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Protein

Zinc transporter ZIP10

Gene

SLC39A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.1 Publication

Miscellaneous

High levels of expression are correlated with invasiveness in several breast cancer lines.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Protein family/group databases

TCDBi2.A.5.4.6 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:SLC39A10
Synonyms:KIAA1265, ZIP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000196950.13
HGNCiHGNC:20861 SLC39A10
MIMi608733 gene
neXtProtiNX_Q9ULF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei759 – 779HelicalSequence analysisAdd BLAST21
Transmembranei801 – 821HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57181
OpenTargetsiENSG00000196950
PharmGKBiPA134944068

Polymorphism and mutation databases

BioMutaiSLC39A10
DMDMi156630627

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000029763226 – 831Zinc transporter ZIP10Add BLAST806

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei536PhosphothreonineCombined sources1
Modified residuei553PhosphothreonineCombined sources1
Modified residuei591PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9ULF5
PaxDbiQ9ULF5
PeptideAtlasiQ9ULF5
PRIDEiQ9ULF5
ProteomicsDBi85012

PTM databases

iPTMnetiQ9ULF5
PhosphoSitePlusiQ9ULF5
SwissPalmiQ9ULF5

Expressioni

Gene expression databases

BgeeiENSG00000196950 Expressed in 197 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_SLC39A10
ExpressionAtlasiQ9ULF5 baseline and differential
GenevisibleiQ9ULF5 HS

Organism-specific databases

HPAiHPA036512
HPA036513
HPA066087

Interactioni

Protein-protein interaction databases

BioGridi121430, 39 interactors
IntActiQ9ULF5, 23 interactors
STRINGi9606.ENSP00000352655

Structurei

3D structure databases

ProteinModelPortaliQ9ULF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 40His-richAdd BLAST15
Compositional biasi101 – 197His-richAdd BLAST97
Compositional biasi458 – 483His-richAdd BLAST26
Compositional biasi607 – 656His-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000013093
HOVERGENiHBG055748
InParanoidiQ9ULF5
KOiK14716
OMAiDPGHGHQ
OrthoDBiEOG091G02WM
PhylomeDBiQ9ULF5
TreeFamiTF318470

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK
60 70 80 90 100
FSKQAAENEK KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN
110 120 130 140 150
HEDLGHDHVS HLDILAVQEG KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN
160 170 180 190 200
HKCDPEKETV EVSVKSDDKH MHDHNHRLRH HHRLHHHLDH NNTHHFHNDS
210 220 230 240 250
ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS NENSEVITPG
260 270 280 290 300
FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD
310 320 330 340 350
NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG
360 370 380 390 400
ANSPISTDLF TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA
410 420 430 440 450
NIGASAWICG IISITVISLL SLLGVILVPI INQGCFKFLL TFLVALAVGT
460 470 480 490 500
MSGDALLHLL PHSQGGHDHS HQHAHGHGHS HGHESNKFLE EYDAVLKGLV
510 520 530 540 550
ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST IGRKLSDHKL
560 570 580 590 600
NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE
610 620 630 640 650
EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH
660 670 680 690 700
SHGPCHSGSD LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI
710 720 730 740 750
STSIAVFCHE LPHELGDFAV LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT
760 770 780 790 800
AVGQYANNIT LWIFAVTAGM FLYVALVDML PEMLHGDGDN EEHGFCPVGQ
810 820 830
FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F
Length:831
Mass (Da):94,132
Last modified:August 21, 2007 - v2
Checksum:iE196111D12BC20ED
GO
Isoform 2 (identifier: Q9ULF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-450: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,363
Checksum:i348C2C05EE85730E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ENT5E7ENT5_HUMAN
Zinc transporter ZIP10
SLC39A10
126Annotation score:
E7EV45E7EV45_HUMAN
Zinc transporter ZIP10
SLC39A10
130Annotation score:
C9J0F5C9J0F5_HUMAN
Zinc transporter ZIP10
SLC39A10
38Annotation score:
F2Z341F2Z341_HUMAN
Zinc transporter ZIP10
SLC39A10
39Annotation score:

Sequence cautioni

The sequence BAA86579 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43393 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426I → T in CAB43393 (PubMed:17974005).Curated1
Sequence conflicti426I → T in CAH18673 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03465887T → S. Corresponds to variant dbSNP:rs13419724Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559911 – 450Missing in isoform 2. 1 PublicationAdd BLAST450

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033091 mRNA Translation: BAA86579.1 Different initiation.
AK291241 mRNA Translation: BAF83930.1
AK294771 mRNA Translation: BAG57901.1
AL050294 mRNA Translation: CAB43393.1 Sequence problems.
CR749813 mRNA Translation: CAH18673.1
AC013274 Genomic DNA No translation available.
AC064834 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70116.1
BC073909 mRNA Translation: AAH73909.1
BC101516 mRNA Translation: AAI01517.1
BC112223 mRNA Translation: AAI12224.1
CCDSiCCDS33353.1 [Q9ULF5-1]
PIRiT08684
RefSeqiNP_001120729.1, NM_001127257.1 [Q9ULF5-1]
NP_065075.1, NM_020342.2 [Q9ULF5-1]
XP_005246746.2, XM_005246689.4 [Q9ULF5-1]
XP_011509806.1, XM_011511504.2 [Q9ULF5-1]
XP_011509807.1, XM_011511505.2 [Q9ULF5-1]
XP_011509808.1, XM_011511506.2 [Q9ULF5-1]
UniGeneiHs.650158

Genome annotation databases

EnsembliENST00000359634; ENSP00000352655; ENSG00000196950 [Q9ULF5-1]
ENST00000409086; ENSP00000386766; ENSG00000196950 [Q9ULF5-1]
GeneIDi57181
KEGGihsa:57181
UCSCiuc002utg.5 human [Q9ULF5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033091 mRNA Translation: BAA86579.1 Different initiation.
AK291241 mRNA Translation: BAF83930.1
AK294771 mRNA Translation: BAG57901.1
AL050294 mRNA Translation: CAB43393.1 Sequence problems.
CR749813 mRNA Translation: CAH18673.1
AC013274 Genomic DNA No translation available.
AC064834 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70116.1
BC073909 mRNA Translation: AAH73909.1
BC101516 mRNA Translation: AAI01517.1
BC112223 mRNA Translation: AAI12224.1
CCDSiCCDS33353.1 [Q9ULF5-1]
PIRiT08684
RefSeqiNP_001120729.1, NM_001127257.1 [Q9ULF5-1]
NP_065075.1, NM_020342.2 [Q9ULF5-1]
XP_005246746.2, XM_005246689.4 [Q9ULF5-1]
XP_011509806.1, XM_011511504.2 [Q9ULF5-1]
XP_011509807.1, XM_011511505.2 [Q9ULF5-1]
XP_011509808.1, XM_011511506.2 [Q9ULF5-1]
UniGeneiHs.650158

3D structure databases

ProteinModelPortaliQ9ULF5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121430, 39 interactors
IntActiQ9ULF5, 23 interactors
STRINGi9606.ENSP00000352655

Protein family/group databases

TCDBi2.A.5.4.6 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

iPTMnetiQ9ULF5
PhosphoSitePlusiQ9ULF5
SwissPalmiQ9ULF5

Polymorphism and mutation databases

BioMutaiSLC39A10
DMDMi156630627

Proteomic databases

EPDiQ9ULF5
PaxDbiQ9ULF5
PeptideAtlasiQ9ULF5
PRIDEiQ9ULF5
ProteomicsDBi85012

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359634; ENSP00000352655; ENSG00000196950 [Q9ULF5-1]
ENST00000409086; ENSP00000386766; ENSG00000196950 [Q9ULF5-1]
GeneIDi57181
KEGGihsa:57181
UCSCiuc002utg.5 human [Q9ULF5-1]

Organism-specific databases

CTDi57181
DisGeNETi57181
EuPathDBiHostDB:ENSG00000196950.13
GeneCardsiSLC39A10
H-InvDBiHIX0002690
HGNCiHGNC:20861 SLC39A10
HPAiHPA036512
HPA036513
HPA066087
MIMi608733 gene
neXtProtiNX_Q9ULF5
OpenTargetsiENSG00000196950
PharmGKBiPA134944068
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00760000119115
HOGENOMiHOG000013093
HOVERGENiHBG055748
InParanoidiQ9ULF5
KOiK14716
OMAiDPGHGHQ
OrthoDBiEOG091G02WM
PhylomeDBiQ9ULF5
TreeFamiTF318470

Enzyme and pathway databases

ReactomeiR-HSA-442380 Zinc influx into cells by the SLC39 gene family

Miscellaneous databases

ChiTaRSiSLC39A10 human
GeneWikiiSLC39A10
GenomeRNAii57181
PROiPR:Q9ULF5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196950 Expressed in 197 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_SLC39A10
ExpressionAtlasiQ9ULF5 baseline and differential
GenevisibleiQ9ULF5 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
PfamiView protein in Pfam
PF02535 Zip, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS39AA_HUMAN
AccessioniPrimary (citable) accession number: Q9ULF5
Secondary accession number(s): A8K5C6
, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9Y3Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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