UniProtKB - Q9ULC6 (PADI1_HUMAN)
Protein
Protein-arginine deiminase type-1
Gene
PADI1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the deimination of arginine residues of proteins.2 Publications
Catalytic activityi
- EC:3.5.3.152 Publications
Cofactori
Ca2+2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 153 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 155 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 155 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 157 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 157 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 165 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 176 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 179 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 179 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 351 | Calcium 4Combined sources1 Publication | 1 | |
Metal bindingi | 353 | Calcium 3Combined sources1 Publication | 1 | |
Metal bindingi | 364 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 371 | Calcium 3Combined sources1 Publication | 1 | |
Metal bindingi | 372 | Calcium 3; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 375 | Calcium 3Combined sources1 Publication | 1 | |
Metal bindingi | 409 | Calcium 4; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 412 | Calcium 4; via carbonyl oxygenCombined sources1 Publication | 1 | |
Active sitei | 645 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- protein-arginine deiminase activity Source: UniProtKB
GO - Biological processi
- chromatin organization Source: Reactome
- histone citrullination Source: GO_Central
- protein citrullination Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS06945-MONOMER |
BRENDAi | 3.5.3.15, 2681 |
PathwayCommonsi | Q9ULC6 |
Reactomei | R-HSA-3247509, Chromatin modifying enzymes |
Names & Taxonomyi
Protein namesi | Recommended name: Protein-arginine deiminase type-1 (EC:3.5.3.152 Publications)Alternative name(s): Peptidylarginine deiminase I Protein-arginine deiminase type I |
Gene namesi | Name:PADI1 Synonyms:PAD1, PDI1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18367, PADI1 |
MIMi | 607934, gene |
neXtProti | NX_Q9ULC6 |
VEuPathDBi | HostDB:ENSG00000142623.9 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 29943 |
OpenTargetsi | ENSG00000142623 |
PharmGKBi | PA32899 |
Miscellaneous databases
Pharosi | Q9ULC6, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1909486 |
DrugBanki | DB00155, Citrulline |
GuidetoPHARMACOLOGYi | 2894 |
Genetic variation databases
BioMutai | PADI1 |
DMDMi | 56757695 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220023 | 1 – 663 | Protein-arginine deiminase type-1Add BLAST | 663 |
Proteomic databases
jPOSTi | Q9ULC6 |
MassIVEi | Q9ULC6 |
PaxDbi | Q9ULC6 |
PeptideAtlasi | Q9ULC6 |
PRIDEi | Q9ULC6 |
ProteomicsDBi | 84982 |
PTM databases
iPTMneti | Q9ULC6 |
PhosphoSitePlusi | Q9ULC6 |
Expressioni
Tissue specificityi
Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000142623, Expressed in lower esophagus mucosa and 157 other tissues |
Genevisiblei | Q9ULC6, HS |
Organism-specific databases
HPAi | ENSG00000142623, Tissue enhanced (esophagus, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 118980, 8 interactors |
IntActi | Q9ULC6, 3 interactors |
STRINGi | 9606.ENSP00000364620 |
Chemistry databases
BindingDBi | Q9ULC6 |
Miscellaneous databases
RNActi | Q9ULC6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9ULC6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the protein arginine deiminase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QVJA, Eukaryota |
GeneTreei | ENSGT00940000153217 |
HOGENOMi | CLU_021911_0_0_1 |
InParanoidi | Q9ULC6 |
OMAi | VQKCIDW |
OrthoDBi | 787070at2759 |
PhylomeDBi | Q9ULC6 |
TreeFami | TF331952 |
Family and domain databases
Gene3Di | 2.60.40.1700, 1 hit 2.60.40.1860, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR004303, PAD IPR013530, PAD_C IPR036556, PAD_central_sf IPR013732, PAD_N IPR038685, PAD_N_sf IPR013733, Prot_Arg_deaminase_cen_dom |
PANTHERi | PTHR10837, PTHR10837, 1 hit |
Pfami | View protein in Pfam PF03068, PAD, 1 hit PF08527, PAD_M, 1 hit PF08526, PAD_N, 1 hit |
PIRSFi | PIRSF001247, Protein-arginine_deiminase, 1 hit |
SUPFAMi | SSF110083, SSF110083, 1 hit SSF49503, SSF49503, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9ULC6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV
60 70 80 90 100
FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ
110 120 130 140 150
EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL
160 170 180 190 200
LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV
210 220 230 240 250
LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY
260 270 280 290 300
VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT
310 320 330 340 350
QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI
360 370 380 390 400
QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL
410 420 430 440 450
PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN
460 470 480 490 500
FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK
510 520 530 540 550
LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN
560 570 580 590 600
RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK
610 620 630 640 650
PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR
660
RKPFPFKWWN MVP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 420 | V → G in BAA85771 (PubMed:12416996).Curated | 1 | |
Sequence conflicti | 499 | L → P in BAA85771 (PubMed:12416996).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053557 | 649 | V → M. Corresponds to variant dbSNP:rs16824215EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033768 mRNA Translation: BAA85771.1 AJ549502 Genomic DNA Translation: CAE47741.1 AL590644 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94833.1 BC130574 mRNA Translation: AAI30575.1 BC136402 mRNA Translation: AAI36403.1 |
CCDSi | CCDS178.1 |
RefSeqi | NP_037490.2, NM_013358.2 |
Genome annotation databases
Ensembli | ENST00000375471; ENSP00000364620; ENSG00000142623 ENST00000631074; ENSP00000485803; ENSG00000281459 |
GeneIDi | 29943 |
KEGGi | hsa:29943 |
UCSCi | uc001bah.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033768 mRNA Translation: BAA85771.1 AJ549502 Genomic DNA Translation: CAE47741.1 AL590644 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94833.1 BC130574 mRNA Translation: AAI30575.1 BC136402 mRNA Translation: AAI36403.1 |
CCDSi | CCDS178.1 |
RefSeqi | NP_037490.2, NM_013358.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5HP5 | X-ray | 3.20 | A/B | 1-663 | [»] | |
SMRi | Q9ULC6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118980, 8 interactors |
IntActi | Q9ULC6, 3 interactors |
STRINGi | 9606.ENSP00000364620 |
Chemistry databases
BindingDBi | Q9ULC6 |
ChEMBLi | CHEMBL1909486 |
DrugBanki | DB00155, Citrulline |
GuidetoPHARMACOLOGYi | 2894 |
PTM databases
iPTMneti | Q9ULC6 |
PhosphoSitePlusi | Q9ULC6 |
Genetic variation databases
BioMutai | PADI1 |
DMDMi | 56757695 |
Proteomic databases
jPOSTi | Q9ULC6 |
MassIVEi | Q9ULC6 |
PaxDbi | Q9ULC6 |
PeptideAtlasi | Q9ULC6 |
PRIDEi | Q9ULC6 |
ProteomicsDBi | 84982 |
Protocols and materials databases
Antibodypediai | 14640, 83 antibodies |
DNASUi | 29943 |
Genome annotation databases
Ensembli | ENST00000375471; ENSP00000364620; ENSG00000142623 ENST00000631074; ENSP00000485803; ENSG00000281459 |
GeneIDi | 29943 |
KEGGi | hsa:29943 |
UCSCi | uc001bah.2, human |
Organism-specific databases
CTDi | 29943 |
DisGeNETi | 29943 |
GeneCardsi | PADI1 |
HGNCi | HGNC:18367, PADI1 |
HPAi | ENSG00000142623, Tissue enhanced (esophagus, lymphoid tissue) |
MIMi | 607934, gene |
neXtProti | NX_Q9ULC6 |
OpenTargetsi | ENSG00000142623 |
PharmGKBi | PA32899 |
VEuPathDBi | HostDB:ENSG00000142623.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVJA, Eukaryota |
GeneTreei | ENSGT00940000153217 |
HOGENOMi | CLU_021911_0_0_1 |
InParanoidi | Q9ULC6 |
OMAi | VQKCIDW |
OrthoDBi | 787070at2759 |
PhylomeDBi | Q9ULC6 |
TreeFami | TF331952 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS06945-MONOMER |
BRENDAi | 3.5.3.15, 2681 |
PathwayCommonsi | Q9ULC6 |
Reactomei | R-HSA-3247509, Chromatin modifying enzymes |
Miscellaneous databases
BioGRID-ORCSi | 29943, 3 hits in 986 CRISPR screens |
ChiTaRSi | PADI1, human |
GeneWikii | PADI1 |
GenomeRNAii | 29943 |
Pharosi | Q9ULC6, Tchem |
PROi | PR:Q9ULC6 |
RNActi | Q9ULC6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142623, Expressed in lower esophagus mucosa and 157 other tissues |
Genevisiblei | Q9ULC6, HS |
Family and domain databases
Gene3Di | 2.60.40.1700, 1 hit 2.60.40.1860, 1 hit |
InterProi | View protein in InterPro IPR008972, Cupredoxin IPR004303, PAD IPR013530, PAD_C IPR036556, PAD_central_sf IPR013732, PAD_N IPR038685, PAD_N_sf IPR013733, Prot_Arg_deaminase_cen_dom |
PANTHERi | PTHR10837, PTHR10837, 1 hit |
Pfami | View protein in Pfam PF03068, PAD, 1 hit PF08527, PAD_M, 1 hit PF08526, PAD_N, 1 hit |
PIRSFi | PIRSF001247, Protein-arginine_deiminase, 1 hit |
SUPFAMi | SSF110083, SSF110083, 1 hit SSF49503, SSF49503, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PADI1_HUMAN | |
Accessioni | Q9ULC6Primary (citable) accession number: Q9ULC6 Secondary accession number(s): A1L4K6, Q70SX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families