EMCN

Functionⁱ

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endomucin Alternative name(s): Endomucin-2 Gastric cancer antigen Ga34 Mucin-14 Short name: MUC-14
Gene namesⁱ	Name:EMCN Synonyms:EMCN2, MUC14
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164035.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16041 EMCN
MIMⁱ	608350 gene
neXtProtⁱ	NX_Q9ULC0

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 190	ExtracellularSequence analysisAdd BLAST	172
Transmembraneⁱ	191 – 211	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	212 – 261	CytoplasmicSequence analysisAdd BLAST	50

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51705
Open Targets More...OpenTargetsⁱ	ENSG00000164035
PharmGKBⁱ	PA144596436

Polymorphism and mutation databases

BioMutaⁱ	EMCN
DMDMⁱ	50400693

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000019290	19 – 261	EndomucinAdd BLAST		243

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	19	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	28	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	98	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	104	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	164	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	237	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Highly O-glycosylated. Sialic acid-rich glycoprotein.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9ULC0
PeptideAtlas More...PeptideAtlasⁱ	Q9ULC0
PRIDEⁱ	Q9ULC0
ProteomicsDBⁱ	84972 84973 [Q9ULC0-2] 84974 [Q9ULC0-3]
TopDownProteomicsⁱ	Q9ULC0-2 [Q9ULC0-2]

PTM databases

iPTMnetⁱ	Q9ULC0
PhosphoSitePlusⁱ	Q9ULC0

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000164035 Expressed in 194 organ(s), highest expression level in kidney
CleanExⁱ	HS_EMCN
ExpressionAtlasⁱ	Q9ULC0 baseline and differential
Genevisibleⁱ	Q9ULC0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005928

HPAⁱ

HPA005928

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119689, 2 interactors
IntActⁱ	Q9ULC0, 1 interactor
STRINGⁱ	9606.ENSP00000296420

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULC0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	34 – 135	Thr-richAdd BLAST		102

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J0MP Eukaryota ENOG4111AC7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012139
HOGENOMⁱ	HOG000013126
HOVERGENⁱ	HBG052537
InParanoidⁱ	Q9ULC0
KEGG Orthology (KO) More...KOⁱ	K16664
OMAⁱ	RMCWKAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G16TF
PhylomeDBⁱ	Q9ULC0
TreeFamⁱ	TF337783

Family and domain databases

InterProⁱ	View protein in InterPro IPR010740 Endomucin
PANTHERⁱ	PTHR15869 PTHR15869, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07010 Endomucin, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9ULC0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK 
        60         70         80         90        100
NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS 
       110        120        130        140        150
IISNVTVTSV TLPNAVSTLQ SSKPKTETQS SIKTTEIPGS VLQPDASPSK 
       160        170        180        190        200
TGTLTSIPVT IPENTSQSQV IGTEGGKNAS TSATSRSYSS IILPVVIALI 
       210        220        230        240        250
VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL LTVKTISHES 
       260 
GEHSAQGKTK N

Length:261

Mass (Da):27,452

Last modified:July 19, 2004 - v2

Checksum:ⁱ6C88C34F7A81F7D2

GO

Isoform 2 (identifier: Q9ULC0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
140-222: Missing.

« Hide

        10         20         30         40         50
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK 
        60         70         80         90        100
NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS 
       110        120        130        140        150
IISNVTVTSV TLPNAVSTLQ SSKPKTETQS SIKTTEIPGT PENGNDQPQS 
       160        170 
DKESVKLLTV KTISHESGEH SAQGKTKN

Show »

Length:178

Mass (Da):18,848

Checksum:ⁱEEED76BC1E27A383

GO

Isoform 3 (identifier: Q9ULC0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
126-139: TETQSSIKTTEIPG → S

« Hide

        10         20         30         40         50
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK 
        60         70         80         90        100
NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS 
       110        120        130        140        150
IISNVTVTSV TLPNAVSTLQ SSKPKSSVLQ PDASPSKTGT LTSIPVTIPE 
       160        170        180        190        200
NTSQSQVIGT EGGKNASTSA TSRSYSSIIL PVVIALIVIT LSVFVLVGLY 
       210        220        230        240 
RMCWKADPGT PENGNDQPQS DKESVKLLTV KTISHESGEH SAQGKTKN

Note: No experimental confirmation available.

Show »

Length:248

Mass (Da):26,066

Checksum:ⁱB2951B67C96DE8C3

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	D6RHW5	D6RHW5_HUMAN		Endomucin Endomucin	EMCN	165	Annotation score:
	H0YAA7	H0YAA7_HUMAN		Endomucin Endomucin	EMCN	76	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	172	G → D in BAA86228 (PubMed:11418125).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043264	126 – 139	TETQS…TEIPG → S in isoform 3. 1 PublicationAdd BLAST		14
Alternative sequenceⁱVSP_010826	140 – 222	Missing in isoform 2. 2 PublicationsAdd BLAST		83

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB034695 mRNA Translation: BAA86228.1 AF205940 mRNA Translation: AAF76295.1 AK291831 mRNA Translation: BAF84520.1 AK304568 mRNA Translation: BAG65359.1 AC034150 Genomic DNA No translation available. AC097459 Genomic DNA No translation available. AC115623 Genomic DNA No translation available. AC116174 Genomic DNA No translation available. AC138606 Genomic DNA No translation available. AP001964 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06122.1 BC017781 mRNA Translation: AAH17781.1 AY039241 mRNA Translation: AAK68660.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3655.1 [Q9ULC0-1] CCDS54782.1 [Q9ULC0-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153166.1, NM_001159694.1 [Q9ULC0-3] NP_057326.2, NM_016242.3 [Q9ULC0-1] XP_011530326.1, XM_011532024.2 [Q9ULC0-1]
UniGeneⁱ	Hs.152913

Genome annotation databases

Ensemblⁱ	ENST00000296420; ENSP00000296420; ENSG00000164035 [Q9ULC0-1] ENST00000305864; ENSP00000304780; ENSG00000164035 [Q9ULC0-2] ENST00000511970; ENSP00000422432; ENSG00000164035 [Q9ULC0-3]
GeneIDⁱ	51705
KEGGⁱ	hsa:51705
UCSC genome browser More...UCSCⁱ	uc003hvr.3 human [Q9ULC0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULC0	Endomucin, isoform CRA_a		HUMAN		261	UniRef100_Q9ULC0
UPI000020B24B		HUMAN		139

Protein	Similar proteins		Species	Score	Length	Source
Q9ULC0	Endomucin		PONAB		260	UniRef90_Q9ULC0
Endomucin, isoform CRA_a		HUMAN		261
Endomucin		GORGO		261
EMCN isoform 1		PANTR		260
Endomucin		PANPA		260
+12
Q9ULC0-2	Endomucin		GORGO		178	UniRef90_Q9ULC0-2
EMCN isoform 2		PANTR		177
EMCN isoform 5		PONAB		177
Endomucin		PANPA		177

Protein	Similar proteins		Species	Score	Length	Source
Q9ULC0	Endomucin		PONAB		260	UniRef50_Q9ULC0
Endomucin		RAT		250
Endomucin, isoform CRA_a		HUMAN		261
Endomucin		GORGO		261
Endomucin		PANPA		260
+80
Q9ULC0-2	Endomucin		GORGO		178	UniRef50_Q9ULC0-2
EMCN isoform 2		PANTR		177
Endomucin		PANPA		177
EMCN isoform 5		PONAB		177
Endomucin		PAPAN		180
+13

Entry informationⁱ

Entry nameⁱ	MUCEN_HUMAN
Accessionⁱ	Q9ULC0Primary (citable) accession number: Q9ULC0 Secondary accession number(s): A8K716 , B4E347, Q8NEY5, Q8WWE7, Q9NRM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	July 19, 2004
	Last modified:	September 12, 2018
	This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9ULC0 (MUCEN_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Endomucin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ