 240 250
LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV LPSKPLQDRE
260 270 280 290 300
AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG
310 320 330 340 350
QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV
360 370 380 390 400
PVYSPSIDLK SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ
410 420 430 440 450
VLQPHRLRSF SASQSTDREG ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD
460 470 480 490 500
AATTAAASSS SVTRDLSLKT EDDQKDMSRL PAKRRFQADR RLPFKKLKVN
510 520 530 540 550
EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT RPNKKFKCKH
560 570 580 590 600
CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI
610 620 630 640 650
VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS
660 670 680 690 700
SSQAQQVIKR NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV
710 720 730 740 750
NKVAKPKEHA PLASPVENKE VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC
760 770 780 790 800
PYCSLRFFSP ELKQEHESKC EYKKLTCLEC MRTFKSSFSI WRHQVEVHNQ
810 820 830 840 850
NNMAPTENFS LPVLDHNGDV TGSSRPQSQP EPNKVNHIVT TKDDNVFSDS
860 870 880 890 900
SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA
910 920 930 940 950
GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF
960 970 980 990 1000
RLWSHFQSHM SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE
1010 1020 1030 1040 1050
PDSPTGLSEN PTPATEKLFV PQESDTLFYH APPLSAITFK RQFMCKLCHR
1060
TFKTAFSLWS HEQTHN
Length:1,066
Mass (Da):118,870
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1779E26943FDAC8
GO
Isoform 2 (identifier: Q9ULJ3-2) [UniParc]FASTAAdd to basket
Also known as: ZNF295S

The sequence of this isoform differs from the canonical sequence as follows:
     535-735: Missing.

Show »
Length:865
Mass (Da):95,807
Checksum:i722AB5BE41C99614
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5KS07Q5KS07_HUMAN
Zinc finger and BTB domain-containi...
ZBTB21 ZNF295
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVF9E7EVF9_HUMAN
Zinc finger and BTB domain-containi...
ZBTB21
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86541 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti961S → P in AAH63290 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052807185N → S. Corresponds to variant dbSNP:rs871545Ensembl.1
Natural variantiVAR_052808218K → Q. Corresponds to variant dbSNP:rs871546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041349535 – 735Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB041014 mRNA Translation: BAD74063.1
AB041015 mRNA Translation: BAD74064.1
AB033053 mRNA Translation: BAA86541.1 Different initiation.
AP001745 Genomic DNA Translation: BAA95529.1
CH471079 Genomic DNA Translation: EAX09579.1
CH471079 Genomic DNA Translation: EAX09580.1
CH471079 Genomic DNA Translation: EAX09581.1
BC063290 mRNA Translation: AAH63290.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13678.1 [Q9ULJ3-1]
CCDS42934.1 [Q9ULJ3-2]

NCBI Reference Sequences

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RefSeqi
NP_001091872.1, NM_001098402.1 [Q9ULJ3-1]
NP_001091873.1, NM_001098403.1 [Q9ULJ3-2]
NP_001307658.1, NM_001320729.1 [Q9ULJ3-2]
NP_001307660.1, NM_001320731.1 [Q9ULJ3-1]
NP_065778.3, NM_020727.4 [Q9ULJ3-1]
XP_005261178.1, XM_005261121.3 [Q9ULJ3-1]
XP_011527890.1, XM_011529588.2 [Q9ULJ3-1]
XP_011527892.1, XM_011529590.2 [Q9ULJ3-1]
XP_016883849.1, XM_017028360.1 [Q9ULJ3-1]
XP_016883850.1, XM_017028361.1 [Q9ULJ3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310826; ENSP00000308759; ENSG00000173276 [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276 [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276 [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276 [Q9ULJ3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
49854

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:49854

UCSC genome browser

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UCSCi
uc002yzy.5 human [Q9ULJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041014 mRNA Translation: BAD74063.1
AB041015 mRNA Translation: BAD74064.1
AB033053 mRNA Translation: BAA86541.1 Different initiation.
AP001745 Genomic DNA Translation: BAA95529.1
CH471079 Genomic DNA Translation: EAX09579.1
CH471079 Genomic DNA Translation: EAX09580.1
CH471079 Genomic DNA Translation: EAX09581.1
BC063290 mRNA Translation: AAH63290.1
CCDSiCCDS13678.1 [Q9ULJ3-1]
CCDS42934.1 [Q9ULJ3-2]
RefSeqiNP_001091872.1, NM_001098402.1 [Q9ULJ3-1]
NP_001091873.1, NM_001098403.1 [Q9ULJ3-2]
NP_001307658.1, NM_001320729.1 [Q9ULJ3-2]
NP_001307660.1, NM_001320731.1 [Q9ULJ3-1]
NP_065778.3, NM_020727.4 [Q9ULJ3-1]
XP_005261178.1, XM_005261121.3 [Q9ULJ3-1]
XP_011527890.1, XM_011529588.2 [Q9ULJ3-1]
XP_011527892.1, XM_011529590.2 [Q9ULJ3-1]
XP_016883849.1, XM_017028360.1 [Q9ULJ3-1]
XP_016883850.1, XM_017028361.1 [Q9ULJ3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJPNMR-A713-806[»]
SMRiQ9ULJ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119066, 112 interactors
IntActiQ9ULJ3, 21 interactors
MINTiQ9ULJ3
STRINGi9606.ENSP00000308759

PTM databases

iPTMnetiQ9ULJ3
PhosphoSitePlusiQ9ULJ3
SwissPalmiQ9ULJ3

Polymorphism and mutation databases

BioMutaiZBTB21
DMDMi9979550

Proteomic databases

EPDiQ9ULJ3
jPOSTiQ9ULJ3
MassIVEiQ9ULJ3
PaxDbiQ9ULJ3
PeptideAtlasiQ9ULJ3
PRIDEiQ9ULJ3
ProteomicsDBi85046 [Q9ULJ3-1]
85047 [Q9ULJ3-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9ULJ3

Genome annotation databases

EnsembliENST00000310826; ENSP00000308759; ENSG00000173276 [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276 [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276 [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276 [Q9ULJ3-1]
GeneIDi49854
KEGGihsa:49854
UCSCiuc002yzy.5 human [Q9ULJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
49854
DisGeNETi49854

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZBTB21
HGNCiHGNC:13083 ZBTB21
HPAiHPA024655
HPA031757
HPA031758
MIMi616485 gene
neXtProtiNX_Q9ULJ3
OpenTargetsiENSG00000173276
PharmGKBiPA37659

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161028
HOGENOMiHOG000237324
InParanoidiQ9ULJ3
OMAiKRQYMCK
OrthoDBi1318335at2759
PhylomeDBiQ9ULJ3
TreeFamiTF331184

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZBTB21 human
EvolutionaryTraceiQ9ULJ3

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF295

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
49854
PharosiQ9ULJ3

Protein Ontology

More...
PROi
PR:Q9ULJ3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173276 Expressed in 203 organ(s), highest expression level in cauda epididymis
ExpressionAtlasiQ9ULJ3 baseline and differential
GenevisibleiQ9ULJ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR041011 Znf_C2H2_6
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
PF18450 zf_C2H2_6, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT21_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULJ3
Secondary accession number(s): Q5R2W1, Q5R2W2, Q6P4R0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 16, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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