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Entry version 136 (12 Aug 2020)
Sequence version 3 (13 Nov 2007)
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Protein

Cell cycle progression protein 1

Gene

CCPG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9ULG6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell cycle progression protein 1
Alternative name(s):
Cell cycle progression restoration protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCPG1
Synonyms:CCP8, CPR8, KIAA1254
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000260916.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24227, CCPG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611326, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULG6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 217CytoplasmicSequence analysisAdd BLAST217
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei218 – 238Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini239 – 757LumenalSequence analysisAdd BLAST519

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9236

Open Targets

More...
OpenTargetsi
ENSG00000260916

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134967250

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULG6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCPG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160380597

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003105381 – 757Cell cycle progression protein 1Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULG6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULG6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULG6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULG6

PeptideAtlas

More...
PeptideAtlasi
Q9ULG6

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULG6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1897
85016 [Q9ULG6-1]
85017 [Q9ULG6-2]
85018 [Q9ULG6-3]
85019 [Q9ULG6-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9ULG6, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULG6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000260916, Expressed in calcaneal tendon and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULG6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULG6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000260916, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1.

Interacts with GTP-bound CDC42 and SRC (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114665, 40 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULG6, 30 interactors

Molecular INTeraction database

More...
MINTi
Q9ULG6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000403400

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULG6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULG6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 308Interaction with MCF2L and SRCBy similarityAdd BLAST308

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili248 – 272Sequence analysisAdd BLAST25
Coiled coili306 – 450Sequence analysisAdd BLAST145
Coiled coili504 – 530Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi176 – 181Poly-Arg6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCPG1 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWDZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018722_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULG6

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDAFHHW

Database of Orthologous Groups

More...
OrthoDBi
667993at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULG6

TreeFam database of animal gene trees

More...
TreeFami
TF333202

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033588, CCPG1

The PANTHER Classification System

More...
PANTHERi
PTHR28638:SF2, PTHR28638:SF2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL
60 70 80 90 100
QALQIEQGES SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA
110 120 130 140 150
SDDSDIVTLE PPKLEEIGNQ EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE
160 170 180 190 200
TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA RKKTVSASES EDRLVAEQET
210 220 230 240 250
EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI QKRQQLVRKI
260 270 280 290 300
HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK
310 320 330 340 350
TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE
360 370 380 390 400
NQKLKQHLEE EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL
410 420 430 440 450
QQLSGSQLHG KSDSPNVYTE KKEIAILRER LTELERKLTF EQQRSDLWER
460 470 480 490 500
LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK SKETFLGSVK ETFDAMKNST
510 520 530 540 550
KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT KNIFDEKGNK
560 570 580 590 600
RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF
610 620 630 640 650
KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP
660 670 680 690 700
IRMDEFRQII QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF
710 720 730 740 750
VNDVKDYLRN MKEYEVDNDG VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK

PCHYSSL
Length:757
Mass (Da):87,340
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDF496D4431A7976
GO
Isoform 2 (identifier: Q9ULG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-151: TFCQPET → MSTFFLI

Show »
Length:613
Mass (Da):71,854
Checksum:i0114FEFFF8D22908
GO
Isoform 3 (identifier: Q9ULG6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-694: Missing.
     745-757: RSVYIKPCHYSSL → SRPDKKQRMV...LGQLPFDPQY

Show »
Length:424
Mass (Da):48,569
Checksum:iB8A999B9C6722C32
GO
Isoform 4 (identifier: Q9ULG6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     582-598: HNRGPTMQNDGRKEKPV → SRPYYAKRWKERKASSL
     599-757: Missing.

Show »
Length:598
Mass (Da):68,395
Checksum:i6307C36112F2E2F1
GO
Isoform 5 (identifier: Q9ULG6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-757: RSVYIKPCHYSSL → SRPDKKQRMV...LGQLPFDPQY

Show »
Length:807
Mass (Da):93,488
Checksum:i0C87EB9BE5B8AFD0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BV63H3BV63_HUMAN
Cell cycle progression protein 1
CCPG1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNE2H3BNE2_HUMAN
Cell cycle progression protein 1
CCPG1
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQN1H3BQN1_HUMAN
Cell cycle progression protein 1
CCPG1
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTZ1H3BTZ1_HUMAN
Cell cycle progression protein 1
CCPG1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPP4H3BPP4_HUMAN
Cell cycle progression protein 1
CCPG1
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN32H3BN32_HUMAN
Cell cycle progression protein 1
CCPG1
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR24H3BR24_HUMAN
Cell cycle progression protein 1
CCPG1
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB69314 differs from that shown. Reason: Frameshift.Curated
The sequence AAB69314 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH15203 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH29398 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAK14914 differs from that shown. Reason: Frameshift.Curated
The sequence BAA86568 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti196A → G in BAA86568 (PubMed:10574462).Curated1
Sequence conflicti270E → G in BAB14042 (PubMed:14702039).Curated1
Sequence conflicti483E → G in AAH29398 (PubMed:15489334).Curated1
Sequence conflicti483E → G in AAB69314 (PubMed:9383053).Curated1
Sequence conflicti553G → N in AAB69314 (PubMed:9383053).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03706344S → P. Corresponds to variant dbSNP:rs11555304Ensembl.1
Natural variantiVAR_037064161E → V1 PublicationCorresponds to variant dbSNP:rs17853336Ensembl.1
Natural variantiVAR_037065418Y → H. Corresponds to variant dbSNP:rs34958422Ensembl.1
Natural variantiVAR_037066436R → L1 PublicationCorresponds to variant dbSNP:rs17857026Ensembl.1
Natural variantiVAR_037067477A → V1 PublicationCorresponds to variant dbSNP:rs1063562Ensembl.1
Natural variantiVAR_037068517A → D1 PublicationCorresponds to variant dbSNP:rs1063563Ensembl.1
Natural variantiVAR_037069553G → D. Corresponds to variant dbSNP:rs1063565Ensembl.1
Natural variantiVAR_037070553G → S. Corresponds to variant dbSNP:rs1063564Ensembl.1
Natural variantiVAR_037071590N → K. Corresponds to variant dbSNP:rs1063566Ensembl.1
Natural variantiVAR_037072627K → E1 PublicationCorresponds to variant dbSNP:rs17853335Ensembl.1
Natural variantiVAR_037073646T → I1 PublicationCorresponds to variant dbSNP:rs17857027Ensembl.1
Natural variantiVAR_037074673H → R. Corresponds to variant dbSNP:rs1063567Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0293111 – 144Missing in isoform 2. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_029312145 – 151TFCQPET → MSTFFLI in isoform 2. 1 Publication7
Alternative sequenceiVSP_029313312 – 694Missing in isoform 3. 1 PublicationAdd BLAST383
Alternative sequenceiVSP_029314582 – 598HNRGP…KEKPV → SRPYYAKRWKERKASSL in isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_029315599 – 757Missing in isoform 4. 2 PublicationsAdd BLAST159
Alternative sequenceiVSP_029316745 – 757RSVYI…HYSSL → SRPDKKQRMVNIENSRHRKQ EQKHLQPQPYKREGKWHKYG RTNGRQMANLEIELGQLPFD PQY in isoform 3 and isoform 5. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033080 mRNA Translation: BAA86568.2 Different initiation.
AF212228 mRNA Translation: AAK14914.1 Frameshift.
AK022459 mRNA Translation: BAB14042.1
AK292795 mRNA Translation: BAF85484.1
AC013355 Genomic DNA No translation available.
AC018926 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77481.1
BC015203 mRNA Translation: AAH15203.1 Sequence problems.
BC029398 mRNA Translation: AAH29398.1 Sequence problems.
BC034914 mRNA Translation: AAH34914.1
BC039871 mRNA Translation: AAH39871.1
AF011794 mRNA Translation: AAB69314.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42039.1 [Q9ULG6-1]
CCDS55966.1 [Q9ULG6-5]
CCDS55967.1 [Q9ULG6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001191379.1, NM_001204450.1 [Q9ULG6-5]
NP_001191380.1, NM_001204451.1 [Q9ULG6-3]
NP_004739.3, NM_004748.4 [Q9ULG6-1]
NP_065790.2, NM_020739.3 [Q9ULG6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310958; ENSP00000311656; ENSG00000260916 [Q9ULG6-1]
ENST00000425574; ENSP00000415128; ENSG00000260916 [Q9ULG6-3]
ENST00000442196; ENSP00000403400; ENSG00000260916 [Q9ULG6-5]
ENST00000569205; ENSP00000454456; ENSG00000260916 [Q9ULG6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9236

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9236

UCSC genome browser

More...
UCSCi
uc002acv.3, human [Q9ULG6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033080 mRNA Translation: BAA86568.2 Different initiation.
AF212228 mRNA Translation: AAK14914.1 Frameshift.
AK022459 mRNA Translation: BAB14042.1
AK292795 mRNA Translation: BAF85484.1
AC013355 Genomic DNA No translation available.
AC018926 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77481.1
BC015203 mRNA Translation: AAH15203.1 Sequence problems.
BC029398 mRNA Translation: AAH29398.1 Sequence problems.
BC034914 mRNA Translation: AAH34914.1
BC039871 mRNA Translation: AAH39871.1
AF011794 mRNA Translation: AAB69314.1 Sequence problems.
CCDSiCCDS42039.1 [Q9ULG6-1]
CCDS55966.1 [Q9ULG6-5]
CCDS55967.1 [Q9ULG6-3]
RefSeqiNP_001191379.1, NM_001204450.1 [Q9ULG6-5]
NP_001191380.1, NM_001204451.1 [Q9ULG6-3]
NP_004739.3, NM_004748.4 [Q9ULG6-1]
NP_065790.2, NM_020739.3 [Q9ULG6-1]

3D structure databases

SMRiQ9ULG6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114665, 40 interactors
IntActiQ9ULG6, 30 interactors
MINTiQ9ULG6
STRINGi9606.ENSP00000403400

PTM databases

GlyGeniQ9ULG6, 1 site
iPTMnetiQ9ULG6
PhosphoSitePlusiQ9ULG6

Polymorphism and mutation databases

BioMutaiCCPG1
DMDMi160380597

Proteomic databases

EPDiQ9ULG6
jPOSTiQ9ULG6
MassIVEiQ9ULG6
PaxDbiQ9ULG6
PeptideAtlasiQ9ULG6
PRIDEiQ9ULG6
ProteomicsDBi1897
85016 [Q9ULG6-1]
85017 [Q9ULG6-2]
85018 [Q9ULG6-3]
85019 [Q9ULG6-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
57643, 64 antibodies

The DNASU plasmid repository

More...
DNASUi
9236

Genome annotation databases

EnsembliENST00000310958; ENSP00000311656; ENSG00000260916 [Q9ULG6-1]
ENST00000425574; ENSP00000415128; ENSG00000260916 [Q9ULG6-3]
ENST00000442196; ENSP00000403400; ENSG00000260916 [Q9ULG6-5]
ENST00000569205; ENSP00000454456; ENSG00000260916 [Q9ULG6-1]
GeneIDi9236
KEGGihsa:9236
UCSCiuc002acv.3, human [Q9ULG6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9236
DisGeNETi9236
EuPathDBiHostDB:ENSG00000260916.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCPG1
HGNCiHGNC:24227, CCPG1
HPAiENSG00000260916, Low tissue specificity
MIMi611326, gene
neXtProtiNX_Q9ULG6
OpenTargetsiENSG00000260916
PharmGKBiPA134967250

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QWDZ, Eukaryota
GeneTreeiENSGT00940000160497
HOGENOMiCLU_018722_0_0_1
InParanoidiQ9ULG6
OMAiLDAFHHW
OrthoDBi667993at2759
PhylomeDBiQ9ULG6
TreeFamiTF333202

Enzyme and pathway databases

PathwayCommonsiQ9ULG6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9236, 2 hits in 875 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9236
PharosiQ9ULG6, Tbio

Protein Ontology

More...
PROi
PR:Q9ULG6
RNActiQ9ULG6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000260916, Expressed in calcaneal tendon and 197 other tissues
ExpressionAtlasiQ9ULG6, baseline and differential
GenevisibleiQ9ULG6, HS

Family and domain databases

InterProiView protein in InterPro
IPR033588, CCPG1
PANTHERiPTHR28638:SF2, PTHR28638:SF2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCPG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULG6
Secondary accession number(s): A0PJH3
, A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: August 12, 2020
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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