UniProtKB - Q9ULB4 (CADH9_HUMAN)
Protein
Cadherin-9
Gene
CDH9
Organism
Homo sapiens (Human)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
GO - Molecular functioni
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
GO - Biological processi
- adherens junction organization Source: GO_Central
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- cell-cell adhesion Source: UniProtKB
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell-cell junction assembly Source: GO_Central
- cell morphogenesis Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- multicellular organism development Source: GO_Central
- synapse assembly Source: Ensembl
- synaptic membrane adhesion Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9ULB4 |
Reactomei | R-HSA-418990, Adherens junctions interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-9 |
Gene namesi | Name:CDH9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1768, CDH9 |
MIMi | 609974, gene |
neXtProti | NX_Q9ULB4 |
VEuPathDBi | HostDB:ENSG00000113100.9 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass type I membrane protein Curated
Plasma Membrane
- catenin complex Source: GO_Central
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- adherens junction Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 54 – 615 | ExtracellularSequence analysisAdd BLAST | 562 | |
Transmembranei | 616 – 636 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 637 – 789 | CytoplasmicSequence analysisAdd BLAST | 153 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1007 |
OpenTargetsi | ENSG00000113100 |
PharmGKBi | PA26305 |
Miscellaneous databases
Pharosi | Q9ULB4, Tbio |
Genetic variation databases
BioMutai | CDH9 |
DMDMi | 119370307 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000003779 | 22 – 53 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000003780 | 54 – 789 | Cadherin-9Add BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 437 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 455 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 536 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 786 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9ULB4 |
MassIVEi | Q9ULB4 |
MaxQBi | Q9ULB4 |
PaxDbi | Q9ULB4 |
PeptideAtlasi | Q9ULB4 |
PRIDEi | Q9ULB4 |
ProteomicsDBi | 84970 |
PTM databases
GlyGeni | Q9ULB4, 4 sites |
iPTMneti | Q9ULB4 |
PhosphoSitePlusi | Q9ULB4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000113100, Expressed in corpus callosum and 114 other tissues |
ExpressionAtlasi | Q9ULB4, baseline and differential |
Genevisiblei | Q9ULB4, HS |
Organism-specific databases
HPAi | ENSG00000113100, Tissue enriched (brain) |
Interactioni
GO - Molecular functioni
- cadherin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107442, 3 interactors |
IntActi | Q9ULB4, 1 interactor |
STRINGi | 9606.ENSP00000231021 |
Miscellaneous databases
RNActi | Q9ULB4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 159 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 160 – 268 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 269 – 383 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 384 – 486 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 487 – 608 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 122 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000160496 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | Q9ULB4 |
OMAi | HDTFNII |
OrthoDBi | 201053at2759 |
PhylomeDBi | Q9ULB4 |
TreeFami | TF329887 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9ULB4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR
60 70 80 90 100
TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL
110 120 130 140 150
FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH
160 170 180 190 200
DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN
310 320 330 340 350
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS
360 370 380 390 400
NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS
410 420 430 440 450
IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES
460 470 480 490 500
SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA
510 520 530 540 550
KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM
560 570 580 590 600
TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC
610 620 630 640 650
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD
660 670 680 690 700
DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI
710 720 730 740 750
RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL
760 770 780
SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EPN0 | E7EPN0_HUMAN | Cadherin-9 | CDH9 | 132 | Annotation score: | ||
D6RBT9 | D6RBT9_HUMAN | Cadherin-9 | CDH9 | 81 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | T → I in BAA87416 (PubMed:10861224).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029799 | 6 | Y → C1 PublicationCorresponds to variant dbSNP:rs2288467Ensembl. | 1 | |
Natural variantiVAR_029800 | 38 | A → V1 PublicationCorresponds to variant dbSNP:rs2288466Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB035302 mRNA Translation: BAA87416.1 BC107594 mRNA Translation: AAI07595.1 BC113745 mRNA Translation: AAI13746.1 |
CCDSi | CCDS3893.1 |
RefSeqi | NP_057363.3, NM_016279.3 |
Genome annotation databases
Ensembli | ENST00000231021; ENSP00000231021; ENSG00000113100 |
GeneIDi | 1007 |
KEGGi | hsa:1007 |
UCSCi | uc003jgs.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB035302 mRNA Translation: BAA87416.1 BC107594 mRNA Translation: AAI07595.1 BC113745 mRNA Translation: AAI13746.1 |
CCDSi | CCDS3893.1 |
RefSeqi | NP_057363.3, NM_016279.3 |
3D structure databases
SMRi | Q9ULB4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107442, 3 interactors |
IntActi | Q9ULB4, 1 interactor |
STRINGi | 9606.ENSP00000231021 |
PTM databases
GlyGeni | Q9ULB4, 4 sites |
iPTMneti | Q9ULB4 |
PhosphoSitePlusi | Q9ULB4 |
Genetic variation databases
BioMutai | CDH9 |
DMDMi | 119370307 |
Proteomic databases
jPOSTi | Q9ULB4 |
MassIVEi | Q9ULB4 |
MaxQBi | Q9ULB4 |
PaxDbi | Q9ULB4 |
PeptideAtlasi | Q9ULB4 |
PRIDEi | Q9ULB4 |
ProteomicsDBi | 84970 |
Protocols and materials databases
Antibodypediai | 2349, 166 antibodies |
Genome annotation databases
Ensembli | ENST00000231021; ENSP00000231021; ENSG00000113100 |
GeneIDi | 1007 |
KEGGi | hsa:1007 |
UCSCi | uc003jgs.2, human |
Organism-specific databases
CTDi | 1007 |
DisGeNETi | 1007 |
GeneCardsi | CDH9 |
HGNCi | HGNC:1768, CDH9 |
HPAi | ENSG00000113100, Tissue enriched (brain) |
MIMi | 609974, gene |
neXtProti | NX_Q9ULB4 |
OpenTargetsi | ENSG00000113100 |
PharmGKBi | PA26305 |
VEuPathDBi | HostDB:ENSG00000113100.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000160496 |
HOGENOMi | CLU_005284_3_1_1 |
InParanoidi | Q9ULB4 |
OMAi | HDTFNII |
OrthoDBi | 201053at2759 |
PhylomeDBi | Q9ULB4 |
TreeFami | TF329887 |
Enzyme and pathway databases
PathwayCommonsi | Q9ULB4 |
Reactomei | R-HSA-418990, Adherens junctions interactions |
Miscellaneous databases
BioGRID-ORCSi | 1007, 1 hit in 867 CRISPR screens |
GeneWikii | CDH9 |
GenomeRNAii | 1007 |
Pharosi | Q9ULB4, Tbio |
PROi | PR:Q9ULB4 |
RNActi | Q9ULB4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113100, Expressed in corpus callosum and 114 other tissues |
ExpressionAtlasi | Q9ULB4, baseline and differential |
Genevisiblei | Q9ULB4, HS |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR027397, Catenin-bd_sf |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CADH9_HUMAN | |
Accessioni | Q9ULB4Primary (citable) accession number: Q9ULB4 Secondary accession number(s): Q3B7I5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot