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UniProtKB - Q9ULC6 (PADI1_HUMAN)

Entry version 156 (07 Apr 2021)
Sequence version 2 (21 Dec 2004)
Previous versions | rss
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Protein

Protein-arginine deiminase type-1

Gene

PADI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the deimination of arginine residues of proteins.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi153Calcium 1Combined sources1 Publication1
Metal bindingi155Calcium 1Combined sources1 Publication1
Metal bindingi155Calcium 2Combined sources1 Publication1
Metal bindingi157Calcium 1Combined sources1 Publication1
Metal bindingi157Calcium 2Combined sources1 Publication1
Metal bindingi165Calcium 1Combined sources1 Publication1
Metal bindingi176Calcium 1Combined sources1 Publication1
Metal bindingi179Calcium 1Combined sources1 Publication1
Metal bindingi179Calcium 2Combined sources1 Publication1
Metal bindingi351Calcium 4Combined sources1 Publication1
Metal bindingi353Calcium 3Combined sources1 Publication1
Metal bindingi364Calcium 2Combined sources1 Publication1
Metal bindingi371Calcium 3Combined sources1 Publication1
Metal bindingi372Calcium 3; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi375Calcium 3Combined sources1 Publication1
Metal bindingi409Calcium 4; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi412Calcium 4; via carbonyl oxygenCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei645NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS06945-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.5.3.15, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9ULC6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3247509, Chromatin modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.152 Publications)
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PADI1
Synonyms:PAD1, PDI1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18367, PADI1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607934, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9ULC6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142623.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		29943

Open Targets

More...OpenTargetsi		ENSG00000142623

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32899

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9ULC6, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1909486

Drug and drug target database

More...DrugBanki		DB00155, Citrulline

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2894

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PADI1

Domain mapping of disease mutations (DMDM)

More...DMDMi		56757695

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002200231 – 663Protein-arginine deiminase type-1Add BLAST663

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9ULC6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9ULC6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9ULC6

PeptideAtlas

More...PeptideAtlasi		Q9ULC6

PRoteomics IDEntifications database

More...PRIDEi		Q9ULC6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84982

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9ULC6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9ULC6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in epidermal keratinocytes (at protein level). Epidermis, prostate, testis, placenta, spleen and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142623, Expressed in lower esophagus mucosa and 157 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9ULC6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142623, Tissue enhanced (esophagus, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118980, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q9ULC6, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364620

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9ULC6

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9ULC6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ULC6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVJA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153217

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021911_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9ULC6

Identification of Orthologs from Complete Genome Data

More...OMAi		VQKCIDW

Database of Orthologous Groups

More...OrthoDBi		787070at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9ULC6

TreeFam database of animal gene trees

More...TreeFami		TF331952

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.1700, 1 hit
2.60.40.1860, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008972, Cupredoxin
IPR004303, PAD
IPR013530, PAD_C
IPR036556, PAD_central_sf
IPR013732, PAD_N
IPR038685, PAD_N_sf
IPR013733, Prot_Arg_deaminase_cen_dom

The PANTHER Classification System

More...PANTHERi		PTHR10837, PTHR10837, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03068, PAD, 1 hit
PF08527, PAD_M, 1 hit
PF08526, PAD_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001247, Protein-arginine_deiminase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF110083, SSF110083, 1 hit
SSF49503, SSF49503, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ULC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV 
        60         70         80         90        100
FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ 
       110        120        130        140        150
EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL 
       160        170        180        190        200
LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV 
       210        220        230        240        250
LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY 
       260        270        280        290        300
VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT 
       310        320        330        340        350
QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI 
       360        370        380        390        400
QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL 
       410        420        430        440        450
PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN 
       460        470        480        490        500
FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK 
       510        520        530        540        550
LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN 
       560        570        580        590        600
RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK 
       610        620        630        640        650
PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR 
       660 
RKPFPFKWWN MVP
Length:663
Mass (Da):74,666
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4674CEBC03A7E7CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti420V → G in BAA85771 (PubMed:12416996).Curated1
Sequence conflicti499L → P in BAA85771 (PubMed:12416996).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053557649V → M. Corresponds to variant dbSNP:rs16824215EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB033768 mRNA Translation: BAA85771.1
AJ549502 Genomic DNA Translation: CAE47741.1
AL590644 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94833.1
BC130574 mRNA Translation: AAI30575.1
BC136402 mRNA Translation: AAI36403.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS178.1

NCBI Reference Sequences

More...RefSeqi		NP_037490.2, NM_013358.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375471; ENSP00000364620; ENSG00000142623
ENST00000631074; ENSP00000485803; ENSG00000281459

Database of genes from NCBI RefSeq genomes

More...GeneIDi		29943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:29943

UCSC genome browser

More...UCSCi		uc001bah.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033768 mRNA Translation: BAA85771.1
AJ549502 Genomic DNA Translation: CAE47741.1
AL590644 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW94833.1
BC130574 mRNA Translation: AAI30575.1
BC136402 mRNA Translation: AAI36403.1
CCDSiCCDS178.1
RefSeqiNP_037490.2, NM_013358.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HP5X-ray3.20A/B1-663[»]
SMRiQ9ULC6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118980, 8 interactors
IntActiQ9ULC6, 3 interactors
STRINGi9606.ENSP00000364620

Chemistry databases

BindingDBiQ9ULC6
ChEMBLiCHEMBL1909486
DrugBankiDB00155, Citrulline
GuidetoPHARMACOLOGYi2894

PTM databases

iPTMnetiQ9ULC6
PhosphoSitePlusiQ9ULC6

Genetic variation databases

BioMutaiPADI1
DMDMi56757695

Proteomic databases

jPOSTiQ9ULC6
MassIVEiQ9ULC6
PaxDbiQ9ULC6
PeptideAtlasiQ9ULC6
PRIDEiQ9ULC6
ProteomicsDBi84982

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		14640, 83 antibodies

The DNASU plasmid repository

More...DNASUi		29943

Genome annotation databases

EnsembliENST00000375471; ENSP00000364620; ENSG00000142623
ENST00000631074; ENSP00000485803; ENSG00000281459
GeneIDi29943
KEGGihsa:29943
UCSCiuc001bah.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		29943
DisGeNETi29943

GeneCards: human genes, protein and diseases

More...GeneCardsi		PADI1
HGNCiHGNC:18367, PADI1
HPAiENSG00000142623, Tissue enhanced (esophagus, lymphoid tissue)
MIMi607934, gene
neXtProtiNX_Q9ULC6
OpenTargetsiENSG00000142623
PharmGKBiPA32899
VEuPathDBiHostDB:ENSG00000142623.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVJA, Eukaryota
GeneTreeiENSGT00940000153217
HOGENOMiCLU_021911_0_0_1
InParanoidiQ9ULC6
OMAiVQKCIDW
OrthoDBi787070at2759
PhylomeDBiQ9ULC6
TreeFamiTF331952

Enzyme and pathway databases

BioCyciMetaCyc:HS06945-MONOMER
BRENDAi3.5.3.15, 2681
PathwayCommonsiQ9ULC6
ReactomeiR-HSA-3247509, Chromatin modifying enzymes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		29943, 3 hits in 986 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PADI1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PADI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		29943
PharosiQ9ULC6, Tchem

Protein Ontology

More...PROi		PR:Q9ULC6
RNActiQ9ULC6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142623, Expressed in lower esophagus mucosa and 157 other tissues
GenevisibleiQ9ULC6, HS

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972, Cupredoxin
IPR004303, PAD
IPR013530, PAD_C
IPR036556, PAD_central_sf
IPR013732, PAD_N
IPR038685, PAD_N_sf
IPR013733, Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837, PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068, PAD, 1 hit
PF08527, PAD_M, 1 hit
PF08526, PAD_N, 1 hit
PIRSFiPIRSF001247, Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083, SSF110083, 1 hit
SSF49503, SSF49503, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPADI1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ULC6
Secondary accession number(s): A1L4K6, Q70SX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 21, 2004
Last modified: April 7, 2021
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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