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UniProtKB - Q9ULD0 (OGDHL_HUMAN)

Protein

2-oxoglutarate dehydrogenase-like, mitochondrial

Gene

OGDHL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

thiamine diphosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141CalciumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi141 – 145By similarity5

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandCalcium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BRENDAi1.2.4.2 2681

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase-like, mitochondrial (EC:1.2.4.-)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1-like
Short name:
OGDC-E1-like
Alpha-ketoglutarate dehydrogenase-like
Gene namesi
Name:OGDHL
Synonyms:KIAA1290
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000197444.9
HGNCiHGNC:25590 OGDHL
MIMi617513 gene
neXtProtiNX_Q9ULD0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi55753
OpenTargetsiENSG00000197444
PharmGKBiPA134878907

Polymorphism and mutation databases

BioMutaiOGDHL
DMDMi160419019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 73MitochondrionSequence analysisAdd BLAST73
ChainiPRO_000031098374 – 10102-oxoglutarate dehydrogenase-like, mitochondrialAdd BLAST937

Proteomic databases

EPDiQ9ULD0
PaxDbiQ9ULD0
PeptideAtlasiQ9ULD0
PRIDEiQ9ULD0
ProteomicsDBi84986
84987 [Q9ULD0-2]
84988 [Q9ULD0-3]

PTM databases

iPTMnetiQ9ULD0
PhosphoSitePlusiQ9ULD0

Expressioni

Gene expression databases

BgeeiENSG00000197444 Expressed in 131 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OGDHL
GenevisibleiQ9ULD0 HS

Organism-specific databases

HPAiHPA052497

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-3940481,EBI-518675

Protein-protein interaction databases

BioGridi120871, 7 interactors
DIPiDIP-61552N
IntActiQ9ULD0, 5 interactors
MINTiQ9ULD0
STRINGi9606.ENSP00000363216

Structurei

3D structure databases

ProteinModelPortaliQ9ULD0
SMRiQ9ULD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 48Poly-Gly4

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
HOVERGENiHBG001892
InParanoidiQ9ULD0
KOiK00164
OMAiDDSDAYP
OrthoDBiEOG091G025G
PhylomeDBiQ9ULD0
TreeFamiTF300695

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ULD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQLRLLPSR LGVQAARLLA AHDVPVFGWR SRSSGPPATF PSSKGGGGSS 
        60         70         80         90        100
YMEEMYFAWL ENPQSVHKSW DSFFREASEE AFSGSAQPRP PSVVHESRSA 
       110        120        130        140        150
VSSRTKTSKL VEDHLAVQSL IRAYQIRGHH VAQLDPLGIL DADLDSFVPS 
       160        170        180        190        200
DLITTIDKLA FYDLQEADLD KEFQLPTTTF IGGSENTLSL REIIRRLENT 
       210        220        230        240        250
YCQHIGLEFM FINDVEQCQW IRQKFETPGV MQFSSEEKRT LLARLVRSMR 
       260        270        280        290        300
FEDFLARKWS SEKRFGLEGC EVMIPALKTI IDKSSEMGIE NVILGMPHRG 
       310        320        330        340        350
RLNVLANVIR KDLEQIFCQF DPKLEAADEG SGDVKYHLGM YHERINRVTN 
       360        370        380        390        400
RNITLSLVAN PSHLEAVDPV VQGKTKAEQF YRGDAQGKKV MSILVHGDAA 
       410        420        430        440        450
FAGQGVVYET FHLSDLPSYT TNGTVHVVVN NQIGFTTDPR MARSSPYPTD 
       460        470        480        490        500
VARVVNAPIF HVNADDPEAV IYVCSVAAEW RNTFNKDVVV DLVCYRRRGH 
       510        520        530        540        550
NEMDEPMFTQ PLMYKQIHRQ VPVLKKYADK LIAEGTVTLQ EFEEEIAKYD 
       560        570        580        590        600
RICEEAYGRS KDKKILHIKH WLDSPWPGFF NVDGEPKSMT CPATGIPEDM 
       610        620        630        640        650
LTHIGSVASS VPLEDFKIHT GLSRILRGRA DMTKNRTVDW ALAEYMAFGS 
       660        670        680        690        700
LLKEGIHVRL SGQDVERGTF SHRHHVLHDQ EVDRRTCVPM NHLWPDQAPY 
       710        720        730        740        750
TVCNSSLSEY GVLGFELGYA MASPNALVLW EAQFGDFHNT AQCIIDQFIS 
       760        770        780        790        800
TGQAKWVRHN GIVLLLPHGM EGMGPEHSSA RPERFLQMSN DDSDAYPAFT 
       810        820        830        840        850
KDFEVSQLYD CNWIVVNCST PANYFHVLRR QILLPFRKPL IIFTPKSLLR 
       860        870        880        890        900
HPEAKSSFDQ MVSGTSFQRV IPEDGAAARA PEQVQRLIFC TGKVYYDLVK 
       910        920        930        940        950
ERSSQDLEEK VAITRLEQIS PFPFDLIKQE AEKYPGAELA WCQEEHKNMG 
       960        970        980        990       1000
YYDYISPRFM TILRRARPIW YVGRDPAAAP ATGNRNTHLV SLKKFLDTAF 
      1010
NLQAFEGKTF
Length:1,010
Mass (Da):114,481
Last modified:November 13, 2007 - v3
Checksum:i95A836DE079E804C
GO
Isoform 2 (identifier: Q9ULD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-125: Missing.

Show »
Length:953
Mass (Da):108,148
Checksum:i70EB6121D698658F
GO
Isoform 3 (identifier: Q9ULD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:801
Mass (Da):91,232
Checksum:i611D2A4D3E43C51B
GO

Sequence cautioni

The sequence BAA86604 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → G in BAA91855 (PubMed:14702039).Curated1
Sequence conflicti319Q → R in BAA91855 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037125511P → L1 PublicationCorresponds to variant dbSNP:rs17856755Ensembl.1
Natural variantiVAR_037126573D → N1 PublicationCorresponds to variant dbSNP:rs17852386Ensembl.1
Natural variantiVAR_037127623S → C. Corresponds to variant dbSNP:rs34877195Ensembl.1
Natural variantiVAR_037128637T → M1 PublicationCorresponds to variant dbSNP:rs11101224Ensembl.1
Natural variantiVAR_037129725N → S. Corresponds to variant dbSNP:rs2293239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413511 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_04135069 – 125Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033116 mRNA Translation: BAA86604.2 Different initiation.
AK001713 mRNA Translation: BAA91855.1
AK290226 mRNA Translation: BAF82915.1
AK296551 mRNA Translation: BAG59174.1
AK303729 mRNA Translation: BAG64705.1
AC069546 Genomic DNA No translation available.
BC026320 mRNA Translation: AAH26320.1
CCDSiCCDS44390.1 [Q9ULD0-2]
CCDS44391.1 [Q9ULD0-3]
CCDS7234.1 [Q9ULD0-1]
RefSeqiNP_001137468.1, NM_001143996.1 [Q9ULD0-2]
NP_001137469.1, NM_001143997.1 [Q9ULD0-3]
NP_001334748.1, NM_001347819.1 [Q9ULD0-1]
NP_001334749.1, NM_001347820.1 [Q9ULD0-2]
NP_001334750.1, NM_001347821.1 [Q9ULD0-3]
NP_001334751.1, NM_001347822.1 [Q9ULD0-3]
NP_060715.2, NM_018245.2 [Q9ULD0-1]
XP_011538248.1, XM_011539946.1 [Q9ULD0-1]
UniGeneiHs.17860

Genome annotation databases

EnsembliENST00000374103; ENSP00000363216; ENSG00000197444 [Q9ULD0-1]
ENST00000419399; ENSP00000401356; ENSG00000197444 [Q9ULD0-2]
ENST00000432695; ENSP00000390240; ENSG00000197444 [Q9ULD0-3]
GeneIDi55753
KEGGihsa:55753
UCSCiuc001jie.4 human [Q9ULD0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033116 mRNA Translation: BAA86604.2 Different initiation.
AK001713 mRNA Translation: BAA91855.1
AK290226 mRNA Translation: BAF82915.1
AK296551 mRNA Translation: BAG59174.1
AK303729 mRNA Translation: BAG64705.1
AC069546 Genomic DNA No translation available.
BC026320 mRNA Translation: AAH26320.1
CCDSiCCDS44390.1 [Q9ULD0-2]
CCDS44391.1 [Q9ULD0-3]
CCDS7234.1 [Q9ULD0-1]
RefSeqiNP_001137468.1, NM_001143996.1 [Q9ULD0-2]
NP_001137469.1, NM_001143997.1 [Q9ULD0-3]
NP_001334748.1, NM_001347819.1 [Q9ULD0-1]
NP_001334749.1, NM_001347820.1 [Q9ULD0-2]
NP_001334750.1, NM_001347821.1 [Q9ULD0-3]
NP_001334751.1, NM_001347822.1 [Q9ULD0-3]
NP_060715.2, NM_018245.2 [Q9ULD0-1]
XP_011538248.1, XM_011539946.1 [Q9ULD0-1]
UniGeneiHs.17860

3D structure databases

ProteinModelPortaliQ9ULD0
SMRiQ9ULD0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120871, 7 interactors
DIPiDIP-61552N
IntActiQ9ULD0, 5 interactors
MINTiQ9ULD0
STRINGi9606.ENSP00000363216

PTM databases

iPTMnetiQ9ULD0
PhosphoSitePlusiQ9ULD0

Polymorphism and mutation databases

BioMutaiOGDHL
DMDMi160419019

Proteomic databases

EPDiQ9ULD0
PaxDbiQ9ULD0
PeptideAtlasiQ9ULD0
PRIDEiQ9ULD0
ProteomicsDBi84986
84987 [Q9ULD0-2]
84988 [Q9ULD0-3]

Protocols and materials databases

DNASUi55753
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374103; ENSP00000363216; ENSG00000197444 [Q9ULD0-1]
ENST00000419399; ENSP00000401356; ENSG00000197444 [Q9ULD0-2]
ENST00000432695; ENSP00000390240; ENSG00000197444 [Q9ULD0-3]
GeneIDi55753
KEGGihsa:55753
UCSCiuc001jie.4 human [Q9ULD0-1]

Organism-specific databases

CTDi55753
DisGeNETi55753
EuPathDBiHostDB:ENSG00000197444.9
GeneCardsiOGDHL
HGNCiHGNC:25590 OGDHL
HPAiHPA052497
MIMi617513 gene
neXtProtiNX_Q9ULD0
OpenTargetsiENSG00000197444
PharmGKBiPA134878907
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0450 Eukaryota
COG0567 LUCA
GeneTreeiENSGT00530000063092
HOGENOMiHOG000259586
HOVERGENiHBG001892
InParanoidiQ9ULD0
KOiK00164
OMAiDDSDAYP
OrthoDBiEOG091G025G
PhylomeDBiQ9ULD0
TreeFamiTF300695

Enzyme and pathway databases

BRENDAi1.2.4.2 2681

Miscellaneous databases

ChiTaRSiOGDHL human
GenomeRNAii55753
PROiPR:Q9ULD0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197444 Expressed in 131 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_OGDHL
GenevisibleiQ9ULD0 HS

Family and domain databases

InterProiView protein in InterPro
IPR032106 2-oxogl_dehyd_N
IPR011603 2oxoglutarate_DH_E1
IPR001017 DH_E1
IPR031717 KGD_C
IPR029061 THDP-binding
IPR005475 Transketolase-like_Pyr-bd
PANTHERiPTHR23152 PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078 2-oxogl_dehyd_N, 1 hit
PF00676 E1_dh, 1 hit
PF16870 OxoGdeHyase_C, 1 hit
PF02779 Transket_pyr, 1 hit
PIRSFiPIRSF000157 Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
TIGRFAMsiTIGR00239 2oxo_dh_E1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOGDHL_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD0
Secondary accession number(s): A8K2G1
, B4DKG2, B4E193, Q8TAN9, Q9NVA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 12, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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