Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 21

Gene

ZBTB21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcription repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 21
Alternative name(s):
Zinc finger protein 295
Gene namesi
Name:ZBTB21
Synonyms:KIAA1227, ZNF295
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000173276.13
HGNCiHGNC:13083 ZBTB21
MIMi616485 gene
neXtProtiNX_Q9ULJ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi49854
OpenTargetsiENSG00000173276
PharmGKBiPA37659

Polymorphism and mutation databases

BioMutaiZBTB21
DMDMi9979550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475151 – 1066Zinc finger and BTB domain-containing protein 21Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki312Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei345PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei411PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei431PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei605PhosphoserineCombined sources1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki702Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei714PhosphoserineCombined sources1
Cross-linki763Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki875Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki935Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1003PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ULJ3
PaxDbiQ9ULJ3
PeptideAtlasiQ9ULJ3
PRIDEiQ9ULJ3
ProteomicsDBi85046
85047 [Q9ULJ3-2]

PTM databases

iPTMnetiQ9ULJ3
PhosphoSitePlusiQ9ULJ3

Expressioni

Tissue specificityi

Ubiquitous in fetal and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000173276 Expressed in 203 organ(s), highest expression level in cauda epididymis
CleanExiHS_ZNF295
ExpressionAtlasiQ9ULJ3 baseline and differential
GenevisibleiQ9ULJ3 HS

Organism-specific databases

HPAiHPA024655
HPA031757
HPA031758

Interactioni

Subunit structurei

Homodimer. Interacts with ZBTB14.1 Publication

Protein-protein interaction databases

BioGridi119066, 110 interactors
IntActiQ9ULJ3, 6 interactors
MINTiQ9ULJ3
STRINGi9606.ENSP00000308759

Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ULJ3
SMRiQ9ULJ3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULJ3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 96BTBPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 96Mediates homodimerizationAdd BLAST67

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00810000125416
HOGENOMiHOG000237324
HOVERGENiHBG056929
InParanoidiQ9ULJ3
OMAiKCEYKKL
OrthoDBiEOG091G01Q4
PhylomeDBiQ9ULJ3
TreeFamiTF331184

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULJ3-1) [UniParc]FASTAAdd to basket
Also known as: ZNF295L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA
60 70 80 90 100
SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA
110 120 130 140 150
AVQELGYSLG ISFLTNIVSK TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI
160 170 180 190 200
VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI AVKANTNKPH VPKPIEPLHN
210 220 230 240 250
LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV LPSKPLQDRE
260 270 280 290 300
AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG
310 320 330 340 350
QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV
360 370 380 390 400
PVYSPSIDLK SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ
410 420 430 440 450
VLQPHRLRSF SASQSTDREG ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD
460 470 480 490 500
AATTAAASSS SVTRDLSLKT EDDQKDMSRL PAKRRFQADR RLPFKKLKVN
510 520 530 540 550
EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT RPNKKFKCKH
560 570 580 590 600
CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI
610 620 630 640 650
VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS
660 670 680 690 700
SSQAQQVIKR NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV
710 720 730 740 750
NKVAKPKEHA PLASPVENKE VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC
760 770 780 790 800
PYCSLRFFSP ELKQEHESKC EYKKLTCLEC MRTFKSSFSI WRHQVEVHNQ
810 820 830 840 850
NNMAPTENFS LPVLDHNGDV TGSSRPQSQP EPNKVNHIVT TKDDNVFSDS
860 870 880 890 900
SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA
910 920 930 940 950
GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF
960 970 980 990 1000
RLWSHFQSHM SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE
1010 1020 1030 1040 1050
PDSPTGLSEN PTPATEKLFV PQESDTLFYH APPLSAITFK RQFMCKLCHR
1060
TFKTAFSLWS HEQTHN
Length:1,066
Mass (Da):118,870
Last modified:December 1, 2000 - v2
Checksum:iE1779E26943FDAC8
GO
Isoform 2 (identifier: Q9ULJ3-2) [UniParc]FASTAAdd to basket
Also known as: ZNF295S

The sequence of this isoform differs from the canonical sequence as follows:
     535-735: Missing.

Show »
Length:865
Mass (Da):95,807
Checksum:i722AB5BE41C99614
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5KS07Q5KS07_HUMAN
Zinc finger and BTB domain-containi...
ZBTB21 ZNF295
49Annotation score:
E7EVF9E7EVF9_HUMAN
Zinc finger and BTB domain-containi...
ZBTB21
118Annotation score:

Sequence cautioni

The sequence BAA86541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti961S → P in AAH63290 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052807185N → S. Corresponds to variant dbSNP:rs871545Ensembl.1
Natural variantiVAR_052808218K → Q. Corresponds to variant dbSNP:rs871546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041349535 – 735Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041014 mRNA Translation: BAD74063.1
AB041015 mRNA Translation: BAD74064.1
AB033053 mRNA Translation: BAA86541.1 Different initiation.
AP001745 Genomic DNA Translation: BAA95529.1
CH471079 Genomic DNA Translation: EAX09579.1
CH471079 Genomic DNA Translation: EAX09580.1
CH471079 Genomic DNA Translation: EAX09581.1
BC063290 mRNA Translation: AAH63290.1
CCDSiCCDS13678.1 [Q9ULJ3-1]
CCDS42934.1 [Q9ULJ3-2]
RefSeqiNP_001091872.1, NM_001098402.1 [Q9ULJ3-1]
NP_001091873.1, NM_001098403.1 [Q9ULJ3-2]
NP_001307658.1, NM_001320729.1 [Q9ULJ3-2]
NP_001307660.1, NM_001320731.1 [Q9ULJ3-1]
NP_065778.3, NM_020727.4 [Q9ULJ3-1]
XP_005261178.1, XM_005261121.3 [Q9ULJ3-1]
XP_011527890.1, XM_011529588.2 [Q9ULJ3-1]
XP_011527892.1, XM_011529590.2 [Q9ULJ3-1]
XP_016883849.1, XM_017028360.1 [Q9ULJ3-1]
XP_016883850.1, XM_017028361.1 [Q9ULJ3-1]
UniGeneiHs.434947
Hs.618406

Genome annotation databases

EnsembliENST00000310826; ENSP00000308759; ENSG00000173276 [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276 [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276 [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276 [Q9ULJ3-1]
GeneIDi49854
KEGGihsa:49854
UCSCiuc002yzy.5 human [Q9ULJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041014 mRNA Translation: BAD74063.1
AB041015 mRNA Translation: BAD74064.1
AB033053 mRNA Translation: BAA86541.1 Different initiation.
AP001745 Genomic DNA Translation: BAA95529.1
CH471079 Genomic DNA Translation: EAX09579.1
CH471079 Genomic DNA Translation: EAX09580.1
CH471079 Genomic DNA Translation: EAX09581.1
BC063290 mRNA Translation: AAH63290.1
CCDSiCCDS13678.1 [Q9ULJ3-1]
CCDS42934.1 [Q9ULJ3-2]
RefSeqiNP_001091872.1, NM_001098402.1 [Q9ULJ3-1]
NP_001091873.1, NM_001098403.1 [Q9ULJ3-2]
NP_001307658.1, NM_001320729.1 [Q9ULJ3-2]
NP_001307660.1, NM_001320731.1 [Q9ULJ3-1]
NP_065778.3, NM_020727.4 [Q9ULJ3-1]
XP_005261178.1, XM_005261121.3 [Q9ULJ3-1]
XP_011527890.1, XM_011529588.2 [Q9ULJ3-1]
XP_011527892.1, XM_011529590.2 [Q9ULJ3-1]
XP_016883849.1, XM_017028360.1 [Q9ULJ3-1]
XP_016883850.1, XM_017028361.1 [Q9ULJ3-1]
UniGeneiHs.434947
Hs.618406

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJPNMR-A713-806[»]
ProteinModelPortaliQ9ULJ3
SMRiQ9ULJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119066, 110 interactors
IntActiQ9ULJ3, 6 interactors
MINTiQ9ULJ3
STRINGi9606.ENSP00000308759

PTM databases

iPTMnetiQ9ULJ3
PhosphoSitePlusiQ9ULJ3

Polymorphism and mutation databases

BioMutaiZBTB21
DMDMi9979550

Proteomic databases

EPDiQ9ULJ3
PaxDbiQ9ULJ3
PeptideAtlasiQ9ULJ3
PRIDEiQ9ULJ3
ProteomicsDBi85046
85047 [Q9ULJ3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310826; ENSP00000308759; ENSG00000173276 [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276 [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276 [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276 [Q9ULJ3-1]
GeneIDi49854
KEGGihsa:49854
UCSCiuc002yzy.5 human [Q9ULJ3-1]

Organism-specific databases

CTDi49854
DisGeNETi49854
EuPathDBiHostDB:ENSG00000173276.13
GeneCardsiZBTB21
HGNCiHGNC:13083 ZBTB21
HPAiHPA024655
HPA031757
HPA031758
MIMi616485 gene
neXtProtiNX_Q9ULJ3
OpenTargetsiENSG00000173276
PharmGKBiPA37659
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00810000125416
HOGENOMiHOG000237324
HOVERGENiHBG056929
InParanoidiQ9ULJ3
OMAiKCEYKKL
OrthoDBiEOG091G01Q4
PhylomeDBiQ9ULJ3
TreeFamiTF331184

Miscellaneous databases

ChiTaRSiZBTB21 human
EvolutionaryTraceiQ9ULJ3
GeneWikiiZNF295
GenomeRNAii49854
PROiPR:Q9ULJ3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173276 Expressed in 203 organ(s), highest expression level in cauda epididymis
CleanExiHS_ZNF295
ExpressionAtlasiQ9ULJ3 baseline and differential
GenevisibleiQ9ULJ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT21_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ3
Secondary accession number(s): Q5R2W1, Q5R2W2, Q6P4R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again