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UniProtKB - Q9ULD8 (KCNH3_HUMAN)

Entry version 175 (02 Dec 2020)
Sequence version 2 (28 Nov 2002)
Previous versions | rss
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Protein

Potassium voltage-gated channel subfamily H member 3

Gene

KCNH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi582 – 697cNMPAdd BLAST116

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULD8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296072, Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.20.5, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Brain-specific eag-like channel 1
Short name:
BEC1
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
ELK2
Voltage-gated potassium channel subunit Kv12.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNH3
Synonyms:KIAA1282
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000135519.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:6252, KCNH3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604527, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULD8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 228CytoplasmicSequence analysisAdd BLAST228
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei229 – 249Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini250 – 259ExtracellularSequence analysis10
Transmembranei260 – 280Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini281 – 302CytoplasmicSequence analysisAdd BLAST22
Transmembranei303 – 323Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini324 – 331ExtracellularSequence analysis8
Transmembranei332 – 352Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini353 – 361CytoplasmicSequence analysis9
Transmembranei362 – 382Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini383 – 453ExtracellularSequence analysisAdd BLAST71
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei454 – 474Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini475 – 479ExtracellularSequence analysis5
Transmembranei480 – 500Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini501 – 1083CytoplasmicSequence analysisAdd BLAST583

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23416

Open Targets

More...OpenTargetsi		ENSG00000135519

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30038

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULD8, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2363017

Drug and drug target database

More...DrugBanki		DB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine

DrugCentral

More...DrugCentrali		Q9ULD8

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		576

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNH3

Domain mapping of disease mutations (DMDM)

More...DMDMi		26006814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000540051 – 1083Potassium voltage-gated channel subfamily H member 3Add BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi428N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULD8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULD8

PeptideAtlas

More...PeptideAtlasi		Q9ULD8

PRoteomics IDEntifications database

More...PRIDEi		Q9ULD8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85003

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9ULD8, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULD8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULD8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135519, Expressed in right frontal lobe and 130 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULD8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULD8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135519, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9ULD8, 2 interactors

Molecular INTeraction database

More...MINTi		Q9ULD8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000257981

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULD8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULD8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 90PASPROSITE-ProRule annotationAdd BLAST73
Domaini93 – 145PACPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi465 – 470Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi951 – 1057Pro-richAdd BLAST107

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0498, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005746_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULD8

Identification of Orthologs from Complete Genome Data

More...OMAi		YIGQQEI

Database of Orthologous Groups

More...OrthoDBi		247304at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULD8

TreeFam database of animal gene trees

More...TreeFami		TF313130

Family and domain databases

Conserved Domains Database

More...CDDi		cd00038, CAP_ED, 1 hit
cd00130, PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR003938, K_chnl_volt-dep_EAG/ELK/ERG
IPR003950, K_chnl_volt-dep_ELK
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF13426, PAS_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01463, EAGCHANLFMLY
PR01465, ELKCHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00100, cNMP, 1 hit
SM00086, PAC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51206, SSF51206, 1 hit
SSF55785, SSF55785, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00229, sensory_box, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS50113, PAC, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9ULD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC 
        60         70         80         90        100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 
       110        120        130        140        150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDRWKETGG 
       160        170        180        190        200
GRRRYGRARS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 
       210        220        230        240        250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 
       260        270        280        290        300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 
       310        320        330        340        350
HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD 
       360        370        380        390        400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ 
       410        420        430        440        450
ELARRLETPY YLVGRRPAGG NSSGQSDNCS SSSEANGTGL ELLGGPSLRS 
       460        470        480        490        500
AYITSLYFAL SSLTSVGFGN VSANTDTEKI FSICTMLIGA LMHAVVFGNV 
       510        520        530        540        550
TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE YFQATWAVNN 
       560        570        580        590        600
GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP 
       610        620        630        640        650
AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP 
       660        670        680        690        700
RREQVVKANA DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL 
       710        720        730        740        750
SYNLGAGGGS AEVDTSSLSG DNTLMSTLEE KETDGEQGPT VSPAPADEPS 
       760        770        780        790        800
SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG GRGRPGRAGA LKAEAGPSAP 
       810        820        830        840        850
PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS FRVGQSGPEC 
       860        870        880        890        900
SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ 
       910        920        930        940        950
SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ 
       960        970        980        990       1000
PPAGSVLSGT WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS 
      1010       1020       1030       1040       1050
EPPASGDLCS EPSTPASPPP SEEGARTGPA EPVSQAEATS TGEPPPGSGG 
      1060       1070       1080 
LALPWDPHSL EMVLIGCHGS GTVQWTQEEG TGV
Length:1,083
Mass (Da):117,129
Last modified:November 28, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF35C8968D7418CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITH0A0A3B3ITH0_HUMAN
Potassium voltage-gated channel sub...
KCNH3
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86596 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB022696 mRNA Translation: BAA83590.1
AB033108 mRNA Translation: BAA86596.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8786.1

NCBI Reference Sequences

More...RefSeqi		NP_001300959.1, NM_001314030.1
NP_036416.1, NM_012284.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000257981; ENSP00000257981; ENSG00000135519

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23416

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23416

UCSC genome browser

More...UCSCi		uc001ruh.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022696 mRNA Translation: BAA83590.1
AB033108 mRNA Translation: BAA86596.1 Different initiation.
CCDSiCCDS8786.1
RefSeqiNP_001300959.1, NM_001314030.1
NP_036416.1, NM_012284.2

3D structure databases

SMRiQ9ULD8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9ULD8, 2 interactors
MINTiQ9ULD8
STRINGi9606.ENSP00000257981

Chemistry databases

ChEMBLiCHEMBL2363017
DrugBankiDB00228, Enflurane
DB01110, Miconazole
DB01069, Promethazine
DrugCentraliQ9ULD8
GuidetoPHARMACOLOGYi576

Protein family/group databases

TCDBi1.A.1.20.5, the voltage-gated ion channel (vic) superfamily

PTM databases

GlyGeniQ9ULD8, 3 sites
iPTMnetiQ9ULD8
PhosphoSitePlusiQ9ULD8

Polymorphism and mutation databases

BioMutaiKCNH3
DMDMi26006814

Proteomic databases

jPOSTiQ9ULD8
PaxDbiQ9ULD8
PeptideAtlasiQ9ULD8
PRIDEiQ9ULD8
ProteomicsDBi85003

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25968, 88 antibodies

Genome annotation databases

EnsembliENST00000257981; ENSP00000257981; ENSG00000135519
GeneIDi23416
KEGGihsa:23416
UCSCiuc001ruh.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23416
DisGeNETi23416
EuPathDBiHostDB:ENSG00000135519.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNH3
HGNCiHGNC:6252, KCNH3
HPAiENSG00000135519, Tissue enhanced (brain)
MIMi604527, gene
neXtProtiNX_Q9ULD8
OpenTargetsiENSG00000135519
PharmGKBiPA30038

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0498, Eukaryota
GeneTreeiENSGT00940000161742
HOGENOMiCLU_005746_6_0_1
InParanoidiQ9ULD8
OMAiYIGQQEI
OrthoDBi247304at2759
PhylomeDBiQ9ULD8
TreeFamiTF313130

Enzyme and pathway databases

PathwayCommonsiQ9ULD8
ReactomeiR-HSA-1296072, Voltage gated Potassium channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23416, 12 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNH3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNH3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23416
PharosiQ9ULD8, Tclin

Protein Ontology

More...PROi		PR:Q9ULD8
RNActiQ9ULD8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135519, Expressed in right frontal lobe and 130 other tissues
ExpressionAtlasiQ9ULD8, baseline and differential
GenevisibleiQ9ULD8, HS

Family and domain databases

CDDicd00038, CAP_ED, 1 hit
cd00130, PAS, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR003938, K_chnl_volt-dep_EAG/ELK/ERG
IPR003950, K_chnl_volt-dep_ELK
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF13426, PAS_9, 1 hit
PRINTSiPR01463, EAGCHANLFMLY
PR01465, ELKCHANNEL
SMARTiView protein in SMART
SM00100, cNMP, 1 hit
SM00086, PAC, 1 hit
SUPFAMiSSF51206, SSF51206, 1 hit
SSF55785, SSF55785, 1 hit
TIGRFAMsiTIGR00229, sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS50113, PAC, 1 hit
PS50112, PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD8
Secondary accession number(s): Q9UQ06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: December 2, 2020
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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