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Entry version 126 (18 Sep 2019)
Sequence version 4 (18 May 2010)
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Protein

Zinc finger protein 608

Gene

ZNF608

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor, which represses ZNF609 transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri553 – 578C2H2-typeAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 608
Alternative name(s):
Renal carcinoma antigen NY-REN-36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF608
Synonyms:KIAA1281
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29238 ZNF608

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULD9

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57507

Open Targets

More...
OpenTargetsi
ENSG00000168916

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134945727

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF608

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804201 – 1512Zinc finger protein 608Add BLAST1512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei421PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei481PhosphothreonineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei627PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Cross-linki880Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei895PhosphoserineCombined sources1
Modified residuei964PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Cross-linki1118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1310Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9ULD9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9ULD9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9ULD9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULD9

PeptideAtlas

More...
PeptideAtlasi
Q9ULD9

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULD9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85004 [Q9ULD9-1]
85005 [Q9ULD9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000168916 Expressed in 184 organ(s), highest expression level in stomach

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9ULD9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULD9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005545

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121571, 7 interactors

Database of interacting proteins

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DIPi
DIP-29419N

Protein interaction database and analysis system

More...
IntActi
Q9ULD9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307746

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULD9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili278 – 304Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 57Poly-Thr4
Compositional biasi310 – 315Poly-Pro6
Compositional biasi441 – 444Poly-Ala4
Compositional biasi754 – 764Poly-ThrAdd BLAST11
Compositional biasi809 – 822Poly-LysAdd BLAST14
Compositional biasi929 – 1007Ser-richAdd BLAST79

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri553 – 578C2H2-typeAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IIE1 Eukaryota
ENOG410Z79M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082539

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULD9

Identification of Orthologs from Complete Genome Data

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OMAi
HSPYYHG

Database of Orthologous Groups

More...
OrthoDBi
60503at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULD9

TreeFam database of animal gene trees

More...
TreeFami
TF329775

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040010 ZN608/ZN609
IPR013087 Znf_C2H2_type

The PANTHER Classification System

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PANTHERi
PTHR21564 PTHR21564, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM
60 70 80 90 100
NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE
110 120 130 140 150
TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN
160 170 180 190 200
SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG
210 220 230 240 250
AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF
260 270 280 290 300
HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT
310 320 330 340 350
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV
360 370 380 390 400
GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT
410 420 430 440 450
YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS
460 470 480 490 500
FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR
510 520 530 540 550
KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP
560 570 580 590 600
VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE
610 620 630 640 650
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS
660 670 680 690 700
IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL
710 720 730 740 750
EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI
760 770 780 790 800
AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT
810 820 830 840 850
VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP
860 870 880 890 900
GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS
910 920 930 940 950
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG
960 970 980 990 1000
SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY
1010 1020 1030 1040 1050
DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK
1060 1070 1080 1090 1100
KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA
1110 1120 1130 1140 1150
YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS
1160 1170 1180 1190 1200
ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA
1210 1220 1230 1240 1250
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK
1260 1270 1280 1290 1300
YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH
1310 1320 1330 1340 1350
PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP
1360 1370 1380 1390 1400
YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN
1410 1420 1430 1440 1450
TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD
1460 1470 1480 1490 1500
RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA
1510
SASGMFPGQR RE
Length:1,512
Mass (Da):162,208
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i46A41B939FEBD054
GO
Isoform 2 (identifier: Q9ULD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.

Note: No experimental confirmation available.
Show »
Length:1,085
Mass (Da):118,140
Checksum:i403673466FB904E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KPE6B3KPE6_HUMAN
Zinc finger protein 608
ZNF608
707Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGB8A0A0C4DGB8_HUMAN
Zinc finger protein 608
ZNF608
715Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2RRB2A2RRB2_HUMAN
ZNF608 protein
ZNF608
447Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1512E → G in CAH18418 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031148721T → N4 PublicationsCorresponds to variant dbSNP:rs6862252Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0236641 – 427Missing in isoform 2. 1 PublicationAdd BLAST427

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB033107 mRNA Translation: BAA86595.2 Different initiation.
CR749624 mRNA Translation: CAH18418.1
AC112196 Genomic DNA No translation available.
AC113398 Genomic DNA No translation available.
BC038370 mRNA Translation: AAH38370.1
BC103742 mRNA Translation: AAI03743.1
BC151226 mRNA Translation: AAI51227.1
AF155106 mRNA Translation: AAD42872.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34219.1 [Q9ULD9-1]

NCBI Reference Sequences

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RefSeqi
NP_065798.2, NM_020747.2 [Q9ULD9-1]
XP_005272094.1, XM_005272037.2 [Q9ULD9-1]
XP_005272095.1, XM_005272038.1 [Q9ULD9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000306315; ENSP00000307746; ENSG00000168916 [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916 [Q9ULD9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57507

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57507

UCSC genome browser

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UCSCi
uc003ktq.2 human [Q9ULD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033107 mRNA Translation: BAA86595.2 Different initiation.
CR749624 mRNA Translation: CAH18418.1
AC112196 Genomic DNA No translation available.
AC113398 Genomic DNA No translation available.
BC038370 mRNA Translation: AAH38370.1
BC103742 mRNA Translation: AAI03743.1
BC151226 mRNA Translation: AAI51227.1
AF155106 mRNA Translation: AAD42872.1
CCDSiCCDS34219.1 [Q9ULD9-1]
RefSeqiNP_065798.2, NM_020747.2 [Q9ULD9-1]
XP_005272094.1, XM_005272037.2 [Q9ULD9-1]
XP_005272095.1, XM_005272038.1 [Q9ULD9-1]

3D structure databases

SMRiQ9ULD9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121571, 7 interactors
DIPiDIP-29419N
IntActiQ9ULD9, 3 interactors
STRINGi9606.ENSP00000307746

PTM databases

iPTMnetiQ9ULD9
PhosphoSitePlusiQ9ULD9

Polymorphism and mutation databases

BioMutaiZNF608
DMDMi296453083

Proteomic databases

EPDiQ9ULD9
jPOSTiQ9ULD9
MassIVEiQ9ULD9
PaxDbiQ9ULD9
PeptideAtlasiQ9ULD9
PRIDEiQ9ULD9
ProteomicsDBi85004 [Q9ULD9-1]
85005 [Q9ULD9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306315; ENSP00000307746; ENSG00000168916 [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916 [Q9ULD9-2]
GeneIDi57507
KEGGihsa:57507
UCSCiuc003ktq.2 human [Q9ULD9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57507
DisGeNETi57507

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF608
HGNCiHGNC:29238 ZNF608
HPAiHPA005545
neXtProtiNX_Q9ULD9
OpenTargetsiENSG00000168916
PharmGKBiPA134945727

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIE1 Eukaryota
ENOG410Z79M LUCA
GeneTreeiENSGT00390000008748
HOGENOMiHOG000082539
InParanoidiQ9ULD9
OMAiHSPYYHG
OrthoDBi60503at2759
PhylomeDBiQ9ULD9
TreeFamiTF329775

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF608 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57507

Pharos

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Pharosi
Q9ULD9

Protein Ontology

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PROi
PR:Q9ULD9

Gene expression databases

BgeeiENSG00000168916 Expressed in 184 organ(s), highest expression level in stomach
ExpressionAtlasiQ9ULD9 baseline and differential
GenevisibleiQ9ULD9 HS

Family and domain databases

InterProiView protein in InterPro
IPR040010 ZN608/ZN609
IPR013087 Znf_C2H2_type
PANTHERiPTHR21564 PTHR21564, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN608_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD9
Secondary accession number(s): A7E2W9
, Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 126 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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