Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9ULD5 (ZN777_HUMAN)

Entry version 154 (02 Jun 2021)
Sequence version 3 (08 May 2019)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger protein 777

Gene

ZNF777

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri546 – 568C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 716C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri722 – 744C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri778 – 800C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri806 – 828C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULD5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 777
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF777
Synonyms:KIAA1285
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:22213, ZNF777

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULD5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196453.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000196453

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162410383

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULD5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF777

Domain mapping of disease mutations (DMDM)

More...DMDMi		152112417

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002936921 – 831Zinc finger protein 777Add BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei496PhosphoserineCombined sources1
Modified residuei502PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei623PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULD5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULD5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULD5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULD5

PeptideAtlas

More...PeptideAtlasi		Q9ULD5

PRoteomics IDEntifications database

More...PRIDEi		Q9ULD5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULD5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULD5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196453, Expressed in endothelial cell and 189 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULD5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196453, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118035, 63 interactors

Protein interaction database and analysis system

More...IntActi		Q9ULD5, 19 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000247930

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULD5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULD5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini285 – 356KRABPROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 143DisorderedSequence analysisAdd BLAST143
Regioni339 – 364DisorderedSequence analysisAdd BLAST26
Regioni398 – 432DisorderedSequence analysisAdd BLAST35
Regioni488 – 545DisorderedSequence analysisAdd BLAST58
Regioni600 – 634DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Polar residuesSequence analysisAdd BLAST17
Compositional biasi48 – 67Polar residuesSequence analysisAdd BLAST20
Compositional biasi82 – 101Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 568C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri636 – 658C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri664 – 686C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri694 – 716C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri722 – 744C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri750 – 772C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri778 – 800C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri806 – 828C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155153

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_76_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULD5

Identification of Orthologs from Complete Genome Data

More...OMAi		ERGPAFN

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULD5

TreeFam database of animal gene trees

More...TreeFami		TF337777

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR022137, Znf_prot_DUF3669

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12417, DUF3669, 1 hit
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ULD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENQRSSPLS FPSVPQEETL RQAPAGLPRE TLFQSRVLPP KEIPSLSPTI 
        60         70         80         90        100
PRQGSLPQTS SAPKQETSGR MPHVLQKGPS LLCSAASEQE TSLQGPLASQ 
       110        120        130        140        150
EGTQYPPPAA AEQEVSLLSH SPHHQEAPVH SPEAPEKDPL TLSPTVPETD 
       160        170        180        190        200
MDPLLQSPVS QKDTPFQISS AVQKEQPLPT AEITRLAVWA AVQAVERKLE 
       210        220        230        240        250
AQAMRLLTLE GRTGTNEKKI ADCEKTAVEF ANHLESKWVV LGTLLQEYGL 
       260        270        280        290        300
LQRRLENMEN LLKNRNFWIL RLPPGSNGEV PKVPVTFDDV AVHFSEQEWG 
       310        320        330        340        350
NLSEWQKELY KNVMRGNYES LVSMDYAISK PDLMSQMERG ERPTMQEQED 
       360        370        380        390        400
SEEGETPTDP SAAHDGIVIK IEVQTNDEGS ESLETPEPLM GQVEEHGFQD 
       410        420        430        440        450
SELGDPCGEQ PDLDMQEPEN TLEESTEGSS EFSELKQMLV QQRNCTEGIV 
       460        470        480        490        500
IKTEEQDEEE EEEEEDELPQ HLQSLGQLSG RYEASMYQTP LPGEMSPEGE 
       510        520        530        540        550
ESPPPLQLGN PAVKRLAPSV HGERHLSENR GASSQQQRNR RGERPFTCME 
       560        570        580        590        600
CGKSFRLKIN LIIHQRNHIK EGPYECAECE ISFRHKQQLT LHQRIHRVRG 
       610        620        630        640        650
GCVSPERGPT FNPKHALKPR PKSPSSGSGG GGPKPYKCPE CDSSFSHKSS 
       660        670        680        690        700
LTKHQITHTG ERPYTCPECK KSFRLHISLV IHQRVHAGKH EVSFICSLCG 
       710        720        730        740        750
KSFSRPSHLL RHQRTHTGER PFKCPECEKS FSEKSKLTNH CRVHSRERPH 
       760        770        780        790        800
ACPECGKSFI RKHHLLEHRR IHTGERPYHC AECGKRFTQK HHLLEHQRAH 
       810        820        830 
TGERPYPCTH CAKCFRYKQS LKYHLRTHTG E
Length:831
Mass (Da):93,762
Last modified:May 8, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AE3346E1A4EDF80
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH23985 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA86599 differs from that shown. Contaminating sequence. Vector contamination at the C-terminus.Curated
The sequence BAA86599 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC11033 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti446T → TA in BAC11033 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05745170R → W. Corresponds to variant dbSNP:rs3735318Ensembl.1
Natural variantiVAR_057452115V → A. Corresponds to variant dbSNP:rs3735319Ensembl.1
Natural variantiVAR_061965512A → T1 PublicationCorresponds to variant dbSNP:rs17852167Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC073314 Genomic DNA No translation available.
AB033111 mRNA Translation: BAA86599.1 Sequence problems.
BC023985 mRNA Translation: AAH23985.2 Different initiation.
AK074515 mRNA Translation: BAC11033.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43675.1

NCBI Reference Sequences

More...RefSeqi		NP_056509.2, NM_015694.2
XP_011514357.1, XM_011516055.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000247930; ENSP00000247930; ENSG00000196453

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27153

UCSC genome browser

More...UCSCi		uc003wfv.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073314 Genomic DNA No translation available.
AB033111 mRNA Translation: BAA86599.1 Sequence problems.
BC023985 mRNA Translation: AAH23985.2 Different initiation.
AK074515 mRNA Translation: BAC11033.1 Different initiation.
CCDSiCCDS43675.1
RefSeqiNP_056509.2, NM_015694.2
XP_011514357.1, XM_011516055.2

3D structure databases

SMRiQ9ULD5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118035, 63 interactors
IntActiQ9ULD5, 19 interactors
STRINGi9606.ENSP00000247930

PTM databases

iPTMnetiQ9ULD5
PhosphoSitePlusiQ9ULD5

Genetic variation databases

BioMutaiZNF777
DMDMi152112417

Proteomic databases

EPDiQ9ULD5
jPOSTiQ9ULD5
MassIVEiQ9ULD5
PaxDbiQ9ULD5
PeptideAtlasiQ9ULD5
PRIDEiQ9ULD5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		827, 75 antibodies

The DNASU plasmid repository

More...DNASUi		27153

Genome annotation databases

EnsembliENST00000247930; ENSP00000247930; ENSG00000196453
GeneIDi27153
KEGGihsa:27153
UCSCiuc003wfv.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27153

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF777
HGNCiHGNC:22213, ZNF777
HPAiENSG00000196453, Tissue enriched (placenta)
neXtProtiNX_Q9ULD5
OpenTargetsiENSG00000196453
PharmGKBiPA162410383
VEuPathDBiHostDB:ENSG00000196453.7

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000155153
HOGENOMiCLU_002678_76_2_1
InParanoidiQ9ULD5
OMAiERGPAFN
OrthoDBi1318335at2759
PhylomeDBiQ9ULD5
TreeFamiTF337777

Enzyme and pathway databases

PathwayCommonsiQ9ULD5
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27153, 15 hits in 1015 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27153
PharosiQ9ULD5, Tdark

Protein Ontology

More...PROi		PR:Q9ULD5
RNActiQ9ULD5, protein

Gene expression databases

BgeeiENSG00000196453, Expressed in endothelial cell and 189 other tissues
GenevisibleiQ9ULD5, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
IPR022137, Znf_prot_DUF3669
PfamiView protein in Pfam
PF12417, DUF3669, 1 hit
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 9 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN777_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD5
Secondary accession number(s): Q8N2R2, Q8N659
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 8, 2019
Last modified: June 2, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again