UniProtKB - Q9ULB4 (CADH9_HUMAN)

BLAST

>sp|Q9ULB4|CADH9_HUMAN Cadherin-9 OS=Homo sapiens OX=9606 GN=CDH9 PE=2 SV=2
MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQF
FLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREE
KSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQ
VTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKD
MGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGEN
AEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLH
LGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYS
VDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILD
INDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIV
DNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSC
TAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYN
DEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRL
KENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADM
YGGDDSDRD

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History
Entry version 137 (12 Sep 2018)
Sequence version 2 (12 Dec 2006)
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Protein

Cadherin-9

Gene

CDH9

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adherens junction organization Source: Reactome
cell-cell adhesion
Source: UniProtKB
Non-traceable author statementⁱ
- 10861224
homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
synapse assembly Source: Ensembl
synaptic membrane adhesion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418990 Adherens junctions interactions

Reactomeⁱ

R-HSA-418990 Adherens junctions interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cadherin-9
Gene namesⁱ	Name:CDH9
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113100.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1768 CDH9
MIMⁱ	609974 gene
neXtProtⁱ	NX_Q9ULB4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	54 – 615	ExtracellularSequence analysisAdd BLAST	562
Transmembraneⁱ	616 – 636	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	637 – 789	CytoplasmicSequence analysisAdd BLAST	153

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1007
Open Targets More...OpenTargetsⁱ	ENSG00000113100
PharmGKBⁱ	PA26305

Polymorphism and mutation databases

BioMutaⁱ	CDH9
DMDMⁱ	119370307

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST	21
PropeptideⁱPRO_0000003779	22 – 53	Sequence analysisAdd BLAST	32
ChainⁱPRO_0000003780	54 – 789	Cadherin-9Add BLAST	736

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	255	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	437	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	455	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	536	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	786	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9ULB4
PaxDbⁱ	Q9ULB4
PeptideAtlas More...PeptideAtlasⁱ	Q9ULB4
PRIDEⁱ	Q9ULB4
ProteomicsDBⁱ	84970

PTM databases

iPTMnetⁱ	Q9ULB4
PhosphoSitePlusⁱ	Q9ULB4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000113100 Expressed in 85 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_CDH9
ExpressionAtlasⁱ	Q9ULB4 baseline and differential
Genevisibleⁱ	Q9ULB4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007167

HPAⁱ

HPA007167

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107442, 3 interactors
STRINGⁱ	9606.ENSP00000231021

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9ULB4
SMRⁱ	Q9ULB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	54 – 159	Cadherin 1PROSITE-ProRule annotationAdd BLAST	106
Domainⁱ	160 – 268	Cadherin 2PROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	269 – 383	Cadherin 3PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	384 – 486	Cadherin 4PROSITE-ProRule annotationAdd BLAST	103
Domainⁱ	487 – 608	Cadherin 5PROSITE-ProRule annotationAdd BLAST	122

Domainⁱ

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118954
HOGENOMⁱ	HOG000231252
HOVERGENⁱ	HBG005217
InParanoidⁱ	Q9ULB4
KEGG Orthology (KO) More...KOⁱ	K06801
OMAⁱ	LFIWTYM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0298
PhylomeDBⁱ	Q9ULB4
TreeFamⁱ	TF329887

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 2 hits PS50268 CADHERIN_2, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9ULB4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR 
        60         70         80         90        100
TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL 
       110        120        130        140        150
FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH 
       160        170        180        190        200
DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS 
       210        220        230        240        250
ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG 
       260        270        280        290        300
TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN 
       310        320        330        340        350
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS 
       360        370        380        390        400
NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS 
       410        420        430        440        450
IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES 
       460        470        480        490        500
SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA 
       510        520        530        540        550
KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM 
       560        570        580        590        600
TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC 
       610        620        630        640        650
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD 
       660        670        680        690        700
DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI 
       710        720        730        740        750
RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL 
       760        770        780 
SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD

Length:789

Mass (Da):88,689

Last modified:December 12, 2006 - v2

Checksum:ⁱC580DA16B769047C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EPN0	E7EPN0_HUMAN	Cadherin-9 Cadherin-9	CDH9	132	Annotation score:
D6RBT9	D6RBT9_HUMAN	Cadherin-9 Cadherin-9	CDH9	81	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	18	T → I in BAA87416 (PubMed:10861224).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029799	6	Y → C1 PublicationCorresponds to variant dbSNP:rs2288467Ensembl.		1
Natural variantⁱVAR_029800	38	A → V1 PublicationCorresponds to variant dbSNP:rs2288466Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035302 mRNA Translation: BAA87416.1 BC107594 mRNA Translation: AAI07595.1 BC113745 mRNA Translation: AAI13746.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3893.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057363.3, NM_016279.3
UniGeneⁱ	Hs.272212

Genome annotation databases

Ensemblⁱ	ENST00000231021; ENSP00000231021; ENSG00000113100
GeneIDⁱ	1007
KEGGⁱ	hsa:1007
UCSC genome browser More...UCSCⁱ	uc003jgs.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9ULB4	Cadherin-9 (Fragment)		HUMAN		81	UniRef100_Q9ULB4
UPI0007DBCE65		PANTR		240
Cadherin-9 (Fragment)		HUMAN		132

Protein	Similar proteins		Species	Score	Length	Source
Q9ULB4	Cadherin-9 (Fragment)		HUMAN		81	UniRef90_Q9ULB4
Cadherin-9		MYOBR		888
Uncharacterized protein		PIG		822
Cadherin-9		PTEAL		821
Cadherin-9 isoform 1		CAMFR		819
+137

Protein	Similar proteins		Species	Score	Length	Source
Q9ULB4	Cadherin-8	)	MOUSE		799	UniRef50_P97291
Cadherin-8		RAT		799
Cadherin-20		HUMAN		801
Cadherin-6		BOVIN		790
Cadherin-6		CHICK		790
+2919

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035302 mRNA Translation: BAA87416.1 BC107594 mRNA Translation: AAI07595.1 BC113745 mRNA Translation: AAI13746.1
CCDSⁱ	CCDS3893.1
RefSeqⁱ	NP_057363.3, NM_016279.3
UniGeneⁱ	Hs.272212

3D structure databases

ProteinModelPortalⁱ	Q9ULB4
SMRⁱ	Q9ULB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107442, 3 interactors
STRINGⁱ	9606.ENSP00000231021

PTM databases

iPTMnetⁱ	Q9ULB4
PhosphoSitePlusⁱ	Q9ULB4

Polymorphism and mutation databases

BioMutaⁱ	CDH9
DMDMⁱ	119370307

Proteomic databases

MaxQBⁱ	Q9ULB4
PaxDbⁱ	Q9ULB4
PeptideAtlasⁱ	Q9ULB4
PRIDEⁱ	Q9ULB4
ProteomicsDBⁱ	84970

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000231021; ENSP00000231021; ENSG00000113100
GeneIDⁱ	1007
KEGGⁱ	hsa:1007
UCSCⁱ	uc003jgs.2 human

Organism-specific databases

CTDⁱ	1007
DisGeNETⁱ	1007
EuPathDBⁱ	HostDB:ENSG00000113100.9
GeneCardsⁱ	CDH9
H-InvDBⁱ	HIX0031940
HGNCⁱ	HGNC:1768 CDH9
HPAⁱ	HPA007167
MIMⁱ	609974 gene
neXtProtⁱ	NX_Q9ULB4
OpenTargetsⁱ	ENSG00000113100
PharmGKBⁱ	PA26305
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
GeneTreeⁱ	ENSGT00760000118954
HOGENOMⁱ	HOG000231252
HOVERGENⁱ	HBG005217
InParanoidⁱ	Q9ULB4
KOⁱ	K06801
OMAⁱ	LFIWTYM
OrthoDBⁱ	EOG091G0298
PhylomeDBⁱ	Q9ULB4
TreeFamⁱ	TF329887

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418990 Adherens junctions interactions

Reactomeⁱ

R-HSA-418990 Adherens junctions interactions

Miscellaneous databases

GeneWikiⁱ	CDH9
GenomeRNAiⁱ	1007
Protein Ontology More...PROⁱ	PR:Q9ULB4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113100 Expressed in 85 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_CDH9
ExpressionAtlasⁱ	Q9ULB4 baseline and differential
Genevisibleⁱ	Q9ULB4 HS

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR027397 Catenin_binding_dom_sf
Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits
SUPFAMⁱ	SSF49313 SSF49313, 5 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 2 hits PS50268 CADHERIN_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CADH9_HUMAN
Accessionⁱ	Q9ULB4Primary (citable) accession number: Q9ULB4 Secondary accession number(s): Q3B7I5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	December 12, 2006
	Last modified:	September 12, 2018
	This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9ULB4 (CADH9_HUMAN)

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Cadherin-9

CDH9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ