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Protein

2-oxoglutarate dehydrogenase-like, mitochondrial

Gene

OGDHL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141CalciumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi141 – 145By similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandCalcium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BRENDAi1.2.4.2 2681

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase-like, mitochondrial (EC:1.2.4.-)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1-like
Short name:
OGDC-E1-like
Alpha-ketoglutarate dehydrogenase-like
Gene namesi
Name:OGDHL
Synonyms:KIAA1290
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000197444.9
HGNCiHGNC:25590 OGDHL
MIMi617513 gene
neXtProtiNX_Q9ULD0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi55753
OpenTargetsiENSG00000197444
PharmGKBiPA134878907

Polymorphism and mutation databases

BioMutaiOGDHL
DMDMi160419019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 73MitochondrionSequence analysisAdd BLAST73
ChainiPRO_000031098374 – 10102-oxoglutarate dehydrogenase-like, mitochondrialAdd BLAST937

Proteomic databases

EPDiQ9ULD0
PaxDbiQ9ULD0
PeptideAtlasiQ9ULD0
PRIDEiQ9ULD0
ProteomicsDBi84986
84987 [Q9ULD0-2]
84988 [Q9ULD0-3]

PTM databases

iPTMnetiQ9ULD0
PhosphoSitePlusiQ9ULD0

Expressioni

Gene expression databases

BgeeiENSG00000197444
CleanExiHS_OGDHL
GenevisibleiQ9ULD0 HS

Organism-specific databases

HPAiHPA052497

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-3940481,EBI-518675

Protein-protein interaction databases

BioGridi120871, 7 interactors
DIPiDIP-61552N
IntActiQ9ULD0, 5 interactors
MINTiQ9ULD0
STRINGi9606.ENSP00000363216

Structurei

3D structure databases

ProteinModelPortaliQ9ULD0
SMRiQ9ULD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 48Poly-Gly4

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
HOVERGENiHBG001892
InParanoidiQ9ULD0
KOiK00164
OMAiDDSDAYP
OrthoDBiEOG091G025G
PhylomeDBiQ9ULD0
TreeFamiTF300695

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQLRLLPSR LGVQAARLLA AHDVPVFGWR SRSSGPPATF PSSKGGGGSS
60 70 80 90 100
YMEEMYFAWL ENPQSVHKSW DSFFREASEE AFSGSAQPRP PSVVHESRSA
110 120 130 140 150
VSSRTKTSKL VEDHLAVQSL IRAYQIRGHH VAQLDPLGIL DADLDSFVPS
160 170 180 190 200
DLITTIDKLA FYDLQEADLD KEFQLPTTTF IGGSENTLSL REIIRRLENT
210 220 230 240 250
YCQHIGLEFM FINDVEQCQW IRQKFETPGV MQFSSEEKRT LLARLVRSMR
260 270 280 290 300
FEDFLARKWS SEKRFGLEGC EVMIPALKTI IDKSSEMGIE NVILGMPHRG
310 320 330 340 350
RLNVLANVIR KDLEQIFCQF DPKLEAADEG SGDVKYHLGM YHERINRVTN
360 370 380 390 400
RNITLSLVAN PSHLEAVDPV VQGKTKAEQF YRGDAQGKKV MSILVHGDAA
410 420 430 440 450
FAGQGVVYET FHLSDLPSYT TNGTVHVVVN NQIGFTTDPR MARSSPYPTD
460 470 480 490 500
VARVVNAPIF HVNADDPEAV IYVCSVAAEW RNTFNKDVVV DLVCYRRRGH
510 520 530 540 550
NEMDEPMFTQ PLMYKQIHRQ VPVLKKYADK LIAEGTVTLQ EFEEEIAKYD
560 570 580 590 600
RICEEAYGRS KDKKILHIKH WLDSPWPGFF NVDGEPKSMT CPATGIPEDM
610 620 630 640 650
LTHIGSVASS VPLEDFKIHT GLSRILRGRA DMTKNRTVDW ALAEYMAFGS
660 670 680 690 700
LLKEGIHVRL SGQDVERGTF SHRHHVLHDQ EVDRRTCVPM NHLWPDQAPY
710 720 730 740 750
TVCNSSLSEY GVLGFELGYA MASPNALVLW EAQFGDFHNT AQCIIDQFIS
760 770 780 790 800
TGQAKWVRHN GIVLLLPHGM EGMGPEHSSA RPERFLQMSN DDSDAYPAFT
810 820 830 840 850
KDFEVSQLYD CNWIVVNCST PANYFHVLRR QILLPFRKPL IIFTPKSLLR
860 870 880 890 900
HPEAKSSFDQ MVSGTSFQRV IPEDGAAARA PEQVQRLIFC TGKVYYDLVK
910 920 930 940 950
ERSSQDLEEK VAITRLEQIS PFPFDLIKQE AEKYPGAELA WCQEEHKNMG
960 970 980 990 1000
YYDYISPRFM TILRRARPIW YVGRDPAAAP ATGNRNTHLV SLKKFLDTAF
1010
NLQAFEGKTF
Length:1,010
Mass (Da):114,481
Last modified:November 13, 2007 - v3
Checksum:i95A836DE079E804C
GO
Isoform 2 (identifier: Q9ULD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-125: Missing.

Show »
Length:953
Mass (Da):108,148
Checksum:i70EB6121D698658F
GO
Isoform 3 (identifier: Q9ULD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:801
Mass (Da):91,232
Checksum:i611D2A4D3E43C51B
GO

Sequence cautioni

The sequence BAA86604 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → G in BAA91855 (PubMed:14702039).Curated1
Sequence conflicti319Q → R in BAA91855 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037125511P → L1 PublicationCorresponds to variant dbSNP:rs17856755Ensembl.1
Natural variantiVAR_037126573D → N1 PublicationCorresponds to variant dbSNP:rs17852386Ensembl.1
Natural variantiVAR_037127623S → C. Corresponds to variant dbSNP:rs34877195Ensembl.1
Natural variantiVAR_037128637T → M1 PublicationCorresponds to variant dbSNP:rs11101224Ensembl.1
Natural variantiVAR_037129725N → S. Corresponds to variant dbSNP:rs2293239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413511 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_04135069 – 125Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033116 mRNA Translation: BAA86604.2 Different initiation.
AK001713 mRNA Translation: BAA91855.1
AK290226 mRNA Translation: BAF82915.1
AK296551 mRNA Translation: BAG59174.1
AK303729 mRNA Translation: BAG64705.1
AC069546 Genomic DNA No translation available.
BC026320 mRNA Translation: AAH26320.1
CCDSiCCDS44390.1 [Q9ULD0-2]
CCDS44391.1 [Q9ULD0-3]
CCDS7234.1 [Q9ULD0-1]
RefSeqiNP_001137468.1, NM_001143996.1 [Q9ULD0-2]
NP_001137469.1, NM_001143997.1 [Q9ULD0-3]
NP_001334748.1, NM_001347819.1 [Q9ULD0-1]
NP_001334749.1, NM_001347820.1 [Q9ULD0-2]
NP_001334750.1, NM_001347821.1 [Q9ULD0-3]
NP_001334751.1, NM_001347822.1 [Q9ULD0-3]
NP_060715.2, NM_018245.2 [Q9ULD0-1]
XP_011538248.1, XM_011539946.1 [Q9ULD0-1]
UniGeneiHs.17860

Genome annotation databases

EnsembliENST00000374103; ENSP00000363216; ENSG00000197444 [Q9ULD0-1]
ENST00000419399; ENSP00000401356; ENSG00000197444 [Q9ULD0-2]
ENST00000432695; ENSP00000390240; ENSG00000197444 [Q9ULD0-3]
GeneIDi55753
KEGGihsa:55753
UCSCiuc001jie.4 human [Q9ULD0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOGDHL_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD0
Secondary accession number(s): A8K2G1
, B4DKG2, B4E193, Q8TAN9, Q9NVA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 18, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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