UniProtKB - Q9ULD9 (ZN608_HUMAN)
Protein
Zinc finger protein 608
Gene
ZNF608
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor, which represses ZNF609 transcription.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 553 – 578 | C2H2-typeAdd BLAST | 26 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9ULD9 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 608Alternative name(s): Renal carcinoma antigen NY-REN-36 |
Gene namesi | Name:ZNF608 Synonyms:KIAA1281 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000168916.15 |
HGNCi | HGNC:29238, ZNF608 |
neXtProti | NX_Q9ULD9 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 57507 |
OpenTargetsi | ENSG00000168916 |
PharmGKBi | PA134945727 |
Miscellaneous databases
Pharosi | Q9ULD9, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF608 |
DMDMi | 296453083 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280420 | 1 – 1512 | Zinc finger protein 608Add BLAST | 1512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 283 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 421 | PhosphoserineBy similarity | 1 | |
Modified residuei | 424 | PhosphoserineBy similarity | 1 | |
Modified residuei | 481 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 493 | PhosphoserineBy similarity | 1 | |
Modified residuei | 627 | PhosphoserineCombined sources | 1 | |
Modified residuei | 782 | PhosphoserineCombined sources | 1 | |
Cross-linki | 880 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 895 | PhosphoserineCombined sources | 1 | |
Modified residuei | 964 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1098 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1176 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1199 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1216 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1234 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1250 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1292 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1310 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1414 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9ULD9 |
jPOSTi | Q9ULD9 |
MassIVEi | Q9ULD9 |
PaxDbi | Q9ULD9 |
PeptideAtlasi | Q9ULD9 |
PRIDEi | Q9ULD9 |
ProteomicsDBi | 85004 [Q9ULD9-1] 85005 [Q9ULD9-2] |
PTM databases
iPTMneti | Q9ULD9 |
PhosphoSitePlusi | Q9ULD9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168916, Expressed in stomach and 197 other tissues |
ExpressionAtlasi | Q9ULD9, baseline and differential |
Genevisiblei | Q9ULD9, HS |
Organism-specific databases
HPAi | ENSG00000168916, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121571, 7 interactors |
DIPi | DIP-29419N |
IntActi | Q9ULD9, 3 interactors |
STRINGi | 9606.ENSP00000307746 |
Miscellaneous databases
RNActi | Q9ULD9, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 278 – 304 | Sequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 54 – 57 | Poly-Thr | 4 | |
Compositional biasi | 310 – 315 | Poly-Pro | 6 | |
Compositional biasi | 441 – 444 | Poly-Ala | 4 | |
Compositional biasi | 754 – 764 | Poly-ThrAdd BLAST | 11 | |
Compositional biasi | 809 – 822 | Poly-LysAdd BLAST | 14 | |
Compositional biasi | 929 – 1007 | Ser-richAdd BLAST | 79 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 553 – 578 | C2H2-typeAdd BLAST | 26 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QSUK, Eukaryota |
GeneTreei | ENSGT00390000008748 |
HOGENOMi | CLU_004142_1_0_1 |
InParanoidi | Q9ULD9 |
OMAi | DRHSPFS |
PhylomeDBi | Q9ULD9 |
TreeFami | TF329775 |
Family and domain databases
InterProi | View protein in InterPro IPR040010, ZN608/ZN609 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21564, PTHR21564, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM
60 70 80 90 100
NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE
110 120 130 140 150
TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN
160 170 180 190 200
SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG
210 220 230 240 250
AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF
260 270 280 290 300
HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT
310 320 330 340 350
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV
360 370 380 390 400
GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT
410 420 430 440 450
YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS
460 470 480 490 500
FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR
510 520 530 540 550
KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP
560 570 580 590 600
VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE
610 620 630 640 650
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS
660 670 680 690 700
IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL
710 720 730 740 750
EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI
760 770 780 790 800
AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT
810 820 830 840 850
VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP
860 870 880 890 900
GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS
910 920 930 940 950
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG
960 970 980 990 1000
SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY
1010 1020 1030 1040 1050
DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK
1060 1070 1080 1090 1100
KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA
1110 1120 1130 1140 1150
YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS
1160 1170 1180 1190 1200
ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA
1210 1220 1230 1240 1250
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK
1260 1270 1280 1290 1300
YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH
1310 1320 1330 1340 1350
PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP
1360 1370 1380 1390 1400
YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN
1410 1420 1430 1440 1450
TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD
1460 1470 1480 1490 1500
RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA
1510
SASGMFPGQR RE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB3KPE6 | B3KPE6_HUMAN | Zinc finger protein 608 | ZNF608 | 707 | Annotation score: | ||
A0A0C4DGB8 | A0A0C4DGB8_HUMAN | Zinc finger protein 608 | ZNF608 | 715 | Annotation score: | ||
A2RRB2 | A2RRB2_HUMAN | ZNF608 protein | ZNF608 | 447 | Annotation score: |
Sequence cautioni
The sequence BAA86595 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1512 | E → G in CAH18418 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031148 | 721 | T → N4 PublicationsCorresponds to variant dbSNP:rs6862252Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023664 | 1 – 427 | Missing in isoform 2. 1 PublicationAdd BLAST | 427 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033107 mRNA Translation: BAA86595.2 Different initiation. CR749624 mRNA Translation: CAH18418.1 AC112196 Genomic DNA No translation available. AC113398 Genomic DNA No translation available. BC038370 mRNA Translation: AAH38370.1 BC103742 mRNA Translation: AAI03743.1 BC151226 mRNA Translation: AAI51227.1 AF155106 mRNA Translation: AAD42872.1 |
CCDSi | CCDS34219.1 [Q9ULD9-1] |
RefSeqi | NP_065798.2, NM_020747.2 [Q9ULD9-1] XP_005272094.1, XM_005272037.2 [Q9ULD9-1] XP_005272095.1, XM_005272038.1 [Q9ULD9-1] |
Genome annotation databases
Ensembli | ENST00000306315; ENSP00000307746; ENSG00000168916 [Q9ULD9-1] ENST00000504926; ENSP00000427657; ENSG00000168916 [Q9ULD9-2] |
GeneIDi | 57507 |
KEGGi | hsa:57507 |
UCSCi | uc003ktq.2, human [Q9ULD9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033107 mRNA Translation: BAA86595.2 Different initiation. CR749624 mRNA Translation: CAH18418.1 AC112196 Genomic DNA No translation available. AC113398 Genomic DNA No translation available. BC038370 mRNA Translation: AAH38370.1 BC103742 mRNA Translation: AAI03743.1 BC151226 mRNA Translation: AAI51227.1 AF155106 mRNA Translation: AAD42872.1 |
CCDSi | CCDS34219.1 [Q9ULD9-1] |
RefSeqi | NP_065798.2, NM_020747.2 [Q9ULD9-1] XP_005272094.1, XM_005272037.2 [Q9ULD9-1] XP_005272095.1, XM_005272038.1 [Q9ULD9-1] |
3D structure databases
SMRi | Q9ULD9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121571, 7 interactors |
DIPi | DIP-29419N |
IntActi | Q9ULD9, 3 interactors |
STRINGi | 9606.ENSP00000307746 |
PTM databases
iPTMneti | Q9ULD9 |
PhosphoSitePlusi | Q9ULD9 |
Polymorphism and mutation databases
BioMutai | ZNF608 |
DMDMi | 296453083 |
Proteomic databases
EPDi | Q9ULD9 |
jPOSTi | Q9ULD9 |
MassIVEi | Q9ULD9 |
PaxDbi | Q9ULD9 |
PeptideAtlasi | Q9ULD9 |
PRIDEi | Q9ULD9 |
ProteomicsDBi | 85004 [Q9ULD9-1] 85005 [Q9ULD9-2] |
Protocols and materials databases
Antibodypediai | 1014, 86 antibodies |
Genome annotation databases
Ensembli | ENST00000306315; ENSP00000307746; ENSG00000168916 [Q9ULD9-1] ENST00000504926; ENSP00000427657; ENSG00000168916 [Q9ULD9-2] |
GeneIDi | 57507 |
KEGGi | hsa:57507 |
UCSCi | uc003ktq.2, human [Q9ULD9-1] |
Organism-specific databases
CTDi | 57507 |
DisGeNETi | 57507 |
EuPathDBi | HostDB:ENSG00000168916.15 |
GeneCardsi | ZNF608 |
HGNCi | HGNC:29238, ZNF608 |
HPAi | ENSG00000168916, Low tissue specificity |
neXtProti | NX_Q9ULD9 |
OpenTargetsi | ENSG00000168916 |
PharmGKBi | PA134945727 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSUK, Eukaryota |
GeneTreei | ENSGT00390000008748 |
HOGENOMi | CLU_004142_1_0_1 |
InParanoidi | Q9ULD9 |
OMAi | DRHSPFS |
PhylomeDBi | Q9ULD9 |
TreeFami | TF329775 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULD9 |
Miscellaneous databases
BioGRID-ORCSi | 57507, 4 hits in 849 CRISPR screens |
ChiTaRSi | ZNF608, human |
GenomeRNAii | 57507 |
Pharosi | Q9ULD9, Tdark |
PROi | PR:Q9ULD9 |
RNActi | Q9ULD9, protein |
Gene expression databases
Bgeei | ENSG00000168916, Expressed in stomach and 197 other tissues |
ExpressionAtlasi | Q9ULD9, baseline and differential |
Genevisiblei | Q9ULD9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR040010, ZN608/ZN609 IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21564, PTHR21564, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN608_HUMAN | |
Accessioni | Q9ULD9Primary (citable) accession number: Q9ULD9 Secondary accession number(s): A7E2W9 Q9Y5A1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations