UniProtKB - Q9ULC6 (PADI1_HUMAN)

BLAST

>sp|Q9ULC6|PADI1_HUMAN Protein-arginine deiminase type-1 OS=Homo sapiens OX=9606 GN=PADI1 PE=1 SV=2
MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVK
EPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLE
VDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDM
SPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVER
QPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNT
QPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIE
APHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTV
GGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFV
PTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDN
LHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPK
PYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWN
MVP

Align
Format
Add to basket Added to basket
History
Entry version 141 (07 Nov 2018)
Sequence version 2 (21 Dec 2004)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Protein-arginine deiminase type-1

Gene

PADI1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalyzes the deimination of arginine residues of proteins.2 Publications

Catalytic activityⁱ

Protein L-arginine + H₂O = protein L-citrulline + NH₃.2 Publications

Cofactorⁱ

Ca²⁺2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	153	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	155	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	155	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	157	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	157	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	165	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	176	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	179	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	179	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	351	Calcium 4Combined sources1 Publication	1
Metal bindingⁱ	353	Calcium 3Combined sources1 Publication	1
Metal bindingⁱ	364	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	371	Calcium 3Combined sources1 Publication	1
Metal bindingⁱ	372	Calcium 3; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	375	Calcium 3Combined sources1 Publication	1
Metal bindingⁱ	409	Calcium 4; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	412	Calcium 4; via carbonyl oxygenCombined sources1 Publication	1
Active siteⁱ	645	NucleophileBy similarity	1

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27393304
protein-arginine deiminase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 27393304

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone citrullination
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein citrullination
Source: UniProtKB
Inferred from direct assayⁱ
- 27393304

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06945-MONOMER
BRENDAⁱ	3.5.3.15 2681
Reactomeⁱ	R-HSA-3247509 Chromatin modifying enzymes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein-arginine deiminase type-1 (EC:3.5.3.152 Publications) Alternative name(s): Peptidylarginine deiminase I Protein-arginine deiminase type I
Gene namesⁱ	Name:PADI1 Synonyms:PAD1, PDI1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142623.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18367 PADI1
MIMⁱ	607934 gene
neXtProtⁱ	NX_Q9ULC6

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	29943
Open Targets More...OpenTargetsⁱ	ENSG00000142623
PharmGKBⁱ	PA32899

Chemistry databases

ChEMBLⁱ	CHEMBL1909486
Drug and drug target database More...DrugBankⁱ	DB00155 L-Citrulline
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2894

Polymorphism and mutation databases

BioMutaⁱ	PADI1
DMDMⁱ	56757695

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220023	1 – 663	Protein-arginine deiminase type-1Add BLAST		663

Proteomic databases

PaxDbⁱ	Q9ULC6
PeptideAtlas More...PeptideAtlasⁱ	Q9ULC6
PRIDEⁱ	Q9ULC6
ProteomicsDBⁱ	84982

PTM databases

iPTMnetⁱ	Q9ULC6
PhosphoSitePlusⁱ	Q9ULC6

Expressionⁱ

Tissue specificityⁱ

Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000142623 Expressed in 152 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_PADI1
Genevisibleⁱ	Q9ULC6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA062294

HPAⁱ

HPA062294

Interactionⁱ

Subunit structureⁱ

Monomer.1 Publication

Protein-protein interaction databases

BioGridⁱ	118980, 4 interactors
IntActⁱ	Q9ULC6, 1 interactor
STRINGⁱ	9606.ENSP00000364620

Chemistry databases

BindingDBⁱ

Q9ULC6

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	11 – 13	Combined sources	3
Beta strandⁱ	15 – 20	Combined sources	6
Beta strandⁱ	25 – 27	Combined sources	3
Beta strandⁱ	39 – 53	Combined sources	15
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	60 – 62	Combined sources	3
Beta strandⁱ	68 – 70	Combined sources	3
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	77 – 80	Combined sources	4
Beta strandⁱ	90 – 97	Combined sources	8
Beta strandⁱ	105 – 121	Combined sources	17
Beta strandⁱ	124 – 128	Combined sources	5
Beta strandⁱ	147 – 150	Combined sources	4
Helixⁱ	165 – 167	Combined sources	3
Helixⁱ	175 – 179	Combined sources	5
Beta strandⁱ	180 – 189	Combined sources	10
Helixⁱ	191 – 194	Combined sources	4
Beta strandⁱ	197 – 202	Combined sources	6
Turnⁱ	205 – 210	Combined sources	6
Beta strandⁱ	211 – 218	Combined sources	8
Helixⁱ	222 – 224	Combined sources	3
Beta strandⁱ	225 – 229	Combined sources	5
Beta strandⁱ	235 – 237	Combined sources	3
Beta strandⁱ	246 – 253	Combined sources	8
Beta strandⁱ	263 – 273	Combined sources	11
Beta strandⁱ	280 – 291	Combined sources	12
Beta strandⁱ	303 – 309	Combined sources	7
Beta strandⁱ	314 – 316	Combined sources	3
Helixⁱ	319 – 331	Combined sources	13
Beta strandⁱ	335 – 339	Combined sources	5
Helixⁱ	341 – 344	Combined sources	4
Turnⁱ	351 – 353	Combined sources	3
Beta strandⁱ	354 – 360	Combined sources	7
Beta strandⁱ	365 – 371	Combined sources	7
Beta strandⁱ	376 – 378	Combined sources	3
Helixⁱ	381 – 384	Combined sources	4
Beta strandⁱ	392 – 395	Combined sources	4
Helixⁱ	405 – 407	Combined sources	3
Helixⁱ	409 – 411	Combined sources	3
Beta strandⁱ	412 – 414	Combined sources	3
Beta strandⁱ	418 – 420	Combined sources	3
Beta strandⁱ	423 – 425	Combined sources	3
Beta strandⁱ	430 – 435	Combined sources	6
Helixⁱ	446 – 454	Combined sources	9
Beta strandⁱ	461 – 464	Combined sources	4
Beta strandⁱ	468 – 470	Combined sources	3
Turnⁱ	473 – 476	Combined sources	4
Beta strandⁱ	477 – 481	Combined sources	5
Beta strandⁱ	483 – 494	Combined sources	12
Helixⁱ	495 – 506	Combined sources	12
Beta strandⁱ	507 – 509	Combined sources	3
Helixⁱ	528 – 531	Combined sources	4
Helixⁱ	536 – 558	Combined sources	23
Turnⁱ	562 – 564	Combined sources	3
Beta strandⁱ	565 – 569	Combined sources	5
Beta strandⁱ	572 – 575	Combined sources	4
Beta strandⁱ	578 – 583	Combined sources	6
Beta strandⁱ	586 – 588	Combined sources	3
Beta strandⁱ	590 – 592	Combined sources	3
Beta strandⁱ	595 – 599	Combined sources	5
Helixⁱ	611 – 620	Combined sources	10
Helixⁱ	621 – 623	Combined sources	3
Beta strandⁱ	626 – 630	Combined sources	5
Turnⁱ	633 – 636	Combined sources	4
Helixⁱ	637 – 639	Combined sources	3
Helixⁱ	643 – 646	Combined sources	4
Beta strandⁱ	647 – 651	Combined sources	5
Helixⁱ	658 – 660	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9ULC6
SMRⁱ	Q9ULC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IF3F Eukaryota ENOG410ZKF3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008680
HOGENOMⁱ	HOG000220908
HOVERGENⁱ	HBG053016
InParanoidⁱ	Q9ULC6
KEGG Orthology (KO) More...KOⁱ	K01481
OMAⁱ	GRRMAKV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02QG
PhylomeDBⁱ	Q9ULC6
TreeFamⁱ	TF331952

Family and domain databases

Gene3Dⁱ	2.60.40.1700, 1 hit 2.60.40.1860, 1 hit
InterProⁱ	View protein in InterPro IPR008972 Cupredoxin IPR004303 PAD IPR013530 PAD_C IPR036556 PAD_central_sf IPR013732 PAD_N IPR038685 PAD_N_sf IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERⁱ	PTHR10837 PTHR10837, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03068 PAD, 1 hit PF08527 PAD_M, 1 hit PF08526 PAD_N, 1 hit
PIRSFⁱ	PIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMⁱ	SSF110083 SSF110083, 1 hit SSF49503 SSF49503, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9ULC6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV 
        60         70         80         90        100
FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ 
       110        120        130        140        150
EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL 
       160        170        180        190        200
LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV 
       210        220        230        240        250
LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY 
       260        270        280        290        300
VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT 
       310        320        330        340        350
QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI 
       360        370        380        390        400
QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL 
       410        420        430        440        450
PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN 
       460        470        480        490        500
FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK 
       510        520        530        540        550
LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN 
       560        570        580        590        600
RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK 
       610        620        630        640        650
PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR 
       660 
RKPFPFKWWN MVP

Length:663

Mass (Da):74,666

Last modified:December 21, 2004 - v2

Checksum:ⁱ4674CEBC03A7E7CA

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	420	V → G in BAA85771 (PubMed:12416996).Curated		1
Sequence conflictⁱ	499	L → P in BAA85771 (PubMed:12416996).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053557	649	V → M. Corresponds to variant dbSNP:rs16824215Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB033768 mRNA Translation: BAA85771.1 AJ549502 Genomic DNA Translation: CAE47741.1 AL590644 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94833.1 BC130574 mRNA Translation: AAI30575.1 BC136402 mRNA Translation: AAI36403.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS178.1
NCBI Reference Sequences More...RefSeqⁱ	NP_037490.2, NM_013358.2
UniGeneⁱ	Hs.412941

Genome annotation databases

Ensemblⁱ	ENST00000375471; ENSP00000364620; ENSG00000142623 ENST00000631074; ENSP00000485803; ENSG00000281459
GeneIDⁱ	29943
KEGGⁱ	hsa:29943
UCSC genome browser More...UCSCⁱ	uc001bah.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9ULC6	cDNA FLJ59736, highly similar to Protein-arginine deiminase type-1		HUMAN		134	UniRef100_Q9ULC6
cDNA FLJ60413, highly similar to Protein-arginine deiminase type-1 (EC3.5.3.15)		HUMAN		220
UPI0008101734		HUMAN		684
UPI0007DC5355		HUMAN		612

Protein	Similar proteins		Species	Score	Length	Source
Q9ULC6	cDNA FLJ59736, highly similar to Protein-arginine deiminase type-1		HUMAN		134	UniRef90_Q9ULC6
Uncharacterized protein		NOMLE		664
PADI1 isoform 1		PANTR		663
Uncharacterized protein		PANPA		663
Peptidyl arginine deiminase 1		MACFA		663
+23

Protein	Similar proteins		Species	Score	Length	Source
Q9ULC6	Protein-arginine deiminase type-3		HUMAN		664	UniRef50_Q9ULW8
Protein-arginine deiminase type-3		RAT		664
Protein-arginine deiminase type-3		MOUSE		664
Uncharacterized protein		CERAT		664
LOW QUALITY PROTEIN: protein-arginine deiminase type-3		Enhydra lutris kenyoni		664
+149

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB033768 mRNA Translation: BAA85771.1 AJ549502 Genomic DNA Translation: CAE47741.1 AL590644 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94833.1 BC130574 mRNA Translation: AAI30575.1 BC136402 mRNA Translation: AAI36403.1
CCDSⁱ	CCDS178.1
RefSeqⁱ	NP_037490.2, NM_013358.2
UniGeneⁱ	Hs.412941

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5HP5	X-ray	3.20	A/B	1-663	[»]
ProteinModelPortalⁱ	Q9ULC6
SMRⁱ	Q9ULC6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118980, 4 interactors
IntActⁱ	Q9ULC6, 1 interactor
STRINGⁱ	9606.ENSP00000364620

Chemistry databases

BindingDBⁱ	Q9ULC6
ChEMBLⁱ	CHEMBL1909486
DrugBankⁱ	DB00155 L-Citrulline
GuidetoPHARMACOLOGYⁱ	2894

PTM databases

iPTMnetⁱ	Q9ULC6
PhosphoSitePlusⁱ	Q9ULC6

Polymorphism and mutation databases

BioMutaⁱ	PADI1
DMDMⁱ	56757695

Proteomic databases

PaxDbⁱ	Q9ULC6
PeptideAtlasⁱ	Q9ULC6
PRIDEⁱ	Q9ULC6
ProteomicsDBⁱ	84982

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	29943
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375471; ENSP00000364620; ENSG00000142623 ENST00000631074; ENSP00000485803; ENSG00000281459
GeneIDⁱ	29943
KEGGⁱ	hsa:29943
UCSCⁱ	uc001bah.2 human

Organism-specific databases

CTDⁱ	29943
DisGeNETⁱ	29943
EuPathDBⁱ	HostDB:ENSG00000142623.9
GeneCardsⁱ	PADI1
HGNCⁱ	HGNC:18367 PADI1
HPAⁱ	HPA062294
MIMⁱ	607934 gene
neXtProtⁱ	NX_Q9ULC6
OpenTargetsⁱ	ENSG00000142623
PharmGKBⁱ	PA32899
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF3F Eukaryota ENOG410ZKF3 LUCA
GeneTreeⁱ	ENSGT00390000008680
HOGENOMⁱ	HOG000220908
HOVERGENⁱ	HBG053016
InParanoidⁱ	Q9ULC6
KOⁱ	K01481
OMAⁱ	GRRMAKV
OrthoDBⁱ	EOG091G02QG
PhylomeDBⁱ	Q9ULC6
TreeFamⁱ	TF331952

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06945-MONOMER
BRENDAⁱ	3.5.3.15 2681
Reactomeⁱ	R-HSA-3247509 Chromatin modifying enzymes

Miscellaneous databases

ChiTaRSⁱ	PADI1 human
GeneWikiⁱ	PADI1
GenomeRNAiⁱ	29943
Protein Ontology More...PROⁱ	PR:Q9ULC6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142623 Expressed in 152 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_PADI1
Genevisibleⁱ	Q9ULC6 HS

Family and domain databases

Gene3Dⁱ	2.60.40.1700, 1 hit 2.60.40.1860, 1 hit
InterProⁱ	View protein in InterPro IPR008972 Cupredoxin IPR004303 PAD IPR013530 PAD_C IPR036556 PAD_central_sf IPR013732 PAD_N IPR038685 PAD_N_sf IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERⁱ	PTHR10837 PTHR10837, 1 hit
Pfamⁱ	View protein in Pfam PF03068 PAD, 1 hit PF08527 PAD_M, 1 hit PF08526 PAD_N, 1 hit
PIRSFⁱ	PIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMⁱ	SSF110083 SSF110083, 1 hit SSF49503 SSF49503, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PADI1_HUMAN
Accessionⁱ	Q9ULC6Primary (citable) accession number: Q9ULC6 Secondary accession number(s): A1L4K6, Q70SX6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9ULC6 (PADI1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein-arginine deiminase type-1

PADI1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ