UniProtKB - Q9ULH0 (KDIS_HUMAN)
Kinase D-interacting substrate of 220 kDa
KIDINS220
Functioni
GO - Molecular functioni
- PDZ domain binding Source: UniProtKB
- protein kinase regulator activity Source: GO_Central
GO - Biological processi
- activation of MAPKK activity Source: Reactome
- cellular response to nerve growth factor stimulus Source: UniProtKB
- dendrite morphogenesis Source: Ensembl
- in utero embryonic development Source: Ensembl
- nerve growth factor signaling pathway Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
Keywordsi
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9ULH0 |
Reactomei | R-HSA-170984, ARMS-mediated activation |
SignaLinki | Q9ULH0 |
SIGNORi | Q9ULH0 |
Protein family/group databases
TCDBi | 8.A.28.1.8, the ankyrin (ankyrin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Kinase D-interacting substrate of 220 kDaAlternative name(s): Ankyrin repeat-rich membrane-spanning protein |
Gene namesi | Name:KIDINS220 Synonyms:ARMS, KIAA1250 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29508, KIDINS220 |
MIMi | 615759, gene |
neXtProti | NX_Q9ULH0 |
VEuPathDBi | HostDB:ENSG00000134313.14 |
Subcellular locationi
Endosome
- Late endosome By similarity
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Note: Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Cytosol
- cytosol Source: Reactome
Endosome
- late endosome Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
- protein-containing complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 499 | CytoplasmicSequence analysisAdd BLAST | 499 | |
Transmembranei | 500 – 520 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 521 – 524 | ExtracellularSequence analysis | 4 | |
Transmembranei | 525 – 545 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 546 – 659 | CytoplasmicSequence analysisAdd BLAST | 114 | |
Transmembranei | 660 – 680 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 681 – 685 | ExtracellularSequence analysis | 5 | |
Transmembranei | 686 – 706 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 707 – 1771 | CytoplasmicSequence analysisAdd BLAST | 1065 |
Keywords - Cellular componenti
Endosome, MembranePathology & Biotechi
Involvement in diseasei
Spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077995 | 1350 – 1771 | Missing in SINO; no effect on protein abundance. 1 PublicationAdd BLAST | 422 | |
Natural variantiVAR_077996 | 1366 – 1771 | Missing in SINO; no effect on protein abundance; no effect on subcellular localization. 1 PublicationAdd BLAST | 406 |
Keywords - Diseasei
Disease variant, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration, ObesityOrganism-specific databases
DisGeNETi | 57498 |
MalaCardsi | KIDINS220 |
MIMi | 617296, phenotype |
OpenTargetsi | ENSG00000134313 |
Orphaneti | 521390, Spastic paraplegia-intellectual disability-nystagmus-obesity syndrome |
PharmGKBi | PA164721911 |
Miscellaneous databases
Pharosi | Q9ULH0, Tbio |
Genetic variation databases
BioMutai | KIDINS220 |
DMDMi | 172044825 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000322119 | 1 – 1771 | Kinase D-interacting substrate of 220 kDaAdd BLAST | 1771 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 882 | PhosphoserineCombined sources | 1 | |
Modified residuei | 885 | PhosphoserineCombined sources | 1 | |
Modified residuei | 914 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 918 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1163 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1352 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1359 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1361 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1362 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1365 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1521 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1526 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1555 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1574 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1623 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1633 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1679 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1681 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1684 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9ULH0 |
jPOSTi | Q9ULH0 |
MassIVEi | Q9ULH0 |
PaxDbi | Q9ULH0 |
PeptideAtlasi | Q9ULH0 |
PRIDEi | Q9ULH0 |
ProteomicsDBi | 85020 [Q9ULH0-1] 85021 [Q9ULH0-2] 85022 [Q9ULH0-3] 85023 [Q9ULH0-4] 85024 [Q9ULH0-5] |
PTM databases
iPTMneti | Q9ULH0 |
MetOSitei | Q9ULH0 |
PhosphoSitePlusi | Q9ULH0 |
SwissPalmi | Q9ULH0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000134313, Expressed in neocortex and 247 other tissues |
ExpressionAtlasi | Q9ULH0, baseline and differential |
Genevisiblei | Q9ULH0, HS |
Organism-specific databases
HPAi | ENSG00000134313, Low tissue specificity |
Interactioni
Subunit structurei
Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner.
Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation. Isoform 2 interacts (via C-terminal domain) with MAGI2 isoform 1 (via PDZ domain).
Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1.
Interacts (via PDZ-binding motif) with SNTA1 and SNTB2 (via PDZ domains).
Interacts with EPHA4 and PRKD1.
By similarityBinary interactionsi
Hide detailsIsoform 2 [Q9ULH0-2]
With | #Exp. | IntAct |
---|---|---|
FHL3 [Q13643] | 3 | EBI-11046235,EBI-741101 |
KRT34 [O76011] | 3 | EBI-11046235,EBI-1047093 |
GO - Molecular functioni
- PDZ domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121565, 99 interactors |
IntActi | Q9ULH0, 67 interactors |
STRINGi | 9606.ENSP00000256707 |
Miscellaneous databases
RNActi | Q9ULH0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 4 – 33 | ANK 1Add BLAST | 30 | |
Repeati | 37 – 66 | ANK 2Add BLAST | 30 | |
Repeati | 70 – 99 | ANK 3Add BLAST | 30 | |
Repeati | 103 – 132 | ANK 4Add BLAST | 30 | |
Repeati | 136 – 165 | ANK 5Add BLAST | 30 | |
Repeati | 169 – 198 | ANK 6Add BLAST | 30 | |
Repeati | 202 – 231 | ANK 7Add BLAST | 30 | |
Repeati | 235 – 264 | ANK 8Add BLAST | 30 | |
Repeati | 268 – 297 | ANK 9Add BLAST | 30 | |
Repeati | 301 – 330 | ANK 10Add BLAST | 30 | |
Repeati | 334 – 363 | ANK 11Add BLAST | 30 | |
Repeati | 367 – 396 | ANK 12Add BLAST | 30 | |
Domaini | 440 – 953 | KAP NTPaseAdd BLAST | 514 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1089 – 1092 | Mediates interaction with CRKLBy similarity | 4 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1766 – 1771 | PDZ-bindingBy similarity | 6 |
Domaini
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0502, Eukaryota |
GeneTreei | ENSGT00940000156714 |
HOGENOMi | CLU_001438_0_0_1 |
InParanoidi | Q9ULH0 |
OMAi | FQIDFNW |
OrthoDBi | 58543at2759 |
PhylomeDBi | Q9ULH0 |
TreeFami | TF344032 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011646, KAP_P-loop IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 4 hits PF07693, KAP_NTPase, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 11 hits |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 10 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN
60 70 80 90 100
LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR
110 120 130 140 150
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA
160 170 180 190 200
DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG
210 220 230 240 250
ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHTE
260 270 280 290 300
IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ
310 320 330 340 350
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV
360 370 380 390 400
VELLLDKGAK VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP
410 420 430 440 450
NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI
460 470 480 490 500
LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL
510 520 530 540 550
IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF IVIYFGGRRE
560 570 580 590 600
GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT
610 620 630 640 650
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK
660 670 680 690 700
WKKTCCLPSF VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV
710 720 730 740 750
GLAFVLNCRT WWQVLDSLLN SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE
760 770 780 790 800
LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF
810 820 830 840 850
IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS
860 870 880 890 900
NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR
910 920 930 940 950
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG
960 970 980 990 1000
RLLRANQISF NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT
1010 1020 1030 1040 1050
IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC
1060 1070 1080 1090 1100
TVNLDPKLRE IIADVRAARE QISIGGLAYP PLPLHEGPPR APSGYSQPPS
1110 1120 1130 1140 1150
VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF FAPYLYTPRY
1160 1170 1180 1190 1200
YPGGSQHLIS RPSVKTSLPR DQNNGLEVIK EDAAEGLSSP TDSSRGSGPA
1210 1220 1230 1240 1250
PGPVVLLNSL NVDAVCEKLK QIEGLDQSML PQYCTTIKKA NINGRVLAQC
1260 1270 1280 1290 1300
NIDELKKEMN MNFGDWHLFR STVLEMRNAE SHVVPEDPRF LSESSSGPAP
1310 1320 1330 1340 1350
HGEPARRASH NELPHTELSS QTPYTLNFSF EELNTLGLDE GAPRHSNLSW
1360 1370 1380 1390 1400
QSQTRRTPSL SSLNSQDSSI EISKLTDKVQ AEYRDAYREY IAQMSQLEGG
1410 1420 1430 1440 1450
PGSTTISGRS SPHSTYYMGQ SSSGGSIHSN LEQEKGKDSE PKPDDGRKSF
1460 1470 1480 1490 1500
LMKRGDVIDY SSSGVSTNDA SPLDPITEED EKSDQSGSKL LPGKKSSERS
1510 1520 1530 1540 1550
SLFQTDLKLK GSGLRYQKLP SDEDESGTEE SDNTPLLKDD KDRKAEGKVE
1560 1570 1580 1590 1600
RVPKSPEHSA EPIRTFIKAK EYLSDALLDK KDSSDSGVRS SESSPNHSLH
1610 1620 1630 1640 1650
NEVADDSQLE KANLIELEDD SHSGKRGIPH SLSGLQDPII ARMSICSEDK
1660 1670 1680 1690 1700
KSPSECSLIA SSPEENWPAC QKAYNLNRTP STVTLNNNSA PANRANQNFD
1710 1720 1730 1740 1750
EMEGIRETSQ VILRPSSSPN PTTIQNENLK SMTHKRSQRS SYTRLSKDPP
1760 1770
ELHAAASSES TGFGEERESI L
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PH70 | E9PH70_HUMAN | Kinase D-interacting substrate of 2... | KIDINS220 | 1,305 | Annotation score: | ||
H0Y8E4 | H0Y8E4_HUMAN | Kinase D-interacting substrate of 2... | KIDINS220 | 1,057 | Annotation score: | ||
A0A1W2PPB7 | A0A1W2PPB7_HUMAN | Kinase D-interacting substrate of 2... | KIDINS220 | 1,316 | Annotation score: | ||
A0A1W2PPY4 | A0A1W2PPY4_HUMAN | Kinase D-interacting substrate of 2... | KIDINS220 | 269 | Annotation score: | ||
H7C584 | H7C584_HUMAN | Kinase D-interacting substrate of 2... | KIDINS220 | 151 | Annotation score: | ||
F8WAY8 | F8WAY8_HUMAN | Kinase D-interacting substrate of 2... | KIDINS220 | 36 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1335 | T → P in CAE45935 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1613 | N → D in BAB14285 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048285 | 538 | I → T. Corresponds to variant dbSNP:rs2289229Ensembl. | 1 | |
Natural variantiVAR_039399 | 1307 | R → H. Corresponds to variant dbSNP:rs2304591Ensembl. | 1 | |
Natural variantiVAR_077995 | 1350 – 1771 | Missing in SINO; no effect on protein abundance. 1 PublicationAdd BLAST | 422 | |
Natural variantiVAR_077996 | 1366 – 1771 | Missing in SINO; no effect on protein abundance; no effect on subcellular localization. 1 PublicationAdd BLAST | 406 | |
Natural variantiVAR_039400 | 1608 | Q → H3 PublicationsCorresponds to variant dbSNP:rs1044280Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031861 | 1 – 1228 | Missing in isoform 5. 1 PublicationAdd BLAST | 1228 | |
Alternative sequenceiVSP_031862 | 1 – 42 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_031863 | 135 | L → LQ in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_031864 | 1005 – 1030 | ISKNI…RNFEV → CCGADSCDRDRIGISKSVLV AMLMES in isoform 3. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_031865 | 1031 – 1771 | Missing in isoform 3. 1 PublicationAdd BLAST | 741 | |
Alternative sequenceiVSP_031866 | 1138 – 1194 | Missing in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_031867 | 1177 – 1195 | Missing in isoform 4. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033076 mRNA Translation: BAA86564.2 Different initiation. AK022873 mRNA Translation: BAB14285.1 AK023926 mRNA Translation: BAB14728.1 Different initiation. AL133620 mRNA Translation: CAB63746.1 AL137553 mRNA Translation: CAB70807.1 BX640878 mRNA Translation: CAE45935.1 BC094714 mRNA Translation: AAH94714.1 BC130610 mRNA Translation: AAI30611.1 |
CCDSi | CCDS42650.1 [Q9ULH0-1] CCDS86818.1 [Q9ULH0-4] CCDS86819.1 [Q9ULH0-3] |
PIRi | T43458 |
RefSeqi | NP_065789.1, NM_020738.2 [Q9ULH0-1] |
Genome annotation databases
Ensembli | ENST00000256707; ENSP00000256707; ENSG00000134313 [Q9ULH0-1] ENST00000319688; ENSP00000319947; ENSG00000134313 [Q9ULH0-3] ENST00000473731; ENSP00000418974; ENSG00000134313 [Q9ULH0-4] |
GeneIDi | 57498 |
KEGGi | hsa:57498 |
UCSCi | uc002qzc.2, human [Q9ULH0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033076 mRNA Translation: BAA86564.2 Different initiation. AK022873 mRNA Translation: BAB14285.1 AK023926 mRNA Translation: BAB14728.1 Different initiation. AL133620 mRNA Translation: CAB63746.1 AL137553 mRNA Translation: CAB70807.1 BX640878 mRNA Translation: CAE45935.1 BC094714 mRNA Translation: AAH94714.1 BC130610 mRNA Translation: AAI30611.1 |
CCDSi | CCDS42650.1 [Q9ULH0-1] CCDS86818.1 [Q9ULH0-4] CCDS86819.1 [Q9ULH0-3] |
PIRi | T43458 |
RefSeqi | NP_065789.1, NM_020738.2 [Q9ULH0-1] |
3D structure databases
SMRi | Q9ULH0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121565, 99 interactors |
IntActi | Q9ULH0, 67 interactors |
STRINGi | 9606.ENSP00000256707 |
Protein family/group databases
TCDBi | 8.A.28.1.8, the ankyrin (ankyrin) family |
PTM databases
iPTMneti | Q9ULH0 |
MetOSitei | Q9ULH0 |
PhosphoSitePlusi | Q9ULH0 |
SwissPalmi | Q9ULH0 |
Genetic variation databases
BioMutai | KIDINS220 |
DMDMi | 172044825 |
Proteomic databases
EPDi | Q9ULH0 |
jPOSTi | Q9ULH0 |
MassIVEi | Q9ULH0 |
PaxDbi | Q9ULH0 |
PeptideAtlasi | Q9ULH0 |
PRIDEi | Q9ULH0 |
ProteomicsDBi | 85020 [Q9ULH0-1] 85021 [Q9ULH0-2] 85022 [Q9ULH0-3] 85023 [Q9ULH0-4] 85024 [Q9ULH0-5] |
Protocols and materials databases
Antibodypediai | 6605, 264 antibodies |
Genome annotation databases
Ensembli | ENST00000256707; ENSP00000256707; ENSG00000134313 [Q9ULH0-1] ENST00000319688; ENSP00000319947; ENSG00000134313 [Q9ULH0-3] ENST00000473731; ENSP00000418974; ENSG00000134313 [Q9ULH0-4] |
GeneIDi | 57498 |
KEGGi | hsa:57498 |
UCSCi | uc002qzc.2, human [Q9ULH0-1] |
Organism-specific databases
CTDi | 57498 |
DisGeNETi | 57498 |
GeneCardsi | KIDINS220 |
HGNCi | HGNC:29508, KIDINS220 |
HPAi | ENSG00000134313, Low tissue specificity |
MalaCardsi | KIDINS220 |
MIMi | 615759, gene 617296, phenotype |
neXtProti | NX_Q9ULH0 |
OpenTargetsi | ENSG00000134313 |
Orphaneti | 521390, Spastic paraplegia-intellectual disability-nystagmus-obesity syndrome |
PharmGKBi | PA164721911 |
VEuPathDBi | HostDB:ENSG00000134313.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0502, Eukaryota |
GeneTreei | ENSGT00940000156714 |
HOGENOMi | CLU_001438_0_0_1 |
InParanoidi | Q9ULH0 |
OMAi | FQIDFNW |
OrthoDBi | 58543at2759 |
PhylomeDBi | Q9ULH0 |
TreeFami | TF344032 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULH0 |
Reactomei | R-HSA-170984, ARMS-mediated activation |
SignaLinki | Q9ULH0 |
SIGNORi | Q9ULH0 |
Miscellaneous databases
BioGRID-ORCSi | 57498, 41 hits in 998 CRISPR screens |
ChiTaRSi | KIDINS220, human |
GeneWikii | KIDINS220 |
GenomeRNAii | 57498 |
Pharosi | Q9ULH0, Tbio |
PROi | PR:Q9ULH0 |
RNActi | Q9ULH0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134313, Expressed in neocortex and 247 other tissues |
ExpressionAtlasi | Q9ULH0, baseline and differential |
Genevisiblei | Q9ULH0, HS |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011646, KAP_P-loop IPR013761, SAM/pointed_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 4 hits PF07693, KAP_NTPase, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 11 hits |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 10 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KDIS_HUMAN | |
Accessioni | Q9ULH0Primary (citable) accession number: Q9ULH0 Secondary accession number(s): A1L4N4 Q9UF42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot