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Entry version 155 (11 Dec 2019)
Sequence version 3 (04 Jan 2005)
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Protein

Probable palmitoyltransferase ZDHHC8

Gene

ZDHHC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.1 Publication

Miscellaneous

According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei134S-palmitoyl cysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8963896 HDL assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC8 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 8
Short name:
DHHC-8
Zinc finger protein 378
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDHHC8
Synonyms:KIAA1292, ZDHHCL1, ZNF378
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099904.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18474 ZDHHC8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608784 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9ULC8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 52LumenalSequence analysisAdd BLAST18
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 148CytoplasmicSequence analysisAdd BLAST75
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 190LumenalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 765CytoplasmicSequence analysisAdd BLAST554

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
29801

Open Targets

More...
OpenTargetsi
ENSG00000099904

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38339

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9ULC8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZDHHC8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57015419

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128771 – 765Probable palmitoyltransferase ZDHHC8Add BLAST765

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei337PhosphoserineBy similarity1
Modified residuei441Omega-N-methylarginineBy similarity1
Modified residuei606PhosphoserineCombined sources1
Modified residuei627PhosphoserineBy similarity1
Modified residuei675PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9ULC8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9ULC8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ULC8

PeptideAtlas

More...
PeptideAtlasi
Q9ULC8

PRoteomics IDEntifications database

More...
PRIDEi
Q9ULC8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
84983 [Q9ULC8-1]
84984 [Q9ULC8-2]
84985 [Q9ULC8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ULC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9ULC8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9ULC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099904 Expressed in 176 organ(s), highest expression level in tibial nerve

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ULC8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ULC8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003422

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118925, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ULC8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384716

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9ULC8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ULC8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1311 Eukaryota
COG5273 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234346

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ULC8

KEGG Orthology (KO)

More...
KOi
K20030

Identification of Orthologs from Complete Genome Data

More...
OMAi
YANAPLH

Database of Orthologous Groups

More...
OrthoDBi
1264614at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ULC8

TreeFam database of animal gene trees

More...
TreeFami
TF354263

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR030291 ZDHHC8

The PANTHER Classification System

More...
PANTHERi
PTHR12349:SF6 PTHR12349:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01529 DHHC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50216 DHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9ULC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRSPGTRLK PAKYIPVATA AALLVGSSTL FFVFTCPWLT RAVSPAVPVY
60 70 80 90 100
NGIIFLFVLA NFSMATFMDP GVFPRADEDE DKEDDFRAPL YKNVDVRGIQ
110 120 130 140 150
VRMKWCATCH FYRPPRCSHC SVCDNCVEDF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLSAHM VGVVAFGLVY VLNHAEGLGA AHTTITMAVM CVAGLFFIPV
210 220 230 240 250
IGLTGFHVVL VTRGRTTNEQ VTGKFRGGVN PFTRGCCGNV EHVLCSPLAP
260 270 280 290 300
RYVVEPPRLP LAVSLKPPFL RPELLDRAAP LKVKLSDNGL KAGLGRSKSK
310 320 330 340 350
GSLDRLDEKP LDLGPPLPPK IEAGTFSSDL QTPRPGSAES ALSVQRTSPP
360 370 380 390 400
TPAMYKFRPA FPTGPKVPFC GPGEQVPGPD SLTLGDDSIR SLDFVSEPSL
410 420 430 440 450
DLPDYGPGGL HAAYPPSPPL SASDAFSGAL RSLSLKASSR RGGDHVALQP
460 470 480 490 500
LRSEGGPPTP HRSIFAPHAL PNRNGSLSYD SLLNPGSPGG HACPAHPAVG
510 520 530 540 550
VAGYHSPYLH PGATGDPPRP LPRSFSPVLG PRPREPSPVR YDNLSRTIMA
560 570 580 590 600
SIQERKDREE RERLLRSQAD SLFGDSGVYD APSSYSLQQA SVLSEGPRGP
610 620 630 640 650
ALRYGSRDDL VAGPGFGGAR NPALQTSLSS LSSSVSRAPR TSSSSLQADQ
660 670 680 690 700
ASSNAPGPRP SSGSHRSPAR QGLPSPPGTP HSPSYAGPKA VAFIHTDLPE
710 720 730 740 750
PPPSLTVQRD HPQLKTPPSK LNGQSPGLAR LGPATGPPGP SASPTRHTLV
760
KKVSGVGGTT YEISV
Length:765
Mass (Da):81,443
Last modified:January 4, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i005FCA33D7FD7397
GO
Isoform 2 (identifier: Q9ULC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-220: Missing.

Show »
Length:673
Mass (Da):71,235
Checksum:iF3D56B647811FEB9
GO
Isoform 3 (identifier: Q9ULC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-765: DHPQLKTPPS...VGGTTYEISV → GRIGTCTRGW...SSLFPSLSGP

Show »
Length:778
Mass (Da):83,173
Checksum:iD1C3554FD5C9BA17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVM2C9JVM2_HUMAN
Palmitoyltransferase
ZDHHC8
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18420 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG30243 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012572129 – 220Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_012573710 – 765DHPQL…YEISV → GRIGTCTRGWGRRGQPWVPP GLHLCHLGRPEDRPPLRAPW SQAAGAPPRGAMCRLHLAAS SLFPSLSGP in isoform 3. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY894890 mRNA Translation: AAX73369.1
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02984.1
BC053544 mRNA Translation: AAH53544.1
AK131238 mRNA Translation: BAD18420.1 Different initiation.
CR456357 mRNA Translation: CAG30243.1 Different initiation.
AB033118 mRNA Translation: BAA86606.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13776.1 [Q9ULC8-1]
CCDS54502.1 [Q9ULC8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001171953.1, NM_001185024.1 [Q9ULC8-3]
NP_037505.1, NM_013373.3 [Q9ULC8-1]
XP_006724302.1, XM_006724239.2 [Q9ULC8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320602; ENSP00000317804; ENSG00000099904 [Q9ULC8-2]
ENST00000334554; ENSP00000334490; ENSG00000099904 [Q9ULC8-1]
ENST00000405930; ENSP00000384716; ENSG00000099904 [Q9ULC8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
29801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29801

UCSC genome browser

More...
UCSCi
uc002zrq.4 human [Q9ULC8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894890 mRNA Translation: AAX73369.1
AC006547 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX02984.1
BC053544 mRNA Translation: AAH53544.1
AK131238 mRNA Translation: BAD18420.1 Different initiation.
CR456357 mRNA Translation: CAG30243.1 Different initiation.
AB033118 mRNA Translation: BAA86606.1
CCDSiCCDS13776.1 [Q9ULC8-1]
CCDS54502.1 [Q9ULC8-3]
RefSeqiNP_001171953.1, NM_001185024.1 [Q9ULC8-3]
NP_037505.1, NM_013373.3 [Q9ULC8-1]
XP_006724302.1, XM_006724239.2 [Q9ULC8-3]

3D structure databases

SMRiQ9ULC8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi118925, 3 interactors
IntActiQ9ULC8, 1 interactor
STRINGi9606.ENSP00000384716

PTM databases

iPTMnetiQ9ULC8
PhosphoSitePlusiQ9ULC8
SwissPalmiQ9ULC8

Polymorphism and mutation databases

BioMutaiZDHHC8
DMDMi57015419

Proteomic databases

jPOSTiQ9ULC8
MassIVEiQ9ULC8
PaxDbiQ9ULC8
PeptideAtlasiQ9ULC8
PRIDEiQ9ULC8
ProteomicsDBi84983 [Q9ULC8-1]
84984 [Q9ULC8-2]
84985 [Q9ULC8-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29801

Genome annotation databases

EnsembliENST00000320602; ENSP00000317804; ENSG00000099904 [Q9ULC8-2]
ENST00000334554; ENSP00000334490; ENSG00000099904 [Q9ULC8-1]
ENST00000405930; ENSP00000384716; ENSG00000099904 [Q9ULC8-3]
GeneIDi29801
KEGGihsa:29801
UCSCiuc002zrq.4 human [Q9ULC8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
29801
DisGeNETi29801
EuPathDBiHostDB:ENSG00000099904.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ZDHHC8
HGNCiHGNC:18474 ZDHHC8
HPAiHPA003422
MIMi608784 gene
neXtProtiNX_Q9ULC8
OpenTargetsiENSG00000099904
PharmGKBiPA38339

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00940000158044
HOGENOMiHOG000234346
InParanoidiQ9ULC8
KOiK20030
OMAiYANAPLH
OrthoDBi1264614at2759
PhylomeDBiQ9ULC8
TreeFamiTF354263

Enzyme and pathway databases

ReactomeiR-HSA-8963896 HDL assembly

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZDHHC8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29801
PharosiQ9ULC8 Tbio

Protein Ontology

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PROi
PR:Q9ULC8
RNActiQ9ULC8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000099904 Expressed in 176 organ(s), highest expression level in tibial nerve
ExpressionAtlasiQ9ULC8 baseline and differential
GenevisibleiQ9ULC8 HS

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
IPR030291 ZDHHC8
PANTHERiPTHR12349:SF6 PTHR12349:SF6, 1 hit
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDHC8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULC8
Secondary accession number(s): Q2TGE9
, Q6ICL1, Q6ZNF5, Q7Z6L9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: January 4, 2005
Last modified: December 11, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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