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Protein

Uncharacterized protein KIAA1257

Gene

KIAA1257

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1257
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114656.10
HGNCiHGNC:29231 KIAA1257
neXtProtiNX_Q9ULG3

Pathology & Biotechi

Organism-specific databases

DisGeNETi57501
OpenTargetsiENSG00000114656
PharmGKBiPA142671603

Polymorphism and mutation databases

BioMutaiKIAA1257
DMDMi172044692

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206791 – 409Uncharacterized protein KIAA1257Add BLAST409

Proteomic databases

PaxDbiQ9ULG3
PeptideAtlasiQ9ULG3
PRIDEiQ9ULG3
ProteomicsDBi85014
85015 [Q9ULG3-2]

PTM databases

iPTMnetiQ9ULG3
PhosphoSitePlusiQ9ULG3
SwissPalmiQ9ULG3

Expressioni

Gene expression databases

BgeeiENSG00000114656 Expressed in 101 organ(s), highest expression level in testis
CleanExiHS_KIAA1257
ExpressionAtlasiQ9ULG3 baseline and differential
GenevisibleiQ9ULG3 HS

Organism-specific databases

HPAiHPA042811
HPA048445

Structurei

3D structure databases

ProteinModelPortaliQ9ULG3
SMRiQ9ULG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J2PC Eukaryota
ENOG4112AA9 LUCA
GeneTreeiENSGT00390000007219
HOGENOMiHOG000113162
InParanoidiQ9ULG3
OMAiTHCLPCS
OrthoDBiEOG091G09IU
PhylomeDBiQ9ULG3
TreeFamiTF335973

Family and domain databases

InterProiView protein in InterPro
IPR027876 DUF4550
PfamiView protein in Pfam
PF15084 DUF4550, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULG3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLHAWEWEE DPASIEPISS ITSFYQSTSE CDVEEHLKAK ARAQESDSDR
60 70 80 90 100
PCSSIESSSE PASTFSSDVP HVVPCKFTIS LAFPVNMGQK GKYASLIEKY
110 120 130 140 150
KKHPKTDSSV TKMRRFYHIE YFLLPDDEEP KKVDILLFPM VAKVFLESGV
160 170 180 190 200
KTVKPWHEGD KAWVSWEQTF NITVTKELLK KINFHKITLR LWNTKDKMSR
210 220 230 240 250
KVRYYRLKTA GFTDDVGAFH KSEVRHLVLN QRKLSEQGIE NTNIVREESN
260 270 280 290 300
QEHPPGKQEK TEKHPKSLQG SHQAEPETSS KNSEEYEKSL KMDDSSTIQW
310 320 330 340 350
SVSRTPTISL AGASMMEIKE LIESESLSSL TNILDRQRSQ IKGKDSEGRR
360 370 380 390 400
KIQRRHKKPL AEEEADPTLT GPRKQSAFSI QLAVMPLLAG THCLPCSQQL

LLVLWPERP
Length:409
Mass (Da):46,740
Last modified:February 26, 2008 - v2
Checksum:i7B8A2DB2DD7F2B30
GO
Isoform 2 (identifier: Q9ULG3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Note: No experimental confirmation available.
Show »
Length:297
Mass (Da):34,344
Checksum:i13B3DD963BAF3B8D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RH05D6RH05_HUMAN
HCG20001, isoform CRA_b
KIAA1257 hCG_20001
400Annotation score:
A0A1B0GVL5A0A1B0GVL5_HUMAN
Uncharacterized protein KIAA1257
KIAA1257
298Annotation score:
A0A2R8YFM9A0A2R8YFM9_HUMAN
Uncharacterized protein KIAA1257
KIAA1257
1,081Annotation score:
A0A2R8YAI9A0A2R8YAI9_HUMAN
Uncharacterized protein KIAA1257
KIAA1257
32Annotation score:

Sequence cautioni

The sequence AAH38736 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA86571 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW79289 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317391 – 112Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033083 mRNA Translation: BAA86571.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79289.1 Different initiation.
BC031632 mRNA Translation: AAH31632.1
BC038736 mRNA Translation: AAH38736.1 Different initiation.
CCDSiCCDS46905.1 [Q9ULG3-1]
CCDS87133.1 [Q9ULG3-2]
RefSeqiNP_001335451.1, NM_001348522.1 [Q9ULG3-2]
NP_001335452.1, NM_001348523.1 [Q9ULG3-2]
NP_065792.1, NM_020741.2 [Q9ULG3-1]
UniGeneiHs.518247
Hs.734225

Genome annotation databases

EnsembliENST00000265068; ENSP00000265068; ENSG00000114656 [Q9ULG3-1]
ENST00000515659; ENSP00000422539; ENSG00000114656 [Q9ULG3-2]
GeneIDi57501
KEGGihsa:57501
UCSCiuc003eli.5 human [Q9ULG3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033083 mRNA Translation: BAA86571.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79289.1 Different initiation.
BC031632 mRNA Translation: AAH31632.1
BC038736 mRNA Translation: AAH38736.1 Different initiation.
CCDSiCCDS46905.1 [Q9ULG3-1]
CCDS87133.1 [Q9ULG3-2]
RefSeqiNP_001335451.1, NM_001348522.1 [Q9ULG3-2]
NP_001335452.1, NM_001348523.1 [Q9ULG3-2]
NP_065792.1, NM_020741.2 [Q9ULG3-1]
UniGeneiHs.518247
Hs.734225

3D structure databases

ProteinModelPortaliQ9ULG3
SMRiQ9ULG3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9ULG3
PhosphoSitePlusiQ9ULG3
SwissPalmiQ9ULG3

Polymorphism and mutation databases

BioMutaiKIAA1257
DMDMi172044692

Proteomic databases

PaxDbiQ9ULG3
PeptideAtlasiQ9ULG3
PRIDEiQ9ULG3
ProteomicsDBi85014
85015 [Q9ULG3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265068; ENSP00000265068; ENSG00000114656 [Q9ULG3-1]
ENST00000515659; ENSP00000422539; ENSG00000114656 [Q9ULG3-2]
GeneIDi57501
KEGGihsa:57501
UCSCiuc003eli.5 human [Q9ULG3-1]

Organism-specific databases

CTDi57501
DisGeNETi57501
EuPathDBiHostDB:ENSG00000114656.10
GeneCardsiKIAA1257
HGNCiHGNC:29231 KIAA1257
HPAiHPA042811
HPA048445
neXtProtiNX_Q9ULG3
OpenTargetsiENSG00000114656
PharmGKBiPA142671603
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2PC Eukaryota
ENOG4112AA9 LUCA
GeneTreeiENSGT00390000007219
HOGENOMiHOG000113162
InParanoidiQ9ULG3
OMAiTHCLPCS
OrthoDBiEOG091G09IU
PhylomeDBiQ9ULG3
TreeFamiTF335973

Miscellaneous databases

ChiTaRSiKIAA1257 human
GenomeRNAii57501
PROiPR:Q9ULG3

Gene expression databases

BgeeiENSG00000114656 Expressed in 101 organ(s), highest expression level in testis
CleanExiHS_KIAA1257
ExpressionAtlasiQ9ULG3 baseline and differential
GenevisibleiQ9ULG3 HS

Family and domain databases

InterProiView protein in InterPro
IPR027876 DUF4550
PfamiView protein in Pfam
PF15084 DUF4550, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK1257_HUMAN
AccessioniPrimary (citable) accession number: Q9ULG3
Secondary accession number(s): Q8IXY7, Q8N5T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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