UniProtKB - Q9ULH4 (LRFN2_HUMAN)
Protein
Leucine-rich repeat and fibronectin type-III domain-containing protein 2
Gene
LRFN2
Organism
Homo sapiens (Human)
Status
Functioni
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).By similarity
GO - Biological processi
- modulation of chemical synaptic transmission Source: Ensembl
- regulation of postsynapse organization Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9ULH4 |
Reactomei | R-HSA-8849932, Synaptic adhesion-like molecules |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat and fibronectin type-III domain-containing protein 2Alternative name(s): Synaptic adhesion-like molecule 1 |
Gene namesi | Name:LRFN2 Synonyms:KIAA1246, SALM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21226, LRFN2 |
MIMi | 612808, gene |
neXtProti | NX_Q9ULH4 |
VEuPathDBi | HostDB:ENSG00000156564.8 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane By similarity
Other locations
Plasma Membrane
- integral component of postsynaptic density membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cell surface Source: GO_Central
- Schaffer collateral - CA1 synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 534 | ExtracellularSequence analysisAdd BLAST | 514 | |
Transmembranei | 535 – 555 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 556 – 789 | CytoplasmicSequence analysisAdd BLAST | 234 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 787 – 789 | Missing : Loss of DLG1-, DLG3- and DLG4-binding. 1 Publication | 3 |
Organism-specific databases
DisGeNETi | 57497 |
OpenTargetsi | ENSG00000156564 |
PharmGKBi | PA134913285 |
Miscellaneous databases
Pharosi | Q9ULH4, Tbio |
Genetic variation databases
BioMutai | LRFN2 |
DMDMi | 62286951 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000014838 | 21 – 789 | Leucine-rich repeat and fibronectin type-III domain-containing protein 2Add BLAST | 769 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 310 ↔ 359 | PROSITE-ProRule annotation | ||
Glycosylationi | 332 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 341 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 384 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9ULH4 |
MassIVEi | Q9ULH4 |
PaxDbi | Q9ULH4 |
PeptideAtlasi | Q9ULH4 |
PRIDEi | Q9ULH4 |
ProteomicsDBi | 85027 |
PTM databases
GlyGeni | Q9ULH4, 4 sites |
iPTMneti | Q9ULH4 |
PhosphoSitePlusi | Q9ULH4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156564, Expressed in cortical plate and 54 other tissues |
Genevisiblei | Q9ULH4, HS |
Organism-specific databases
HPAi | ENSG00000156564, Tissue enriched (brain) |
Interactioni
Subunit structurei
Forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5. Can form homomeric complexes, but not across cell junctions. Directly interacts with 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity).
Interacts with DLG1, DLG2, DLG3 and DLG4.
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 121564, 7 interactors |
STRINGi | 9606.ENSP00000345985 |
Miscellaneous databases
RNActi | Q9ULH4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 52 | LRRNTAdd BLAST | 32 | |
Repeati | 53 – 74 | LRR 1Add BLAST | 22 | |
Repeati | 77 – 98 | LRR 2Add BLAST | 22 | |
Repeati | 101 – 122 | LRR 3Add BLAST | 22 | |
Repeati | 125 – 146 | LRR 4Add BLAST | 22 | |
Repeati | 150 – 171 | LRR 5Add BLAST | 22 | |
Repeati | 174 – 195 | LRR 6Add BLAST | 22 | |
Repeati | 198 – 219 | LRR 7Add BLAST | 22 | |
Domaini | 242 – 288 | LRRCTAdd BLAST | 47 | |
Domaini | 289 – 375 | Ig-likeAdd BLAST | 87 | |
Domaini | 421 – 518 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 98 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 786 – 789 | PDZ-binding | 4 |
Domaini
The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding.By similarity
Sequence similaritiesi
Belongs to the LRFN family.Curated
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000156417 |
HOGENOMi | CLU_016998_1_0_1 |
InParanoidi | Q9ULH4 |
OMAi | HNIDRLM |
OrthoDBi | 151757at2759 |
PhylomeDBi | Q9ULH4 |
TreeFami | TF350185 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF07679, I-set, 1 hit PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00369, LRR_TYP, 6 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS50835, IG_LIKE, 1 hit PS51450, LRR, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9ULH4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METLLGGLLA FGMAFAVVDA CPKYCVCQNL SESLGTLCPS KGLLFVPPDI
60 70 80 90 100
DRRTVELRLG GNFIIHISRQ DFANMTGLVD LTLSRNTISH IQPFSFLDLE
110 120 130 140 150
SLRSLHLDSN RLPSLGEDTL RGLVNLQHLI VNNNQLGGIA DEAFEDFLLT
160 170 180 190 200
LEDLDLSYNN LHGLPWDSVR RMVNLHQLSL DHNLLDHIAE GTFADLQKLA
210 220 230 240 250
RLDLTSNRLQ KLPPDPIFAR SQASALTATP FAPPLSFSFG GNPLHCNCEL
260 270 280 290 300
LWLRRLERDD DLETCGSPGG LKGRYFWHVR EEEFVCEPPL ITQHTHKLLV
310 320 330 340 350
LEGQAATLKC KAIGDPSPLI HWVAPDDRLV GNSSRTAVYD NGTLDIFITT
360 370 380 390 400
SQDSGAFTCI AANAAGEATA MVEVSIVQLP HLSNSTSRTA PPKSRLSDIT
410 420 430 440 450
GSSKTSRGGG GSGGGEPPKS PPERAVLVSE VTTTSALVKW SVSKSAPRVK
460 470 480 490 500
MYQLQYNCSD DEVLIYRMIP ASNKAFVVNN LVSGTGYDLC VLAMWDDTAT
510 520 530 540 550
TLTATNIVGC AQFFTKADYP QCQSMHSQIL GGTMILVIGG IIVATLLVFI
560 570 580 590 600
VILMVRYKVC NHEAPSKMAA AVSNVYSQTN GAQPPPPSSA PAGAPPQGPP
610 620 630 640 650
KVVVRNELLD FTASLARASD SSSSSSLGSG EAAGLGRAPW RIPPSAPRPK
660 670 680 690 700
PSLDRLMGAF ASLDLKSQRK EELLDSRTPA GRGAGTSARG HHSDREPLLG
710 720 730 740 750
PPAARARSLL PLPLEGKAKR SHSFDMGDFA AAAAGGVVPG GYSPPRKVSN
760 770 780
IWTKRSLSVN GMLLPFEESD LVGARGTFGS SEWVMESTV
Sequence cautioni
The sequence BAA86560 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049894 | 770 | D → N. Corresponds to variant dbSNP:rs3734559Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033072 mRNA Translation: BAA86560.1 Different initiation. AK291474 mRNA Translation: BAF84163.1 AL591063 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04006.1 BC142616 mRNA Translation: AAI42617.1 |
CCDSi | CCDS34443.1 |
RefSeqi | NP_065788.1, NM_020737.2 XP_011513063.1, XM_011514761.2 XP_011513064.1, XM_011514762.2 XP_016866599.1, XM_017011110.1 |
Genome annotation databases
Ensembli | ENST00000338305; ENSP00000345985; ENSG00000156564 |
GeneIDi | 57497 |
KEGGi | hsa:57497 |
UCSCi | uc003oph.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033072 mRNA Translation: BAA86560.1 Different initiation. AK291474 mRNA Translation: BAF84163.1 AL591063 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04006.1 BC142616 mRNA Translation: AAI42617.1 |
CCDSi | CCDS34443.1 |
RefSeqi | NP_065788.1, NM_020737.2 XP_011513063.1, XM_011514761.2 XP_011513064.1, XM_011514762.2 XP_016866599.1, XM_017011110.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121564, 7 interactors |
STRINGi | 9606.ENSP00000345985 |
PTM databases
GlyGeni | Q9ULH4, 4 sites |
iPTMneti | Q9ULH4 |
PhosphoSitePlusi | Q9ULH4 |
Genetic variation databases
BioMutai | LRFN2 |
DMDMi | 62286951 |
Proteomic databases
jPOSTi | Q9ULH4 |
MassIVEi | Q9ULH4 |
PaxDbi | Q9ULH4 |
PeptideAtlasi | Q9ULH4 |
PRIDEi | Q9ULH4 |
ProteomicsDBi | 85027 |
Protocols and materials databases
Antibodypediai | 2525, 108 antibodies |
Genome annotation databases
Ensembli | ENST00000338305; ENSP00000345985; ENSG00000156564 |
GeneIDi | 57497 |
KEGGi | hsa:57497 |
UCSCi | uc003oph.2, human |
Organism-specific databases
CTDi | 57497 |
DisGeNETi | 57497 |
GeneCardsi | LRFN2 |
HGNCi | HGNC:21226, LRFN2 |
HPAi | ENSG00000156564, Tissue enriched (brain) |
MIMi | 612808, gene |
neXtProti | NX_Q9ULH4 |
OpenTargetsi | ENSG00000156564 |
PharmGKBi | PA134913285 |
VEuPathDBi | HostDB:ENSG00000156564.8 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000156417 |
HOGENOMi | CLU_016998_1_0_1 |
InParanoidi | Q9ULH4 |
OMAi | HNIDRLM |
OrthoDBi | 151757at2759 |
PhylomeDBi | Q9ULH4 |
TreeFami | TF350185 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULH4 |
Reactomei | R-HSA-8849932, Synaptic adhesion-like molecules |
Miscellaneous databases
BioGRID-ORCSi | 57497, 2 hits in 982 CRISPR screens |
ChiTaRSi | LRFN2, human |
GenomeRNAii | 57497 |
Pharosi | Q9ULH4, Tbio |
PROi | PR:Q9ULH4 |
RNActi | Q9ULH4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156564, Expressed in cortical plate and 54 other tissues |
Genevisiblei | Q9ULH4, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 2 hits 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF07679, I-set, 1 hit PF13855, LRR_8, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00369, LRR_TYP, 6 hits SM00082, LRRCT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50853, FN3, 1 hit PS50835, IG_LIKE, 1 hit PS51450, LRR, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRFN2_HUMAN | |
Accessioni | Q9ULH4Primary (citable) accession number: Q9ULH4 Secondary accession number(s): A5PKU3, Q5SYP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 29, 2005 | |
Last modified: | April 7, 2021 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families