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Entry version 122 (16 Oct 2019)
Sequence version 4 (18 May 2010)
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Protein

DENN domain-containing protein 2A

Gene

DENND2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND2A
Synonyms:KIAA1277
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:22212 DENND2A

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9ULE3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000146966

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134931054

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9ULE3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DENND2A

Domain mapping of disease mutations (DMDM)

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DMDMi
296439469

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002426821 – 1009DENN domain-containing protein 2AAdd BLAST1009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei551PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9ULE3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9ULE3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9ULE3

PeptideAtlas

More...
PeptideAtlasi
Q9ULE3

PRoteomics IDEntifications database

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PRIDEi
Q9ULE3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
85008 [Q9ULE3-1]
85009 [Q9ULE3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9ULE3

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9ULE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146966 Expressed in 182 organ(s), highest expression level in lower esophagus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9ULE3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULE3 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118031, 1 interactor

Protein interaction database and analysis system

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IntActi
Q9ULE3, 4 interactors

Molecular INTeraction database

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MINTi
Q9ULE3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000275884

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini566 – 715uDENNPROSITE-ProRule annotationAdd BLAST150
Domaini737 – 870cDENNPROSITE-ProRule annotationAdd BLAST134
Domaini872 – 969dDENNPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3569 Eukaryota
ENOG410XT3N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182931

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000273875

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9ULE3

KEGG Orthology (KO)

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KOi
K20161

Identification of Orthologs from Complete Genome Data

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OMAi
ETQMFGG

Database of Orthologous Groups

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OrthoDBi
138384at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULE3

TreeFam database of animal gene trees

More...
TreeFami
TF320336

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDMFSLDMII SDPAAEASRA GKKQLRGVQN PCPSARARPR HKSLNIKDKI
60 70 80 90 100
SEWEGKKEVP TPAPSRRADG QEDYLPSSTV ERRSSDGVRT QVTEAKNGMR
110 120 130 140 150
PGTESTEKER NKGAVNVGGQ DPEPGQDLSQ PEREVDPSWG RGREPRLGKL
160 170 180 190 200
RFQNDPLSVL KQVKKLEQAL KDGSAGLDPQ LPGTCYSPHC PPDKAEAGST
210 220 230 240 250
LPENLGGGSG SEVSQRVHPS DLEGREPTPE LVEDRKGSCR RPWDRSLENV
260 270 280 290 300
YRGSEGSPTK PFINPLPKPR RTFKHAGEGD KDGKPGIGFR KEKRNLPPLP
310 320 330 340 350
SLPPPPLPSS PPPSSVNRRL WTGRQKSSAD HRKSYEFEDL LQSSSESSRV
360 370 380 390 400
DWYAQTKLGL TRTLSEENVY EDILDPPMKE NPYEDIELHG RCLGKKCVLN
410 420 430 440 450
FPASPTSSIP DTLTKQSLSK PAFFRQNSER RNFKLLDTRK LSRDGTGSPS
460 470 480 490 500
KISPPSTPSS PDDIFFNLGD PQNGRKKRKI PKLVLRINAI YEVRRGKKRV
510 520 530 540 550
KRLSQSMESN SGKVTDENSE SDSDTEEKLK AHSQRLVNVK SRLKQAPRYP
560 570 580 590 600
SLARELIEYQ ERQLFEYFVV VSLHKKQAGA AYVPELTQQF PLKLERSFKF
610 620 630 640 650
MREAEDQLKA IPQFCFPDAK DWVPVQQFTS ETFSFVLTGE DGSRRFGYCR
660 670 680 690 700
RLLPGGKGKR LPEVYCIVSR LGCFSLFSRI LDEVEKRRGI SPALVQPLMR
710 720 730 740 750
SVMEAPFPAL GKTILVKNFL PGSGTEVIEL CRPLDSRLEH VDFESLFSSL
760 770 780 790 800
SVRHLVCVFA SLLLERRVIF IADKLSILSK CCHAMVALIY PFAWQHTYIP
810 820 830 840 850
VLPPAMVDIV CSPTPFLIGL LSSSLPLLRE LPLEEVLVVD LVNSRFLRQM
860 870 880 890 900
DDEDSILPRK LQVALEHILE QRNELACEQD EGPLDGRHGP ESSPLNEVVS
910 920 930 940 950
EAFVRFFVEI VGHYSLFLTS GEREERTLQR EAFRKAVSSK SLRHFLEVFM
960 970 980 990 1000
ETQMFRGFIQ ERELRRQDAK GLFEVRAQEY LETLPSGEHS GVNKFLKGLG

NKMKFLHKK
Length:1,009
Mass (Da):113,853
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A596E6999F8AF3E
GO
Isoform 2 (identifier: Q9ULE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     776-800: SILSKCCHAMVALIYPFAWQHTYIP → RYPPWLLLLKRLNDSRSWTL
     801-1009: Missing.

Note: No experimental confirmation available.
Show »
Length:795
Mass (Da):89,514
Checksum:i945B7C1E37FB287B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAT8F8WAT8_HUMAN
DENN domain-containing protein 2A
DENND2A
864Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IY76C9IY76_HUMAN
DENN domain-containing protein 2A
DENND2A
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JD15C9JD15_HUMAN
DENN domain-containing protein 2A
DENND2A
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYZ8C9IYZ8_HUMAN
DENN domain-containing protein 2A
DENND2A
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JAA0C9JAA0_HUMAN
DENN domain-containing protein 2A
DENND2A
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5K8H7C5K8_HUMAN
DENN domain-containing protein 2A
DENND2A
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86591 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti600F → L in AAH49193 (PubMed:15489334).Curated1
Sequence conflicti864A → V in BAA86591 (PubMed:10574462).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026856156P → H2 PublicationsCorresponds to variant dbSNP:rs269243Ensembl.1
Natural variantiVAR_026857729E → K. Corresponds to variant dbSNP:rs2293177Ensembl.1
Natural variantiVAR_026858777I → T. Corresponds to variant dbSNP:rs6464833Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019466776 – 800SILSK…HTYIP → RYPPWLLLLKRLNDSRSWTL in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_019467801 – 1009Missing in isoform 2. 1 PublicationAdd BLAST209

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033103 mRNA Translation: BAA86591.2 Different initiation.
AC006452 Genomic DNA No translation available.
AC069335 Genomic DNA No translation available.
BC049193 mRNA Translation: AAH49193.1
BC115004 mRNA Translation: AAI15005.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43659.1 [Q9ULE3-1]
CCDS83233.1 [Q9ULE3-2]

NCBI Reference Sequences

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RefSeqi
NP_001304981.1, NM_001318052.1 [Q9ULE3-1]
NP_001304982.1, NM_001318053.1 [Q9ULE3-2]
NP_056504.3, NM_015689.4 [Q9ULE3-1]
XP_005250034.1, XM_005249977.3
XP_011514354.1, XM_011516052.2
XP_011514355.1, XM_011516053.2 [Q9ULE3-1]
XP_016867478.1, XM_017011989.1 [Q9ULE3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000275884; ENSP00000275884; ENSG00000146966 [Q9ULE3-1]
ENST00000492720; ENSP00000419464; ENSG00000146966 [Q9ULE3-2]
ENST00000496613; ENSP00000419654; ENSG00000146966 [Q9ULE3-1]
ENST00000537639; ENSP00000442245; ENSG00000146966 [Q9ULE3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27147

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27147

UCSC genome browser

More...
UCSCi
uc003vvw.3 human [Q9ULE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033103 mRNA Translation: BAA86591.2 Different initiation.
AC006452 Genomic DNA No translation available.
AC069335 Genomic DNA No translation available.
BC049193 mRNA Translation: AAH49193.1
BC115004 mRNA Translation: AAI15005.1
CCDSiCCDS43659.1 [Q9ULE3-1]
CCDS83233.1 [Q9ULE3-2]
RefSeqiNP_001304981.1, NM_001318052.1 [Q9ULE3-1]
NP_001304982.1, NM_001318053.1 [Q9ULE3-2]
NP_056504.3, NM_015689.4 [Q9ULE3-1]
XP_005250034.1, XM_005249977.3
XP_011514354.1, XM_011516052.2
XP_011514355.1, XM_011516053.2 [Q9ULE3-1]
XP_016867478.1, XM_017011989.1 [Q9ULE3-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi118031, 1 interactor
IntActiQ9ULE3, 4 interactors
MINTiQ9ULE3
STRINGi9606.ENSP00000275884

PTM databases

iPTMnetiQ9ULE3
PhosphoSitePlusiQ9ULE3
SwissPalmiQ9ULE3

Polymorphism and mutation databases

BioMutaiDENND2A
DMDMi296439469

Proteomic databases

jPOSTiQ9ULE3
MassIVEiQ9ULE3
PaxDbiQ9ULE3
PeptideAtlasiQ9ULE3
PRIDEiQ9ULE3
ProteomicsDBi85008 [Q9ULE3-1]
85009 [Q9ULE3-2]

Genome annotation databases

EnsembliENST00000275884; ENSP00000275884; ENSG00000146966 [Q9ULE3-1]
ENST00000492720; ENSP00000419464; ENSG00000146966 [Q9ULE3-2]
ENST00000496613; ENSP00000419654; ENSG00000146966 [Q9ULE3-1]
ENST00000537639; ENSP00000442245; ENSG00000146966 [Q9ULE3-1]
GeneIDi27147
KEGGihsa:27147
UCSCiuc003vvw.3 human [Q9ULE3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27147

GeneCards: human genes, protein and diseases

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GeneCardsi
DENND2A
HGNCiHGNC:22212 DENND2A
neXtProtiNX_Q9ULE3
OpenTargetsiENSG00000146966
PharmGKBiPA134931054

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3569 Eukaryota
ENOG410XT3N LUCA
GeneTreeiENSGT00950000182931
HOGENOMiHOG000273875
InParanoidiQ9ULE3
KOiK20161
OMAiETQMFGG
OrthoDBi138384at2759
PhylomeDBiQ9ULE3
TreeFamiTF320336

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DENND2A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27147
PharosiQ9ULE3

Protein Ontology

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PROi
PR:Q9ULE3

Gene expression databases

BgeeiENSG00000146966 Expressed in 182 organ(s), highest expression level in lower esophagus
ExpressionAtlasiQ9ULE3 baseline and differential
GenevisibleiQ9ULE3 HS

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULE3
Secondary accession number(s): C9JUI3, Q1RMD5, Q86XY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 122 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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