UniProtKB - Q9UL54 (TAOK2_HUMAN)
Protein
Serine/threonine-protein kinase TAO2
Gene
TAOK2
Organism
Homo sapiens (Human)
Status
Functioni
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.8 Publications
Catalytic activityi
Cofactori
Mg2+By similarity
Activity regulationi
Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following arsenic trioxide (As2O3) treatment.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 57 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 151 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 42 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase kinase kinase activity Source: ARUK-UCL
- mitogen-activated protein kinase kinase binding Source: UniProtKB
- neuropilin binding Source: ARUK-UCL
- protein serine/threonine kinase activity Source: UniProtKB
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: ARUK-UCL
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- activation of JUN kinase activity Source: ARUK-UCL
- activation of MAPK activity Source: ARUK-UCL
- activation of MAPKK activity Source: UniProtKB
- activation of protein kinase activity Source: GO_Central
- apoptotic process Source: UniProtKB
- axonogenesis Source: ARUK-UCL
- basal dendrite arborization Source: ARUK-UCL
- basal dendrite morphogenesis Source: ARUK-UCL
- cell migration Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- focal adhesion assembly Source: UniProtKB
- MAPK cascade Source: GO_Central
- mitotic G2 DNA damage checkpoint Source: UniProtKB
- neuron projection morphogenesis Source: GO_Central
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of protein autophosphorylation Source: ARUK-UCL
- positive regulation of stress-activated MAPK cascade Source: UniProtKB
- protein autophosphorylation Source: ARUK-UCL
- protein targeting to membrane Source: UniProtKB
- regulation of actin cytoskeleton organization Source: ARUK-UCL
- regulation of cell growth Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- signal transduction by protein phosphorylation Source: GO_Central
- stress-activated MAPK cascade Source: UniProtKB
- stress-activated protein kinase signaling cascade Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UL54 |
SignaLinki | Q9UL54 |
SIGNORi | Q9UL54 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase TAO2 (EC:2.7.11.1)Alternative name(s): Kinase from chicken homolog C Short name: hKFC-C Prostate-derived sterile 20-like kinase 1 Short name: PSK-1 Short name: PSK1 Short name: Prostate-derived STE20-like kinase 1 Thousand and one amino acid protein kinase 2 |
Gene namesi | Name:TAOK2 Synonyms:KIAA0881, MAP3K17, PSK, PSK1 ORF Names:UNQ2971/PRO7431 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000149930.17 |
HGNCi | HGNC:16835, TAOK2 |
MIMi | 613199, gene |
neXtProti | NX_Q9UL54 |
Subcellular locationi
Cytoskeleton
Nucleus
Other locations
- Cytoplasmic vesicle membrane Curated; Multi-pass membrane protein Curated
Note: Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.
Other locations
Note: In dendrites, colocalizes with PCDH8.By similarity
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- axon Source: ARUK-UCL
- axonal growth cone Source: ARUK-UCL
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- dendritic growth cone Source: ARUK-UCL
- integral component of membrane Source: UniProtKB-KW
- neuron projection Source: ARUK-UCL
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 965 – 985 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 987 – 1007 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1012 – 1032 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1043 – 1063 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1166 – 1186 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 57 | K → A: Loss of kinase activity. In isoform 1, excluded from the nucleus. No effect on microtubule-binding. 4 Publications | 1 | |
Mutagenesisi | 169 | D → A: Loss of kinase activity; No effect on MAP3K7-mediated activation of NF-kappa-B. 1 Publication | 1 | |
Mutagenesisi | 919 | D → N: No effect on kinase activity, nor on JNK activation, but severe reduction in nuclear localization and apoptotic membrane blebbing. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9344 |
OpenTargetsi | ENSG00000149930 |
PharmGKBi | PA134907964 |
Miscellaneous databases
Pharosi | Q9UL54, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1075195 |
DrugBanki | DB04522, Dexfosfoserine DB12010, Fostamatinib |
DrugCentrali | Q9UL54 |
Polymorphism and mutation databases
BioMutai | TAOK2 |
DMDMi | 116242813 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086733 | 1 – 1235 | Serine/threonine-protein kinase TAO2Add BLAST | 1235 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 9 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 181 | PhosphoserineCombined sources1 Publication | 1 | ||
Modified residuei | 414 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 656 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 777 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 825 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 827 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: Q9UL54-2) | |||||
Modified residuei | 1011 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1031 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Isoforms 1 and 2 are autophosphorylated.
C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.
Autophosphorylated. Phosphorylated by ATM.
Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UL54 |
jPOSTi | Q9UL54 |
MassIVEi | Q9UL54 |
PaxDbi | Q9UL54 |
PeptideAtlasi | Q9UL54 |
PRIDEi | Q9UL54 |
ProteomicsDBi | 7250 84953 [Q9UL54-1] 84954 [Q9UL54-2] 84955 [Q9UL54-3] |
PTM databases
iPTMneti | Q9UL54 |
PhosphoSitePlusi | Q9UL54 |
Expressioni
Tissue specificityi
Ubiquitously expressed, with a higher level of expression in testis and brain.2 Publications
Gene expression databases
Bgeei | ENSG00000149930, Expressed in right testis and 192 other tissues |
Genevisiblei | Q9UL54, HS |
Organism-specific databases
HPAi | ENSG00000149930, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates.
Interacts with tubulins through the C-terminal domain.
Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation.
Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity).
By similarityBinary interactionsi
Hide detailsGO - Molecular functioni
- mitogen-activated protein kinase kinase binding Source: UniProtKB
- neuropilin binding Source: ARUK-UCL
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 114750, 32 interactors |
IntActi | Q9UL54, 24 interactors |
STRINGi | 9606.ENSP00000310094 |
Chemistry databases
BindingDBi | Q9UL54 |
Miscellaneous databases
RNActi | Q9UL54, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 281 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 486 – 547 | Sequence analysisAdd BLAST | 62 | |
Coiled coili | 574 – 601 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 681 – 713 | Sequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 330 – 336 | Poly-Glu | 7 | |
Compositional biasi | 347 – 370 | Ser-richAdd BLAST | 24 | |
Compositional biasi | 378 – 406 | Glu-richAdd BLAST | 29 | |
Compositional biasi | 791 – 907 | Glu-richAdd BLAST | 117 | |
Compositional biasi | 943 – 1060 | Leu-richAdd BLAST | 118 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0577, Eukaryota |
GeneTreei | ENSGT00940000159991 |
HOGENOMi | CLU_276301_0_0_1 |
InParanoidi | Q9UL54 |
OMAi | LRDHTAW |
OrthoDBi | 617606at2759 |
PhylomeDBi | Q9UL54 |
TreeFami | TF351444 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UL54-1) [UniParc]FASTAAdd to basket
Also known as: PSK1-alpha, TAO2
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN
60 70 80 90 100
SEVVAIKKMS YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT
110 120 130 140 150
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA VTHGALQGLA YLHSHNMIHR
160 170 180 190 200
DVKAGNILLS EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG
210 220 230 240 250
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPVLQSGHW
260 270 280 290 300
SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA
310 320 330 340 350
VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEEEAEPYMH RAGTLTSLES
360 370 380 390 400
SHSVPSMSIS ASSQSSSVNS LADASDNEEE EEEEEEEEEE EEGPEAREMA
410 420 430 440 450
MMQEGEHTVT SHSSIIHRLP GSDNLYDDPY QPEITPSPLQ PPAAPAPTST
460 470 480 490 500
TSSARRRAYC RNRDHFATIR TASLVSRQIQ EHEQDSALRE QLSGYKRMRR
510 520 530 540 550
QHQKQLLALE SRLRGEREEH SARLQRELEA QRAGFGAEAE KLARRHQAIG
560 570 580 590 600
EKEARAAQAE ERKFQQHILG QQKKELAALL EAQKRTYKLR KEQLKEELQE
610 620 630 640 650
NPSTPKREKA EWLLRQKEQL QQCQAEEEAG LLRRQRQYFE LQCRQYKRKM
660 670 680 690 700
LLARHSLDQD LLREDLNKKQ TQKDLECALL LRQHEATREL ELRQLQAVQR
710 720 730 740 750
TRAELTRLQH QTELGNQLEY NKRREQELRQ KHAAQVRQQP KSLKVRAGQR
760 770 780 790 800
PPGLPLPIPG ALGPPNTGTP IEQQPCSPGQ EAVLDQRMLG EEEEAVGERR
810 820 830 840 850
ILGKEGATLE PKQQRILGEE SGAPSPSPQK HGSLVDEEVW GLPEEIEELR
860 870 880 890 900
VPSLVPQERS IVGQEEAGTW SLWGKEDESL LDEEFELGWV QGPALTPVPE
910 920 930 940 950
EEEEEEEGAP IGTPRDPGDG CPSPDIPPEP PPTHLRPCPA SQLPGLLSHG
960 970 980 990 1000
LLAGLSFAVG SSSGLLPLLL LLLLPLLAAQ GGGGLQAALL ALEVGLVGLG
1010 1020 1030 1040 1050
ASYLLLCTAL HLPSSLFLLL AQGTALGAVL GLSWRRGLMG VPLGLGAAWL
1060 1070 1080 1090 1100
LAWPGLALPL VAMAAGGRWV RQQGPRVRRG ISRLWLRVLL RLSPMAFRAL
1110 1120 1130 1140 1150
QGCGAVGDRG LFALYPKTNK DGFRSRLPVP GPRRRNPRTT QHPLALLARV
1160 1170 1180 1190 1200
WVLCKGWNWR LARASQGLAS HLPPWAIHTL ASWGLLRGER PTRIPRLLPR
1210 1220 1230
SQRQLGPPAS RQPLPGTLAG RRSRTRQSRA LPPWR
Sequence cautioni
The sequence AAQ89301 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA74904 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 | M → T in AAI51222 (Ref. 7) Curated | 1 | |
Sequence conflicti | 189 | M → T in AAI42664 (Ref. 7) Curated | 1 | |
Sequence conflicti | 1211 | R → H in AAD45616 (PubMed:10660600).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015967 | 1 – 173 | Missing in isoform 3. 1 PublicationAdd BLAST | 173 | |
Alternative sequenceiVSP_015968 | 174 – 218 | SIMAP…TCIEL → MMGTSQGHVARKSRNWGLNP SRLSSIPLSSTPCHLSPSSL SPFSV in isoform 3. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_015969 | 745 – 1049 | VRAGQ…LGAAW → SKELQIKKQFQETCKIQTRQ YKALRAHLLETTPKAQHKSL LKRLKEEQTRKLAILAEQYD QSISEMLSSQALRLDETQEA EFQALRQQLQQELELLNAYQ SKIKIRTESQHERELRELEQ RVALRRALLEQRVEEELLAL QTGRSERIRSLLERQAREIE AFDAESMRLGFSSMALGGIP AEAAAQGYPAPPPAPAWPSR PVPRSGAHWSHGPPPPGMPP PAWRQPSLLAPPGPPNWLGP PTQSGTPRGGALLLLRNSPQ PLRRAASGGSGSENVGPPAA AVPGPLSRSTSVASHILNGS SHFYS in isoform 2. 4 PublicationsAdd BLAST | 305 | |
Alternative sequenceiVSP_044894 | 745 – 857 | Missing in isoform 4. 1 PublicationAdd BLAST | 113 | |
Alternative sequenceiVSP_015970 | 1050 – 1235 | Missing in isoform 2. 4 PublicationsAdd BLAST | 186 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061943 mRNA Translation: AAD45616.1 AF263313 mRNA Translation: AAG38503.1 AB020688 mRNA Translation: BAA74904.2 Different initiation. AK291473 mRNA Translation: BAF84162.1 AL137701 mRNA Translation: CAB70882.1 AC093512 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79963.1 CH471238 Genomic DNA Translation: EAW79964.1 BC136653 mRNA Translation: AAI36654.1 BC136655 mRNA Translation: AAI36656.1 BC142663 mRNA Translation: AAI42664.1 BC144344 mRNA Translation: AAI44345.1 BC151221 mRNA Translation: AAI51222.1 BC152413 mRNA Translation: AAI52414.1 AY358942 mRNA Translation: AAQ89301.1 Different initiation. |
CCDSi | CCDS10662.1 [Q9UL54-2] CCDS10663.1 [Q9UL54-1] CCDS58448.1 [Q9UL54-4] |
PIRi | T46444 |
RefSeqi | NP_001238972.1, NM_001252043.1 [Q9UL54-4] NP_004774.1, NM_004783.3 [Q9UL54-2] NP_057235.2, NM_016151.3 [Q9UL54-1] |
Genome annotation databases
Ensembli | ENST00000279394; ENSP00000279394; ENSG00000149930 [Q9UL54-2] ENST00000308893; ENSP00000310094; ENSG00000149930 [Q9UL54-1] ENST00000416441; ENSP00000393048; ENSG00000149930 [Q9UL54-3] ENST00000543033; ENSP00000440336; ENSG00000149930 [Q9UL54-4] |
GeneIDi | 9344 |
KEGGi | hsa:9344 |
UCSCi | uc002dva.3, human [Q9UL54-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061943 mRNA Translation: AAD45616.1 AF263313 mRNA Translation: AAG38503.1 AB020688 mRNA Translation: BAA74904.2 Different initiation. AK291473 mRNA Translation: BAF84162.1 AL137701 mRNA Translation: CAB70882.1 AC093512 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79963.1 CH471238 Genomic DNA Translation: EAW79964.1 BC136653 mRNA Translation: AAI36654.1 BC136655 mRNA Translation: AAI36656.1 BC142663 mRNA Translation: AAI42664.1 BC144344 mRNA Translation: AAI44345.1 BC151221 mRNA Translation: AAI51222.1 BC152413 mRNA Translation: AAI52414.1 AY358942 mRNA Translation: AAQ89301.1 Different initiation. |
CCDSi | CCDS10662.1 [Q9UL54-2] CCDS10663.1 [Q9UL54-1] CCDS58448.1 [Q9UL54-4] |
PIRi | T46444 |
RefSeqi | NP_001238972.1, NM_001252043.1 [Q9UL54-4] NP_004774.1, NM_004783.3 [Q9UL54-2] NP_057235.2, NM_016151.3 [Q9UL54-1] |
3D structure databases
SMRi | Q9UL54 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114750, 32 interactors |
IntActi | Q9UL54, 24 interactors |
STRINGi | 9606.ENSP00000310094 |
Chemistry databases
BindingDBi | Q9UL54 |
ChEMBLi | CHEMBL1075195 |
DrugBanki | DB04522, Dexfosfoserine DB12010, Fostamatinib |
DrugCentrali | Q9UL54 |
PTM databases
iPTMneti | Q9UL54 |
PhosphoSitePlusi | Q9UL54 |
Polymorphism and mutation databases
BioMutai | TAOK2 |
DMDMi | 116242813 |
Proteomic databases
EPDi | Q9UL54 |
jPOSTi | Q9UL54 |
MassIVEi | Q9UL54 |
PaxDbi | Q9UL54 |
PeptideAtlasi | Q9UL54 |
PRIDEi | Q9UL54 |
ProteomicsDBi | 7250 84953 [Q9UL54-1] 84954 [Q9UL54-2] 84955 [Q9UL54-3] |
Protocols and materials databases
Antibodypediai | 2082, 211 antibodies |
Genome annotation databases
Ensembli | ENST00000279394; ENSP00000279394; ENSG00000149930 [Q9UL54-2] ENST00000308893; ENSP00000310094; ENSG00000149930 [Q9UL54-1] ENST00000416441; ENSP00000393048; ENSG00000149930 [Q9UL54-3] ENST00000543033; ENSP00000440336; ENSG00000149930 [Q9UL54-4] |
GeneIDi | 9344 |
KEGGi | hsa:9344 |
UCSCi | uc002dva.3, human [Q9UL54-1] |
Organism-specific databases
CTDi | 9344 |
DisGeNETi | 9344 |
EuPathDBi | HostDB:ENSG00000149930.17 |
GeneCardsi | TAOK2 |
HGNCi | HGNC:16835, TAOK2 |
HPAi | ENSG00000149930, Low tissue specificity |
MIMi | 613199, gene |
neXtProti | NX_Q9UL54 |
OpenTargetsi | ENSG00000149930 |
PharmGKBi | PA134907964 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0577, Eukaryota |
GeneTreei | ENSGT00940000159991 |
HOGENOMi | CLU_276301_0_0_1 |
InParanoidi | Q9UL54 |
OMAi | LRDHTAW |
OrthoDBi | 617606at2759 |
PhylomeDBi | Q9UL54 |
TreeFami | TF351444 |
Enzyme and pathway databases
PathwayCommonsi | Q9UL54 |
SignaLinki | Q9UL54 |
SIGNORi | Q9UL54 |
Miscellaneous databases
BioGRID-ORCSi | 9344, 4 hits in 876 CRISPR screens |
ChiTaRSi | TAOK2, human |
GeneWikii | TAOK2 |
GenomeRNAii | 9344 |
Pharosi | Q9UL54, Tchem |
PROi | PR:Q9UL54 |
RNActi | Q9UL54, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149930, Expressed in right testis and 192 other tissues |
Genevisiblei | Q9UL54, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAOK2_HUMAN | |
Accessioni | Q9UL54Primary (citable) accession number: Q9UL54 Secondary accession number(s): A5PKY1 Q9NSW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human and mouse protein kinases
Human and mouse protein kinases: classification and index