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UniProtKB - Q9ULJ3 (ZBT21_HUMAN)

Entry version 193 (29 Sep 2021)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
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Protein

Zinc finger and BTB domain-containing protein 21

Gene

ZBTB21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcription repressor.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULJ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 21
Alternative name(s):
Zinc finger protein 295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB21
Synonyms:KIAA1227, ZNF295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13083, ZBTB21

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616485, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULJ3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173276

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		49854

Open Targets

More...OpenTargetsi		ENSG00000173276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37659

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULJ3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZBTB21

Domain mapping of disease mutations (DMDM)

More...DMDMi		9979550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475151 – 1066Zinc finger and BTB domain-containing protein 21Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki312Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei345PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Cross-linki383Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei411PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei431PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei605PhosphoserineCombined sources1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki702Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei714PhosphoserineCombined sources1
Cross-linki763Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki785Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki875Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki935Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1003PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULJ3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULJ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULJ3

PeptideAtlas

More...PeptideAtlasi		Q9ULJ3

PRoteomics IDEntifications database

More...PRIDEi		Q9ULJ3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85046 [Q9ULJ3-1]
85047 [Q9ULJ3-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9ULJ3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULJ3

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9ULJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous in fetal and adult tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173276, Expressed in cauda epididymis and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULJ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULJ3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173276, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with ZBTB14.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119066, 118 interactors

Protein interaction database and analysis system

More...IntActi		Q9ULJ3, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000308759

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULJ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9ULJ3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULJ3

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9ULJ3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 96BTBPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 96Mediates homodimerizationAdd BLAST67
Regioni154 – 196DisorderedSequence analysisAdd BLAST43
Regioni388 – 442DisorderedSequence analysisAdd BLAST55
Regioni454 – 485DisorderedSequence analysisAdd BLAST32
Regioni498 – 525DisorderedSequence analysisAdd BLAST28
Regioni806 – 840DisorderedSequence analysisAdd BLAST35
Regioni879 – 906DisorderedSequence analysisAdd BLAST28
Regioni963 – 1014DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 184Polar residuesSequence analysisAdd BLAST31
Compositional biasi389 – 403Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi406 – 421Polar residuesSequence analysisAdd BLAST16
Compositional biasi466 – 485Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi820 – 840Polar residuesSequence analysisAdd BLAST21
Compositional biasi978 – 999Pro residuesSequence analysisAdd BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014382_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULJ3

Identification of Orthologs from Complete Genome Data

More...OMAi		RSVIVCR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULJ3

TreeFam database of animal gene trees

More...TreeFami		TF331184

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR041011, Znf_C2H2_6
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 2 hits
PF18450, zf_C2H2_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULJ3-1) [UniParc]FASTAAdd to basket
Also known as: ZNF295L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA 
        60         70         80         90        100
SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA 
       110        120        130        140        150
AVQELGYSLG ISFLTNIVSK TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI 
       160        170        180        190        200
VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI AVKANTNKPH VPKPIEPLHN 
       210        220        230        240        250
LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV LPSKPLQDRE 
       260        270        280        290        300
AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG 
       310        320        330        340        350
QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV 
       360        370        380        390        400
PVYSPSIDLK SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ 
       410        420        430        440        450
VLQPHRLRSF SASQSTDREG ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD 
       460        470        480        490        500
AATTAAASSS SVTRDLSLKT EDDQKDMSRL PAKRRFQADR RLPFKKLKVN 
       510        520        530        540        550
EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT RPNKKFKCKH 
       560        570        580        590        600
CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI 
       610        620        630        640        650
VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS 
       660        670        680        690        700
SSQAQQVIKR NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV 
       710        720        730        740        750
NKVAKPKEHA PLASPVENKE VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC 
       760        770        780        790        800
PYCSLRFFSP ELKQEHESKC EYKKLTCLEC MRTFKSSFSI WRHQVEVHNQ 
       810        820        830        840        850
NNMAPTENFS LPVLDHNGDV TGSSRPQSQP EPNKVNHIVT TKDDNVFSDS 
       860        870        880        890        900
SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA 
       910        920        930        940        950
GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF 
       960        970        980        990       1000
RLWSHFQSHM SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE 
      1010       1020       1030       1040       1050
PDSPTGLSEN PTPATEKLFV PQESDTLFYH APPLSAITFK RQFMCKLCHR 
      1060 
TFKTAFSLWS HEQTHN
Length:1,066
Mass (Da):118,870
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1779E26943FDAC8
GO
Isoform 2 (identifier: Q9ULJ3-2) [UniParc]FASTAAdd to basket
Also known as: ZNF295S

The sequence of this isoform differs from the canonical sequence as follows:
     535-735: Missing.

Show »
Length:865
Mass (Da):95,807
Checksum:i722AB5BE41C99614
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5KS07Q5KS07_HUMAN
Zinc finger and BTB domain-containi...
ZBTB21 ZNF295
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVF9E7EVF9_HUMAN
Zinc finger and BTB domain-containi...
ZBTB21
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86541 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti961S → P in AAH63290 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052807185N → S. Corresponds to variant dbSNP:rs871545Ensembl.1
Natural variantiVAR_052808218K → Q. Corresponds to variant dbSNP:rs871546Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041349535 – 735Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB041014 mRNA Translation: BAD74063.1
AB041015 mRNA Translation: BAD74064.1
AB033053 mRNA Translation: BAA86541.1 Different initiation.
AP001745 Genomic DNA Translation: BAA95529.1
CH471079 Genomic DNA Translation: EAX09579.1
CH471079 Genomic DNA Translation: EAX09580.1
CH471079 Genomic DNA Translation: EAX09581.1
BC063290 mRNA Translation: AAH63290.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13678.1 [Q9ULJ3-1]
CCDS42934.1 [Q9ULJ3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001091872.1, NM_001098402.1 [Q9ULJ3-1]
NP_001091873.1, NM_001098403.1 [Q9ULJ3-2]
NP_001307658.1, NM_001320729.1 [Q9ULJ3-2]
NP_001307660.1, NM_001320731.1 [Q9ULJ3-1]
NP_065778.3, NM_020727.4 [Q9ULJ3-1]
XP_005261178.1, XM_005261121.3 [Q9ULJ3-1]
XP_011527890.1, XM_011529588.2 [Q9ULJ3-1]
XP_011527892.1, XM_011529590.2 [Q9ULJ3-1]
XP_016883849.1, XM_017028360.1 [Q9ULJ3-1]
XP_016883850.1, XM_017028361.1 [Q9ULJ3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310826; ENSP00000308759; ENSG00000173276 [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276 [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276 [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276 [Q9ULJ3-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		49854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:49854

UCSC genome browser

More...UCSCi		uc002yzy.5, human [Q9ULJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041014 mRNA Translation: BAD74063.1
AB041015 mRNA Translation: BAD74064.1
AB033053 mRNA Translation: BAA86541.1 Different initiation.
AP001745 Genomic DNA Translation: BAA95529.1
CH471079 Genomic DNA Translation: EAX09579.1
CH471079 Genomic DNA Translation: EAX09580.1
CH471079 Genomic DNA Translation: EAX09581.1
BC063290 mRNA Translation: AAH63290.1
CCDSiCCDS13678.1 [Q9ULJ3-1]
CCDS42934.1 [Q9ULJ3-2]
RefSeqiNP_001091872.1, NM_001098402.1 [Q9ULJ3-1]
NP_001091873.1, NM_001098403.1 [Q9ULJ3-2]
NP_001307658.1, NM_001320729.1 [Q9ULJ3-2]
NP_001307660.1, NM_001320731.1 [Q9ULJ3-1]
NP_065778.3, NM_020727.4 [Q9ULJ3-1]
XP_005261178.1, XM_005261121.3 [Q9ULJ3-1]
XP_011527890.1, XM_011529588.2 [Q9ULJ3-1]
XP_011527892.1, XM_011529590.2 [Q9ULJ3-1]
XP_016883849.1, XM_017028360.1 [Q9ULJ3-1]
XP_016883850.1, XM_017028361.1 [Q9ULJ3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJPNMR-A713-806[»]
BMRBiQ9ULJ3
SMRiQ9ULJ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119066, 118 interactors
IntActiQ9ULJ3, 21 interactors
STRINGi9606.ENSP00000308759

PTM databases

GlyGeniQ9ULJ3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9ULJ3
PhosphoSitePlusiQ9ULJ3
SwissPalmiQ9ULJ3

Genetic variation databases

BioMutaiZBTB21
DMDMi9979550

Proteomic databases

EPDiQ9ULJ3
jPOSTiQ9ULJ3
MassIVEiQ9ULJ3
PaxDbiQ9ULJ3
PeptideAtlasiQ9ULJ3
PRIDEiQ9ULJ3
ProteomicsDBi85046 [Q9ULJ3-1]
85047 [Q9ULJ3-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9ULJ3, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9340, 85 antibodies

The DNASU plasmid repository

More...DNASUi		49854

Genome annotation databases

EnsembliENST00000310826; ENSP00000308759; ENSG00000173276 [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276 [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276 [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276 [Q9ULJ3-1]
GeneIDi49854
KEGGihsa:49854
UCSCiuc002yzy.5, human [Q9ULJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		49854
DisGeNETi49854

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZBTB21
HGNCiHGNC:13083, ZBTB21
HPAiENSG00000173276, Low tissue specificity
MIMi616485, gene
neXtProtiNX_Q9ULJ3
OpenTargetsiENSG00000173276
PharmGKBiPA37659
VEuPathDBiHostDB:ENSG00000173276

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161028
HOGENOMiCLU_014382_0_0_1
InParanoidiQ9ULJ3
OMAiRSVIVCR
PhylomeDBiQ9ULJ3
TreeFamiTF331184

Enzyme and pathway databases

PathwayCommonsiQ9ULJ3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		49854, 5 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZBTB21, human
EvolutionaryTraceiQ9ULJ3

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF295

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		49854
PharosiQ9ULJ3, Tbio

Protein Ontology

More...PROi		PR:Q9ULJ3
RNActiQ9ULJ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173276, Expressed in cauda epididymis and 217 other tissues
ExpressionAtlasiQ9ULJ3, baseline and differential
GenevisibleiQ9ULJ3, HS

Family and domain databases

Gene3Di3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR041011, Znf_C2H2_6
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 2 hits
PF18450, zf_C2H2_6, 1 hit
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 9 hits
SUPFAMiSSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT21_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULJ3
Secondary accession number(s): Q5R2W1, Q5R2W2, Q6P4R0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 29, 2021
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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