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Protein

ATPase family AAA domain-containing protein 2B

Gene

ATAD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi441 – 448ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: GO_Central
  • histone binding Source: GO_Central
  • lysine-acetylated histone binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATAD2B
Synonyms:KIAA1240
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119778.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29230 ATAD2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615347 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULI0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377039

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2176775

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2720

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATAD2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439432

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507891 – 1458ATPase family AAA domain-containing protein 2BAdd BLAST1458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei221PhosphothreonineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1347PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULI0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULI0

PeptideAtlas

More...
PeptideAtlasi
Q9ULI0

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULI0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85032
85033 [Q9ULI0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULI0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119778 Expressed in 203 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATAD2B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULI0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULI0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034555

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds acetylated lysine residues in histone H1.4, H2A, H2B, H3 and H4 (in vitro).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119961, 1 interactor

Protein interaction database and analysis system

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IntActi
Q9ULI0, 1 interactor

Molecular INTeraction database

More...
MINTi
Q9ULI0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000238789

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9ULI0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9ULI0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULI0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9ULI0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini975 – 1045BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili943 – 974Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi257 – 262Poly-Glu6
Compositional biasi1247 – 1250Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0730 Eukaryota
KOG0732 Eukaryota
COG0464 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034119

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080873

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULI0

KEGG Orthology (KO)

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KOi
K22531

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0152

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULI0

TreeFam database of animal gene trees

More...
TreeFami
TF314783

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004 AAA, 1 hit
PF00439 Bromodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00297 BROMO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674 AAA, 1 hit
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVNTRKSSLR LLGSKSPGPG PGPGAGAEPG ATGGSSHFIS SRTRSSKTRA
60 70 80 90 100
ASCPAAKAGG SGGAGVTLDE ARKVEVDGSL SDSHVSPPAK RTLKQPDSVC
110 120 130 140 150
KDKSKSRSTG QREEWNLSTG QARLTSQPGA TLPNGHSGLS LRSHPLRGEK
160 170 180 190 200
KGDGDLSCIN GDMEVRKSCR SRKNRFESVN QSLLFDQLVN STAEAVLQEM
210 220 230 240 250
DNINIRQNRR SGEVERLRMW TDTEFENMDM YSRVKRRRKS LRRNSYGIQN
260 270 280 290 300
HHEVSTEGEE EESQEEDGDI EVEEAEGEEN DRPYNLRQRK TVDRYQAPPI
310 320 330 340 350
VPAHQKKREN TLFDIHRSPA RRSHIRRKKH AIHSSDTTSS DEERFERRKS
360 370 380 390 400
KSMARARNRC LPMNFRAEDL ASGILRERVK VGASLADVDP MNIDKSVRFD
410 420 430 440 450
SIGGLSHHIH ALKEMVVFPL LYPEIFEKFK IQPPRGCLFY GPPGTGKTLV
460 470 480 490 500
ARALANECSQ GDKKVAFFMR KGADCLSKWV GESERQLRLL FDQAYLMRPS
510 520 530 540 550
IIFFDEIDGL APVRSSRQDQ IHSSIVSTLL ALMDGLDNRG EIVVIGATNR
560 570 580 590 600
LDSIDPALRR PGRFDREFLF NLPDQKARKH ILQIHTRDWN PKLSDAFLGE
610 620 630 640 650
LAEKCVGYCG ADIKALCTEA ALIALRRRYP QIYASSHKLQ LDVSSIVLSA
660 670 680 690 700
QDFYHAMQNI VPASQRAVMS SGHALSPIIR PLLERSFNNI LAVLQKVFPH
710 720 730 740 750
AEISQSDKKE DIETLILEDS EDENALSIFE TNCHSGSPKK QSSSAAIHKP
760 770 780 790 800
YLHFTMSPYH QPTSYRPRLL LSGERGSGQT SHLAPALLHT LERFSVHRLD
810 820 830 840 850
LPALYSVSAK TPEESCAQIF REARRTVPSI VYMPHIGDWW EAVSETVRAT
860 870 880 890 900
FLTLLQDIPS FSPIFLLSTS ETMYSELPEE VKCIFRIQYE EVLYIQRPIE
910 920 930 940 950
EDRRKFFQEL ILNQASMAPP RRKHAALCAM EVLPLALPSP PRQLSESEKS
960 970 980 990 1000
RMEDQEENTL RELRLFLRDV TKRLATDKRF NIFSKPVDIE EVSDYLEVIK
1010 1020 1030 1040 1050
EPMDLSTVIT KIDKHNYLTA KDFLKDIDLI CSNALEYNPD KDPGDKIIRH
1060 1070 1080 1090 1100
RACTLKDTAH AIIAAELDPE FNKLCEEIKE ARIKRGLSVT SEQINPHSTG
1110 1120 1130 1140 1150
ARKTETRVEE AFRHKQRNPM DVWHNSANKC AFRVRRKSRR RSQWGKGIIK
1160 1170 1180 1190 1200
KRKVNNLKKD EEDTKFADYE NHTEDRKLLE NGEFEVSTDC HEENGEETGD
1210 1220 1230 1240 1250
LSMTNDESSC DIMDLDQGQR LNNGAGTKEN FASTEEESSN ESLLVNSSSS
1260 1270 1280 1290 1300
LNPEQTSRKE TFLKGNCLNG EASTDSFEGI PVLECQNGKL EVVSFCDSGD
1310 1320 1330 1340 1350
KCSSEQKILL EDQSKEKPET STENHGDDLE KLEALECSNN EKLEPGSDVE
1360 1370 1380 1390 1400
VKDAELDKEG ASKVKKYRKL ILEQAKTTSL ELVPEEPSEP VPPLIVDRER
1410 1420 1430 1440 1450
LKKLLDLLVD KSNNLAVDQL ERLYSLLSQC IYRHRKDYDK SQLVEEMERT

VHMFETFL
Length:1,458
Mass (Da):164,914
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE7480D7EEBE6F9C
GO
Isoform 2 (identifier: Q9ULI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     988-992: Missing.

Show »
Length:1,453
Mass (Da):164,328
Checksum:i826AB705C4CB3A49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYF1H7BYF1_HUMAN
ATPase family AAA domain-containing...
ATAD2B
734Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1G9C9J1G9_HUMAN
ATPase family AAA domain-containing...
ATAD2B
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JG15C9JG15_HUMAN
ATPase family AAA domain-containing...
ATAD2B
370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti207Q → R in BAC04429 (PubMed:14702039).Curated1
Sequence conflicti291T → A in BAC04429 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055467118S → P. Corresponds to variant dbSNP:rs10210982Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023276988 – 992Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009242 Genomic DNA No translation available.
AC066692 Genomic DNA No translation available.
AC079924 Genomic DNA No translation available.
AK094821 mRNA Translation: BAC04429.1
AK131301 mRNA Translation: BAD18469.1 Different initiation.
AB033066 mRNA Translation: BAA86554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46227.1 [Q9ULI0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001229267.2, NM_001242338.2
NP_060022.2, NM_017552.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.467862
Hs.656359

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238789; ENSP00000238789; ENSG00000119778

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54454

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54454

UCSC genome browser

More...
UCSCi
uc002rek.5 human [Q9ULI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009242 Genomic DNA No translation available.
AC066692 Genomic DNA No translation available.
AC079924 Genomic DNA No translation available.
AK094821 mRNA Translation: BAC04429.1
AK131301 mRNA Translation: BAD18469.1 Different initiation.
AB033066 mRNA Translation: BAA86554.1
CCDSiCCDS46227.1 [Q9ULI0-1]
RefSeqiNP_001229267.2, NM_001242338.2
NP_060022.2, NM_017552.3
UniGeneiHs.467862
Hs.656359

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKWNMR-A958-1080[»]
3LXJX-ray2.33A/B/C/D952-1086[»]
ProteinModelPortaliQ9ULI0
SMRiQ9ULI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119961, 1 interactor
IntActiQ9ULI0, 1 interactor
MINTiQ9ULI0
STRINGi9606.ENSP00000238789

Chemistry databases

BindingDBiQ9ULI0
ChEMBLiCHEMBL2176775
GuidetoPHARMACOLOGYi2720

PTM databases

iPTMnetiQ9ULI0
PhosphoSitePlusiQ9ULI0

Polymorphism and mutation databases

BioMutaiATAD2B
DMDMi296439432

Proteomic databases

EPDiQ9ULI0
PaxDbiQ9ULI0
PeptideAtlasiQ9ULI0
PRIDEiQ9ULI0
ProteomicsDBi85032
85033 [Q9ULI0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238789; ENSP00000238789; ENSG00000119778
GeneIDi54454
KEGGihsa:54454
UCSCiuc002rek.5 human [Q9ULI0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54454
EuPathDBiHostDB:ENSG00000119778.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ATAD2B
HGNCiHGNC:29230 ATAD2B
HPAiHPA034555
MIMi615347 gene
neXtProtiNX_Q9ULI0
PharmGKBiPA162377039

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0730 Eukaryota
KOG0732 Eukaryota
COG0464 LUCA
HOGENOMiHOG000034119
HOVERGENiHBG080873
InParanoidiQ9ULI0
KOiK22531
OrthoDBiEOG091G0152
PhylomeDBiQ9ULI0
TreeFamiTF314783

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATAD2B human
EvolutionaryTraceiQ9ULI0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54454

Protein Ontology

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PROi
PR:Q9ULI0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000119778 Expressed in 203 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_ATAD2B
ExpressionAtlasiQ9ULI0 baseline and differential
GenevisibleiQ9ULI0 HS

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATD2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULI0
Secondary accession number(s): B9ZVQ5, Q6ZNA6, Q8N9E7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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