UniProtKB - Q9ULH0 (KDIS_HUMAN)

BLAST

>sp|Q9ULH0|KDIS_HUMAN Kinase D-interacting substrate of 220 kDa OS=Homo sapiens OX=9606 GN=KIDINS220 PE=1 SV=3
MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN
GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV
ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK
GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL
MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ
DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK
VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT
QIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLE
DEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFF
IVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFT
DYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSF
VIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLN
SQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACE
QDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHL
PVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNR
RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISF
NWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLE
IDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYP
PLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPF
FAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPA
PGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMN
MNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSS
QTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQ
AEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSE
PKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERS
SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERVPKSPEHSA
EPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLEKANLIELEDD
SHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWPACQKAYNLNRTP
STVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRS
SYTRLSKDPPELHAAASSESTGFGEERESIL

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History
Entry version 139 (12 Sep 2018)
Sequence version 3 (26 Feb 2008)
Previous versions | rss
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Protein

Kinase D-interacting substrate of 220 kDa

Gene

KIDINS220

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.By similarity1 Publication

GO - Molecular functionⁱ

PDZ domain binding Source: UniProtKB
protein kinase regulator activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPKK activity Source: Reactome
cellular response to nerve growth factor stimulus Source: UniProtKB
dendrite morphogenesis Source: Ensembl
in utero embryonic development Source: Ensembl
nerve growth factor signaling pathway Source: UniProtKB
positive regulation of neuron projection development Source: UniProtKB
regulation of protein kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurogenesis

Biological process

Neurogenesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-170984 ARMS-mediated activation
SignaLinkⁱ	Q9ULH0
SIGNORⁱ	Q9ULH0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Kinase D-interacting substrate of 220 kDa Alternative name(s): Ankyrin repeat-rich membrane-spanning protein
Gene namesⁱ	Name:KIDINS220 Synonyms:ARMS, KIAA1250
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134313.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29508 KIDINS220
MIMⁱ	615759 gene
neXtProtⁱ	NX_Q9ULH0

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 499	CytoplasmicSequence analysisAdd BLAST	499
Transmembraneⁱ	500 – 520	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	521 – 524	ExtracellularSequence analysis	4
Transmembraneⁱ	525 – 545	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	546 – 659	CytoplasmicSequence analysisAdd BLAST	114
Transmembraneⁱ	660 – 680	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	681 – 685	ExtracellularSequence analysis	5
Transmembraneⁱ	686 – 706	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	707 – 1771	CytoplasmicSequence analysisAdd BLAST	1065

Keywords - Cellular componentⁱ

Endosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spastic paraplegia, intellectual disability, nystagmus, and obesity (SINO)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal dominant syndrome characterized by rapid growth in infancy, obesity, global developmental delay, intellectual disability, spastic paraplegia, ocular defects, and dysmorphic facial features.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077995	1350 – 1771	Missing in SINO; no effect on protein abundance. 1 PublicationAdd BLAST		422
Natural variantⁱVAR_077996	1366 – 1771	Missing in SINO; no effect on protein abundance; no effect on subcellular localization. 1 PublicationAdd BLAST		406

Keywords - Diseaseⁱ

Disease mutation, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration, Obesity

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57498
MalaCards human disease database More...MalaCardsⁱ	KIDINS220
MIMⁱ	617296 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000134313
PharmGKBⁱ	PA164721911

Polymorphism and mutation databases

BioMutaⁱ	KIDINS220
DMDMⁱ	172044825

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000322119	1 – 1771	Kinase D-interacting substrate of 220 kDaAdd BLAST		1771

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	882	PhosphoserineCombined sources	1
Modified residueⁱ	885	PhosphoserineCombined sources	1
Modified residueⁱ	914	PhosphothreonineCombined sources	1
Modified residueⁱ	918	PhosphoserineCombined sources	1
Modified residueⁱ	1163	PhosphoserineCombined sources	1
Modified residueⁱ	1296	PhosphoserineCombined sources	1
Modified residueⁱ	1352	PhosphoserineCombined sources	1
Modified residueⁱ	1359	PhosphoserineCombined sources	1
Modified residueⁱ	1361	PhosphoserineCombined sources	1
Modified residueⁱ	1362	PhosphoserineCombined sources	1
Modified residueⁱ	1365	PhosphoserineCombined sources	1
Modified residueⁱ	1521	PhosphoserineCombined sources	1
Modified residueⁱ	1526	PhosphoserineCombined sources	1
Modified residueⁱ	1555	PhosphoserineCombined sources	1
Modified residueⁱ	1574	PhosphoserineCombined sources	1
Modified residueⁱ	1623	PhosphoserineCombined sources	1
Modified residueⁱ	1633	PhosphoserineCombined sources	1
Modified residueⁱ	1679	PhosphothreonineCombined sources	1
Modified residueⁱ	1681	PhosphoserineCombined sources	1
Modified residueⁱ	1684	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9ULH0
PaxDbⁱ	Q9ULH0
PeptideAtlas More...PeptideAtlasⁱ	Q9ULH0
PRIDEⁱ	Q9ULH0
ProteomicsDBⁱ	85020 85021 [Q9ULH0-2] 85022 [Q9ULH0-3] 85023 [Q9ULH0-4] 85024 [Q9ULH0-5]

PTM databases

iPTMnetⁱ	Q9ULH0
PhosphoSitePlusⁱ	Q9ULH0
SwissPalmⁱ	Q9ULH0

Expressionⁱ

Tissue specificityⁱ

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000134313 Expressed in 235 organ(s), highest expression level in neocortex
ExpressionAtlasⁱ	Q9ULH0 baseline and differential
Genevisibleⁱ	Q9ULH0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014790

HPAⁱ

HPA014790

Interactionⁱ

Subunit structureⁱ

Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation. Isoform 2 interacts (via C-terminal domain) with MAGI2 isoform 1 (via PDZ domain). Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts (via PDZ-binding motif) with SNTA1 and SNTB2 (via PDZ domains). Interacts with EPHA4 and PRKD1.By similarity

GO - Molecular functionⁱ

PDZ domain binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121565, 66 interactors
IntActⁱ	Q9ULH0, 45 interactors
STRINGⁱ	9606.ENSP00000256707

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULH0
SMRⁱ	Q9ULH0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	4 – 33	ANK 1Add BLAST	30
Repeatⁱ	37 – 66	ANK 2Add BLAST	30
Repeatⁱ	70 – 99	ANK 3Add BLAST	30
Repeatⁱ	103 – 132	ANK 4Add BLAST	30
Repeatⁱ	136 – 165	ANK 5Add BLAST	30
Repeatⁱ	169 – 198	ANK 6Add BLAST	30
Repeatⁱ	202 – 231	ANK 7Add BLAST	30
Repeatⁱ	235 – 264	ANK 8Add BLAST	30
Repeatⁱ	268 – 297	ANK 9Add BLAST	30
Repeatⁱ	301 – 330	ANK 10Add BLAST	30
Repeatⁱ	334 – 363	ANK 11Add BLAST	30
Repeatⁱ	367 – 396	ANK 12Add BLAST	30
Domainⁱ	440 – 953	KAP NTPaseAdd BLAST	514

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1089 – 1092	Mediates interaction with CRKLBy similarity		4

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1766 – 1771	PDZ-bindingBy similarity		6

Domainⁱ

The transmembrane domain mediates interaction with NTRK1.By similarity

Keywords - Domainⁱ

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0502 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148967
InParanoidⁱ	Q9ULH0
KEGG Orthology (KO) More...KOⁱ	K12460
OMAⁱ	HSTYYMG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01EB
PhylomeDBⁱ	Q9ULH0
TreeFamⁱ	TF344032

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 3 hits
Gene3Dⁱ	1.25.40.20, 2 hits
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR011646 KAP_P-loop IPR013761 SAM/pointed_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 4 hits PF07693 KAP_NTPase, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 11 hits
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF48403 SSF48403, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 10 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9ULH0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN 
        60         70         80         90        100
LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR 
       110        120        130        140        150
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA 
       160        170        180        190        200
DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG 
       210        220        230        240        250
ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHTE 
       260        270        280        290        300
IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ 
       310        320        330        340        350
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV 
       360        370        380        390        400
VELLLDKGAK VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP 
       410        420        430        440        450
NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI 
       460        470        480        490        500
LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL 
       510        520        530        540        550
IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF IVIYFGGRRE 
       560        570        580        590        600
GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT 
       610        620        630        640        650
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK 
       660        670        680        690        700
WKKTCCLPSF VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV 
       710        720        730        740        750
GLAFVLNCRT WWQVLDSLLN SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE 
       760        770        780        790        800
LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF 
       810        820        830        840        850
IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS 
       860        870        880        890        900
NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR 
       910        920        930        940        950
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG 
       960        970        980        990       1000
RLLRANQISF NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT 
      1010       1020       1030       1040       1050
IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC 
      1060       1070       1080       1090       1100
TVNLDPKLRE IIADVRAARE QISIGGLAYP PLPLHEGPPR APSGYSQPPS 
      1110       1120       1130       1140       1150
VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF FAPYLYTPRY 
      1160       1170       1180       1190       1200
YPGGSQHLIS RPSVKTSLPR DQNNGLEVIK EDAAEGLSSP TDSSRGSGPA 
      1210       1220       1230       1240       1250
PGPVVLLNSL NVDAVCEKLK QIEGLDQSML PQYCTTIKKA NINGRVLAQC 
      1260       1270       1280       1290       1300
NIDELKKEMN MNFGDWHLFR STVLEMRNAE SHVVPEDPRF LSESSSGPAP 
      1310       1320       1330       1340       1350
HGEPARRASH NELPHTELSS QTPYTLNFSF EELNTLGLDE GAPRHSNLSW 
      1360       1370       1380       1390       1400
QSQTRRTPSL SSLNSQDSSI EISKLTDKVQ AEYRDAYREY IAQMSQLEGG 
      1410       1420       1430       1440       1450
PGSTTISGRS SPHSTYYMGQ SSSGGSIHSN LEQEKGKDSE PKPDDGRKSF 
      1460       1470       1480       1490       1500
LMKRGDVIDY SSSGVSTNDA SPLDPITEED EKSDQSGSKL LPGKKSSERS 
      1510       1520       1530       1540       1550
SLFQTDLKLK GSGLRYQKLP SDEDESGTEE SDNTPLLKDD KDRKAEGKVE 
      1560       1570       1580       1590       1600
RVPKSPEHSA EPIRTFIKAK EYLSDALLDK KDSSDSGVRS SESSPNHSLH 
      1610       1620       1630       1640       1650
NEVADDSQLE KANLIELEDD SHSGKRGIPH SLSGLQDPII ARMSICSEDK 
      1660       1670       1680       1690       1700
KSPSECSLIA SSPEENWPAC QKAYNLNRTP STVTLNNNSA PANRANQNFD 
      1710       1720       1730       1740       1750
EMEGIRETSQ VILRPSSSPN PTTIQNENLK SMTHKRSQRS SYTRLSKDPP 
      1760       1770 
ELHAAASSES TGFGEERESI L

Length:1,771

Mass (Da):196,542

Last modified:February 26, 2008 - v3

Checksum:ⁱFD1F99DB88B6996D

Isoform 2 (identifier: Q9ULH0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-42: Missing.
1138-1194: Missing.

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        10         20         30         40         50
MIAAEQGNLE IVKELIKNGA NCNLEDLDNW TALISASKEG HVHIVEELLK 
        60         70         80         90        100
CGVNLEHRDM GGWTALMWAC YKGRTDVVEL LLSHGANPSV TGLYSVYPII 
       110        120        130        140        150
WAAGRGHADI VHLLLQNGAK VNCSDKYGTT PLVWAARKGH LECVKHLLAM 
       160        170        180        190        200
GADVDQEGAN SMTALIVAVK GGYTQSVKEI LKRNPNVNLT DKDGNTALMI 
       210        220        230        240        250
ASKEGHTEIV QDLLDAGTYV NIPDRSGDTV LIGAVRGGHV EIVRALLQKY 
       260        270        280        290        300
ADIDIRGQDN KTALYWAVEK GNATMVRDIL QCNPDTEICT KDGETPLIKA 
       310        320        330        340        350
TKMRNIEVVE LLLDKGAKVS AVDKKGDTPL HIAIRGRSRK LAELLLRNPK 
       360        370        380        390        400
DGRLLYRPNK AGETPYNIDC SHQKSILTQI FGARHLSPTE TDGDMLGYDL 
       410        420        430        440        450
YSSALADILS EPTMQPPICV GLYAQWGSGK SFLLKKLEDE MKTFAGQQIE 
       460        470        480        490        500
PLFQFSWLIV FLTLLLCGGL GLLFAFTVHP NLGIAVSLSF LALLYIFFIV 
       510        520        530        540        550
IYFGGRREGE SWNWAWVLST RLARHIGYLE LLLKLMFVNP PELPEQTTKA 
       560        570        580        590        600
LPVRFLFTDY NRLSSVGGET SLAEMIATLS DACEREFGFL ATRLFRVFKT 
       610        620        630        640        650
EDTQGKKKWK KTCCLPSFVI FLFIIGCIIS GITLLAIFRV DPKHLTVNAV 
       660        670        680        690        700
LISIASVVGL AFVLNCRTWW QVLDSLLNSQ RKRLHNAASK LHKLKSEGFM 
       710        720        730        740        750
KVLKCEVELM ARMAKTIDSF TQNQTRLVVI IDGLDACEQD KVLQMLDTVR 
       760        770        780        790        800
VLFSKGPFIA IFASDPHIII KAINQNLNSV LRDSNINGHD YMRNIVHLPV 
       810        820        830        840        850
FLNSRGLSNA RKFLVTSATN GDVPCSDTTG IQEDADRRVS QNSLGEMTKL 
       860        870        880        890        900
GSKTALNRRD TYRRRQMQRT ITRQMSFDLT KLLVTEDWFS DISPQTMRRL 
       910        920        930        940        950
LNIVSVTGRL LRANQISFNW DRLASWINLT EQWPYRTSWL ILYLEETEGI 
       960        970        980        990       1000
PDQMTLKTIY ERISKNIPTT KDVEPLLEID GDIRNFEVFL SSRTPVLVAR 
      1010       1020       1030       1040       1050
DVKVFLPCTV NLDPKLREII ADVRAAREQI SIGGLAYPPL PLHEGPPRAP 
      1060       1070       1080       1090       1100
SGYSQPPSVC SSTSFNGPFA GGVVSPQPHS SYYSGMTGPQ HPFYNRGSGP 
      1110       1120       1130       1140       1150
APGPVVLLNS LNVDAVCEKL KQIEGLDQSM LPQYCTTIKK ANINGRVLAQ 
      1160       1170       1180       1190       1200
CNIDELKKEM NMNFGDWHLF RSTVLEMRNA ESHVVPEDPR FLSESSSGPA 
      1210       1220       1230       1240       1250
PHGEPARRAS HNELPHTELS SQTPYTLNFS FEELNTLGLD EGAPRHSNLS 
      1260       1270       1280       1290       1300
WQSQTRRTPS LSSLNSQDSS IEISKLTDKV QAEYRDAYRE YIAQMSQLEG 
      1310       1320       1330       1340       1350
GPGSTTISGR SSPHSTYYMG QSSSGGSIHS NLEQEKGKDS EPKPDDGRKS 
      1360       1370       1380       1390       1400
FLMKRGDVID YSSSGVSTND ASPLDPITEE DEKSDQSGSK LLPGKKSSER 
      1410       1420       1430       1440       1450
SSLFQTDLKL KGSGLRYQKL PSDEDESGTE ESDNTPLLKD DKDRKAEGKV 
      1460       1470       1480       1490       1500
ERVPKSPEHS AEPIRTFIKA KEYLSDALLD KKDSSDSGVR SSESSPNHSL 
      1510       1520       1530       1540       1550
HNEVADDSQL EKANLIELED DSHSGKRGIP HSLSGLQDPI IARMSICSED 
      1560       1570       1580       1590       1600
KKSPSECSLI ASSPEENWPA CQKAYNLNRT PSTVTLNNNS APANRANQNF 
      1610       1620       1630       1640       1650
DEMEGIRETS QVILRPSSSP NPTTIQNENL KSMTHKRSQR SSYTRLSKDP 
      1660       1670 
PELHAAASSE STGFGEERES IL

Show »

Length:1,672

Mass (Da):185,546

Checksum:ⁱ103CE2C56521F5A8

Isoform 3 (identifier: Q9ULH0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: L → LQ
     1005-1030: ISKNIPTTKDVEPLLEIDGDIRNFEV → CCGADSCDRDRIGISKSVLVAMLMES
     1031-1771: Missing.

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        10         20         30         40         50
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN 
        60         70         80         90        100
LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR 
       110        120        130        140        150
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLQYSVY PIIWAAGRGH 
       160        170        180        190        200
ADIVHLLLQN GAKVNCSDKY GTTPLVWAAR KGHLECVKHL LAMGADVDQE 
       210        220        230        240        250
GANSMTALIV AVKGGYTQSV KEILKRNPNV NLTDKDGNTA LMIASKEGHT 
       260        270        280        290        300
EIVQDLLDAG TYVNIPDRSG DTVLIGAVRG GHVEIVRALL QKYADIDIRG 
       310        320        330        340        350
QDNKTALYWA VEKGNATMVR DILQCNPDTE ICTKDGETPL IKATKMRNIE 
       360        370        380        390        400
VVELLLDKGA KVSAVDKKGD TPLHIAIRGR SRKLAELLLR NPKDGRLLYR 
       410        420        430        440        450
PNKAGETPYN IDCSHQKSIL TQIFGARHLS PTETDGDMLG YDLYSSALAD 
       460        470        480        490        500
ILSEPTMQPP ICVGLYAQWG SGKSFLLKKL EDEMKTFAGQ QIEPLFQFSW 
       510        520        530        540        550
LIVFLTLLLC GGLGLLFAFT VHPNLGIAVS LSFLALLYIF FIVIYFGGRR 
       560        570        580        590        600
EGESWNWAWV LSTRLARHIG YLELLLKLMF VNPPELPEQT TKALPVRFLF 
       610        620        630        640        650
TDYNRLSSVG GETSLAEMIA TLSDACEREF GFLATRLFRV FKTEDTQGKK 
       660        670        680        690        700
KWKKTCCLPS FVIFLFIIGC IISGITLLAI FRVDPKHLTV NAVLISIASV 
       710        720        730        740        750
VGLAFVLNCR TWWQVLDSLL NSQRKRLHNA ASKLHKLKSE GFMKVLKCEV 
       760        770        780        790        800
ELMARMAKTI DSFTQNQTRL VVIIDGLDAC EQDKVLQMLD TVRVLFSKGP 
       810        820        830        840        850
FIAIFASDPH IIIKAINQNL NSVLRDSNIN GHDYMRNIVH LPVFLNSRGL 
       860        870        880        890        900
SNARKFLVTS ATNGDVPCSD TTGIQEDADR RVSQNSLGEM TKLGSKTALN 
       910        920        930        940        950
RRDTYRRRQM QRTITRQMSF DLTKLLVTED WFSDISPQTM RRLLNIVSVT 
       960        970        980        990       1000
GRLLRANQIS FNWDRLASWI NLTEQWPYRT SWLILYLEET EGIPDQMTLK 
      1010       1020       1030 
TIYERCCGAD SCDRDRIGIS KSVLVAMLME S

Show »

Length:1,031

Mass (Da):115,312

Checksum:ⁱD9E866461C13A2F5

Isoform 4 (identifier: Q9ULH0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1177-1195: Missing.

« Hide

        10         20         30         40         50
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN 
        60         70         80         90        100
LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR 
       110        120        130        140        150
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA 
       160        170        180        190        200
DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG 
       210        220        230        240        250
ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHTE 
       260        270        280        290        300
IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ 
       310        320        330        340        350
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV 
       360        370        380        390        400
VELLLDKGAK VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP 
       410        420        430        440        450
NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI 
       460        470        480        490        500
LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL 
       510        520        530        540        550
IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF IVIYFGGRRE 
       560        570        580        590        600
GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT 
       610        620        630        640        650
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK 
       660        670        680        690        700
WKKTCCLPSF VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV 
       710        720        730        740        750
GLAFVLNCRT WWQVLDSLLN SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE 
       760        770        780        790        800
LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF 
       810        820        830        840        850
IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS 
       860        870        880        890        900
NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR 
       910        920        930        940        950
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG 
       960        970        980        990       1000
RLLRANQISF NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT 
      1010       1020       1030       1040       1050
IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC 
      1060       1070       1080       1090       1100
TVNLDPKLRE IIADVRAARE QISIGGLAYP PLPLHEGPPR APSGYSQPPS 
      1110       1120       1130       1140       1150
VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF FAPYLYTPRY 
      1160       1170       1180       1190       1200
YPGGSQHLIS RPSVKTSLPR DQNNGLGSGP APGPVVLLNS LNVDAVCEKL 
      1210       1220       1230       1240       1250
KQIEGLDQSM LPQYCTTIKK ANINGRVLAQ CNIDELKKEM NMNFGDWHLF 
      1260       1270       1280       1290       1300
RSTVLEMRNA ESHVVPEDPR FLSESSSGPA PHGEPARRAS HNELPHTELS 
      1310       1320       1330       1340       1350
SQTPYTLNFS FEELNTLGLD EGAPRHSNLS WQSQTRRTPS LSSLNSQDSS 
      1360       1370       1380       1390       1400
IEISKLTDKV QAEYRDAYRE YIAQMSQLEG GPGSTTISGR SSPHSTYYMG 
      1410       1420       1430       1440       1450
QSSSGGSIHS NLEQEKGKDS EPKPDDGRKS FLMKRGDVID YSSSGVSTND 
      1460       1470       1480       1490       1500
ASPLDPITEE DEKSDQSGSK LLPGKKSSER SSLFQTDLKL KGSGLRYQKL 
      1510       1520       1530       1540       1550
PSDEDESGTE ESDNTPLLKD DKDRKAEGKV ERVPKSPEHS AEPIRTFIKA 
      1560       1570       1580       1590       1600
KEYLSDALLD KKDSSDSGVR SSESSPNHSL HNEVADDSQL EKANLIELED 
      1610       1620       1630       1640       1650
DSHSGKRGIP HSLSGLQDPI IARMSICSED KKSPSECSLI ASSPEENWPA 
      1660       1670       1680       1690       1700
CQKAYNLNRT PSTVTLNNNS APANRANQNF DEMEGIRETS QVILRPSSSP 
      1710       1720       1730       1740       1750
NPTTIQNENL KSMTHKRSQR SSYTRLSKDP PELHAAASSE STGFGEERES 

IL

Show »

Length:1,752

Mass (Da):194,569

Checksum:ⁱC8FBB42BE1147C90

Isoform 5 (identifier: Q9ULH0-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1228: Missing.

« Hide

        10         20         30         40         50
MLPQYCTTIK KANINGRVLA QCNIDELKKE MNMNFGDWHL FRSTVLEMRN 
        60         70         80         90        100
AESHVVPEDP RFLSESSSGP APHGEPARRA SHNELPHTEL SSQTPYTLNF 
       110        120        130        140        150
SFEELNTLGL DEGAPRHSNL SWQSQTRRTP SLSSLNSQDS SIEISKLTDK 
       160        170        180        190        200
VQAEYRDAYR EYIAQMSQLE GGPGSTTISG RSSPHSTYYM GQSSSGGSIH 
       210        220        230        240        250
SNLEQEKGKD SEPKPDDGRK SFLMKRGDVI DYSSSGVSTN DASPLDPITE 
       260        270        280        290        300
EDEKSDQSGS KLLPGKKSSE RSSLFQTDLK LKGSGLRYQK LPSDEDESGT 
       310        320        330        340        350
EESDNTPLLK DDKDRKAEGK VERVPKSPEH SAEPIRTFIK AKEYLSDALL 
       360        370        380        390        400
DKKDSSDSGV RSSESSPNHS LHNEVADDSQ LEKANLIELE DDSHSGKRGI 
       410        420        430        440        450
PHSLSGLQDP IIARMSICSE DKKSPSECSL IASSPEENWP ACQKAYNLNR 
       460        470        480        490        500
TPSTVTLNNN SAPANRANQN FDEMEGIRET SQVILRPSSS PNPTTIQNEN 
       510        520        530        540 
LKSMTHKRSQ RSSYTRLSKD PPELHAAASS ESTGFGEERE SIL

Show »

Length:543

Mass (Da):59,967

Checksum:ⁱB4A46C01CC4C1F37

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
E9PH70	E9PH70_HUMAN	Kinase D-interacting substrate of 2... Kinase D-interacting substrate of 220 kDa	KIDINS220	1,305	Annotation score:
H0Y8E4	H0Y8E4_HUMAN	Kinase D-interacting substrate of 2... Kinase D-interacting substrate of 220 kDa	KIDINS220	1,057	Annotation score:
A0A1W2PPB7	A0A1W2PPB7_HUMAN	Kinase D-interacting substrate of 2... Kinase D-interacting substrate of 220 kDa	KIDINS220	1,316	Annotation score:
H7C584	H7C584_HUMAN	Kinase D-interacting substrate of 2... Kinase D-interacting substrate of 220 kDa	KIDINS220	151	Annotation score:
F8WAY8	F8WAY8_HUMAN	Kinase D-interacting substrate of 2... Kinase D-interacting substrate of 220 kDa	KIDINS220	36	Annotation score:
A0A1W2PPY4	A0A1W2PPY4_HUMAN	Kinase D-interacting substrate of 2... Kinase D-interacting substrate of 220 kDa	KIDINS220	269	Annotation score:

Sequence cautionⁱ

The sequence BAA86564 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB14728 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1335	T → P in CAE45935 (PubMed:17974005).Curated		1
Sequence conflictⁱ	1613	N → D in BAB14285 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048285	538	I → T. Corresponds to variant dbSNP:rs2289229Ensembl.	1
Natural variantⁱVAR_039399	1307	R → H. Corresponds to variant dbSNP:rs2304591Ensembl.	1
Natural variantⁱVAR_077995	1350 – 1771	Missing in SINO; no effect on protein abundance. 1 PublicationAdd BLAST	422
Natural variantⁱVAR_077996	1366 – 1771	Missing in SINO; no effect on protein abundance; no effect on subcellular localization. 1 PublicationAdd BLAST	406
Natural variantⁱVAR_039400	1608	Q → H3 PublicationsCorresponds to variant dbSNP:rs1044280Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_031861	1 – 1228	Missing in isoform 5. 1 PublicationAdd BLAST	1228
Alternative sequenceⁱVSP_031862	1 – 42	Missing in isoform 2. 1 PublicationAdd BLAST	42
Alternative sequenceⁱVSP_031863	135	L → LQ in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_031864	1005 – 1030	ISKNI…RNFEV → CCGADSCDRDRIGISKSVLV AMLMES in isoform 3. 1 PublicationAdd BLAST	26
Alternative sequenceⁱVSP_031865	1031 – 1771	Missing in isoform 3. 1 PublicationAdd BLAST	741
Alternative sequenceⁱVSP_031866	1138 – 1194	Missing in isoform 2. 1 PublicationAdd BLAST	57
Alternative sequenceⁱVSP_031867	1177 – 1195	Missing in isoform 4. 1 PublicationAdd BLAST	19

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB033076 mRNA Translation: BAA86564.2 Different initiation. AK022873 mRNA Translation: BAB14285.1 AK023926 mRNA Translation: BAB14728.1 Different initiation. AL133620 mRNA Translation: CAB63746.1 AL137553 mRNA Translation: CAB70807.1 BX640878 mRNA Translation: CAE45935.1 BC094714 mRNA Translation: AAH94714.1 BC130610 mRNA Translation: AAI30611.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42650.1 [Q9ULH0-1] CCDS86818.1 [Q9ULH0-4] CCDS86819.1 [Q9ULH0-3]
PIRⁱ	T43458
NCBI Reference Sequences More...RefSeqⁱ	NP_065789.1, NM_020738.2 [Q9ULH0-1]
UniGeneⁱ	Hs.467627 Hs.593330 Hs.9873

Genome annotation databases

Ensemblⁱ	ENST00000256707; ENSP00000256707; ENSG00000134313 [Q9ULH0-1] ENST00000319688; ENSP00000319947; ENSG00000134313 [Q9ULH0-3] ENST00000473731; ENSP00000418974; ENSG00000134313 [Q9ULH0-4]
GeneIDⁱ	57498
KEGGⁱ	hsa:57498
UCSC genome browser More...UCSCⁱ	uc002qzc.2 human [Q9ULH0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULH0	Kinase D interacting substrate 220		FELCA		1784	UniRef90_Q9ULH0
Kinase D interacting substrate 220		COLAP		1777
Kinase D interacting substrate 220		RHIRO		1777
Kinase D interacting substrate 220		MACFA		1777
Kinase D interacting substrate 220		SAIBB		1773
+186
Q9ULH0-2	Kinase D interacting substrate 220		FELCA		1716	UniRef90_Q9ULH0-2
kinase D-interacting substrate of 220 kDa isoform X1		TARSY		1715
Kinase D interacting substrate 220		CALJA		1713
Kidins220 protein		MOUSE		1672
KIDINS220 isoform 5 (Fragment)		PANTR		1305
+59
Q9ULH0-3	KIDINS220 isoform 6		PANTR		1031	UniRef90_A0A2I3RZY8
Kinase D-interacting substrate of 220 kDa		East African grey crowned-crane		1005
UPI000D7226F1		ALLSI		1057
UPI000A39FEE4		ANAPL		1010
UPI000D6A2A98		PYTBI		1005
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9ULH0	Kinase D-interacting substrate of 220 kDa		RAT		1762	UniRef50_Q9EQG6
Kinase D-interacting substrate of 220 kDa B		DANRE		1680
Kinase D interacting substrate 220		PIG		1772
Kinase D-interacting substrate of 220 kDa		CASCN		1766
Kinase D-interacting substrate 220		MOUSE		1763
+1008
Q9ULH0-3	Kinase D-interacting substrate, 220kDa (Fragment)		Iconisemion striatum		1146	UniRef50_A0A1A7WNK4
Kinase D-interacting substrate of 220 kDa (Fragment)		FUNHE		1302
Kinase D-interacting substrate of 220 kDa		MYODS		1241
Kinase D-interacting substrate 220a		GASAC		1009
KIDINS220 isoform 6		PANTR		1031
+23

Entry informationⁱ

Entry nameⁱ	KDIS_HUMAN
Accessionⁱ	Q9ULH0Primary (citable) accession number: Q9ULH0 Secondary accession number(s): A1L4N4 Q9UF42
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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Supporting data

UniProtKB - Q9ULH0 (KDIS_HUMAN)

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Kinase D-interacting substrate of 220 kDa

KIDINS220

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Cytosol

Endosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ