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Protein

Endomucin

Gene

EMCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Endomucin
Alternative name(s):
Endomucin-2
Gastric cancer antigen Ga34
Mucin-14
Short name:
MUC-14
Gene namesi
Name:EMCN
Synonyms:EMCN2, MUC14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000164035.9
HGNCiHGNC:16041 EMCN
MIMi608350 gene
neXtProtiNX_Q9ULC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 190ExtracellularSequence analysisAdd BLAST172
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 261CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51705
OpenTargetsiENSG00000164035
PharmGKBiPA144596436

Polymorphism and mutation databases

BioMutaiEMCN
DMDMi50400693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001929019 – 261EndomucinAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei237PhosphoserineBy similarity1

Post-translational modificationi

Highly O-glycosylated. Sialic acid-rich glycoprotein.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ULC0
PeptideAtlasiQ9ULC0
PRIDEiQ9ULC0
ProteomicsDBi84972
84973 [Q9ULC0-2]
84974 [Q9ULC0-3]
TopDownProteomicsiQ9ULC0-2 [Q9ULC0-2]

PTM databases

iPTMnetiQ9ULC0
PhosphoSitePlusiQ9ULC0

Expressioni

Tissue specificityi

Expressed in heart, kidney and lung.2 Publications

Gene expression databases

BgeeiENSG00000164035 Expressed in 194 organ(s), highest expression level in kidney
CleanExiHS_EMCN
ExpressionAtlasiQ9ULC0 baseline and differential
GenevisibleiQ9ULC0 HS

Organism-specific databases

HPAiHPA005928

Interactioni

Protein-protein interaction databases

BioGridi119689, 2 interactors
IntActiQ9ULC0, 1 interactor
STRINGi9606.ENSP00000296420

Structurei

3D structure databases

ProteinModelPortaliQ9ULC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 135Thr-richAdd BLAST102

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MP Eukaryota
ENOG4111AC7 LUCA
GeneTreeiENSGT00390000012139
HOGENOMiHOG000013126
HOVERGENiHBG052537
InParanoidiQ9ULC0
KOiK16664
OMAiRMCWKAD
OrthoDBiEOG091G16TF
PhylomeDBiQ9ULC0
TreeFamiTF337783

Family and domain databases

InterProiView protein in InterPro
IPR010740 Endomucin
PANTHERiPTHR15869 PTHR15869, 1 hit
PfamiView protein in Pfam
PF07010 Endomucin, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9ULC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK
60 70 80 90 100
NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS
110 120 130 140 150
IISNVTVTSV TLPNAVSTLQ SSKPKTETQS SIKTTEIPGS VLQPDASPSK
160 170 180 190 200
TGTLTSIPVT IPENTSQSQV IGTEGGKNAS TSATSRSYSS IILPVVIALI
210 220 230 240 250
VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL LTVKTISHES
260
GEHSAQGKTK N
Length:261
Mass (Da):27,452
Last modified:July 19, 2004 - v2
Checksum:i6C88C34F7A81F7D2
GO
Isoform 2 (identifier: Q9ULC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-222: Missing.

Show »
Length:178
Mass (Da):18,848
Checksum:iEEED76BC1E27A383
GO
Isoform 3 (identifier: Q9ULC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-139: TETQSSIKTTEIPG → S

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):26,066
Checksum:iB2951B67C96DE8C3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHW5D6RHW5_HUMAN
Endomucin
EMCN
165Annotation score:
H0YAA7H0YAA7_HUMAN
Endomucin
EMCN
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172G → D in BAA86228 (PubMed:11418125).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043264126 – 139TETQS…TEIPG → S in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_010826140 – 222Missing in isoform 2. 2 PublicationsAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034695 mRNA Translation: BAA86228.1
AF205940 mRNA Translation: AAF76295.1
AK291831 mRNA Translation: BAF84520.1
AK304568 mRNA Translation: BAG65359.1
AC034150 Genomic DNA No translation available.
AC097459 Genomic DNA No translation available.
AC115623 Genomic DNA No translation available.
AC116174 Genomic DNA No translation available.
AC138606 Genomic DNA No translation available.
AP001964 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06122.1
BC017781 mRNA Translation: AAH17781.1
AY039241 mRNA Translation: AAK68660.1
CCDSiCCDS3655.1 [Q9ULC0-1]
CCDS54782.1 [Q9ULC0-3]
RefSeqiNP_001153166.1, NM_001159694.1 [Q9ULC0-3]
NP_057326.2, NM_016242.3 [Q9ULC0-1]
XP_011530326.1, XM_011532024.2 [Q9ULC0-1]
UniGeneiHs.152913

Genome annotation databases

EnsembliENST00000296420; ENSP00000296420; ENSG00000164035 [Q9ULC0-1]
ENST00000305864; ENSP00000304780; ENSG00000164035 [Q9ULC0-2]
ENST00000511970; ENSP00000422432; ENSG00000164035 [Q9ULC0-3]
GeneIDi51705
KEGGihsa:51705
UCSCiuc003hvr.3 human [Q9ULC0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMUCEN_HUMAN
AccessioniPrimary (citable) accession number: Q9ULC0
Secondary accession number(s): A8K716
, B4E347, Q8NEY5, Q8WWE7, Q9NRM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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