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UniProtKB - Q9ULD4 (BRPF3_HUMAN)

Entry version 165 (25 May 2022)
Sequence version 2 (19 Jul 2005)
Previous versions | rss
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Protein

Bromodomain and PHD finger-containing protein 3

Gene

BRPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, which have a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:26620551, PubMed:26677226).

Plays a role in DNA replication initiation by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby facilitating the activation of replication origins (PubMed:26620551).

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653).

3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri212 – 262PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri266 – 299C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri323 – 387PHD-type 2PROSITE-ProRule annotationAdd BLAST65

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULD4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-3214847, HATs acetylate histones
R-HSA-6804758, Regulation of TP53 Activity through Acetylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9ULD4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain and PHD finger-containing protein 31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRPF31 PublicationImported
Synonyms:KIAA12861 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14256, BRPF3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULD4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000096070

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000096070

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25425

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULD4, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3108644

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2731

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BRPF3

Domain mapping of disease mutations (DMDM)

More...DMDMi		71153496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111881 – 1205Bromodomain and PHD finger-containing protein 3Add BLAST1205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei447N6-acetyllysineCombined sources1
Modified residuei449N6-acetyllysineCombined sources1
Modified residuei671N6-acetyllysineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9ULD4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULD4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULD4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9ULD4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULD4

PeptideAtlas

More...PeptideAtlasi		Q9ULD4

PRoteomics IDEntifications database

More...PRIDEi		Q9ULD4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61143
7229
84995 [Q9ULD4-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULD4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000096070, Expressed in skeletal muscle tissue and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9ULD4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULD4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000096070, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of some HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and BRPF3 (PubMed:26620551).

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358).

Interacts with KAT7/HBO1; the interaction is direct (PubMed:26677226).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118036, 163 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-736, MOZ3 histone acetyltransferase complex
CPX-740, MORF3 histone acetyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9ULD4

Protein interaction database and analysis system

More...IntActi		Q9ULD4, 32 interactors

Molecular INTeraction database

More...MINTi		Q9ULD4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350267

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9ULD4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULD4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9ULD4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULD4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini606 – 676BromoPROSITE-ProRule annotationAdd BLAST71
Domaini1076 – 1159PWWPPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni75 – 121DisorderedSequence analysisAdd BLAST47
Regioni387 – 472DisorderedSequence analysisAdd BLAST86
Regioni779 – 897DisorderedSequence analysisAdd BLAST119
Regioni907 – 926DisorderedSequence analysisAdd BLAST20
Regioni931 – 1015DisorderedSequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 90Polar residuesSequence analysisAdd BLAST16
Compositional biasi412 – 432Acidic residuesSequence analysisAdd BLAST21
Compositional biasi834 – 863Pro residuesSequence analysisAdd BLAST30
Compositional biasi869 – 886Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi938 – 952Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi966 – 992Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi993 – 1015Polar residuesSequence analysisAdd BLAST23

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 262PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri266 – 299C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri323 – 387PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0955, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155056

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003589_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULD4

Identification of Orthologs from Complete Genome Data

More...OMAi		KNHCPNS

Database of Orthologous Groups

More...OrthoDBi		566217at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULD4

TreeFam database of animal gene trees

More...TreeFami		TF316118

Family and domain databases

Conserved Domains Database

More...CDDi		cd05839, BR140_related, 1 hit
cd15703, ePHD_BRPF3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035502, BR140-rel_PWWD
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR042005, BRPF3_ePHD
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR000313, PWWP_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00439, Bromodomain, 1 hit
PF10513, EPL1, 1 hit
PF00855, PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00297, BROMO, 1 hit
SM00249, PHD, 2 hits
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS50812, PWWP, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH 
        60         70         80         90        100
RISIYDPLKI ITEDELTAQD ITECNSNKEN SEQPQFPGKS KKPSSKGKKK 
       110        120        130        140        150
ESCSKHASGT SFHLPQPSFR MVDSGIQPEA PPLPAAYYRY IEKPPEDLDA 
       160        170        180        190        200
EVEYDMDEED LAWLDMVNEK RRVDGHSLVS ADTFELLVDR LEKESYLESR 
       210        220        230        240        250
SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH QECYGVPYIP 
       260        270        280        290        300
EGQWLCRCCL QSPSRPVDCI LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC 
       310        320        330        340        350
FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV 
       360        370        380        390        400
TCAQRAGLFM KIEPMRETSL NGTIFTVRKT AYCEAHSPPG AATARRKGDS 
       410        420        430        440        450
PRSISETGDE EGLKEGDGEE EEEEEVEEEE QEAQGGVSGS LKGVPKKSKM 
       460        470        480        490        500
SLKQKIKKEP EEAGQDTPST LPMLAVPQIP SYRLNKICSG LSFQRKNQFM 
       510        520        530        540        550
QRLHNYWLLK RQARNGVPLI RRLHSHLQSQ RNAEQREQDE KTSAVKEELK 
       560        570        580        590        600
YWQKLRHDLE RARLLIELIR KREKLKREQV KVQQAAMELE LMPFNVLLRT 
       610        620        630        640        650
TLDLLQEKDP AHIFAEPVNL SEVPDYLEFI SKPMDFSTMR RKLESHLYRT 
       660        670        680        690        700
LEEFEEDFNL IVTNCMKYNA KDTIFHRAAV RLRDLGGAIL RHARRQAENI 
       710        720        730        740        750
GYDPERGTHL PESPKLEDFY RFSWEDVDNI LIPENRAHLS PEVQLKELLE 
       760        770        780        790        800
KLDLVSAMRS SGARTRRVRL LRREINALRQ KLAQPPPPQP PSLNKTVSNG 
       810        820        830        840        850
ELPAGPQGDA AVLEQALQEE PEDDGDRDDS KLPPPPTLEP TGPAPSLSEQ 
       860        870        880        890        900
ESPPEPPTLK PINDSKPPSR FLKPRKVEED ELLEKSPLQL GNEPLQRLLS 
       910        920        930        940        950
DNGINRLSLM APDTPAGTPL SGVGRRTSVL FKKAKNGVKL QRSPDRVLEN 
       960        970        980        990       1000
GEDHGVAGSP ASPASIEEER HSRKRPRSRS CSESEGERSP QQEEETGMTN 
      1010       1020       1030       1040       1050
GFGKHTESGS DSECSLGLSG GLAFEACSGL TPPKRSRGKP ALSRVPFLEG 
      1060       1070       1080       1090       1100
VNGDSDYNGS GRSLLLPFED RGDLEPLELV WAKCRGYPSY PALIIDPKMP 
      1110       1120       1130       1140       1150
REGLLHNGVP IPVPPLDVLK LGEQKQAEAG EKLFLVLFFD NKRTWQWLPR 
      1160       1170       1180       1190       1200
DKVLPLGVED TVDKLKMLEG RKTSIRKSVQ VAYDRAMIHL SRVRGPHSFV 

TSSYL
Length:1,205
Mass (Da):135,745
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF51DCAB253ED35C7
GO
Isoform 2 (identifier: Q9ULD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-996: Missing.

Show »
Length:935
Mass (Da):106,187
Checksum:i1BCEE6338BAE1ABB
GO
Isoform 3 (identifier: Q9ULD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-996: Missing.
     997-1060: Missing.

Show »
Length:871
Mass (Da):99,713
Checksum:iED046A8987D83B7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PI60E9PI60_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
1,106Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSF3E9PSF3_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
821Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XDC4F6XDC4_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
626Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7B4H0Y7B4_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8WI61A8WI61_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7I6H0Y7I6_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8WI62A8WI62_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ12E9PJ12_HUMAN
Bromodomain and PHD finger-containi...
BRPF3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86600 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1075E → K in BAA86600 (PubMed:10574462).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061042177S → G. Corresponds to variant dbSNP:rs45504893Ensembl.1
Natural variantiVAR_048431278A → G. Corresponds to variant dbSNP:rs17658935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055549727 – 996Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST270
Alternative sequenceiVSP_055550997 – 1060Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB033112 mRNA Translation: BAA86600.1 Different initiation.
Z84485 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03878.1
BC117387 mRNA Translation: AAI17388.1
BC143917 mRNA Translation: AAI43918.1
BC143918 mRNA Translation: AAI43919.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34437.1 [Q9ULD4-1]

NCBI Reference Sequences

More...RefSeqi		NP_056510.2, NM_015695.2 [Q9ULD4-1]
XP_005249067.1, XM_005249010.2 [Q9ULD4-1]
XP_005249068.1, XM_005249011.3 [Q9ULD4-1]
XP_011512791.1, XM_011514489.1 [Q9ULD4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339717.11; ENSP00000345419.7; ENSG00000096070.19 [Q9ULD4-2]
ENST00000357641.10; ENSP00000350267.6; ENSG00000096070.19
ENST00000534694.5; ENSP00000434501.1; ENSG00000096070.19 [Q9ULD4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27154

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000357641.10; ENSP00000350267.6; NM_015695.3; NP_056510.2

UCSC genome browser

More...UCSCi		uc003olv.5, human [Q9ULD4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033112 mRNA Translation: BAA86600.1 Different initiation.
Z84485 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03878.1
BC117387 mRNA Translation: AAI17388.1
BC143917 mRNA Translation: AAI43918.1
BC143918 mRNA Translation: AAI43919.1
CCDSiCCDS34437.1 [Q9ULD4-1]
RefSeqiNP_056510.2, NM_015695.2 [Q9ULD4-1]
XP_005249067.1, XM_005249010.2 [Q9ULD4-1]
XP_005249068.1, XM_005249011.3 [Q9ULD4-1]
XP_011512791.1, XM_011514489.1 [Q9ULD4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PFSX-ray1.90A/B1056-1195[»]
AlphaFoldDBiQ9ULD4
SMRiQ9ULD4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118036, 163 interactors
ComplexPortaliCPX-736, MOZ3 histone acetyltransferase complex
CPX-740, MORF3 histone acetyltransferase complex
CORUMiQ9ULD4
IntActiQ9ULD4, 32 interactors
MINTiQ9ULD4
STRINGi9606.ENSP00000350267

Chemistry databases

BindingDBiQ9ULD4
ChEMBLiCHEMBL3108644
GuidetoPHARMACOLOGYi2731

PTM databases

iPTMnetiQ9ULD4
PhosphoSitePlusiQ9ULD4

Genetic variation databases

BioMutaiBRPF3
DMDMi71153496

Proteomic databases

EPDiQ9ULD4
jPOSTiQ9ULD4
MassIVEiQ9ULD4
MaxQBiQ9ULD4
PaxDbiQ9ULD4
PeptideAtlasiQ9ULD4
PRIDEiQ9ULD4
ProteomicsDBi61143
7229
84995 [Q9ULD4-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9ULD4, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15345, 78 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		27154

Genome annotation databases

EnsembliENST00000339717.11; ENSP00000345419.7; ENSG00000096070.19 [Q9ULD4-2]
ENST00000357641.10; ENSP00000350267.6; ENSG00000096070.19
ENST00000534694.5; ENSP00000434501.1; ENSG00000096070.19 [Q9ULD4-3]
GeneIDi27154
KEGGihsa:27154
MANE-SelectiENST00000357641.10; ENSP00000350267.6; NM_015695.3; NP_056510.2
UCSCiuc003olv.5, human [Q9ULD4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27154

GeneCards: human genes, protein and diseases

More...GeneCardsi		BRPF3
HGNCiHGNC:14256, BRPF3
HPAiENSG00000096070, Low tissue specificity
neXtProtiNX_Q9ULD4
OpenTargetsiENSG00000096070
PharmGKBiPA25425
VEuPathDBiHostDB:ENSG00000096070

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0955, Eukaryota
GeneTreeiENSGT00940000155056
HOGENOMiCLU_003589_1_0_1
InParanoidiQ9ULD4
OMAiKNHCPNS
OrthoDBi566217at2759
PhylomeDBiQ9ULD4
TreeFamiTF316118

Enzyme and pathway databases

PathwayCommonsiQ9ULD4
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-3214847, HATs acetylate histones
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
SignaLinkiQ9ULD4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27154, 19 hits in 1089 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BRPF3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27154
PharosiQ9ULD4, Tchem

Protein Ontology

More...PROi		PR:Q9ULD4
RNActiQ9ULD4, protein

Gene expression databases

BgeeiENSG00000096070, Expressed in skeletal muscle tissue and 173 other tissues
ExpressionAtlasiQ9ULD4, baseline and differential
GenevisibleiQ9ULD4, HS

Family and domain databases

CDDicd05839, BR140_related, 1 hit
cd15703, ePHD_BRPF3, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502, BR140-rel_PWWD
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR042005, BRPF3_ePHD
IPR019542, Enhancer_polycomb-like_N
IPR034732, EPHD
IPR000313, PWWP_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF10513, EPL1, 1 hit
PF00855, PWWP, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00249, PHD, 2 hits
SM00293, PWWP, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 1 hit
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS50812, PWWP, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRPF3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD4
Secondary accession number(s): A6ND56
, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 19, 2005
Last modified: May 25, 2022
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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