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UniProtKB - Q9ULD9 (ZN608_HUMAN)

Entry version 137 (29 Sep 2021)
Sequence version 4 (18 May 2010)
Previous versions | rss
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Protein

Zinc finger protein 608

Gene

ZNF608

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor, which represses ZNF609 transcription.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri553 – 578C2H2-typeAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULD9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 608
Alternative name(s):
Renal carcinoma antigen NY-REN-36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF608
Synonyms:KIAA1281
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29238, ZNF608

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULD9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168916

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57507

Open Targets

More...OpenTargetsi		ENSG00000168916

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134945727

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULD9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF608

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804201 – 1512Zinc finger protein 608Add BLAST1512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei421PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei481PhosphothreonineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei627PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Cross-linki880Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei895PhosphoserineCombined sources1
Modified residuei964PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Cross-linki1118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULD9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULD9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULD9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULD9

PeptideAtlas

More...PeptideAtlasi		Q9ULD9

PRoteomics IDEntifications database

More...PRIDEi		Q9ULD9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85004 [Q9ULD9-1]
85005 [Q9ULD9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168916, Expressed in stomach and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULD9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULD9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168916, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121571, 38 interactors

Database of interacting proteins

More...DIPi		DIP-29419N

Protein interaction database and analysis system

More...IntActi		Q9ULD9, 6 interactors

Molecular INTeraction database

More...MINTi		Q9ULD9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000307746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULD9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULD9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni46 – 74DisorderedSequence analysisAdd BLAST29
Regioni89 – 237DisorderedSequence analysisAdd BLAST149
Regioni260 – 295DisorderedSequence analysisAdd BLAST36
Regioni417 – 545DisorderedSequence analysisAdd BLAST129
Regioni622 – 665DisorderedSequence analysisAdd BLAST44
Regioni713 – 750DisorderedSequence analysisAdd BLAST38
Regioni777 – 858DisorderedSequence analysisAdd BLAST82
Regioni925 – 996DisorderedSequence analysisAdd BLAST72
Regioni1011 – 1066DisorderedSequence analysisAdd BLAST56
Regioni1117 – 1192DisorderedSequence analysisAdd BLAST76
Regioni1220 – 1335DisorderedSequence analysisAdd BLAST116
Regioni1423 – 1459DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili278 – 304Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 67Polar residuesSequence analysisAdd BLAST18
Compositional biasi149 – 181Polar residuesSequence analysisAdd BLAST33
Compositional biasi187 – 219Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi281 – 295Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi490 – 513Polar residuesSequence analysisAdd BLAST24
Compositional biasi524 – 545Polar residuesSequence analysisAdd BLAST22
Compositional biasi713 – 731Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi817 – 858Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi925 – 941Polar residuesSequence analysisAdd BLAST17
Compositional biasi956 – 994Polar residuesSequence analysisAdd BLAST39
Compositional biasi1029 – 1052Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1122 – 1144Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1145 – 1192Polar residuesSequence analysisAdd BLAST48
Compositional biasi1254 – 1275Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1292 – 1323Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi1434 – 1455Basic and acidic residuesSequence analysisAdd BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri553 – 578C2H2-typeAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSUK, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004142_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULD9

Identification of Orthologs from Complete Genome Data

More...OMAi		NHRRIKK

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULD9

TreeFam database of animal gene trees

More...TreeFami		TF329775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040010, ZN608/ZN609
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR21564, PTHR21564, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM 
        60         70         80         90        100
NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE 
       110        120        130        140        150
TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN 
       160        170        180        190        200
SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG 
       210        220        230        240        250
AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF 
       260        270        280        290        300
HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT 
       310        320        330        340        350
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV 
       360        370        380        390        400
GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT 
       410        420        430        440        450
YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS 
       460        470        480        490        500
FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR 
       510        520        530        540        550
KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP 
       560        570        580        590        600
VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE 
       610        620        630        640        650
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS 
       660        670        680        690        700
IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL 
       710        720        730        740        750
EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI 
       760        770        780        790        800
AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT 
       810        820        830        840        850
VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP 
       860        870        880        890        900
GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS 
       910        920        930        940        950
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG 
       960        970        980        990       1000
SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY 
      1010       1020       1030       1040       1050
DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK 
      1060       1070       1080       1090       1100
KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA 
      1110       1120       1130       1140       1150
YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS 
      1160       1170       1180       1190       1200
ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA 
      1210       1220       1230       1240       1250
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK 
      1260       1270       1280       1290       1300
YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH 
      1310       1320       1330       1340       1350
PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP 
      1360       1370       1380       1390       1400
YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN 
      1410       1420       1430       1440       1450
TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD 
      1460       1470       1480       1490       1500
RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA 
      1510 
SASGMFPGQR RE
Length:1,512
Mass (Da):162,208
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46A41B939FEBD054
GO
Isoform 2 (identifier: Q9ULD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.

Show »
Length:1,085
Mass (Da):118,140
Checksum:i403673466FB904E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KPE6B3KPE6_HUMAN
Zinc finger protein 608
ZNF608
707Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2RRB2A2RRB2_HUMAN
ZNF608 protein
ZNF608
447Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGB8A0A0C4DGB8_HUMAN
Zinc finger protein 608
ZNF608
715Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86595 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1512E → G in CAH18418 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031148721T → N4 PublicationsCorresponds to variant dbSNP:rs6862252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0236641 – 427Missing in isoform 2. 1 PublicationAdd BLAST427

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB033107 mRNA Translation: BAA86595.2 Different initiation.
CR749624 mRNA Translation: CAH18418.1
AC112196 Genomic DNA No translation available.
AC113398 Genomic DNA No translation available.
BC038370 mRNA Translation: AAH38370.1
BC103742 mRNA Translation: AAI03743.1
BC151226 mRNA Translation: AAI51227.1
AF155106 mRNA Translation: AAD42872.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34219.1 [Q9ULD9-1]

NCBI Reference Sequences

More...RefSeqi		NP_065798.2, NM_020747.2 [Q9ULD9-1]
XP_005272094.1, XM_005272037.2 [Q9ULD9-1]
XP_005272095.1, XM_005272038.1 [Q9ULD9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306315; ENSP00000307746; ENSG00000168916 [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916 [Q9ULD9-2]
ENST00000513986; ENSP00000421899; ENSG00000168916 [Q9ULD9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57507

UCSC genome browser

More...UCSCi		uc003ktq.2, human [Q9ULD9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033107 mRNA Translation: BAA86595.2 Different initiation.
CR749624 mRNA Translation: CAH18418.1
AC112196 Genomic DNA No translation available.
AC113398 Genomic DNA No translation available.
BC038370 mRNA Translation: AAH38370.1
BC103742 mRNA Translation: AAI03743.1
BC151226 mRNA Translation: AAI51227.1
AF155106 mRNA Translation: AAD42872.1
CCDSiCCDS34219.1 [Q9ULD9-1]
RefSeqiNP_065798.2, NM_020747.2 [Q9ULD9-1]
XP_005272094.1, XM_005272037.2 [Q9ULD9-1]
XP_005272095.1, XM_005272038.1 [Q9ULD9-1]

3D structure databases

SMRiQ9ULD9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121571, 38 interactors
DIPiDIP-29419N
IntActiQ9ULD9, 6 interactors
MINTiQ9ULD9
STRINGi9606.ENSP00000307746

PTM databases

iPTMnetiQ9ULD9
PhosphoSitePlusiQ9ULD9

Genetic variation databases

BioMutaiZNF608
DMDMi296453083

Proteomic databases

EPDiQ9ULD9
jPOSTiQ9ULD9
MassIVEiQ9ULD9
PaxDbiQ9ULD9
PeptideAtlasiQ9ULD9
PRIDEiQ9ULD9
ProteomicsDBi85004 [Q9ULD9-1]
85005 [Q9ULD9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1014, 91 antibodies

The DNASU plasmid repository

More...DNASUi		57507

Genome annotation databases

EnsembliENST00000306315; ENSP00000307746; ENSG00000168916 [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916 [Q9ULD9-2]
ENST00000513986; ENSP00000421899; ENSG00000168916 [Q9ULD9-1]
GeneIDi57507
KEGGihsa:57507
UCSCiuc003ktq.2, human [Q9ULD9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57507
DisGeNETi57507

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF608
HGNCiHGNC:29238, ZNF608
HPAiENSG00000168916, Low tissue specificity
neXtProtiNX_Q9ULD9
OpenTargetsiENSG00000168916
PharmGKBiPA134945727
VEuPathDBiHostDB:ENSG00000168916

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSUK, Eukaryota
GeneTreeiENSGT00390000008748
HOGENOMiCLU_004142_1_0_1
InParanoidiQ9ULD9
OMAiNHRRIKK
PhylomeDBiQ9ULD9
TreeFamiTF329775

Enzyme and pathway databases

PathwayCommonsiQ9ULD9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57507, 8 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF608, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57507
PharosiQ9ULD9, Tdark

Protein Ontology

More...PROi		PR:Q9ULD9
RNActiQ9ULD9, protein

Gene expression databases

BgeeiENSG00000168916, Expressed in stomach and 197 other tissues
ExpressionAtlasiQ9ULD9, baseline and differential
GenevisibleiQ9ULD9, HS

Family and domain databases

InterProiView protein in InterPro
IPR040010, ZN608/ZN609
IPR013087, Znf_C2H2_type
PANTHERiPTHR21564, PTHR21564, 1 hit
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN608_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD9
Secondary accession number(s): A7E2W9
, Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 137 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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