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UniProtKB - Q9UL68 (MYT1L_HUMAN)

Entry version 153 (25 May 2022)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
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Protein

Myelin transcription factor 1-like protein

Gene

MYT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi31Zinc 1PROSITE-ProRule annotation1
Metal bindingi36Zinc 1PROSITE-ProRule annotation1
Metal bindingi49Zinc 1PROSITE-ProRule annotation1
Metal bindingi55Zinc 1PROSITE-ProRule annotation1
Metal bindingi506Zinc 2PROSITE-ProRule annotation1
Metal bindingi511Zinc 2PROSITE-ProRule annotation1
Metal bindingi524Zinc 2PROSITE-ProRule annotation1
Metal bindingi530Zinc 2PROSITE-ProRule annotation1
Metal bindingi550Zinc 3PROSITE-ProRule annotation1
Metal bindingi555Zinc 3PROSITE-ProRule annotation1
Metal bindingi568Zinc 3PROSITE-ProRule annotation1
Metal bindingi574Zinc 3PROSITE-ProRule annotation1
Metal bindingi905Zinc 4PROSITE-ProRule annotation1
Metal bindingi910Zinc 4PROSITE-ProRule annotation1
Metal bindingi923Zinc 4PROSITE-ProRule annotation1
Metal bindingi929Zinc 4PROSITE-ProRule annotation1
Metal bindingi954Zinc 5PROSITE-ProRule annotation1
Metal bindingi959Zinc 5PROSITE-ProRule annotation1
Metal bindingi972Zinc 5PROSITE-ProRule annotation1
Metal bindingi978Zinc 5PROSITE-ProRule annotation1
Metal bindingi1007Zinc 6PROSITE-ProRule annotation1
Metal bindingi1012Zinc 6PROSITE-ProRule annotation1
Metal bindingi1025Zinc 6PROSITE-ProRule annotation1
Metal bindingi1031Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri497 – 540CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri541 – 584CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri896 – 939CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri945 – 988CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri998 – 1041CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UL68

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UL68

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UL68

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1-like protein1 Publication
Short name:
MyT1-L1 Publication
Short name:
MyT1L1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYT1L1 PublicationImported
Synonyms:KIAA11061 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7623, MYT1L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613084, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UL68

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186487

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder, autosomal dominant 39 (MRD39)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features.
Related information in OMIM

Keywords - Diseasei

Autism spectrum disorder, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		23040

MalaCards human disease database

More...MalaCardsi		MYT1L
MIMi616521, phenotype

Open Targets

More...OpenTargetsi		ENSG00000186487

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		178469, Autosomal dominant non-syndromic intellectual disability
528084, Non-specific syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31427

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UL68, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYT1L

Domain mapping of disease mutations (DMDM)

More...DMDMi		327478568

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966731 – 1186Myelin transcription factor 1-like proteinAdd BLAST1186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UL68

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UL68

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UL68

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UL68

PeptideAtlas

More...PeptideAtlasi		Q9UL68

PRoteomics IDEntifications database

More...PRIDEi		Q9UL68

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84961 [Q9UL68-1]
84963 [Q9UL68-3]
84964 [Q9UL68-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UL68

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UL68

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186487, Expressed in frontal cortex and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UL68, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UL68, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186487, Group enriched (brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIN3B.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116679, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q9UL68, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000396103

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UL68, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UL68

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UL68

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni56 – 175DisorderedSequence analysisAdd BLAST120
Regioni220 – 247DisorderedSequence analysisAdd BLAST28
Regioni342 – 372DisorderedSequence analysisAdd BLAST31
Regioni449 – 513DisorderedSequence analysisAdd BLAST65
Regioni659 – 709DisorderedSequence analysisAdd BLAST51
Regioni753 – 780DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1056 – 1130Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi89 – 169Acidic residuesSequence analysisAdd BLAST81
Compositional biasi342 – 358Polar residuesSequence analysisAdd BLAST17
Compositional biasi449 – 507Basic and acidic residuesSequence analysisAdd BLAST59
Compositional biasi684 – 709Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri497 – 540CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri541 – 584CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri896 – 939CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri945 – 988CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri998 – 1041CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3803, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155671

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1622834_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UL68

Identification of Orthologs from Complete Genome Data

More...OMAi		KVQTRDM

Database of Orthologous Groups

More...OrthoDBi		116799at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UL68

TreeFam database of animal gene trees

More...TreeFami		TF317299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08474, MYT1, 1 hit
PF01530, zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103637, SSF103637, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51802, ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 36 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UL68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR 
        60         70         80         90        100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD 
       110        120        130        140        150
EKEEDEGEEY SEDNDEPGDE DEEDEEGDRE EEEEIEEEDE DDDEDGEDVE 
       160        170        180        190        200
DEEEEEEEEE EEEEEEENED HQMNCHNTRI MQDTEKDDNN NDEYDNYDEL 
       210        220        230        240        250
VAKSLLNLGK IAEDAAYRAR TESEMNSNTS NSLEDDSDKN ENLGRKSELS 
       260        270        280        290        300
LDLDSDVVRE TVDSLKLLAQ GHGVVLSENM NDRNYADSMS QQDSRNMNYV 
       310        320        330        340        350
MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN 
       360        370        380        390        400
PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA 
       410        420        430        440        450
KEDGCHERDD DTTSVNSDRS EEVFDMTKGN LTLLEKAIAL ETERAKAMRE 
       460        470        480        490        500
KMAMEAGRRD NMRSYEDQSP RQLPGEDRKP KSSDSHVKKP YYGKDPSRTE 
       510        520        530        540        550
KKESKCPTPG CDGTGHVTGL YPHHRSLSGC PHKDRVPPEI LAMHESVLKC 
       560        570        580        590        600
PTPGCTGRGH VNSNRNSHRS LSGCPIAAAE KLAKAQEKHQ SCDVSKSSQA 
       610        620        630        640        650
SDRVLRPMCF VKQLEIPQYG YRNNVPTTTP RSNLAKELEK YSKTSFEYNS 
       660        670        680        690        700
YDNHTYGKRA IAPKVQTRDI SPKGYDDAKR YCKDPSPSSS STSSYAPSSS 
       710        720        730        740        750
SNLSCGGGSS ASSTCSKSSF DYTHDMEAAH MAATAILNLS TRCREMPQNL 
       760        770        780        790        800
STKPQDLCAT RNPDMEVDEN GTLDLSMNKQ RPRDSCCPIL TPLEPMSPQQ 
       810        820        830        840        850
QAVMNNRCFQ LGEGDCWDLP VDYTKMKPRR IDEDESKDIT PEDLDPFQEA 
       860        870        880        890        900
LEERRYPGEV TIPSPKPKYP QCKESKKDLI TLSGCPLADK SIRSMLATSS 
       910        920        930        940        950
QELKCPTPGC DGSGHITGNY ASHRSLSGCP RAKKSGIRIA QSKEDKEDQE 
       960        970        980        990       1000
PIRCPVPGCD GQGHITGKYA SHRSASGCPL AAKRQKDGYL NGSQFSWKSV 
      1010       1020       1030       1040       1050
KTEGMSCPTP GCDGSGHVSG SFLTHRSLSG CPRATSAMKK AKLSGEQMLT 
      1060       1070       1080       1090       1100
IKQRASNGIE NDEEIKQLDE EIKELNESNS QMEADMIKLR TQITTMESNL 
      1110       1120       1130       1140       1150
KTIEEENKVI EQQNESLLHE LANLSQSLIH SLANIQLPHM DPINEQNFDA 
      1160       1170       1180 
YVTTLTEMYT NQDRYQSPEN KALLENIKQA VRGIQV
Length:1,186
Mass (Da):133,043
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEF068692263FA8C
GO
Isoform 3 (identifier: Q9UL68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1004: Missing.
     1092-1092: Q → QVT

Show »
Length:184
Mass (Da):20,620
Checksum:i40104F07E2F61130
GO
Isoform 4 (identifier: Q9UL68-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: Missing.

Show »
Length:1,184
Mass (Da):132,858
Checksum:i6EA2551E3046F395
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 36 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YF72A0A2R8YF72_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRM3A0A3B3IRM3_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRX5A0A3B3IRX5_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS14A0A3B3IS14_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS61A0A3B3IS61_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISW5A0A3B3ISW5_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRT9A0A3B3IRT9_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISN3A0A3B3ISN3_HUMAN
Myelin transcription factor 1-like ...
MYT1L
824Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITJ8A0A3B3ITJ8_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITL3A0A3B3ITL3_HUMAN
Myelin transcription factor 1-like ...
MYT1L
860Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF14051 differs from that shown. Reason: Frameshift.Curated
The sequence AAI50282 differs from that shown. Aberrant splicing.Curated
The sequence BAA83058 differs from that shown. Aberrant splicing.Curated
The sequence BAA83058 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108 – 159Missing in BAA83058 (PubMed:10470851).CuratedAdd BLAST52
Sequence conflicti108 – 159Missing in AAI50282 (PubMed:15489334).CuratedAdd BLAST52
Sequence conflicti191N → S in AAF14051 (Ref. 1) Curated1
Sequence conflicti935S → R in AAF14051 (Ref. 1) Curated1
Sequence conflicti987D → E in AAF14051 (Ref. 1) Curated1
Sequence conflicti1110I → V in AAF14051 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157221 – 1004Missing in isoform 3. 1 PublicationAdd BLAST1004
Alternative sequenceiVSP_015724493 – 494Missing in isoform 4. 1 Publication2
Alternative sequenceiVSP_0157251092Q → QVT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF036943 mRNA Translation: AAF14051.1 Frameshift.
AB029029 mRNA Translation: BAA83058.2 Sequence problems.
AC008276 Genomic DNA No translation available.
AC009232 Genomic DNA No translation available.
AC009471 Genomic DNA No translation available.
AC011301 Genomic DNA No translation available.
AC093390 Genomic DNA No translation available.
AC106046 Genomic DNA No translation available.
BC071612 mRNA Translation: AAH71612.1
BC137272 mRNA Translation: AAI37273.1
BC137273 mRNA Translation: AAI37274.1
BC150281 mRNA Translation: AAI50282.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46222.1 [Q9UL68-4]
CCDS77378.1 [Q9UL68-1]

NCBI Reference Sequences

More...RefSeqi		NP_001289981.1, NM_001303052.1 [Q9UL68-1]
NP_001316773.1, NM_001329844.1 [Q9UL68-1]
NP_001316774.1, NM_001329845.1 [Q9UL68-1]
NP_001316776.1, NM_001329847.1 [Q9UL68-4]
NP_001316777.1, NM_001329848.1 [Q9UL68-4]
NP_055840.2, NM_015025.3 [Q9UL68-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000399161.8; ENSP00000382114.3; ENSG00000186487.21 [Q9UL68-4]
ENST00000407844.6; ENSP00000384219.1; ENSG00000186487.21 [Q9UL68-3]
ENST00000428368.7; ENSP00000396103.3; ENSG00000186487.21
ENST00000647694.1; ENSP00000497722.1; ENSG00000186487.21
ENST00000647738.2; ENSP00000497479.2; ENSG00000186487.21
ENST00000648316.1; ENSP00000497870.1; ENSG00000186487.21 [Q9UL68-4]
ENST00000648928.1; ENSP00000497017.1; ENSG00000186487.21 [Q9UL68-4]
ENST00000649207.1; ENSP00000496986.1; ENSG00000186487.21 [Q9UL68-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23040

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23040

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000647738.2; ENSP00000497479.2; NM_001303052.2; NP_001289981.1

UCSC genome browser

More...UCSCi		uc002qxd.4, human [Q9UL68-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036943 mRNA Translation: AAF14051.1 Frameshift.
AB029029 mRNA Translation: BAA83058.2 Sequence problems.
AC008276 Genomic DNA No translation available.
AC009232 Genomic DNA No translation available.
AC009471 Genomic DNA No translation available.
AC011301 Genomic DNA No translation available.
AC093390 Genomic DNA No translation available.
AC106046 Genomic DNA No translation available.
BC071612 mRNA Translation: AAH71612.1
BC137272 mRNA Translation: AAI37273.1
BC137273 mRNA Translation: AAI37274.1
BC150281 mRNA Translation: AAI50282.1 Sequence problems.
CCDSiCCDS46222.1 [Q9UL68-4]
CCDS77378.1 [Q9UL68-1]
RefSeqiNP_001289981.1, NM_001303052.1 [Q9UL68-1]
NP_001316773.1, NM_001329844.1 [Q9UL68-1]
NP_001316774.1, NM_001329845.1 [Q9UL68-1]
NP_001316776.1, NM_001329847.1 [Q9UL68-4]
NP_001316777.1, NM_001329848.1 [Q9UL68-4]
NP_055840.2, NM_015025.3 [Q9UL68-4]

3D structure databases

AlphaFoldDBiQ9UL68
SMRiQ9UL68
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116679, 5 interactors
IntActiQ9UL68, 7 interactors
STRINGi9606.ENSP00000396103

PTM databases

iPTMnetiQ9UL68
PhosphoSitePlusiQ9UL68

Genetic variation databases

BioMutaiMYT1L
DMDMi327478568

Proteomic databases

jPOSTiQ9UL68
MassIVEiQ9UL68
MaxQBiQ9UL68
PaxDbiQ9UL68
PeptideAtlasiQ9UL68
PRIDEiQ9UL68
ProteomicsDBi84961 [Q9UL68-1]
84963 [Q9UL68-3]
84964 [Q9UL68-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		62900, 59 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		23040

Genome annotation databases

EnsembliENST00000399161.8; ENSP00000382114.3; ENSG00000186487.21 [Q9UL68-4]
ENST00000407844.6; ENSP00000384219.1; ENSG00000186487.21 [Q9UL68-3]
ENST00000428368.7; ENSP00000396103.3; ENSG00000186487.21
ENST00000647694.1; ENSP00000497722.1; ENSG00000186487.21
ENST00000647738.2; ENSP00000497479.2; ENSG00000186487.21
ENST00000648316.1; ENSP00000497870.1; ENSG00000186487.21 [Q9UL68-4]
ENST00000648928.1; ENSP00000497017.1; ENSG00000186487.21 [Q9UL68-4]
ENST00000649207.1; ENSP00000496986.1; ENSG00000186487.21 [Q9UL68-4]
GeneIDi23040
KEGGihsa:23040
MANE-SelectiENST00000647738.2; ENSP00000497479.2; NM_001303052.2; NP_001289981.1
UCSCiuc002qxd.4, human [Q9UL68-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23040
DisGeNETi23040

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYT1L
HGNCiHGNC:7623, MYT1L
HPAiENSG00000186487, Group enriched (brain, pituitary gland)
MalaCardsiMYT1L
MIMi613084, gene
616521, phenotype
neXtProtiNX_Q9UL68
OpenTargetsiENSG00000186487
Orphaneti178469, Autosomal dominant non-syndromic intellectual disability
528084, Non-specific syndromic intellectual disability
PharmGKBiPA31427
VEuPathDBiHostDB:ENSG00000186487

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3803, Eukaryota
GeneTreeiENSGT00940000155671
HOGENOMiCLU_1622834_0_0_1
InParanoidiQ9UL68
OMAiKVQTRDM
OrthoDBi116799at2759
PhylomeDBiQ9UL68
TreeFamiTF317299

Enzyme and pathway databases

PathwayCommonsiQ9UL68
SignaLinkiQ9UL68
SIGNORiQ9UL68

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23040, 39 hits in 1097 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYT1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23040
PharosiQ9UL68, Tbio

Protein Ontology

More...PROi		PR:Q9UL68
RNActiQ9UL68, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186487, Expressed in frontal cortex and 140 other tissues
ExpressionAtlasiQ9UL68, baseline and differential
GenevisibleiQ9UL68, HS

Family and domain databases

InterProiView protein in InterPro
IPR013681, Myelin_TF
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474, MYT1, 1 hit
PF01530, zf-C2HC, 6 hits
SUPFAMiSSF103637, SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802, ZF_CCHHC, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UL68
Secondary accession number(s): A7E2C7
, B2RP54, Q6IQ17, Q9UPP6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 5, 2011
Last modified: May 25, 2022
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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