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Entry version 149 (08 May 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Bromodomain and PHD finger-containing protein 3

Gene

BRPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri212 – 262PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri266 – 299C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri323 – 387PHD-type 2PROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain and PHD finger-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRPF3
Synonyms:KIAA1286
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14256 BRPF3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULD4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000096070

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25425

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3108644

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2731

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRPF3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111881 – 1205Bromodomain and PHD finger-containing protein 3Add BLAST1205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei447N6-acetyllysineCombined sources1
Modified residuei449N6-acetyllysineCombined sources1
Modified residuei671N6-acetyllysineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULD4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULD4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULD4

PeptideAtlas

More...
PeptideAtlasi
Q9ULD4

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULD4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULD4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000096070 Expressed in 159 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULD4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULD4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA022787

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1753470,EBI-389883

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118036, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-736 MOZ3 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9ULD4

Protein interaction database and analysis system

More...
IntActi
Q9ULD4, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350267

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9ULD4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULD4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini606 – 676BromoPROSITE-ProRule annotationAdd BLAST71
Domaini1076 – 1159PWWPPROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi406 – 432Glu-richAdd BLAST27

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 262PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri266 – 299C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri323 – 387PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000705

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULD4

KEGG Orthology (KO)

More...
KOi
K11350

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMDDECH

Database of Orthologous Groups

More...
OrthoDBi
390348at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULD4

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05839 BR140_related, 1 hit
cd15703 ePHD_BRPF3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR042005 BRPF3_ePHD
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH
60 70 80 90 100
RISIYDPLKI ITEDELTAQD ITECNSNKEN SEQPQFPGKS KKPSSKGKKK
110 120 130 140 150
ESCSKHASGT SFHLPQPSFR MVDSGIQPEA PPLPAAYYRY IEKPPEDLDA
160 170 180 190 200
EVEYDMDEED LAWLDMVNEK RRVDGHSLVS ADTFELLVDR LEKESYLESR
210 220 230 240 250
SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH QECYGVPYIP
260 270 280 290 300
EGQWLCRCCL QSPSRPVDCI LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC
310 320 330 340 350
FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV
360 370 380 390 400
TCAQRAGLFM KIEPMRETSL NGTIFTVRKT AYCEAHSPPG AATARRKGDS
410 420 430 440 450
PRSISETGDE EGLKEGDGEE EEEEEVEEEE QEAQGGVSGS LKGVPKKSKM
460 470 480 490 500
SLKQKIKKEP EEAGQDTPST LPMLAVPQIP SYRLNKICSG LSFQRKNQFM
510 520 530 540 550
QRLHNYWLLK RQARNGVPLI RRLHSHLQSQ RNAEQREQDE KTSAVKEELK
560 570 580 590 600
YWQKLRHDLE RARLLIELIR KREKLKREQV KVQQAAMELE LMPFNVLLRT
610 620 630 640 650
TLDLLQEKDP AHIFAEPVNL SEVPDYLEFI SKPMDFSTMR RKLESHLYRT
660 670 680 690 700
LEEFEEDFNL IVTNCMKYNA KDTIFHRAAV RLRDLGGAIL RHARRQAENI
710 720 730 740 750
GYDPERGTHL PESPKLEDFY RFSWEDVDNI LIPENRAHLS PEVQLKELLE
760 770 780 790 800
KLDLVSAMRS SGARTRRVRL LRREINALRQ KLAQPPPPQP PSLNKTVSNG
810 820 830 840 850
ELPAGPQGDA AVLEQALQEE PEDDGDRDDS KLPPPPTLEP TGPAPSLSEQ
860 870 880 890 900
ESPPEPPTLK PINDSKPPSR FLKPRKVEED ELLEKSPLQL GNEPLQRLLS
910 920 930 940 950
DNGINRLSLM APDTPAGTPL SGVGRRTSVL FKKAKNGVKL QRSPDRVLEN
960 970 980 990 1000
GEDHGVAGSP ASPASIEEER HSRKRPRSRS CSESEGERSP QQEEETGMTN
1010 1020 1030 1040 1050
GFGKHTESGS DSECSLGLSG GLAFEACSGL TPPKRSRGKP ALSRVPFLEG
1060 1070 1080 1090 1100
VNGDSDYNGS GRSLLLPFED RGDLEPLELV WAKCRGYPSY PALIIDPKMP
1110 1120 1130 1140 1150
REGLLHNGVP IPVPPLDVLK LGEQKQAEAG EKLFLVLFFD NKRTWQWLPR
1160 1170 1180 1190 1200
DKVLPLGVED TVDKLKMLEG RKTSIRKSVQ VAYDRAMIHL SRVRGPHSFV

TSSYL
Length:1,205
Mass (Da):135,745
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF51DCAB253ED35C7
GO
Isoform 2 (identifier: Q9ULD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-996: Missing.

Note: No experimental confirmation available.
Show »
Length:935
Mass (Da):106,187
Checksum:i1BCEE6338BAE1ABB
GO
Isoform 3 (identifier: Q9ULD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-996: Missing.
     997-1060: Missing.

Note: No experimental confirmation available.
Show »
Length:871
Mass (Da):99,713
Checksum:iED046A8987D83B7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PSF3E9PSF3_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
821Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI60E9PI60_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
1,106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7B4H0Y7B4_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XDC4F6XDC4_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
626Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8WI61A8WI61_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7I6H0Y7I6_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8WI62A8WI62_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ12E9PJ12_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86600 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1075E → K in BAA86600 (PubMed:10574462).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061042177S → G. Corresponds to variant dbSNP:rs45504893Ensembl.1
Natural variantiVAR_048431278A → G. Corresponds to variant dbSNP:rs17658935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055549727 – 996Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST270
Alternative sequenceiVSP_055550997 – 1060Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB033112 mRNA Translation: BAA86600.1 Different initiation.
Z84485 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03878.1
BC117387 mRNA Translation: AAI17388.1
BC143917 mRNA Translation: AAI43918.1
BC143918 mRNA Translation: AAI43919.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34437.1 [Q9ULD4-1]

NCBI Reference Sequences

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RefSeqi
NP_056510.2, NM_015695.2 [Q9ULD4-1]
XP_005249067.1, XM_005249010.2 [Q9ULD4-1]
XP_005249068.1, XM_005249011.3 [Q9ULD4-1]
XP_011512791.1, XM_011514489.1 [Q9ULD4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000339717; ENSP00000345419; ENSG00000096070 [Q9ULD4-2]
ENST00000357641; ENSP00000350267; ENSG00000096070 [Q9ULD4-1]
ENST00000534694; ENSP00000434501; ENSG00000096070 [Q9ULD4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
27154

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27154

UCSC genome browser

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UCSCi
uc003olv.5 human [Q9ULD4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033112 mRNA Translation: BAA86600.1 Different initiation.
Z84485 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03878.1
BC117387 mRNA Translation: AAI17388.1
BC143917 mRNA Translation: AAI43918.1
BC143918 mRNA Translation: AAI43919.1
CCDSiCCDS34437.1 [Q9ULD4-1]
RefSeqiNP_056510.2, NM_015695.2 [Q9ULD4-1]
XP_005249067.1, XM_005249010.2 [Q9ULD4-1]
XP_005249068.1, XM_005249011.3 [Q9ULD4-1]
XP_011512791.1, XM_011514489.1 [Q9ULD4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PFSX-ray1.90A/B1056-1195[»]
SMRiQ9ULD4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118036, 7 interactors
ComplexPortaliCPX-736 MOZ3 histone acetyltransferase complex
CPX-740 MORF3 histone acetyltransferase complex
CORUMiQ9ULD4
IntActiQ9ULD4, 13 interactors
STRINGi9606.ENSP00000350267

Chemistry databases

BindingDBiQ9ULD4
ChEMBLiCHEMBL3108644
GuidetoPHARMACOLOGYi2731

PTM databases

iPTMnetiQ9ULD4
PhosphoSitePlusiQ9ULD4

Polymorphism and mutation databases

BioMutaiBRPF3
DMDMi71153496

Proteomic databases

EPDiQ9ULD4
jPOSTiQ9ULD4
PaxDbiQ9ULD4
PeptideAtlasiQ9ULD4
PRIDEiQ9ULD4
ProteomicsDBi84995

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339717; ENSP00000345419; ENSG00000096070 [Q9ULD4-2]
ENST00000357641; ENSP00000350267; ENSG00000096070 [Q9ULD4-1]
ENST00000534694; ENSP00000434501; ENSG00000096070 [Q9ULD4-3]
GeneIDi27154
KEGGihsa:27154
UCSCiuc003olv.5 human [Q9ULD4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27154

GeneCards: human genes, protein and diseases

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GeneCardsi
BRPF3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005816
HIX0200828
HGNCiHGNC:14256 BRPF3
HPAiHPA022787
neXtProtiNX_Q9ULD4
OpenTargetsiENSG00000096070
PharmGKBiPA25425

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA
GeneTreeiENSGT00940000155056
HOGENOMiHOG000000705
InParanoidiQ9ULD4
KOiK11350
OMAiCMDDECH
OrthoDBi390348at2759
PhylomeDBiQ9ULD4
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-3214847 HATs acetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BRPF3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27154

Protein Ontology

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PROi
PR:Q9ULD4

Gene expression databases

BgeeiENSG00000096070 Expressed in 159 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ9ULD4 baseline and differential
GenevisibleiQ9ULD4 HS

Family and domain databases

CDDicd05839 BR140_related, 1 hit
cd15703 ePHD_BRPF3, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR042005 BRPF3_ePHD
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRPF3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD4
Secondary accession number(s): A6ND56
, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 19, 2005
Last modified: May 8, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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