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Protein

Protein-arginine deiminase type-1

Gene

PADI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.2 Publications

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.2 Publications

Cofactori

Ca2+2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi153Calcium 1Combined sources1 Publication1
Metal bindingi155Calcium 1Combined sources1 Publication1
Metal bindingi155Calcium 2Combined sources1 Publication1
Metal bindingi157Calcium 1Combined sources1 Publication1
Metal bindingi157Calcium 2Combined sources1 Publication1
Metal bindingi165Calcium 1Combined sources1 Publication1
Metal bindingi176Calcium 1Combined sources1 Publication1
Metal bindingi179Calcium 1Combined sources1 Publication1
Metal bindingi179Calcium 2Combined sources1 Publication1
Metal bindingi351Calcium 4Combined sources1 Publication1
Metal bindingi353Calcium 3Combined sources1 Publication1
Metal bindingi364Calcium 2Combined sources1 Publication1
Metal bindingi371Calcium 3Combined sources1 Publication1
Metal bindingi372Calcium 3; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi375Calcium 3Combined sources1 Publication1
Metal bindingi409Calcium 4; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi412Calcium 4; via carbonyl oxygenCombined sources1 Publication1
Active sitei645NucleophileBy similarity1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • histone citrullination Source: GO_Central
  • protein citrullination Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06945-MONOMER
BRENDAi3.5.3.15 2681
ReactomeiR-HSA-3247509 Chromatin modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.152 Publications)
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:PADI1
Synonyms:PAD1, PDI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142623.9
HGNCiHGNC:18367 PADI1
MIMi607934 gene
neXtProtiNX_Q9ULC6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi29943
OpenTargetsiENSG00000142623
PharmGKBiPA32899

Chemistry databases

ChEMBLiCHEMBL1909486
DrugBankiDB00155 L-Citrulline
GuidetoPHARMACOLOGYi2894

Polymorphism and mutation databases

BioMutaiPADI1
DMDMi56757695

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200231 – 663Protein-arginine deiminase type-1Add BLAST663

Proteomic databases

PaxDbiQ9ULC6
PeptideAtlasiQ9ULC6
PRIDEiQ9ULC6
ProteomicsDBi84982

PTM databases

iPTMnetiQ9ULC6
PhosphoSitePlusiQ9ULC6

Expressioni

Tissue specificityi

Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000142623 Expressed in 152 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_PADI1
GenevisibleiQ9ULC6 HS

Organism-specific databases

HPAiHPA062294

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi118980, 4 interactors
IntActiQ9ULC6, 1 interactor
STRINGi9606.ENSP00000364620

Chemistry databases

BindingDBiQ9ULC6

Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9ULC6
SMRiQ9ULC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00390000008680
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiQ9ULC6
KOiK01481
OMAiGRRMAKV
OrthoDBiEOG091G02QG
PhylomeDBiQ9ULC6
TreeFamiTF331952

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ULC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV
60 70 80 90 100
FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ
110 120 130 140 150
EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL
160 170 180 190 200
LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV
210 220 230 240 250
LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY
260 270 280 290 300
VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT
310 320 330 340 350
QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI
360 370 380 390 400
QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL
410 420 430 440 450
PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN
460 470 480 490 500
FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK
510 520 530 540 550
LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN
560 570 580 590 600
RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK
610 620 630 640 650
PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR
660
RKPFPFKWWN MVP
Length:663
Mass (Da):74,666
Last modified:December 21, 2004 - v2
Checksum:i4674CEBC03A7E7CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti420V → G in BAA85771 (PubMed:12416996).Curated1
Sequence conflicti499L → P in BAA85771 (PubMed:12416996).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053557649V → M. Corresponds to variant dbSNP:rs16824215Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033768 mRNA Translation: BAA85771.1
AJ549502 Genomic DNA Translation: CAE47741.1
AL590644 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94833.1
BC130574 mRNA Translation: AAI30575.1
BC136402 mRNA Translation: AAI36403.1
CCDSiCCDS178.1
RefSeqiNP_037490.2, NM_013358.2
UniGeneiHs.412941

Genome annotation databases

EnsembliENST00000375471; ENSP00000364620; ENSG00000142623
ENST00000631074; ENSP00000485803; ENSG00000281459
GeneIDi29943
KEGGihsa:29943
UCSCiuc001bah.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033768 mRNA Translation: BAA85771.1
AJ549502 Genomic DNA Translation: CAE47741.1
AL590644 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94833.1
BC130574 mRNA Translation: AAI30575.1
BC136402 mRNA Translation: AAI36403.1
CCDSiCCDS178.1
RefSeqiNP_037490.2, NM_013358.2
UniGeneiHs.412941

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HP5X-ray3.20A/B1-663[»]
ProteinModelPortaliQ9ULC6
SMRiQ9ULC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118980, 4 interactors
IntActiQ9ULC6, 1 interactor
STRINGi9606.ENSP00000364620

Chemistry databases

BindingDBiQ9ULC6
ChEMBLiCHEMBL1909486
DrugBankiDB00155 L-Citrulline
GuidetoPHARMACOLOGYi2894

PTM databases

iPTMnetiQ9ULC6
PhosphoSitePlusiQ9ULC6

Polymorphism and mutation databases

BioMutaiPADI1
DMDMi56757695

Proteomic databases

PaxDbiQ9ULC6
PeptideAtlasiQ9ULC6
PRIDEiQ9ULC6
ProteomicsDBi84982

Protocols and materials databases

DNASUi29943
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375471; ENSP00000364620; ENSG00000142623
ENST00000631074; ENSP00000485803; ENSG00000281459
GeneIDi29943
KEGGihsa:29943
UCSCiuc001bah.2 human

Organism-specific databases

CTDi29943
DisGeNETi29943
EuPathDBiHostDB:ENSG00000142623.9
GeneCardsiPADI1
HGNCiHGNC:18367 PADI1
HPAiHPA062294
MIMi607934 gene
neXtProtiNX_Q9ULC6
OpenTargetsiENSG00000142623
PharmGKBiPA32899
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
GeneTreeiENSGT00390000008680
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiQ9ULC6
KOiK01481
OMAiGRRMAKV
OrthoDBiEOG091G02QG
PhylomeDBiQ9ULC6
TreeFamiTF331952

Enzyme and pathway databases

BioCyciMetaCyc:HS06945-MONOMER
BRENDAi3.5.3.15 2681
ReactomeiR-HSA-3247509 Chromatin modifying enzymes

Miscellaneous databases

ChiTaRSiPADI1 human
GeneWikiiPADI1
GenomeRNAii29943
PROiPR:Q9ULC6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142623 Expressed in 152 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_PADI1
GenevisibleiQ9ULC6 HS

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPADI1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULC6
Secondary accession number(s): A1L4K6, Q70SX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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