UniProtKB - Q9ULC0 (MUCEN_HUMAN)
Endomucin
EMCN
Functioni
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
GO - Biological processi
- hematopoietic stem cell homeostasis Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9ULC0 |
SignaLinki | Q9ULC0 |
Names & Taxonomyi
Protein namesi | Recommended name: EndomucinAlternative name(s): Endomucin-2 Gastric cancer antigen Ga34 Mucin-14 Short name: MUC-14 |
Gene namesi | Name:EMCN Synonyms:EMCN2, MUC14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16041, EMCN |
MIMi | 608350, gene |
neXtProti | NX_Q9ULC0 |
VEuPathDBi | HostDB:ENSG00000164035 |
Subcellular locationi
Plasma membrane
Other locations
Note: Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 190 | ExtracellularSequence analysisAdd BLAST | 172 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 212 – 261 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 51705 |
OpenTargetsi | ENSG00000164035 |
PharmGKBi | PA144596436 |
Miscellaneous databases
Pharosi | Q9ULC0, Tbio |
Genetic variation databases
BioMutai | EMCN |
DMDMi | 50400693 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000019290 | 19 – 261 | EndomucinAdd BLAST | 243 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 19 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 164 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 237 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q9ULC0 |
PaxDbi | Q9ULC0 |
PeptideAtlasi | Q9ULC0 |
PRIDEi | Q9ULC0 |
ProteomicsDBi | 84972 [Q9ULC0-1] 84973 [Q9ULC0-2] 84974 [Q9ULC0-3] |
TopDownProteomicsi | Q9ULC0-2 [Q9ULC0-2] |
PTM databases
GlyGeni | Q9ULC0, 18 sites, 7 O-linked glycans (12 sites) |
iPTMneti | Q9ULC0 |
PhosphoSitePlusi | Q9ULC0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000164035, Expressed in kidney and 210 other tissues |
ExpressionAtlasi | Q9ULC0, baseline and differential |
Genevisiblei | Q9ULC0, HS |
Organism-specific databases
HPAi | ENSG00000164035, Low tissue specificity |
Interactioni
Binary interactionsi
Isoform 2 [Q9ULC0-2]
With | #Exp. | IntAct |
---|---|---|
SGTB [Q96EQ0] | 5 | EBI-12164849,EBI-744081 |
Protein-protein interaction databases
BioGRIDi | 119689, 9 interactors |
IntActi | Q9ULC0, 1 interactor |
STRINGi | 9606.ENSP00000296420 |
Miscellaneous databases
RNActi | Q9ULC0, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 183 | DisorderedSequence analysisAdd BLAST | 66 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6VA, Eukaryota |
GeneTreei | ENSGT00390000012139 |
HOGENOMi | CLU_092835_0_0_1 |
InParanoidi | Q9ULC0 |
OMAi | IGATREK |
PhylomeDBi | Q9ULC0 |
TreeFami | TF337783 |
Family and domain databases
InterProi | View protein in InterPro IPR010740, Endomucin |
PANTHERi | PTHR15869, PTHR15869, 1 hit |
Pfami | View protein in Pfam PF07010, Endomucin, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK
60 70 80 90 100
NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS
110 120 130 140 150
IISNVTVTSV TLPNAVSTLQ SSKPKTETQS SIKTTEIPGS VLQPDASPSK
160 170 180 190 200
TGTLTSIPVT IPENTSQSQV IGTEGGKNAS TSATSRSYSS IILPVVIALI
210 220 230 240 250
VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL LTVKTISHES
260
GEHSAQGKTK N
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RHW5 | D6RHW5_HUMAN | Endomucin | EMCN | 165 | Annotation score: | ||
H0YAA7 | H0YAA7_HUMAN | Endomucin | EMCN | 76 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 | G → D in BAA86228 (PubMed:11418125).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043264 | 126 – 139 | TETQS…TEIPG → S in isoform 3. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_010826 | 140 – 222 | Missing in isoform 2. 2 PublicationsAdd BLAST | 83 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB034695 mRNA Translation: BAA86228.1 AF205940 mRNA Translation: AAF76295.1 AK291831 mRNA Translation: BAF84520.1 AK304568 mRNA Translation: BAG65359.1 AC034150 Genomic DNA No translation available. AC097459 Genomic DNA No translation available. AC115623 Genomic DNA No translation available. AC116174 Genomic DNA No translation available. AC138606 Genomic DNA No translation available. AP001964 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06122.1 BC017781 mRNA Translation: AAH17781.1 AY039241 mRNA Translation: AAK68660.1 |
CCDSi | CCDS3655.1 [Q9ULC0-1] CCDS54782.1 [Q9ULC0-3] |
RefSeqi | NP_001153166.1, NM_001159694.1 [Q9ULC0-3] NP_057326.2, NM_016242.3 [Q9ULC0-1] XP_011530326.1, XM_011532024.2 [Q9ULC0-1] |
Genome annotation databases
Ensembli | ENST00000296420; ENSP00000296420; ENSG00000164035 ENST00000305864; ENSP00000304780; ENSG00000164035 [Q9ULC0-2] ENST00000511970; ENSP00000422432; ENSG00000164035 [Q9ULC0-3] |
GeneIDi | 51705 |
KEGGi | hsa:51705 |
MANE-Selecti | ENST00000296420.9; ENSP00000296420.4; NM_016242.4; NP_057326.2 |
UCSCi | uc003hvr.3, human [Q9ULC0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB034695 mRNA Translation: BAA86228.1 AF205940 mRNA Translation: AAF76295.1 AK291831 mRNA Translation: BAF84520.1 AK304568 mRNA Translation: BAG65359.1 AC034150 Genomic DNA No translation available. AC097459 Genomic DNA No translation available. AC115623 Genomic DNA No translation available. AC116174 Genomic DNA No translation available. AC138606 Genomic DNA No translation available. AP001964 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX06122.1 BC017781 mRNA Translation: AAH17781.1 AY039241 mRNA Translation: AAK68660.1 |
CCDSi | CCDS3655.1 [Q9ULC0-1] CCDS54782.1 [Q9ULC0-3] |
RefSeqi | NP_001153166.1, NM_001159694.1 [Q9ULC0-3] NP_057326.2, NM_016242.3 [Q9ULC0-1] XP_011530326.1, XM_011532024.2 [Q9ULC0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119689, 9 interactors |
IntActi | Q9ULC0, 1 interactor |
STRINGi | 9606.ENSP00000296420 |
PTM databases
GlyGeni | Q9ULC0, 18 sites, 7 O-linked glycans (12 sites) |
iPTMneti | Q9ULC0 |
PhosphoSitePlusi | Q9ULC0 |
Genetic variation databases
BioMutai | EMCN |
DMDMi | 50400693 |
Proteomic databases
MassIVEi | Q9ULC0 |
PaxDbi | Q9ULC0 |
PeptideAtlasi | Q9ULC0 |
PRIDEi | Q9ULC0 |
ProteomicsDBi | 84972 [Q9ULC0-1] 84973 [Q9ULC0-2] 84974 [Q9ULC0-3] |
TopDownProteomicsi | Q9ULC0-2 [Q9ULC0-2] |
Protocols and materials databases
Antibodypediai | 989, 212 antibodies from 31 providers |
DNASUi | 51705 |
Genome annotation databases
Ensembli | ENST00000296420; ENSP00000296420; ENSG00000164035 ENST00000305864; ENSP00000304780; ENSG00000164035 [Q9ULC0-2] ENST00000511970; ENSP00000422432; ENSG00000164035 [Q9ULC0-3] |
GeneIDi | 51705 |
KEGGi | hsa:51705 |
MANE-Selecti | ENST00000296420.9; ENSP00000296420.4; NM_016242.4; NP_057326.2 |
UCSCi | uc003hvr.3, human [Q9ULC0-1] |
Organism-specific databases
CTDi | 51705 |
DisGeNETi | 51705 |
GeneCardsi | EMCN |
HGNCi | HGNC:16041, EMCN |
HPAi | ENSG00000164035, Low tissue specificity |
MIMi | 608350, gene |
neXtProti | NX_Q9ULC0 |
OpenTargetsi | ENSG00000164035 |
PharmGKBi | PA144596436 |
VEuPathDBi | HostDB:ENSG00000164035 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6VA, Eukaryota |
GeneTreei | ENSGT00390000012139 |
HOGENOMi | CLU_092835_0_0_1 |
InParanoidi | Q9ULC0 |
OMAi | IGATREK |
PhylomeDBi | Q9ULC0 |
TreeFami | TF337783 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULC0 |
SignaLinki | Q9ULC0 |
Miscellaneous databases
BioGRID-ORCSi | 51705, 7 hits in 1031 CRISPR screens |
ChiTaRSi | EMCN, human |
GeneWikii | EMCN |
GenomeRNAii | 51705 |
Pharosi | Q9ULC0, Tbio |
PROi | PR:Q9ULC0 |
RNActi | Q9ULC0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164035, Expressed in kidney and 210 other tissues |
ExpressionAtlasi | Q9ULC0, baseline and differential |
Genevisiblei | Q9ULC0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR010740, Endomucin |
PANTHERi | PTHR15869, PTHR15869, 1 hit |
Pfami | View protein in Pfam PF07010, Endomucin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MUCEN_HUMAN | |
Accessioni | Q9ULC0Primary (citable) accession number: Q9ULC0 Secondary accession number(s): A8K716 Q9NRM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot