UniProtKB - Q9ULD8 (KCNH3_HUMAN)
Protein
Potassium voltage-gated channel subfamily H member 3
Gene
KCNH3
Organism
Homo sapiens (Human)
Status
Functioni
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 582 – 697 | cNMPAdd BLAST | 116 |
GO - Molecular functioni
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- potassium ion transmembrane transport Source: GO_Central
- potassium ion transport Source: UniProtKB
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of membrane potential Source: GO_Central
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Enzyme and pathway databases
PathwayCommonsi | Q9ULD8 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Protein family/group databases
TCDBi | 1.A.1.20.5, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily H member 3Alternative name(s): Brain-specific eag-like channel 1 Short name: BEC1 Ether-a-go-go-like potassium channel 2 Short name: ELK channel 2 Short name: ELK2 Voltage-gated potassium channel subunit Kv12.2 |
Gene namesi | Name:KCNH3 Synonyms:KIAA1282 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135519.6 |
HGNCi | HGNC:6252, KCNH3 |
MIMi | 604527, gene |
neXtProti | NX_Q9ULD8 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 228 | CytoplasmicSequence analysisAdd BLAST | 228 | |
Transmembranei | 229 – 249 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 250 – 259 | ExtracellularSequence analysis | 10 | |
Transmembranei | 260 – 280 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 302 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 303 – 323 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 324 – 331 | ExtracellularSequence analysis | 8 | |
Transmembranei | 332 – 352 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 361 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 362 – 382 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 453 | ExtracellularSequence analysisAdd BLAST | 71 | |
Intramembranei | 454 – 474 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 475 – 479 | ExtracellularSequence analysis | 5 | |
Transmembranei | 480 – 500 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 501 – 1083 | CytoplasmicSequence analysisAdd BLAST | 583 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23416 |
OpenTargetsi | ENSG00000135519 |
PharmGKBi | PA30038 |
Miscellaneous databases
Pharosi | Q9ULD8, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2363017 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q9ULD8 |
GuidetoPHARMACOLOGYi | 576 |
Polymorphism and mutation databases
BioMutai | KCNH3 |
DMDMi | 26006814 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054005 | 1 – 1083 | Potassium voltage-gated channel subfamily H member 3Add BLAST | 1083 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 421 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 428 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 436 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q9ULD8 |
PaxDbi | Q9ULD8 |
PeptideAtlasi | Q9ULD8 |
PRIDEi | Q9ULD8 |
ProteomicsDBi | 85003 |
PTM databases
GlyGeni | Q9ULD8, 3 sites |
iPTMneti | Q9ULD8 |
PhosphoSitePlusi | Q9ULD8 |
Expressioni
Tissue specificityi
Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.
Gene expression databases
Bgeei | ENSG00000135519, Expressed in right frontal lobe and 130 other tissues |
ExpressionAtlasi | Q9ULD8, baseline and differential |
Genevisiblei | Q9ULD8, HS |
Organism-specific databases
HPAi | ENSG00000135519, Tissue enhanced (brain) |
Interactioni
Subunit structurei
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Binary interactionsi
Q9ULD8
With | #Exp. | IntAct |
---|---|---|
env [P04578] from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2). | 3 | EBI-8079227,EBI-6163496 |
Protein-protein interaction databases
IntActi | Q9ULD8, 2 interactors |
MINTi | Q9ULD8 |
STRINGi | 9606.ENSP00000257981 |
Miscellaneous databases
RNActi | Q9ULD8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 90 | PASPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 93 – 145 | PACPROSITE-ProRule annotationAdd BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 465 – 470 | Selectivity filterBy similarity | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 951 – 1057 | Pro-richAdd BLAST | 107 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0498, Eukaryota |
GeneTreei | ENSGT00940000161742 |
HOGENOMi | CLU_005746_6_0_1 |
InParanoidi | Q9ULD8 |
OMAi | YIGQQEI |
OrthoDBi | 247304at2759 |
PhylomeDBi | Q9ULD8 |
TreeFami | TF313130 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR003950, K_chnl_volt-dep_ELK IPR001610, PAC IPR000014, PAS IPR000700, PAS-assoc_C IPR035965, PAS-like_dom_sf IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF13426, PAS_9, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY PR01465, ELKCHANNEL |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit SM00086, PAC, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit SSF55785, SSF55785, 1 hit |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit PS50113, PAC, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9ULD8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
60 70 80 90 100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
110 120 130 140 150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDRWKETGG
160 170 180 190 200
GRRRYGRARS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
210 220 230 240 250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
260 270 280 290 300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
310 320 330 340 350
HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD
360 370 380 390 400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ
410 420 430 440 450
ELARRLETPY YLVGRRPAGG NSSGQSDNCS SSSEANGTGL ELLGGPSLRS
460 470 480 490 500
AYITSLYFAL SSLTSVGFGN VSANTDTEKI FSICTMLIGA LMHAVVFGNV
510 520 530 540 550
TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE YFQATWAVNN
560 570 580 590 600
GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP
610 620 630 640 650
AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP
660 670 680 690 700
RREQVVKANA DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL
710 720 730 740 750
SYNLGAGGGS AEVDTSSLSG DNTLMSTLEE KETDGEQGPT VSPAPADEPS
760 770 780 790 800
SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG GRGRPGRAGA LKAEAGPSAP
810 820 830 840 850
PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS FRVGQSGPEC
860 870 880 890 900
SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ
910 920 930 940 950
SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ
960 970 980 990 1000
PPAGSVLSGT WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS
1010 1020 1030 1040 1050
EPPASGDLCS EPSTPASPPP SEEGARTGPA EPVSQAEATS TGEPPPGSGG
1060 1070 1080
LALPWDPHSL EMVLIGCHGS GTVQWTQEEG TGV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITH0 | A0A3B3ITH0_HUMAN | Potassium voltage-gated channel sub... | KCNH3 | 154 | Annotation score: |
Sequence cautioni
The sequence BAA86596 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022696 mRNA Translation: BAA83590.1 AB033108 mRNA Translation: BAA86596.1 Different initiation. |
CCDSi | CCDS8786.1 |
RefSeqi | NP_001300959.1, NM_001314030.1 NP_036416.1, NM_012284.2 |
Genome annotation databases
Ensembli | ENST00000257981; ENSP00000257981; ENSG00000135519 |
GeneIDi | 23416 |
KEGGi | hsa:23416 |
UCSCi | uc001ruh.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB022696 mRNA Translation: BAA83590.1 AB033108 mRNA Translation: BAA86596.1 Different initiation. |
CCDSi | CCDS8786.1 |
RefSeqi | NP_001300959.1, NM_001314030.1 NP_036416.1, NM_012284.2 |
3D structure databases
SMRi | Q9ULD8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9ULD8, 2 interactors |
MINTi | Q9ULD8 |
STRINGi | 9606.ENSP00000257981 |
Chemistry databases
ChEMBLi | CHEMBL2363017 |
DrugBanki | DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q9ULD8 |
GuidetoPHARMACOLOGYi | 576 |
Protein family/group databases
TCDBi | 1.A.1.20.5, the voltage-gated ion channel (vic) superfamily |
PTM databases
GlyGeni | Q9ULD8, 3 sites |
iPTMneti | Q9ULD8 |
PhosphoSitePlusi | Q9ULD8 |
Polymorphism and mutation databases
BioMutai | KCNH3 |
DMDMi | 26006814 |
Proteomic databases
jPOSTi | Q9ULD8 |
PaxDbi | Q9ULD8 |
PeptideAtlasi | Q9ULD8 |
PRIDEi | Q9ULD8 |
ProteomicsDBi | 85003 |
Protocols and materials databases
Antibodypediai | 25968, 88 antibodies |
Genome annotation databases
Ensembli | ENST00000257981; ENSP00000257981; ENSG00000135519 |
GeneIDi | 23416 |
KEGGi | hsa:23416 |
UCSCi | uc001ruh.2, human |
Organism-specific databases
CTDi | 23416 |
DisGeNETi | 23416 |
EuPathDBi | HostDB:ENSG00000135519.6 |
GeneCardsi | KCNH3 |
HGNCi | HGNC:6252, KCNH3 |
HPAi | ENSG00000135519, Tissue enhanced (brain) |
MIMi | 604527, gene |
neXtProti | NX_Q9ULD8 |
OpenTargetsi | ENSG00000135519 |
PharmGKBi | PA30038 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0498, Eukaryota |
GeneTreei | ENSGT00940000161742 |
HOGENOMi | CLU_005746_6_0_1 |
InParanoidi | Q9ULD8 |
OMAi | YIGQQEI |
OrthoDBi | 247304at2759 |
PhylomeDBi | Q9ULD8 |
TreeFami | TF313130 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULD8 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels |
Miscellaneous databases
BioGRID-ORCSi | 23416, 12 hits in 845 CRISPR screens |
ChiTaRSi | KCNH3, human |
GeneWikii | KCNH3 |
GenomeRNAii | 23416 |
Pharosi | Q9ULD8, Tclin |
PROi | PR:Q9ULD8 |
RNActi | Q9ULD8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135519, Expressed in right frontal lobe and 130 other tissues |
ExpressionAtlasi | Q9ULD8, baseline and differential |
Genevisiblei | Q9ULD8, HS |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit cd00130, PAS, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR003950, K_chnl_volt-dep_ELK IPR001610, PAC IPR000014, PAS IPR000700, PAS-assoc_C IPR035965, PAS-like_dom_sf IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF13426, PAS_9, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY PR01465, ELKCHANNEL |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit SM00086, PAC, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit SSF55785, SSF55785, 1 hit |
TIGRFAMsi | TIGR00229, sensory_box, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 1 hit PS50113, PAC, 1 hit PS50112, PAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNH3_HUMAN | |
Accessioni | Q9ULD8Primary (citable) accession number: Q9ULD8 Secondary accession number(s): Q9UQ06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2002 |
Last sequence update: | November 28, 2002 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM