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Protein

Chromatin-remodeling ATPase INO80

Gene

INO80

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).7 Publications

Miscellaneous

Although the ATP-dependent helicase activity displayed by the INO80 complex requires INO80 ATPase activity, it is likely that the helicase function is carried out by the other components of the complex, RUVBL1 and RUVBL2, and not by INO80 itself.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated upon binding to double stranded DNA or nucleosomes.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=167 µM for ATP1 Publication

    pH dependencei

    Optimum pH is 7.1 Publication

    Temperature dependencei

    Optimum temperature is 37 degrees Celsius.1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi543 – 550ATPPROSITE-ProRule annotation8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • actin binding Source: UniProtKB-KW
    • alpha-tubulin binding Source: UniProtKB
    • ATPase activity Source: GO_Central
    • ATP binding Source: UniProtKB-KW
    • DNA binding Source: UniProtKB
    • DNA-dependent ATPase activity Source: UniProtKB
    • histone binding Source: GO_Central

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionActin-binding, DNA-binding, Hydrolase
    Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, Mitosis
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-5689603 UCH proteinases
    R-HSA-5696394 DNA Damage Recognition in GG-NER

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Chromatin-remodeling ATPase INO80Curated (EC:3.6.4.-2 Publications)
    Short name:
    hINO80
    Alternative name(s):
    DNA helicase-related INO80 complex homolog 1Curated
    DNA helicase-related protein INO80Curated
    INO80 complex subunit A
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:INO80
    Synonyms:INO80A, INOC1, KIAA1259
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000128908.15

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:26956 INO80

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610169 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9ULG1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi653E → Q: Abolishes DNA-dependent ATPase and nucleosome remodeling activities. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    54617

    Open Targets

    More...
    OpenTargetsi
    ENSG00000128908

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162392040

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    INO80

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    114149322

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002488291 – 1556Chromatin-remodeling ATPase INO80Add BLAST1556

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118N6-acetyllysineCombined sources1
    Modified residuei1512PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9ULG1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9ULG1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9ULG1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9ULG1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9ULG1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9ULG1

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    85013

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9ULG1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9ULG1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000128908 Expressed in 203 organ(s), highest expression level in prostate gland

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_INO80

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9ULG1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9ULG1 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA041417
    HPA041484

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Component of the chromatin remodeling INO80 complex; three different complex modules assemble on different domains of INO80 (PubMed:16230350, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with DDB1 (PubMed:20855601). Interacts with transcriptional repressor protein YY1; the interaction recruits the INO80 complex to YY1 target genes (PubMed:17721549, PubMed:18026119). Interacts with YY1AP1 (PubMed:27939641). Interacts with tubulin alpha (PubMed:20237820).8 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    120076, 39 interactors

    ComplexPortal: manually curated resource of macromolecular complexes

    More...
    ComplexPortali
    CPX-846 INO80 chromatin remodeling complex

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q9ULG1

    Database of interacting proteins

    More...
    DIPi
    DIP-34296N

    Protein interaction database and analysis system

    More...
    IntActi
    Q9ULG1, 22 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9ULG1

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000355205

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6HTSelectron microscopy4.80G267-1556[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9ULG1

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9ULG1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini280 – 405DBINOPROSITE-ProRule annotationAdd BLAST126
    Domaini530 – 701Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST172
    Domaini1105 – 1260Helicase C-terminalPROSITE-ProRule annotationAdd BLAST156

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 266Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D1 PublicationAdd BLAST266
    Regioni212 – 526Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY11 PublicationAdd BLAST315
    Regioni521 – 1556Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL21 PublicationAdd BLAST1036

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The DBINO region is involved in binding to DNA.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0388 Eukaryota
    ENOG410XP0A LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00900000141110

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000231795

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG057875

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9ULG1

    KEGG Orthology (KO)

    More...
    KOi
    K11665

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NTMAEVR

    Database of Orthologous Groups

    More...
    OrthoDBi
    188211at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9ULG1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324408

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00079 HELICc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.10810, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020838 DBINO
    IPR014001 Helicase_ATP-bd
    IPR001650 Helicase_C
    IPR031047 Ino80
    IPR027417 P-loop_NTPase
    IPR038718 SNF2-like_sf
    IPR000330 SNF2_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10799:SF868 PTHR10799:SF868, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13892 DBINO, 1 hit
    PF00271 Helicase_C, 1 hit
    PF00176 SNF2_N, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00487 DEXDc, 1 hit
    SM00490 HELICc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51413 DBINO, 1 hit
    PS51192 HELICASE_ATP_BIND_1, 1 hit
    PS51194 HELICASE_CTER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    Q9ULG1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MASELGARDD GGCTELAKPL YLQYLERALR LDHFLRQTSA IFNRNISSDD
    60 70 80 90 100
    SEDGLDDSNP LLPQSGDPLI QVKEEPPNSL LGETSGAGSS GMLNTYSLNG
    110 120 130 140 150
    VLQSESKCDK GNLYNFSKLK KSRKWLKSIL LSDESSEADS QSEDDDEEEL
    160 170 180 190 200
    NLSREELHNM LRLHKYKKLH QNKYSKDKEL QQYQYYSAGL LSTYDPFYEQ
    210 220 230 240 250
    QRHLLGPKKK KFKEEKKLKA KLKKVKKKRR RDEELSSEES PRRHHHQTKV
    260 270 280 290 300
    FAKFSHDAPP PGTKKKHLSI EQLNARRRKV WLSIVKKELP KANKQKASAR
    310 320 330 340 350
    NLFLTNSRKL AHQCMKEVRR AALQAQKNCK ETLPRARRLT KEMLLYWKKY
    360 370 380 390 400
    EKVEKEHRKR AEKEALEQRK LDEEMREAKR QQRKLNFLIT QTELYAHFMS
    410 420 430 440 450
    RKRDMGHDGI QEEILRKLED SSTQRQIDIG GGVVVNITQE DYDSNHFKAQ
    460 470 480 490 500
    ALKNAENAYH IHQARTRSFD EDAKESRAAA LRAANKSGTG FGESYSLANP
    510 520 530 540 550
    SIRAGEDIPQ PTIFNGKLKG YQLKGMNWLA NLYEQGINGI LADEMGLGKT
    560 570 580 590 600
    VQSIALLAHL AERENIWGPF LIISPASTLN NWHQEFTRFV PKFKVLPYWG
    610 620 630 640 650
    NPHDRKVIRR FWSQKTLYTQ DAPFHVVITS YQLVVQDVKY FQRVKWQYMV
    660 670 680 690 700
    LDEAQALKSS SSVRWKILLQ FQCRNRLLLT GTPIQNTMAE LWALLHFIMP
    710 720 730 740 750
    TLFDSHEEFN EWFSKDIESH AENKSAIDEN QLSRLHMILK PFMLRRIKKD
    760 770 780 790 800
    VENELSDKIE ILMYCQLTSR QKLLYQALKN KISIEDLLQS SMGSTQQAQN
    810 820 830 840 850
    TTSSLMNLVM QFRKVCNHPE LFERQETWSP FHISLKPYHI SKFIYRHGQI
    860 870 880 890 900
    RVFNHSRDRW LRVLSPFAPD YIQRSLFHRK GINEESCFSF LRFIDISPAE
    910 920 930 940 950
    MANLMLQGLL ARWLALFLSL KASYRLHQLR SWGAPEGESH QRYLRNKDFL
    960 970 980 990 1000
    LGVNFPLSFP NLCSCPLLKS LVFSSHCKAV SGYSDQVVHQ RRSATSSLRR
    1010 1020 1030 1040 1050
    CLLTELPSFL CVASPRVTAV PLDSYCNDRS AEYERRVLKE GGSLAAKQCL
    1060 1070 1080 1090 1100
    LNGAPELAAD WLNRRSQFFP EPAGGLWSIR PQNGWSFIRI PGKESLITDS
    1110 1120 1130 1140 1150
    GKLYALDVLL TRLKSQGHRV LIYSQMTRMI DLLEEYMVYR KHTYMRLDGS
    1160 1170 1180 1190 1200
    SKISERRDMV ADFQNRNDIF VFLLSTRAGG LGINLTAADT VIFYDSDWNP
    1210 1220 1230 1240 1250
    TVDQQAMDRA HRLGQTKQVT VYRLICKGTI EERILQRAKE KSEIQRMVIS
    1260 1270 1280 1290 1300
    GGNFKPDTLK PKEVVSLLLD DEELEKKLRL RQEEKRQQEE TNRVKERKRK
    1310 1320 1330 1340 1350
    REKYAEKKKK EDELDGKRRK EGVNLVIPFV PSADNSNLSA DGDDSFISVD
    1360 1370 1380 1390 1400
    SAMPSPFSEI SISSELHTGS IPLDESSSDM LVIVDDPASS APQSRATNSP
    1410 1420 1430 1440 1450
    ASITGSVSDT VNGISIQEMP AAGRGHSARS RGRPKGSGST AKGAGKGRSR
    1460 1470 1480 1490 1500
    KSTAGSAAAM AGAKAGAAAA SAAAYAAYGY NVSKGISASS PLQTSLVRPA
    1510 1520 1530 1540 1550
    GLADFGPSSA SSPLSSPLSK GNNVPGNPKN LHMTSSLAPD SLVRKQGKGT

    NPSGGR
    Length:1,556
    Mass (Da):176,753
    Last modified:September 5, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i712A1EEA26D6A720
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YMN5H0YMN5_HUMAN
    Chromatin-remodeling ATPase INO80
    INO80
    1,104Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087X0U7A0A087X0U7_HUMAN
    Chromatin-remodeling ATPase INO80
    INO80
    192Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YNL3H0YNL3_HUMAN
    Chromatin-remodeling ATPase INO80
    INO80
    91Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKH3H0YKH3_HUMAN
    Chromatin-remodeling ATPase INO80
    INO80
    27Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA86573 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049500882I → V. Corresponds to variant dbSNP:rs34153025Ensembl.1
    Natural variantiVAR_0612331108V → G. Corresponds to variant dbSNP:rs34178030Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB033085 mRNA Translation: BAA86573.1 Different initiation.
    CH471125 Genomic DNA Translation: EAW92469.1
    BC146785 mRNA Translation: AAI46786.1
    AL137280 mRNA Translation: CAB70675.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS10071.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T46350

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_060023.1, NM_017553.2

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.292949

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000361937; ENSP00000355205; ENSG00000128908
    ENST00000401393; ENSP00000384686; ENSG00000128908
    ENST00000648947; ENSP00000497609; ENSG00000128908

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    54617

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:54617

    UCSC genome browser

    More...
    UCSCi
    uc001zni.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB033085 mRNA Translation: BAA86573.1 Different initiation.
    CH471125 Genomic DNA Translation: EAW92469.1
    BC146785 mRNA Translation: AAI46786.1
    AL137280 mRNA Translation: CAB70675.1
    CCDSiCCDS10071.1
    PIRiT46350
    RefSeqiNP_060023.1, NM_017553.2
    UniGeneiHs.292949

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6HTSelectron microscopy4.80G267-1556[»]
    ProteinModelPortaliQ9ULG1
    SMRiQ9ULG1
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi120076, 39 interactors
    ComplexPortaliCPX-846 INO80 chromatin remodeling complex
    CORUMiQ9ULG1
    DIPiDIP-34296N
    IntActiQ9ULG1, 22 interactors
    MINTiQ9ULG1
    STRINGi9606.ENSP00000355205

    PTM databases

    iPTMnetiQ9ULG1
    PhosphoSitePlusiQ9ULG1

    Polymorphism and mutation databases

    BioMutaiINO80
    DMDMi114149322

    Proteomic databases

    EPDiQ9ULG1
    jPOSTiQ9ULG1
    MaxQBiQ9ULG1
    PaxDbiQ9ULG1
    PeptideAtlasiQ9ULG1
    PRIDEiQ9ULG1
    ProteomicsDBi85013

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000361937; ENSP00000355205; ENSG00000128908
    ENST00000401393; ENSP00000384686; ENSG00000128908
    ENST00000648947; ENSP00000497609; ENSG00000128908
    GeneIDi54617
    KEGGihsa:54617
    UCSCiuc001zni.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    54617
    DisGeNETi54617
    EuPathDBiHostDB:ENSG00000128908.15

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    INO80
    HGNCiHGNC:26956 INO80
    HPAiHPA041417
    HPA041484
    MIMi610169 gene
    neXtProtiNX_Q9ULG1
    OpenTargetsiENSG00000128908
    PharmGKBiPA162392040

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0388 Eukaryota
    ENOG410XP0A LUCA
    GeneTreeiENSGT00900000141110
    HOGENOMiHOG000231795
    HOVERGENiHBG057875
    InParanoidiQ9ULG1
    KOiK11665
    OMAiNTMAEVR
    OrthoDBi188211at2759
    PhylomeDBiQ9ULG1
    TreeFamiTF324408

    Enzyme and pathway databases

    ReactomeiR-HSA-5689603 UCH proteinases
    R-HSA-5696394 DNA Damage Recognition in GG-NER

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    INO80 human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    54617

    Protein Ontology

    More...
    PROi
    PR:Q9ULG1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000128908 Expressed in 203 organ(s), highest expression level in prostate gland
    CleanExiHS_INO80
    ExpressionAtlasiQ9ULG1 baseline and differential
    GenevisibleiQ9ULG1 HS

    Family and domain databases

    CDDicd00079 HELICc, 1 hit
    Gene3Di3.40.50.10810, 1 hit
    InterProiView protein in InterPro
    IPR020838 DBINO
    IPR014001 Helicase_ATP-bd
    IPR001650 Helicase_C
    IPR031047 Ino80
    IPR027417 P-loop_NTPase
    IPR038718 SNF2-like_sf
    IPR000330 SNF2_N
    PANTHERiPTHR10799:SF868 PTHR10799:SF868, 1 hit
    PfamiView protein in Pfam
    PF13892 DBINO, 1 hit
    PF00271 Helicase_C, 1 hit
    PF00176 SNF2_N, 1 hit
    SMARTiView protein in SMART
    SM00487 DEXDc, 1 hit
    SM00490 HELICc, 1 hit
    SUPFAMiSSF52540 SSF52540, 2 hits
    PROSITEiView protein in PROSITE
    PS51413 DBINO, 1 hit
    PS51192 HELICASE_ATP_BIND_1, 1 hit
    PS51194 HELICASE_CTER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINO80_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULG1
    Secondary accession number(s): A6H8X4, Q9NTG6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: January 16, 2019
    This is version 154 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
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