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Entry version 159 (25 May 2022)
Sequence version 3 (13 Nov 2007)
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Protein

2-oxoglutarate dehydrogenase-like, mitochondrial

Gene

OGDHL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2 while reducing NAD+ to NADH (By similarity).

The OGDHC complex is mainly active in the mitochondrion (By similarity).

Involved in the inhibition of cell proliferation and in apoptosis (PubMed:23152800, PubMed:31175094).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

thiamine diphosphateBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi141Calcium 1By similarity1
Metal bindingi143Calcium 1By similarity1
Metal bindingi145Calcium 1By similarity1
Metal bindingi166Calcium 2By similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi170Calcium 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandCalcium, Metal-binding, Thiamine pyrophosphate

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.2.4.2, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9ULD0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9ULD0

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9ULD0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase-like, mitochondrialBy similarity (EC:1.2.4.2By similarity)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1-like1 Publication
Short name:
OGDC-E1-like1 Publication
Alpha-ketoglutarate dehydrogenase-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OGDHLImported
Synonyms:KIAA1290
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25590, OGDHL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617513, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULD0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000197444

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55753

Open Targets

More...
OpenTargetsi
ENSG00000197444

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134878907

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULD0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
OGDHL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160419019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 73MitochondrionSequence analysisAdd BLAST73
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031098374 – 10102-oxoglutarate dehydrogenase-like, mitochondrialAdd BLAST937

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9ULD0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULD0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULD0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9ULD0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULD0

PeptideAtlas

More...
PeptideAtlasi
Q9ULD0

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULD0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84986 [Q9ULD0-1]
84987 [Q9ULD0-2]
84988 [Q9ULD0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULD0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULD0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain and the liver.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Post-transcriptionally repressed by microRNA miR-214 in cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197444, Expressed in adult mammalian kidney and 149 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULD0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197444, Tissue enhanced (choroid plexus, kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The OGDHC complex comprises multiple copies of three catalytic enzyme components, the 2-oxoglutarate dehydrogenase (OGDH/E1), the dihydrolipoamide dehydrogenase (DLST/E2) and the dihydrolipoamide dehydrogenase (DLD/E3). OGDHL/E1-like isoenzyme may replace OGDH in the OGDHC complex in the brain. The presence of either ODGH/E1 or ODGHL/E1-like isoenzyme in the complex may depend on its tissular distribution.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120871, 57 interactors

Database of interacting proteins

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DIPi
DIP-61552N

Protein interaction database and analysis system

More...
IntActi
Q9ULD0, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9ULD0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363216

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULD0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9ULD0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULD0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni81 – 100DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0450, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004709_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULD0

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMIDQYI

Database of Orthologous Groups

More...
OrthoDBi
134699at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULD0

TreeFam database of animal gene trees

More...
TreeFami
TF300695

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11610, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd

The PANTHER Classification System

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PANTHERi
PTHR23152, PTHR23152, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000157, Oxoglu_dh_E1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00861, Transket_pyr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518, SSF52518, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00239, 2oxo_dh_E1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9ULD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQLRLLPSR LGVQAARLLA AHDVPVFGWR SRSSGPPATF PSSKGGGGSS
60 70 80 90 100
YMEEMYFAWL ENPQSVHKSW DSFFREASEE AFSGSAQPRP PSVVHESRSA
110 120 130 140 150
VSSRTKTSKL VEDHLAVQSL IRAYQIRGHH VAQLDPLGIL DADLDSFVPS
160 170 180 190 200
DLITTIDKLA FYDLQEADLD KEFQLPTTTF IGGSENTLSL REIIRRLENT
210 220 230 240 250
YCQHIGLEFM FINDVEQCQW IRQKFETPGV MQFSSEEKRT LLARLVRSMR
260 270 280 290 300
FEDFLARKWS SEKRFGLEGC EVMIPALKTI IDKSSEMGIE NVILGMPHRG
310 320 330 340 350
RLNVLANVIR KDLEQIFCQF DPKLEAADEG SGDVKYHLGM YHERINRVTN
360 370 380 390 400
RNITLSLVAN PSHLEAVDPV VQGKTKAEQF YRGDAQGKKV MSILVHGDAA
410 420 430 440 450
FAGQGVVYET FHLSDLPSYT TNGTVHVVVN NQIGFTTDPR MARSSPYPTD
460 470 480 490 500
VARVVNAPIF HVNADDPEAV IYVCSVAAEW RNTFNKDVVV DLVCYRRRGH
510 520 530 540 550
NEMDEPMFTQ PLMYKQIHRQ VPVLKKYADK LIAEGTVTLQ EFEEEIAKYD
560 570 580 590 600
RICEEAYGRS KDKKILHIKH WLDSPWPGFF NVDGEPKSMT CPATGIPEDM
610 620 630 640 650
LTHIGSVASS VPLEDFKIHT GLSRILRGRA DMTKNRTVDW ALAEYMAFGS
660 670 680 690 700
LLKEGIHVRL SGQDVERGTF SHRHHVLHDQ EVDRRTCVPM NHLWPDQAPY
710 720 730 740 750
TVCNSSLSEY GVLGFELGYA MASPNALVLW EAQFGDFHNT AQCIIDQFIS
760 770 780 790 800
TGQAKWVRHN GIVLLLPHGM EGMGPEHSSA RPERFLQMSN DDSDAYPAFT
810 820 830 840 850
KDFEVSQLYD CNWIVVNCST PANYFHVLRR QILLPFRKPL IIFTPKSLLR
860 870 880 890 900
HPEAKSSFDQ MVSGTSFQRV IPEDGAAARA PEQVQRLIFC TGKVYYDLVK
910 920 930 940 950
ERSSQDLEEK VAITRLEQIS PFPFDLIKQE AEKYPGAELA WCQEEHKNMG
960 970 980 990 1000
YYDYISPRFM TILRRARPIW YVGRDPAAAP ATGNRNTHLV SLKKFLDTAF
1010
NLQAFEGKTF
Length:1,010
Mass (Da):114,481
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95A836DE079E804C
GO
Isoform 2 (identifier: Q9ULD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-125: Missing.

Show »
Length:953
Mass (Da):108,148
Checksum:i70EB6121D698658F
GO
Isoform 3 (identifier: Q9ULD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:801
Mass (Da):91,232
Checksum:i611D2A4D3E43C51B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86604 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti97S → G in BAA91855 (PubMed:14702039).Curated1
Sequence conflicti319Q → R in BAA91855 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037125511P → L1 PublicationCorresponds to variant dbSNP:rs17856755Ensembl.1
Natural variantiVAR_037126573D → N1 PublicationCorresponds to variant dbSNP:rs17852386Ensembl.1
Natural variantiVAR_037127623S → C. Corresponds to variant dbSNP:rs34877195EnsemblClinVar.1
Natural variantiVAR_037128637T → M1 PublicationCorresponds to variant dbSNP:rs11101224Ensembl.1
Natural variantiVAR_037129725N → S. Corresponds to variant dbSNP:rs2293239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413511 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_04135069 – 125Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033116 mRNA Translation: BAA86604.2 Different initiation.
AK001713 mRNA Translation: BAA91855.1
AK290226 mRNA Translation: BAF82915.1
AK296551 mRNA Translation: BAG59174.1
AK303729 mRNA Translation: BAG64705.1
AC069546 Genomic DNA No translation available.
BC026320 mRNA Translation: AAH26320.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44390.1 [Q9ULD0-2]
CCDS44391.1 [Q9ULD0-3]
CCDS7234.1 [Q9ULD0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001137468.1, NM_001143996.1 [Q9ULD0-2]
NP_001137469.1, NM_001143997.1 [Q9ULD0-3]
NP_001334748.1, NM_001347819.1 [Q9ULD0-1]
NP_001334749.1, NM_001347820.1 [Q9ULD0-2]
NP_001334750.1, NM_001347821.1 [Q9ULD0-3]
NP_001334751.1, NM_001347822.1 [Q9ULD0-3]
NP_060715.2, NM_018245.2 [Q9ULD0-1]
XP_011538248.1, XM_011539946.1 [Q9ULD0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000374103.9; ENSP00000363216.4; ENSG00000197444.10
ENST00000419399.4; ENSP00000401356.1; ENSG00000197444.10 [Q9ULD0-2]
ENST00000432695.2; ENSP00000390240.1; ENSG00000197444.10 [Q9ULD0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55753

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55753

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000374103.9; ENSP00000363216.4; NM_018245.3; NP_060715.2

UCSC genome browser

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UCSCi
uc001jie.4, human [Q9ULD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033116 mRNA Translation: BAA86604.2 Different initiation.
AK001713 mRNA Translation: BAA91855.1
AK290226 mRNA Translation: BAF82915.1
AK296551 mRNA Translation: BAG59174.1
AK303729 mRNA Translation: BAG64705.1
AC069546 Genomic DNA No translation available.
BC026320 mRNA Translation: AAH26320.1
CCDSiCCDS44390.1 [Q9ULD0-2]
CCDS44391.1 [Q9ULD0-3]
CCDS7234.1 [Q9ULD0-1]
RefSeqiNP_001137468.1, NM_001143996.1 [Q9ULD0-2]
NP_001137469.1, NM_001143997.1 [Q9ULD0-3]
NP_001334748.1, NM_001347819.1 [Q9ULD0-1]
NP_001334749.1, NM_001347820.1 [Q9ULD0-2]
NP_001334750.1, NM_001347821.1 [Q9ULD0-3]
NP_001334751.1, NM_001347822.1 [Q9ULD0-3]
NP_060715.2, NM_018245.2 [Q9ULD0-1]
XP_011538248.1, XM_011539946.1 [Q9ULD0-1]

3D structure databases

AlphaFoldDBiQ9ULD0
SMRiQ9ULD0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120871, 57 interactors
DIPiDIP-61552N
IntActiQ9ULD0, 9 interactors
MINTiQ9ULD0
STRINGi9606.ENSP00000363216

PTM databases

iPTMnetiQ9ULD0
PhosphoSitePlusiQ9ULD0

Genetic variation databases

BioMutaiOGDHL
DMDMi160419019

Proteomic databases

EPDiQ9ULD0
jPOSTiQ9ULD0
MassIVEiQ9ULD0
MaxQBiQ9ULD0
PaxDbiQ9ULD0
PeptideAtlasiQ9ULD0
PRIDEiQ9ULD0
ProteomicsDBi84986 [Q9ULD0-1]
84987 [Q9ULD0-2]
84988 [Q9ULD0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
44978, 65 antibodies from 21 providers

The DNASU plasmid repository

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DNASUi
55753

Genome annotation databases

EnsembliENST00000374103.9; ENSP00000363216.4; ENSG00000197444.10
ENST00000419399.4; ENSP00000401356.1; ENSG00000197444.10 [Q9ULD0-2]
ENST00000432695.2; ENSP00000390240.1; ENSG00000197444.10 [Q9ULD0-3]
GeneIDi55753
KEGGihsa:55753
MANE-SelectiENST00000374103.9; ENSP00000363216.4; NM_018245.3; NP_060715.2
UCSCiuc001jie.4, human [Q9ULD0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55753
DisGeNETi55753

GeneCards: human genes, protein and diseases

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GeneCardsi
OGDHL
HGNCiHGNC:25590, OGDHL
HPAiENSG00000197444, Tissue enhanced (choroid plexus, kidney, liver)
MIMi617513, gene
neXtProtiNX_Q9ULD0
OpenTargetsiENSG00000197444
PharmGKBiPA134878907
VEuPathDBiHostDB:ENSG00000197444

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0450, Eukaryota
GeneTreeiENSGT00950000183125
HOGENOMiCLU_004709_1_1_1
InParanoidiQ9ULD0
OMAiIMIDQYI
OrthoDBi134699at2759
PhylomeDBiQ9ULD0
TreeFamiTF300695

Enzyme and pathway databases

BRENDAi1.2.4.2, 2681
PathwayCommonsiQ9ULD0
SignaLinkiQ9ULD0
SIGNORiQ9ULD0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55753, 8 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
OGDHL, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55753
PharosiQ9ULD0, Tbio

Protein Ontology

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PROi
PR:Q9ULD0
RNActiQ9ULD0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197444, Expressed in adult mammalian kidney and 149 other tissues
GenevisibleiQ9ULD0, HS

Family and domain databases

Gene3Di3.40.50.11610, 1 hit
InterProiView protein in InterPro
IPR032106, 2-oxogl_dehyd_N
IPR011603, 2oxoglutarate_DH_E1
IPR001017, DH_E1
IPR031717, KGD_C
IPR042179, KGD_C_sf
IPR029061, THDP-binding
IPR005475, Transketolase-like_Pyr-bd
PANTHERiPTHR23152, PTHR23152, 1 hit
PfamiView protein in Pfam
PF16078, 2-oxogl_dehyd_N, 1 hit
PF00676, E1_dh, 1 hit
PF16870, OxoGdeHyase_C, 1 hit
PF02779, Transket_pyr, 1 hit
PIRSFiPIRSF000157, Oxoglu_dh_E1, 1 hit
SMARTiView protein in SMART
SM00861, Transket_pyr, 1 hit
SUPFAMiSSF52518, SSF52518, 2 hits
TIGRFAMsiTIGR00239, 2oxo_dh_E1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOGDHL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULD0
Secondary accession number(s): A8K2G1
, B4DKG2, B4E193, Q8TAN9, Q9NVA0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 25, 2022
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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