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Entry version 151 (29 Sep 2021)
Sequence version 3 (23 Oct 2007)
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Protein

Kinesin-like protein KIF26A

Gene

KIF26A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).

By similarity

Caution

In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi469 – 476ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9ULI4

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2132295, MHC class II antigen presentation
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF26A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF26A
Synonyms:KIAA1236
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20226, KIF26A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613231, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULI4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000066735

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26153

Open Targets

More...
OpenTargetsi
ENSG00000066735

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134888008

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULI4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIF26A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160014128

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003072991 – 1882Kinesin-like protein KIF26AAdd BLAST1882

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei1262PhosphoserineCombined sources1
Modified residuei1662PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULI4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULI4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULI4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9ULI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULI4

PeptideAtlas

More...
PeptideAtlasi
Q9ULI4

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULI4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85039

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066735, Expressed in subventricular zone (outer) (primate) and 161 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULI4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULI4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000066735, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GRB2 (via SH2 domain).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117584, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULI4, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000388241

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULI4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULI4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini371 – 725Kinesin motorPROSITE-ProRule annotationAdd BLAST355

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 66DisorderedSequence analysisAdd BLAST66
Regioni149 – 201DisorderedSequence analysisAdd BLAST53
Regioni316 – 337DisorderedSequence analysisAdd BLAST22
Regioni729 – 785DisorderedSequence analysisAdd BLAST57
Regioni851 – 915DisorderedSequence analysisAdd BLAST65
Regioni940 – 993DisorderedSequence analysisAdd BLAST54
Regioni1121 – 1237DisorderedSequence analysisAdd BLAST117
Regioni1335 – 1728DisorderedSequence analysisAdd BLAST394

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1784 – 1812Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi947 – 961Pro residuesSequence analysisAdd BLAST15
Compositional biasi1198 – 1216Polar residuesSequence analysisAdd BLAST19
Compositional biasi1461 – 1475Pro residuesSequence analysisAdd BLAST15
Compositional biasi1620 – 1638Polar residuesSequence analysisAdd BLAST19
Compositional biasi1660 – 1690Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4280, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159075

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULI4

Identification of Orthologs from Complete Genome Data

More...
OMAi
GECDAQA

Database of Orthologous Groups

More...
OrthoDBi
29955at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULI4

TreeFam database of animal gene trees

More...
TreeFami
TF105235

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027640, Kinesin-like_fam
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR24115, PTHR24115, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00225, Kinesin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00380, KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00129, KISc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50067, KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ULI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGRGVPLCA AQPAVAEGGP AREPPPLLEV SPRKRLPAGP DQDPCGSRPA
60 70 80 90 100
PEGAGAGPEQ GHSAGGGGWC RHCHTKLVEL KRQAWKLVSG PGTTLRDPCL
110 120 130 140 150
SALLLDKLPA PGALPACRPE AERRCDVCAT HLQQLTREAM HLLQAPASHE
160 170 180 190 200
DLDAPHGGPS LAPPSTTTSS RDTPGPAGPA GRQPGRAGPD RTKGLAWSPG
210 220 230 240 250
PSVQVSVAPA GLGGALSTVT IQAQQCLEGM WSVSRVNSFL PPACLAEAAV
260 270 280 290 300
AAVAVADTVR ECPPVAGPDG LSKAWGRGGV CTSALVTPTP GSVGGSTGPS
310 320 330 340 350
AAASFFIRAM QKLSLASKRK KPHPPPPPAT RGTSTYPTDF SGVLQLWPPP
360 370 380 390 400
APPCLLRAAS KTKDNPGSIG KVKVMLRIWP AQGAQRSAEA MSFLKVDPRK
410 420 430 440 450
KQVILYDPAA GPPGSAGPRR AATAAVPKMF AFDAVFPQDS EQAEVCSGTV
460 470 480 490 500
ADVLQSVVSG ADGCIFSFGH MSLGKSYTMI GKDSSPQSLG IVPCAISWLF
510 520 530 540 550
RLIEERRERT GTRFSVRVSA VEVCGRDQSL RDLLAEVAPG SLQDTQSPGV
560 570 580 590 600
YLREDPVCGA QLQNQSELRA PTAEKAAFYL DAALAARSTS RAGCGEDARR
610 620 630 640 650
SSHMLFTLHV YQYRMEKCGR GGMSGGRSRL HLIDLGSCEA AAGRAGEAAG
660 670 680 690 700
GPLCLSLSAL GSVILALVNG AKHVPYRDHR LTMLLRESLA TAGCRTTMIA
710 720 730 740 750
HVSDAPAQHA ETLSTVQLAA RIHRLRRKKA KYASSSSGGE SSCEEGRARR
760 770 780 790 800
PPHLRPFHPR TVALDPDRTP PCLPGDPDYS SSSEQSCDTV IYVGPGGAAL
810 820 830 840 850
SDRELTDNEG PPDFVPIIPA LSRHRPSKGP RDADHFRCST FAELQERLEC
860 870 880 890 900
MDGNEGPSGG PGGTDGAQAS PARGGRKPSP PEAASPRKAV GTPMAASTPR
910 920 930 940 950
GSSGPDTHQG TPEPCKAIVW GDQREDSSAW PELLVPEKAA VSGGRRPLPS
960 970 980 990 1000
PAPPPPQLLE ACRAPEEPGG GGTDGVARTP PVGMSGQVAG SPMLPGATCP
1010 1020 1030 1040 1050
RLAAGSRCPE RGLLTTTVTL QRPVELNGED ELVFTVVEEL SLGALAGAGR
1060 1070 1080 1090 1100
PTSLASFDSD CSLRALASGS RPVSIISSIN DEFDAYTSQA PEGGPLEGAA
1110 1120 1130 1140 1150
WAGSSHGSSI SSWLSEVSVC TADSRDPTPQ PRFSPDSLAG LDPGGPPALD
1160 1170 1180 1190 1200
GSLGDGSSGF LGPDRPDSPG PTWGPCPGEV AAVAPSRPGR EPQAGPSRWA
1210 1220 1230 1240 1250
SAAQTIHSSL PRKPRTASAT TRVGCARLGQ SPPGRGGLFE DPWLLRVGEC
1260 1270 1280 1290 1300
DTQAASAGRA PSPTLGSPRL PEAQVMLACA QRVVDGCEVA ARAARRPEAV
1310 1320 1330 1340 1350
ARIPPLRRGA TTLGVTTPAV SWGDAPTEVV ACSGSLKASP TSKKGLAPKA
1360 1370 1380 1390 1400
GFLPRPSGAA PPAPPTRKSS LEQRSSPASA PPHAVNPARV GAAAVLRGEE
1410 1420 1430 1440 1450
EPRPSSRADH SVPRATSSLK ARASKVEAAH RLAGHASLER YEGLAHSSSK
1460 1470 1480 1490 1500
GREAPGRPPR AVPKLGVPPS SPTHGPAPAC RSGAAKAVGA PKPPVGGGKG
1510 1520 1530 1540 1550
RGLVAGGSRA LGPSVKLSTA SVTGRSPGGP VAGPRAAPRA GPSVGAKAGR
1560 1570 1580 1590 1600
GTVMGTKQAL RAAHSRVHEL SASGAPGRGG SSWGSADSDS GHDSGVNVGE
1610 1620 1630 1640 1650
ERPPTGPALP SPYSKVTAPR RPQRYSSGHG SDNSSVLSGE LPPAMGRTAL
1660 1670 1680 1690 1700
FHHSGGSSGY ESLRRDSEAT GSASSAPDSM SESGAASPGA RTRSLKSPKK
1710 1720 1730 1740 1750
RATGLQRRRL IPAPLPDTTA LGRKPSLPGQ WVDLPPPLAG SLKEPFEIKV
1760 1770 1780 1790 1800
YEIDDVERLQ RPRPTPREAP TQGLACVSTR LRLAERRQQR LREVQAKHKH
1810 1820 1830 1840 1850
LCEELAETQG RLMLEPGRWL EQFEVDPELE PESAEYLAAL ERATAALEQC
1860 1870 1880
VNLCKAHVMM VTCFDISVAA SAAIPGPQEV DV
Length:1,882
Mass (Da):194,590
Last modified:October 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC35E3458BCF3D147
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFF0C9JFF0_HUMAN
Kinesin-like protein KIF26A
KIF26A
1,743Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH09415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1284 – 1287VDGC → ERER in AAH25353 (PubMed:15489334).Curated4
Sequence conflicti1513P → L in AAH25353 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL359399 Genomic DNA No translation available.
AB033062 mRNA Translation: BAA86550.2
BC009415 mRNA Translation: AAH09415.1 Different initiation.
BC025353 mRNA Translation: AAH25353.1
AL117589 mRNA Translation: CAB56009.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45171.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17319

NCBI Reference Sequences

More...
RefSeqi
NP_056471.1, NM_015656.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000423312; ENSP00000388241; ENSG00000066735

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26153

UCSC genome browser

More...
UCSCi
uc001yos.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359399 Genomic DNA No translation available.
AB033062 mRNA Translation: BAA86550.2
BC009415 mRNA Translation: AAH09415.1 Different initiation.
BC025353 mRNA Translation: AAH25353.1
AL117589 mRNA Translation: CAB56009.1
CCDSiCCDS45171.1
PIRiT17319
RefSeqiNP_056471.1, NM_015656.1

3D structure databases

SMRiQ9ULI4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117584, 12 interactors
IntActiQ9ULI4, 10 interactors
STRINGi9606.ENSP00000388241

PTM databases

iPTMnetiQ9ULI4
PhosphoSitePlusiQ9ULI4

Genetic variation databases

BioMutaiKIF26A
DMDMi160014128

Proteomic databases

EPDiQ9ULI4
jPOSTiQ9ULI4
MassIVEiQ9ULI4
MaxQBiQ9ULI4
PaxDbiQ9ULI4
PeptideAtlasiQ9ULI4
PRIDEiQ9ULI4
ProteomicsDBi85039

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28168, 85 antibodies

The DNASU plasmid repository

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DNASUi
26153

Genome annotation databases

EnsembliENST00000423312; ENSP00000388241; ENSG00000066735
GeneIDi26153
KEGGihsa:26153
UCSCiuc001yos.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26153
DisGeNETi26153

GeneCards: human genes, protein and diseases

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GeneCardsi
KIF26A
HGNCiHGNC:20226, KIF26A
HPAiENSG00000066735, Low tissue specificity
MIMi613231, gene
neXtProtiNX_Q9ULI4
OpenTargetsiENSG00000066735
PharmGKBiPA134888008
VEuPathDBiHostDB:ENSG00000066735

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4280, Eukaryota
GeneTreeiENSGT00940000159075
InParanoidiQ9ULI4
OMAiGECDAQA
OrthoDBi29955at2759
PhylomeDBiQ9ULI4
TreeFamiTF105235

Enzyme and pathway databases

PathwayCommonsiQ9ULI4
ReactomeiR-HSA-2132295, MHC class II antigen presentation
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26153, 3 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KIF26A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26153
PharosiQ9ULI4, Tbio

Protein Ontology

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PROi
PR:Q9ULI4
RNActiQ9ULI4, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000066735, Expressed in subventricular zone (outer) (primate) and 161 other tissues
ExpressionAtlasiQ9ULI4, baseline and differential
GenevisibleiQ9ULI4, HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640, Kinesin-like_fam
IPR001752, Kinesin_motor_dom
IPR036961, Kinesin_motor_dom_sf
IPR027417, P-loop_NTPase
PANTHERiPTHR24115, PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225, Kinesin, 1 hit
PRINTSiPR00380, KINESINHEAVY
SMARTiView protein in SMART
SM00129, KISc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067, KINESIN_MOTOR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI26A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULI4
Secondary accession number(s): Q8TAZ7, Q96GK3, Q9UFL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: September 29, 2021
This is version 151 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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