UniProtKB - Q9ULD5 (ZN777_HUMAN)
Protein
Zinc finger protein 777
Gene
ZNF777
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 546 – 568 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 574 – 596 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 636 – 658 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 664 – 686 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 694 – 716 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 722 – 744 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 750 – 772 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 778 – 800 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 806 – 828 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9ULD5 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 777 |
Gene namesi | Name:ZNF777 Synonyms:KIAA1285 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196453.7 |
HGNCi | HGNC:22213, ZNF777 |
neXtProti | NX_Q9ULD5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000196453 |
PharmGKBi | PA162410383 |
Miscellaneous databases
Pharosi | Q9ULD5, Tdark |
Polymorphism and mutation databases
BioMutai | ZNF777 |
DMDMi | 152112417 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000293692 | 1 – 831 | Zinc finger protein 777Add BLAST | 831 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 157 | PhosphoserineCombined sources | 1 | |
Cross-linki | 330 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 452 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 496 | PhosphoserineCombined sources | 1 | |
Modified residuei | 502 | PhosphoserineCombined sources | 1 | |
Modified residuei | 604 | PhosphoserineCombined sources | 1 | |
Modified residuei | 623 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9ULD5 |
jPOSTi | Q9ULD5 |
MassIVEi | Q9ULD5 |
PaxDbi | Q9ULD5 |
PeptideAtlasi | Q9ULD5 |
PRIDEi | Q9ULD5 |
PTM databases
iPTMneti | Q9ULD5 |
PhosphoSitePlusi | Q9ULD5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196453, Expressed in endothelial cell and 189 other tissues |
Genevisiblei | Q9ULD5, HS |
Organism-specific databases
HPAi | ENSG00000196453, Tissue enriched (placenta) |
Interactioni
Binary interactionsi
Hide detailsQ9ULD5
Protein-protein interaction databases
BioGRIDi | 118035, 63 interactors |
IntActi | Q9ULD5, 19 interactors |
STRINGi | 9606.ENSP00000247930 |
Miscellaneous databases
RNActi | Q9ULD5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 285 – 356 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 338 – 467 | Glu-richAdd BLAST | 130 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 546 – 568 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 574 – 596 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 636 – 658 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 664 – 686 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 694 – 716 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 722 – 744 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 750 – 772 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 778 – 800 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 806 – 828 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155153 |
HOGENOMi | CLU_002678_76_2_1 |
InParanoidi | Q9ULD5 |
OMAi | ERGPAFN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9ULD5 |
TreeFami | TF337777 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR022137, DUF3669_Znf IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF12417, DUF3669, 1 hit PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
Q9ULD5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENQRSSPLS FPSVPQEETL RQAPAGLPRE TLFQSRVLPP KEIPSLSPTI
60 70 80 90 100
PRQGSLPQTS SAPKQETSGR MPHVLQKGPS LLCSAASEQE TSLQGPLASQ
110 120 130 140 150
EGTQYPPPAA AEQEVSLLSH SPHHQEAPVH SPEAPEKDPL TLSPTVPETD
160 170 180 190 200
MDPLLQSPVS QKDTPFQISS AVQKEQPLPT AEITRLAVWA AVQAVERKLE
210 220 230 240 250
AQAMRLLTLE GRTGTNEKKI ADCEKTAVEF ANHLESKWVV LGTLLQEYGL
260 270 280 290 300
LQRRLENMEN LLKNRNFWIL RLPPGSNGEV PKVPVTFDDV AVHFSEQEWG
310 320 330 340 350
NLSEWQKELY KNVMRGNYES LVSMDYAISK PDLMSQMERG ERPTMQEQED
360 370 380 390 400
SEEGETPTDP SAAHDGIVIK IEVQTNDEGS ESLETPEPLM GQVEEHGFQD
410 420 430 440 450
SELGDPCGEQ PDLDMQEPEN TLEESTEGSS EFSELKQMLV QQRNCTEGIV
460 470 480 490 500
IKTEEQDEEE EEEEEDELPQ HLQSLGQLSG RYEASMYQTP LPGEMSPEGE
510 520 530 540 550
ESPPPLQLGN PAVKRLAPSV HGERHLSENR GASSQQQRNR RGERPFTCME
560 570 580 590 600
CGKSFRLKIN LIIHQRNHIK EGPYECAECE ISFRHKQQLT LHQRIHRVRG
610 620 630 640 650
GCVSPERGPT FNPKHALKPR PKSPSSGSGG GGPKPYKCPE CDSSFSHKSS
660 670 680 690 700
LTKHQITHTG ERPYTCPECK KSFRLHISLV IHQRVHAGKH EVSFICSLCG
710 720 730 740 750
KSFSRPSHLL RHQRTHTGER PFKCPECEKS FSEKSKLTNH CRVHSRERPH
760 770 780 790 800
ACPECGKSFI RKHHLLEHRR IHTGERPYHC AECGKRFTQK HHLLEHQRAH
810 820 830
TGERPYPCTH CAKCFRYKQS LKYHLRTHTG E
Sequence cautioni
The sequence AAH23985 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA86599 differs from that shown. Contaminating sequence. Vector contamination at the C-terminus.Curated
The sequence BAA86599 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC11033 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 446 | T → TA in BAC11033 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057451 | 70 | R → W. Corresponds to variant dbSNP:rs3735318Ensembl. | 1 | |
Natural variantiVAR_057452 | 115 | V → A. Corresponds to variant dbSNP:rs3735319Ensembl. | 1 | |
Natural variantiVAR_061965 | 512 | A → T1 PublicationCorresponds to variant dbSNP:rs17852167Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073314 Genomic DNA No translation available. AB033111 mRNA Translation: BAA86599.1 Sequence problems. BC023985 mRNA Translation: AAH23985.2 Different initiation. AK074515 mRNA Translation: BAC11033.1 Different initiation. |
CCDSi | CCDS43675.1 |
RefSeqi | NP_056509.2, NM_015694.2 XP_011514357.1, XM_011516055.2 |
Genome annotation databases
Ensembli | ENST00000247930; ENSP00000247930; ENSG00000196453 |
GeneIDi | 27153 |
KEGGi | hsa:27153 |
UCSCi | uc003wfv.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC073314 Genomic DNA No translation available. AB033111 mRNA Translation: BAA86599.1 Sequence problems. BC023985 mRNA Translation: AAH23985.2 Different initiation. AK074515 mRNA Translation: BAC11033.1 Different initiation. |
CCDSi | CCDS43675.1 |
RefSeqi | NP_056509.2, NM_015694.2 XP_011514357.1, XM_011516055.2 |
3D structure databases
SMRi | Q9ULD5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118035, 63 interactors |
IntActi | Q9ULD5, 19 interactors |
STRINGi | 9606.ENSP00000247930 |
PTM databases
iPTMneti | Q9ULD5 |
PhosphoSitePlusi | Q9ULD5 |
Polymorphism and mutation databases
BioMutai | ZNF777 |
DMDMi | 152112417 |
Proteomic databases
EPDi | Q9ULD5 |
jPOSTi | Q9ULD5 |
MassIVEi | Q9ULD5 |
PaxDbi | Q9ULD5 |
PeptideAtlasi | Q9ULD5 |
PRIDEi | Q9ULD5 |
Protocols and materials databases
Antibodypediai | 827, 72 antibodies |
Genome annotation databases
Ensembli | ENST00000247930; ENSP00000247930; ENSG00000196453 |
GeneIDi | 27153 |
KEGGi | hsa:27153 |
UCSCi | uc003wfv.4, human |
Organism-specific databases
CTDi | 27153 |
EuPathDBi | HostDB:ENSG00000196453.7 |
GeneCardsi | ZNF777 |
HGNCi | HGNC:22213, ZNF777 |
HPAi | ENSG00000196453, Tissue enriched (placenta) |
neXtProti | NX_Q9ULD5 |
OpenTargetsi | ENSG00000196453 |
PharmGKBi | PA162410383 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155153 |
HOGENOMi | CLU_002678_76_2_1 |
InParanoidi | Q9ULD5 |
OMAi | ERGPAFN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9ULD5 |
TreeFami | TF337777 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULD5 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 27153, 12 hits in 864 CRISPR screens |
GenomeRNAii | 27153 |
Pharosi | Q9ULD5, Tdark |
PROi | PR:Q9ULD5 |
RNActi | Q9ULD5, protein |
Gene expression databases
Bgeei | ENSG00000196453, Expressed in endothelial cell and 189 other tissues |
Genevisiblei | Q9ULD5, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR022137, DUF3669_Znf IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF12417, DUF3669, 1 hit PF01352, KRAB, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN777_HUMAN | |
Accessioni | Q9ULD5Primary (citable) accession number: Q9ULD5 Secondary accession number(s): Q8N2R2, Q8N659 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | May 8, 2019 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations