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Protein

Cadherin-9

Gene

CDH9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-9
Gene namesi
Name:CDH9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113100.9
HGNCiHGNC:1768 CDH9
MIMi609974 gene
neXtProtiNX_Q9ULB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 615ExtracellularSequence analysisAdd BLAST562
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Topological domaini637 – 789CytoplasmicSequence analysisAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1007
OpenTargetsiENSG00000113100
PharmGKBiPA26305

Polymorphism and mutation databases

BioMutaiCDH9
DMDMi119370307

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000377922 – 53Sequence analysisAdd BLAST32
ChainiPRO_000000378054 – 789Cadherin-9Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei786PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9ULB4
PaxDbiQ9ULB4
PeptideAtlasiQ9ULB4
PRIDEiQ9ULB4
ProteomicsDBi84970

PTM databases

iPTMnetiQ9ULB4
PhosphoSitePlusiQ9ULB4

Expressioni

Gene expression databases

BgeeiENSG00000113100 Expressed in 85 organ(s), highest expression level in corpus callosum
CleanExiHS_CDH9
ExpressionAtlasiQ9ULB4 baseline and differential
GenevisibleiQ9ULB4 HS

Organism-specific databases

HPAiHPA007167

Interactioni

Protein-protein interaction databases

BioGridi107442, 3 interactors
STRINGi9606.ENSP00000231021

Structurei

3D structure databases

ProteinModelPortaliQ9ULB4
SMRiQ9ULB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 608Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ9ULB4
KOiK06801
OMAiLFIWTYM
OrthoDBiEOG091G0298
PhylomeDBiQ9ULB4
TreeFamiTF329887

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9ULB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR
60 70 80 90 100
TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL
110 120 130 140 150
FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH
160 170 180 190 200
DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN
310 320 330 340 350
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS
360 370 380 390 400
NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS
410 420 430 440 450
IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES
460 470 480 490 500
SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA
510 520 530 540 550
KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM
560 570 580 590 600
TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC
610 620 630 640 650
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD
660 670 680 690 700
DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI
710 720 730 740 750
RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL
760 770 780
SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD
Length:789
Mass (Da):88,689
Last modified:December 12, 2006 - v2
Checksum:iC580DA16B769047C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EPN0E7EPN0_HUMAN
Cadherin-9
CDH9
132Annotation score:
D6RBT9D6RBT9_HUMAN
Cadherin-9
CDH9
81Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18T → I in BAA87416 (PubMed:10861224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0297996Y → C1 PublicationCorresponds to variant dbSNP:rs2288467Ensembl.1
Natural variantiVAR_02980038A → V1 PublicationCorresponds to variant dbSNP:rs2288466Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035302 mRNA Translation: BAA87416.1
BC107594 mRNA Translation: AAI07595.1
BC113745 mRNA Translation: AAI13746.1
CCDSiCCDS3893.1
RefSeqiNP_057363.3, NM_016279.3
UniGeneiHs.272212

Genome annotation databases

EnsembliENST00000231021; ENSP00000231021; ENSG00000113100
GeneIDi1007
KEGGihsa:1007
UCSCiuc003jgs.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035302 mRNA Translation: BAA87416.1
BC107594 mRNA Translation: AAI07595.1
BC113745 mRNA Translation: AAI13746.1
CCDSiCCDS3893.1
RefSeqiNP_057363.3, NM_016279.3
UniGeneiHs.272212

3D structure databases

ProteinModelPortaliQ9ULB4
SMRiQ9ULB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107442, 3 interactors
STRINGi9606.ENSP00000231021

PTM databases

iPTMnetiQ9ULB4
PhosphoSitePlusiQ9ULB4

Polymorphism and mutation databases

BioMutaiCDH9
DMDMi119370307

Proteomic databases

MaxQBiQ9ULB4
PaxDbiQ9ULB4
PeptideAtlasiQ9ULB4
PRIDEiQ9ULB4
ProteomicsDBi84970

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231021; ENSP00000231021; ENSG00000113100
GeneIDi1007
KEGGihsa:1007
UCSCiuc003jgs.2 human

Organism-specific databases

CTDi1007
DisGeNETi1007
EuPathDBiHostDB:ENSG00000113100.9
GeneCardsiCDH9
H-InvDBiHIX0031940
HGNCiHGNC:1768 CDH9
HPAiHPA007167
MIMi609974 gene
neXtProtiNX_Q9ULB4
OpenTargetsiENSG00000113100
PharmGKBiPA26305
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00760000118954
HOGENOMiHOG000231252
HOVERGENiHBG005217
InParanoidiQ9ULB4
KOiK06801
OMAiLFIWTYM
OrthoDBiEOG091G0298
PhylomeDBiQ9ULB4
TreeFamiTF329887

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Miscellaneous databases

GeneWikiiCDH9
GenomeRNAii1007
PROiPR:Q9ULB4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113100 Expressed in 85 organ(s), highest expression level in corpus callosum
CleanExiHS_CDH9
ExpressionAtlasiQ9ULB4 baseline and differential
GenevisibleiQ9ULB4 HS

Family and domain databases

Gene3Di4.10.900.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin
IPR015919 Cadherin-like
IPR020894 Cadherin_CS
IPR000233 Cadherin_cytoplasmic-dom
IPR027397 Catenin_binding_dom_sf
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF01049 Cadherin_C, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 5 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCADH9_HUMAN
AccessioniPrimary (citable) accession number: Q9ULB4
Secondary accession number(s): Q3B7I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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