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Entry version 137 (08 May 2019)
Sequence version 3 (05 Apr 2011)
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Protein

Myelin transcription factor 1-like protein

Gene

MYT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri497 – 540CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri541 – 584CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri896 – 939CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri945 – 988CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri998 – 1041CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin transcription factor 1-like protein1 Publication
Short name:
MyT1-L1 Publication
Short name:
MyT1L1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYT1L1 PublicationImported
Synonyms:KIAA11061 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7623 MYT1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613084 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UL68

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal dominant 39 (MRD39)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features.
Related information in OMIM

Keywords - Diseasei

Autism spectrum disorder, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
23040

MalaCards human disease database

More...
MalaCardsi
MYT1L
MIMi616521 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186487

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
178469 Autosomal dominant non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31427

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYT1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478568

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966731 – 1186Myelin transcription factor 1-like proteinAdd BLAST1186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UL68

PeptideAtlas

More...
PeptideAtlasi
Q9UL68

PRoteomics IDEntifications database

More...
PRIDEi
Q9UL68

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84961
84963 [Q9UL68-3]
84964 [Q9UL68-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UL68

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UL68

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186487 Expressed in 122 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UL68 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UL68 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060245

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SIN3B.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116679, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UL68, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000396103

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UL68

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1056 – 1130Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi97 – 169Asp/Glu-richAdd BLAST73
Compositional biasi686 – 719Ser-richAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYT1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 65CCHHC-type 1PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri497 – 540CCHHC-type 2PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri541 – 584CCHHC-type 3PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri896 – 939CCHHC-type 4PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri945 – 988CCHHC-type 5PROSITE-ProRule annotationAdd BLAST44
Zinc fingeri998 – 1041CCHHC-type 6PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3803 Eukaryota
ENOG410ZPWS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155671

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234099

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UL68

KEGG Orthology (KO)

More...
KOi
K23193

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSNMSCG

Database of Orthologous Groups

More...
OrthoDBi
116799at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UL68

TreeFam database of animal gene trees

More...
TreeFami
TF317299

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637 SSF103637, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 35 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UL68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD
110 120 130 140 150
EKEEDEGEEY SEDNDEPGDE DEEDEEGDRE EEEEIEEEDE DDDEDGEDVE
160 170 180 190 200
DEEEEEEEEE EEEEEEENED HQMNCHNTRI MQDTEKDDNN NDEYDNYDEL
210 220 230 240 250
VAKSLLNLGK IAEDAAYRAR TESEMNSNTS NSLEDDSDKN ENLGRKSELS
260 270 280 290 300
LDLDSDVVRE TVDSLKLLAQ GHGVVLSENM NDRNYADSMS QQDSRNMNYV
310 320 330 340 350
MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN
360 370 380 390 400
PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA
410 420 430 440 450
KEDGCHERDD DTTSVNSDRS EEVFDMTKGN LTLLEKAIAL ETERAKAMRE
460 470 480 490 500
KMAMEAGRRD NMRSYEDQSP RQLPGEDRKP KSSDSHVKKP YYGKDPSRTE
510 520 530 540 550
KKESKCPTPG CDGTGHVTGL YPHHRSLSGC PHKDRVPPEI LAMHESVLKC
560 570 580 590 600
PTPGCTGRGH VNSNRNSHRS LSGCPIAAAE KLAKAQEKHQ SCDVSKSSQA
610 620 630 640 650
SDRVLRPMCF VKQLEIPQYG YRNNVPTTTP RSNLAKELEK YSKTSFEYNS
660 670 680 690 700
YDNHTYGKRA IAPKVQTRDI SPKGYDDAKR YCKDPSPSSS STSSYAPSSS
710 720 730 740 750
SNLSCGGGSS ASSTCSKSSF DYTHDMEAAH MAATAILNLS TRCREMPQNL
760 770 780 790 800
STKPQDLCAT RNPDMEVDEN GTLDLSMNKQ RPRDSCCPIL TPLEPMSPQQ
810 820 830 840 850
QAVMNNRCFQ LGEGDCWDLP VDYTKMKPRR IDEDESKDIT PEDLDPFQEA
860 870 880 890 900
LEERRYPGEV TIPSPKPKYP QCKESKKDLI TLSGCPLADK SIRSMLATSS
910 920 930 940 950
QELKCPTPGC DGSGHITGNY ASHRSLSGCP RAKKSGIRIA QSKEDKEDQE
960 970 980 990 1000
PIRCPVPGCD GQGHITGKYA SHRSASGCPL AAKRQKDGYL NGSQFSWKSV
1010 1020 1030 1040 1050
KTEGMSCPTP GCDGSGHVSG SFLTHRSLSG CPRATSAMKK AKLSGEQMLT
1060 1070 1080 1090 1100
IKQRASNGIE NDEEIKQLDE EIKELNESNS QMEADMIKLR TQITTMESNL
1110 1120 1130 1140 1150
KTIEEENKVI EQQNESLLHE LANLSQSLIH SLANIQLPHM DPINEQNFDA
1160 1170 1180
YVTTLTEMYT NQDRYQSPEN KALLENIKQA VRGIQV
Length:1,186
Mass (Da):133,043
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEF068692263FA8C
GO
Isoform 3 (identifier: Q9UL68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1004: Missing.
     1092-1092: Q → QVT

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):20,620
Checksum:i40104F07E2F61130
GO
Isoform 4 (identifier: Q9UL68-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: Missing.

Show »
Length:1,184
Mass (Da):132,858
Checksum:i6EA2551E3046F395
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 35 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YF72A0A2R8YF72_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRM3A0A3B3IRM3_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS14A0A3B3IS14_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISW5A0A3B3ISW5_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS61A0A3B3IS61_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRX5A0A3B3IRX5_HUMAN
Myelin transcription factor 1-like ...
MYT1L
1,146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS77A0A3B3IS77_HUMAN
Myelin transcription factor 1-like ...
MYT1L
889Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IUE2A0A3B3IUE2_HUMAN
Myelin transcription factor 1-like ...
MYT1L
742Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITS6A0A3B3ITS6_HUMAN
Myelin transcription factor 1-like ...
MYT1L
645Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITL3A0A3B3ITL3_HUMAN
Myelin transcription factor 1-like ...
MYT1L
860Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF14051 differs from that shown. Reason: Frameshift at position 1185.Curated
The sequence AAI50282 differs from that shown. Aberrant splicing.Curated
The sequence BAA83058 differs from that shown. Aberrant splicing.Curated
The sequence BAA83058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108 – 159Missing in BAA83058 (PubMed:10470851).CuratedAdd BLAST52
Sequence conflicti108 – 159Missing in AAI50282 (PubMed:15489334).CuratedAdd BLAST52
Sequence conflicti191N → S in AAF14051 (Ref. 1) Curated1
Sequence conflicti935S → R in AAF14051 (Ref. 1) Curated1
Sequence conflicti987D → E in AAF14051 (Ref. 1) Curated1
Sequence conflicti1110I → V in AAF14051 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0157221 – 1004Missing in isoform 3. 1 PublicationAdd BLAST1004
Alternative sequenceiVSP_015724493 – 494Missing in isoform 4. 1 Publication2
Alternative sequenceiVSP_0157251092Q → QVT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF036943 mRNA Translation: AAF14051.1 Frameshift.
AB029029 mRNA Translation: BAA83058.2 Sequence problems.
AC008276 Genomic DNA No translation available.
AC009232 Genomic DNA No translation available.
AC009471 Genomic DNA No translation available.
AC011301 Genomic DNA No translation available.
AC093390 Genomic DNA No translation available.
AC106046 Genomic DNA No translation available.
BC071612 mRNA Translation: AAH71612.1
BC137272 mRNA Translation: AAI37273.1
BC137273 mRNA Translation: AAI37274.1
BC150281 mRNA Translation: AAI50282.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46222.1 [Q9UL68-4]
CCDS77378.1 [Q9UL68-1]

NCBI Reference Sequences

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RefSeqi
NP_001289981.1, NM_001303052.1 [Q9UL68-1]
NP_001316773.1, NM_001329844.1 [Q9UL68-1]
NP_001316774.1, NM_001329845.1 [Q9UL68-1]
NP_001316776.1, NM_001329847.1 [Q9UL68-4]
NP_001316777.1, NM_001329848.1 [Q9UL68-4]
NP_055840.2, NM_015025.3 [Q9UL68-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000399161; ENSP00000382114; ENSG00000186487 [Q9UL68-4]
ENST00000407844; ENSP00000384219; ENSG00000186487 [Q9UL68-3]
ENST00000428368; ENSP00000396103; ENSG00000186487 [Q9UL68-1]
ENST00000647694; ENSP00000497722; ENSG00000186487 [Q9UL68-1]
ENST00000647738; ENSP00000497479; ENSG00000186487 [Q9UL68-1]
ENST00000648316; ENSP00000497870; ENSG00000186487 [Q9UL68-4]
ENST00000648928; ENSP00000497017; ENSG00000186487 [Q9UL68-4]
ENST00000649207; ENSP00000496986; ENSG00000186487 [Q9UL68-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23040

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23040

UCSC genome browser

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UCSCi
uc002qxd.4 human [Q9UL68-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036943 mRNA Translation: AAF14051.1 Frameshift.
AB029029 mRNA Translation: BAA83058.2 Sequence problems.
AC008276 Genomic DNA No translation available.
AC009232 Genomic DNA No translation available.
AC009471 Genomic DNA No translation available.
AC011301 Genomic DNA No translation available.
AC093390 Genomic DNA No translation available.
AC106046 Genomic DNA No translation available.
BC071612 mRNA Translation: AAH71612.1
BC137272 mRNA Translation: AAI37273.1
BC137273 mRNA Translation: AAI37274.1
BC150281 mRNA Translation: AAI50282.1 Sequence problems.
CCDSiCCDS46222.1 [Q9UL68-4]
CCDS77378.1 [Q9UL68-1]
RefSeqiNP_001289981.1, NM_001303052.1 [Q9UL68-1]
NP_001316773.1, NM_001329844.1 [Q9UL68-1]
NP_001316774.1, NM_001329845.1 [Q9UL68-1]
NP_001316776.1, NM_001329847.1 [Q9UL68-4]
NP_001316777.1, NM_001329848.1 [Q9UL68-4]
NP_055840.2, NM_015025.3 [Q9UL68-4]

3D structure databases

SMRiQ9UL68
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116679, 3 interactors
IntActiQ9UL68, 6 interactors
STRINGi9606.ENSP00000396103

PTM databases

iPTMnetiQ9UL68
PhosphoSitePlusiQ9UL68

Polymorphism and mutation databases

BioMutaiMYT1L
DMDMi327478568

Proteomic databases

PaxDbiQ9UL68
PeptideAtlasiQ9UL68
PRIDEiQ9UL68
ProteomicsDBi84961
84963 [Q9UL68-3]
84964 [Q9UL68-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399161; ENSP00000382114; ENSG00000186487 [Q9UL68-4]
ENST00000407844; ENSP00000384219; ENSG00000186487 [Q9UL68-3]
ENST00000428368; ENSP00000396103; ENSG00000186487 [Q9UL68-1]
ENST00000647694; ENSP00000497722; ENSG00000186487 [Q9UL68-1]
ENST00000647738; ENSP00000497479; ENSG00000186487 [Q9UL68-1]
ENST00000648316; ENSP00000497870; ENSG00000186487 [Q9UL68-4]
ENST00000648928; ENSP00000497017; ENSG00000186487 [Q9UL68-4]
ENST00000649207; ENSP00000496986; ENSG00000186487 [Q9UL68-4]
GeneIDi23040
KEGGihsa:23040
UCSCiuc002qxd.4 human [Q9UL68-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23040
DisGeNETi23040

GeneCards: human genes, protein and diseases

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GeneCardsi
MYT1L
HGNCiHGNC:7623 MYT1L
HPAiHPA060245
MalaCardsiMYT1L
MIMi613084 gene
616521 phenotype
neXtProtiNX_Q9UL68
OpenTargetsiENSG00000186487
Orphaneti178469 Autosomal dominant non-syndromic intellectual disability
PharmGKBiPA31427

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3803 Eukaryota
ENOG410ZPWS LUCA
GeneTreeiENSGT00940000155671
HOGENOMiHOG000234099
InParanoidiQ9UL68
KOiK23193
OMAiSSNMSCG
OrthoDBi116799at2759
PhylomeDBiQ9UL68
TreeFamiTF317299

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYT1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23040

Protein Ontology

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PROi
PR:Q9UL68

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186487 Expressed in 122 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ9UL68 baseline and differential
GenevisibleiQ9UL68 HS

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits
SUPFAMiSSF103637 SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYT1L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UL68
Secondary accession number(s): A7E2C7
, B2RP54, Q6IQ17, Q9UPP6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 5, 2011
Last modified: May 8, 2019
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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