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UniProtKB - Q9UL59 (ZN214_HUMAN)
Protein
Zinc finger protein 214
Gene
ZNF214
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 275 – 297 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 303 – 325 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 330 – 352 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 380 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 464 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 470 – 492 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 498 – 520 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 526 – 548 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 554 – 576 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UL59 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9UL59 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 214Alternative name(s): BWSCR2-associated zinc finger protein 1 Short name: BAZ-1 |
Gene namesi | Name:ZNF214 Synonyms:BAZ1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13006, ZNF214 |
MIMi | 605015, gene |
neXtProti | NX_Q9UL59 |
VEuPathDBi | HostDB:ENSG00000149050 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7761 |
OpenTargetsi | ENSG00000149050 |
PharmGKBi | PA37585 |
Miscellaneous databases
Pharosi | Q9UL59, Tbio |
Genetic variation databases
BioMutai | ZNF214 |
DMDMi | 296453038 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047458 | 1 – 606 | Zinc finger protein 214Add BLAST | 606 |
Proteomic databases
jPOSTi | Q9UL59 |
MassIVEi | Q9UL59 |
PaxDbi | Q9UL59 |
PeptideAtlasi | Q9UL59 |
PRIDEi | Q9UL59 |
ProteomicsDBi | 84957 |
PTM databases
iPTMneti | Q9UL59 |
PhosphoSitePlusi | Q9UL59 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149050, Expressed in buccal mucosa cell and 136 other tissues |
Genevisiblei | Q9UL59, HS |
Organism-specific databases
HPAi | ENSG00000149050, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113544, 14 interactors |
IntActi | Q9UL59, 12 interactors |
STRINGi | 9606.ENSP00000278314 |
Miscellaneous databases
RNActi | Q9UL59, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 83 | KRABPROSITE-ProRule annotationAdd BLAST | 81 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 275 – 297 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 303 – 325 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 330 – 352 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 380 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 464 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 470 – 492 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 498 – 520 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 526 – 548 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 554 – 576 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163179 |
HOGENOMi | CLU_002678_0_11_1 |
InParanoidi | Q9UL59 |
OMAi | KFIPWQS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9UL59 |
TreeFami | TF350845 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
i Sequence
Sequence statusi: Complete.
Q9UL59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVTFEDVTI IFTWEEWKFL DSSQKRLYRE VMWENYTNVM SVENWNESYK
60 70 80 90 100
SQEEKFRYLE YENFSYWQGW WNAGAQMYEN QNYGETVQGT DSKDLTQQDR
110 120 130 140 150
SQCQEWLILS TQVPGYGNYE LTFESKSLRN LKYKNFMPWQ SLETKTTQDY
160 170 180 190 200
GREIYMSGSH GFQGGRYRLG ISRKNLSMEK EQKLIVQHSY IPVEEALPQY
210 220 230 240 250
VGVICQEDLL RDSMEEKYCG CNKCKGIYYW NSRCVFHKRN QPGENLCQCS
260 270 280 290 300
ICKACFSQRS DLYRHPRNHI GKKLYGCDEV DGNFHQSSGV HFHQRVHIGE
310 320 330 340 350
VPYSCNACGK SFSQISSLHN HQRVHTEEKF YKIECDKDLS RNSLLHIHQR
360 370 380 390 400
LHIGEKPFKC NQCGKSFNRS SVLHVHQRVH TGEKPYKCDE CGKGFSQSSN
410 420 430 440 450
LRIHQLVHTG EKSYKCEDCG KGFTQRSNLQ IHQRVHTGEK PYKCDDCGKD
460 470 480 490 500
FSHSSDLRIH QRVHTGEKPY TCPECGKGFS KSSKLHTHQR VHTGEKPYKC
510 520 530 540 550
EECGKGFSQR SHLLIHQRVH TGEKPYKCHD CGKGFSHSSN LHIHQRVHTG
560 570 580 590 600
EKPYQCAKCG KGFSHSSALR IHQRVHAGEK PYKCREYYKG FDHNSHLHNN
HRRGNL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 252 | C → R in AAF00004 (PubMed:10762538).Curated | 1 | |
Sequence conflicti | 252 | C → R in BAG36248 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 252 | C → R in AAI36773 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057403 | 66 | Y → C. Corresponds to variant dbSNP:rs1156526Ensembl. | 1 | |
Natural variantiVAR_019975 | 128 | L → H. Corresponds to variant dbSNP:rs1156525Ensembl. | 1 | |
Natural variantiVAR_057404 | 160 | H → R. Corresponds to variant dbSNP:rs16921097Ensembl. | 1 | |
Natural variantiVAR_019976 | 185 | I → R. Corresponds to variant dbSNP:rs2239734Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF056617 mRNA Translation: AAF00004.1 AK313462 mRNA Translation: BAG36248.1 AC100875 Genomic DNA No translation available. BC136772 mRNA Translation: AAI36773.1 |
CCDSi | CCDS31418.1 |
RefSeqi | NP_037381.2, NM_013249.2 XP_005253185.1, XM_005253128.3 XP_006718371.1, XM_006718308.3 |
Genome annotation databases
Ensembli | ENST00000278314.5; ENSP00000278314.4; ENSG00000149050.10 ENST00000536068.5; ENSP00000445373.1; ENSG00000149050.10 |
GeneIDi | 7761 |
KEGGi | hsa:7761 |
MANE-Selecti | ENST00000278314.5; ENSP00000278314.4; NM_013249.4; NP_037381.2 |
UCSCi | uc001mfa.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF056617 mRNA Translation: AAF00004.1 AK313462 mRNA Translation: BAG36248.1 AC100875 Genomic DNA No translation available. BC136772 mRNA Translation: AAI36773.1 |
CCDSi | CCDS31418.1 |
RefSeqi | NP_037381.2, NM_013249.2 XP_005253185.1, XM_005253128.3 XP_006718371.1, XM_006718308.3 |
3D structure databases
AlphaFoldDBi | Q9UL59 |
SMRi | Q9UL59 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113544, 14 interactors |
IntActi | Q9UL59, 12 interactors |
STRINGi | 9606.ENSP00000278314 |
PTM databases
iPTMneti | Q9UL59 |
PhosphoSitePlusi | Q9UL59 |
Genetic variation databases
BioMutai | ZNF214 |
DMDMi | 296453038 |
Proteomic databases
jPOSTi | Q9UL59 |
MassIVEi | Q9UL59 |
PaxDbi | Q9UL59 |
PeptideAtlasi | Q9UL59 |
PRIDEi | Q9UL59 |
ProteomicsDBi | 84957 |
Protocols and materials databases
Antibodypediai | 11387, 119 antibodies from 18 providers |
DNASUi | 7761 |
Genome annotation databases
Ensembli | ENST00000278314.5; ENSP00000278314.4; ENSG00000149050.10 ENST00000536068.5; ENSP00000445373.1; ENSG00000149050.10 |
GeneIDi | 7761 |
KEGGi | hsa:7761 |
MANE-Selecti | ENST00000278314.5; ENSP00000278314.4; NM_013249.4; NP_037381.2 |
UCSCi | uc001mfa.3, human |
Organism-specific databases
CTDi | 7761 |
DisGeNETi | 7761 |
GeneCardsi | ZNF214 |
HGNCi | HGNC:13006, ZNF214 |
HPAi | ENSG00000149050, Low tissue specificity |
MIMi | 605015, gene |
neXtProti | NX_Q9UL59 |
OpenTargetsi | ENSG00000149050 |
PharmGKBi | PA37585 |
VEuPathDBi | HostDB:ENSG00000149050 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163179 |
HOGENOMi | CLU_002678_0_11_1 |
InParanoidi | Q9UL59 |
OMAi | KFIPWQS |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9UL59 |
TreeFami | TF350845 |
Enzyme and pathway databases
PathwayCommonsi | Q9UL59 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q9UL59 |
Miscellaneous databases
BioGRID-ORCSi | 7761, 8 hits in 1089 CRISPR screens |
GenomeRNAii | 7761 |
Pharosi | Q9UL59, Tbio |
PROi | PR:Q9UL59 |
RNActi | Q9UL59, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149050, Expressed in buccal mucosa cell and 136 other tissues |
Genevisiblei | Q9UL59, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN214_HUMAN | |
Accessioni | Q9UL59Primary (citable) accession number: Q9UL59 Secondary accession number(s): B2R8Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families