UniProtKB - Q9UL54 (TAOK2_HUMAN)

BLAST

>sp|Q9UL54|TAOK2_HUMAN Serine/threonine-protein kinase TAO2 OS=Homo sapiens OX=9606 GN=TAOK2 PE=1 SV=2
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLP
GSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQ
EHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAE
KLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQE
NPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQD
LLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEY
NKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQ
EAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVW
GLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPE
EEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVG
SSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLL
AQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRG
ISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTT
QHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPR
SQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR

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Format
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History
Entry version 162 (12 Sep 2018)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

Serine/threonine-protein kinase TAO2

Gene

TAOK2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.8 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺By similarity

Activity regulationⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	57	ATPPROSITE-ProRule annotation		1
Active siteⁱ	151	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	34 – 42	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
MAP kinase kinase kinase activity Source: GO_Central
mitogen-activated protein kinase kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279118
neuropilin binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 22683681
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10660600
- 11279118

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: UniProtKB
Inferred from direct assayⁱ
- 10660600
activation of JUN kinase activity
Source: ARUK-UCL
Traceable author statementⁱ
- 22683681
activation of MAPK activity
Source: ARUK-UCL
Traceable author statementⁱ
- 22683681
activation of MAPKK activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10660600
activation of protein kinase activity
Source: ARUK-UCL
Traceable author statementⁱ
- 22683681
apoptotic process
Source: UniProtKB
Non-traceable author statementⁱ
- 10660600
axonogenesis
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22683681
basal dendrite arborization
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 22683681
basal dendrite morphogenesis
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 22683681
cell migration
Source: UniProtKB
Non-traceable author statementⁱ
- 10660600
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17396146
focal adhesion assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 10660600
mitotic G2 DNA damage checkpoint
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17396146
nervous system development Source: GO_Central
positive regulation of JNK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 10660600
positive regulation of protein autophosphorylation
Source: ARUK-UCL
Traceable author statementⁱ
- 22683681
positive regulation of stress-activated MAPK cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17396146
protein autophosphorylation
Source: ARUK-UCL
Traceable author statementⁱ
- 22683681
protein targeting to membrane
Source: UniProtKB
Non-traceable author statementⁱ
- 10660600
regulation of actin cytoskeleton organization
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 22683681
regulation of apoptotic process Source: GO_Central
regulation of cell growth
Source: UniProtKB
Non-traceable author statementⁱ
- 10660600
regulation of cell shape
Source: UniProtKB
Inferred from direct assayⁱ
- 10660600
regulation of mitotic cell cycle Source: GO_Central
stress-activated MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 11279118

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9UL54
SIGNORⁱ	Q9UL54

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase TAO2 (EC:2.7.11.1) Alternative name(s): Kinase from chicken homolog C Short name: hKFC-C Prostate-derived sterile 20-like kinase 1 Short name: PSK-1 Short name: PSK1 Short name: Prostate-derived STE20-like kinase 1 Thousand and one amino acid protein kinase 2
Gene namesⁱ	Name:TAOK2 Synonyms:KIAA0881, MAP3K17, PSK, PSK1 ORF Names:UNQ2971/PRO7431
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149930.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16835 TAOK2
MIMⁱ	613199 gene
neXtProtⁱ	NX_Q9UL54

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	965 – 985	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	987 – 1007	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	1012 – 1032	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	1043 – 1063	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	1166 – 1186	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	57	K → A: Loss of kinase activity. In isoform 1, excluded from the nucleus. No effect on microtubule-binding. 4 Publications	1
Mutagenesisⁱ	169	D → A: Loss of kinase activity; No effect on MAP3K7-mediated activation of NF-kappa-B. 1 Publication	1
Mutagenesisⁱ	919	D → N: No effect on kinase activity, nor on JNK activation, but severe reduction in nuclear localization and apoptotic membrane blebbing. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9344
Open Targets More...OpenTargetsⁱ	ENSG00000149930
PharmGKBⁱ	PA134907964

Chemistry databases

ChEMBLⁱ	CHEMBL1075195
Drug and drug target database More...DrugBankⁱ	DB04522 Phosphonoserine

Polymorphism and mutation databases

BioMutaⁱ	TAOK2
DMDMⁱ	116242813

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086733	1 – 1235	Serine/threonine-protein kinase TAO2Add BLAST		1235

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	9	PhosphoserineCombined sources	1
Modified residueⁱ	181	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	414	PhosphoserineCombined sources	1
Modified residueⁱ	656	PhosphoserineBy similarity	1
Modified residueⁱ	777	PhosphoserineCombined sources	1
Modified residueⁱ	825	PhosphoserineCombined sources	1
Modified residueⁱ	827	PhosphoserineCombined sources	1
Isoform 2 (identifier: Q9UL54-2)
Modified residueⁱ	1011	PhosphoserineCombined sourcesBy similarity	1
Modified residueⁱ	1031	Phosphoserine By similarityCombined sourcesBy similarity	1

Post-translational modificationⁱ

Isoforms 1 and 2 are autophosphorylated.

C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity.

Autophosphorylated. Phosphorylated by ATM.

Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UL54
PaxDbⁱ	Q9UL54
PeptideAtlas More...PeptideAtlasⁱ	Q9UL54
PRIDEⁱ	Q9UL54
ProteomicsDBⁱ	84953 84954 [Q9UL54-2] 84955 [Q9UL54-3]

PTM databases

iPTMnetⁱ	Q9UL54
PhosphoSitePlusⁱ	Q9UL54

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, with a higher level of expression in testis and brain.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000149930 Expressed in 178 organ(s), highest expression level in right testis
CleanExⁱ	HS_TAOK2
Genevisibleⁱ	Q9UL54 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010650

HPAⁱ

HPA010650

Interactionⁱ

Subunit structureⁱ

Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the C-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity).By similarity

GO - Molecular functionⁱ

mitogen-activated protein kinase kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11279118
neuropilin binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 22683681

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114750, 19 interactors
IntActⁱ	Q9UL54, 11 interactors
STRINGⁱ	9606.ENSP00000310094

Chemistry databases

BindingDBⁱ

Q9UL54

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UL54
SMRⁱ	Q9UL54
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 281	Protein kinasePROSITE-ProRule annotationAdd BLAST		254

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	486 – 547	Sequence analysisAdd BLAST	62
Coiled coilⁱ	574 – 601	Sequence analysisAdd BLAST	28
Coiled coilⁱ	681 – 713	Sequence analysisAdd BLAST	33

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	330 – 336	Poly-Glu	7
Compositional biasⁱ	347 – 370	Ser-richAdd BLAST	24
Compositional biasⁱ	378 – 406	Glu-richAdd BLAST	29
Compositional biasⁱ	791 – 907	Glu-richAdd BLAST	117
Compositional biasⁱ	943 – 1060	Leu-richAdd BLAST	118

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0577 Eukaryota ENOG410Y259 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148968
HOGENOMⁱ	HOG000236358
HOVERGENⁱ	HBG094024
InParanoidⁱ	Q9UL54
KEGG Orthology (KO) More...KOⁱ	K04429
OMAⁱ	LRDHTAW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01CN
PhylomeDBⁱ	Q9UL54
TreeFamⁱ	TF351444

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9UL54-1) [UniParc]FASTA Add to basket

Also known as: PSK1-alpha, TAO2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN 
        60         70         80         90        100
SEVVAIKKMS YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT 
       110        120        130        140        150
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA VTHGALQGLA YLHSHNMIHR 
       160        170        180        190        200
DVKAGNILLS EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG 
       210        220        230        240        250
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPVLQSGHW 
       260        270        280        290        300
SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA 
       310        320        330        340        350
VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEEEAEPYMH RAGTLTSLES 
       360        370        380        390        400
SHSVPSMSIS ASSQSSSVNS LADASDNEEE EEEEEEEEEE EEGPEAREMA 
       410        420        430        440        450
MMQEGEHTVT SHSSIIHRLP GSDNLYDDPY QPEITPSPLQ PPAAPAPTST 
       460        470        480        490        500
TSSARRRAYC RNRDHFATIR TASLVSRQIQ EHEQDSALRE QLSGYKRMRR 
       510        520        530        540        550
QHQKQLLALE SRLRGEREEH SARLQRELEA QRAGFGAEAE KLARRHQAIG 
       560        570        580        590        600
EKEARAAQAE ERKFQQHILG QQKKELAALL EAQKRTYKLR KEQLKEELQE 
       610        620        630        640        650
NPSTPKREKA EWLLRQKEQL QQCQAEEEAG LLRRQRQYFE LQCRQYKRKM 
       660        670        680        690        700
LLARHSLDQD LLREDLNKKQ TQKDLECALL LRQHEATREL ELRQLQAVQR 
       710        720        730        740        750
TRAELTRLQH QTELGNQLEY NKRREQELRQ KHAAQVRQQP KSLKVRAGQR 
       760        770        780        790        800
PPGLPLPIPG ALGPPNTGTP IEQQPCSPGQ EAVLDQRMLG EEEEAVGERR 
       810        820        830        840        850
ILGKEGATLE PKQQRILGEE SGAPSPSPQK HGSLVDEEVW GLPEEIEELR 
       860        870        880        890        900
VPSLVPQERS IVGQEEAGTW SLWGKEDESL LDEEFELGWV QGPALTPVPE 
       910        920        930        940        950
EEEEEEEGAP IGTPRDPGDG CPSPDIPPEP PPTHLRPCPA SQLPGLLSHG 
       960        970        980        990       1000
LLAGLSFAVG SSSGLLPLLL LLLLPLLAAQ GGGGLQAALL ALEVGLVGLG 
      1010       1020       1030       1040       1050
ASYLLLCTAL HLPSSLFLLL AQGTALGAVL GLSWRRGLMG VPLGLGAAWL 
      1060       1070       1080       1090       1100
LAWPGLALPL VAMAAGGRWV RQQGPRVRRG ISRLWLRVLL RLSPMAFRAL 
      1110       1120       1130       1140       1150
QGCGAVGDRG LFALYPKTNK DGFRSRLPVP GPRRRNPRTT QHPLALLARV 
      1160       1170       1180       1190       1200
WVLCKGWNWR LARASQGLAS HLPPWAIHTL ASWGLLRGER PTRIPRLLPR 
      1210       1220       1230 
SQRQLGPPAS RQPLPGTLAG RRSRTRQSRA LPPWR

Length:1,235

Mass (Da):138,251

Last modified:October 17, 2006 - v2

Checksum:ⁱ211852E690934307

Isoform 2 (identifier: Q9UL54-2) [UniParc]FASTA Add to basket

Also known as: PSK1-beta

The sequence of this isoform differs from the canonical sequence as follows:
745-1049: VRAGQRPPGL...GVPLGLGAAW → SKELQIKKQF...ILNGSSHFYS
1050-1235: Missing.

« Hide

        10         20         30         40         50
MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN 
        60         70         80         90        100
SEVVAIKKMS YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT 
       110        120        130        140        150
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA VTHGALQGLA YLHSHNMIHR 
       160        170        180        190        200
DVKAGNILLS EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG 
       210        220        230        240        250
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPVLQSGHW 
       260        270        280        290        300
SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA 
       310        320        330        340        350
VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEEEAEPYMH RAGTLTSLES 
       360        370        380        390        400
SHSVPSMSIS ASSQSSSVNS LADASDNEEE EEEEEEEEEE EEGPEAREMA 
       410        420        430        440        450
MMQEGEHTVT SHSSIIHRLP GSDNLYDDPY QPEITPSPLQ PPAAPAPTST 
       460        470        480        490        500
TSSARRRAYC RNRDHFATIR TASLVSRQIQ EHEQDSALRE QLSGYKRMRR 
       510        520        530        540        550
QHQKQLLALE SRLRGEREEH SARLQRELEA QRAGFGAEAE KLARRHQAIG 
       560        570        580        590        600
EKEARAAQAE ERKFQQHILG QQKKELAALL EAQKRTYKLR KEQLKEELQE 
       610        620        630        640        650
NPSTPKREKA EWLLRQKEQL QQCQAEEEAG LLRRQRQYFE LQCRQYKRKM 
       660        670        680        690        700
LLARHSLDQD LLREDLNKKQ TQKDLECALL LRQHEATREL ELRQLQAVQR 
       710        720        730        740        750
TRAELTRLQH QTELGNQLEY NKRREQELRQ KHAAQVRQQP KSLKSKELQI 
       760        770        780        790        800
KKQFQETCKI QTRQYKALRA HLLETTPKAQ HKSLLKRLKE EQTRKLAILA 
       810        820        830        840        850
EQYDQSISEM LSSQALRLDE TQEAEFQALR QQLQQELELL NAYQSKIKIR 
       860        870        880        890        900
TESQHERELR ELEQRVALRR ALLEQRVEEE LLALQTGRSE RIRSLLERQA 
       910        920        930        940        950
REIEAFDAES MRLGFSSMAL GGIPAEAAAQ GYPAPPPAPA WPSRPVPRSG 
       960        970        980        990       1000
AHWSHGPPPP GMPPPAWRQP SLLAPPGPPN WLGPPTQSGT PRGGALLLLR 
      1010       1020       1030       1040 
NSPQPLRRAA SGGSGSENVG PPAAAVPGPL SRSTSVASHI LNGSSHFYS

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Length:1,049

Mass (Da):119,281

Checksum:ⁱD6C5062F47794030

Isoform 3 (identifier: Q9UL54-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-173: Missing.
174-218: SIMAPANSFV...WSLGITCIEL → MMGTSQGHVA...SPSSLSPFSV

« Hide

        10         20         30         40         50
MMGTSQGHVA RKSRNWGLNP SRLSSIPLSS TPCHLSPSSL SPFSVAERKP 
        60         70         80         90        100
PLFNMNAMSA LYHIAQNESP VLQSGHWSEY FRNFVDSCLQ KIPQDRPTSE 
       110        120        130        140        150
VLLKHRFVLR ERPPTVIMDL IQRTKDAVRE LDNLQYRKMK KILFQEAPNG 
       160        170        180        190        200
PGAEAPEEEE EAEPYMHRAG TLTSLESSHS VPSMSISASS QSSSVNSLAD 
       210        220        230        240        250
ASDNEEEEEE EEEEEEEEEG PEAREMAMMQ EGEHTVTSHS SIIHRLPGSD 
       260        270        280        290        300
NLYDDPYQPE ITPSPLQPPA APAPTSTTSS ARRRAYCRNR DHFATIRTAS 
       310        320        330        340        350
LVSRQIQEHE QDSALREQLS GYKRMRRQHQ KQLLALESRL RGEREEHSAR 
       360        370        380        390        400
LQRELEAQRA GFGAEAEKLA RRHQAIGEKE ARAAQAEERK FQQHILGQQK 
       410        420        430        440        450
KELAALLEAQ KRTYKLRKEQ LKEELQENPS TPKREKAEWL LRQKEQLQQC 
       460        470        480        490        500
QAEEEAGLLR RQRQYFELQC RQYKRKMLLA RHSLDQDLLR EDLNKKQTQK 
       510        520        530        540        550
DLECALLLRQ HEATRELELR QLQAVQRTRA ELTRLQHQTE LGNQLEYNKR 
       560        570        580        590        600
REQELRQKHA AQVRQQPKSL KVRAGQRPPG LPLPIPGALG PPNTGTPIEQ 
       610        620        630        640        650
QPCSPGQEAV LDQRMLGEEE EAVGERRILG KEGATLEPKQ QRILGEESGA 
       660        670        680        690        700
PSPSPQKHGS LVDEEVWGLP EEIEELRVPS LVPQERSIVG QEEAGTWSLW 
       710        720        730        740        750
GKEDESLLDE EFELGWVQGP ALTPVPEEEE EEEEGAPIGT PRDPGDGCPS 
       760        770        780        790        800
PDIPPEPPPT HLRPCPASQL PGLLSHGLLA GLSFAVGSSS GLLPLLLLLL 
       810        820        830        840        850
LPLLAAQGGG GLQAALLALE VGLVGLGASY LLLCTALHLP SSLFLLLAQG 
       860        870        880        890        900
TALGAVLGLS WRRGLMGVPL GLGAAWLLAW PGLALPLVAM AAGGRWVRQQ 
       910        920        930        940        950
GPRVRRGISR LWLRVLLRLS PMAFRALQGC GAVGDRGLFA LYPKTNKDGF 
       960        970        980        990       1000
RSRLPVPGPR RRNPRTTQHP LALLARVWVL CKGWNWRLAR ASQGLASHLP 
      1010       1020       1030       1040       1050
PWAIHTLASW GLLRGERPTR IPRLLPRSQR QLGPPASRQP LPGTLAGRRS 
      1060 
RTRQSRALPP WR

Note: No experimental confirmation available.

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Length:1,062

Mass (Da):118,780

Checksum:ⁱA4B2B359EEC9CAAD

Isoform 4 (identifier: Q9UL54-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
745-857: Missing.

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        10         20         30         40         50
MPAGGRAGSL KDPDVAELFF KDDPEKLFSD LREIGHGSFG AVYFARDVRN 
        60         70         80         90        100
SEVVAIKKMS YSGKQSNEKW QDIIKEVRFL QKLRHPNTIQ YRGCYLREHT 
       110        120        130        140        150
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA VTHGALQGLA YLHSHNMIHR 
       160        170        180        190        200
DVKAGNILLS EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG 
       210        220        230        240        250
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPVLQSGHW 
       260        270        280        290        300
SEYFRNFVDS CLQKIPQDRP TSEVLLKHRF VLRERPPTVI MDLIQRTKDA 
       310        320        330        340        350
VRELDNLQYR KMKKILFQEA PNGPGAEAPE EEEEAEPYMH RAGTLTSLES 
       360        370        380        390        400
SHSVPSMSIS ASSQSSSVNS LADASDNEEE EEEEEEEEEE EEGPEAREMA 
       410        420        430        440        450
MMQEGEHTVT SHSSIIHRLP GSDNLYDDPY QPEITPSPLQ PPAAPAPTST 
       460        470        480        490        500
TSSARRRAYC RNRDHFATIR TASLVSRQIQ EHEQDSALRE QLSGYKRMRR 
       510        520        530        540        550
QHQKQLLALE SRLRGEREEH SARLQRELEA QRAGFGAEAE KLARRHQAIG 
       560        570        580        590        600
EKEARAAQAE ERKFQQHILG QQKKELAALL EAQKRTYKLR KEQLKEELQE 
       610        620        630        640        650
NPSTPKREKA EWLLRQKEQL QQCQAEEEAG LLRRQRQYFE LQCRQYKRKM 
       660        670        680        690        700
LLARHSLDQD LLREDLNKKQ TQKDLECALL LRQHEATREL ELRQLQAVQR 
       710        720        730        740        750
TRAELTRLQH QTELGNQLEY NKRREQELRQ KHAAQVRQQP KSLKERSIVG 
       760        770        780        790        800
QEEAGTWSLW GKEDESLLDE EFELGWVQGP ALTPVPEEEE EEEEGAPIGT 
       810        820        830        840        850
PRDPGDGCPS PDIPPEPPPT HLRPCPASQL PGLLSHGLLA GLSFAVGSSS 
       860        870        880        890        900
GLLPLLLLLL LPLLAAQGGG GLQAALLALE VGLVGLGASY LLLCTALHLP 
       910        920        930        940        950
SSLFLLLAQG TALGAVLGLS WRRGLMGVPL GLGAAWLLAW PGLALPLVAM 
       960        970        980        990       1000
AAGGRWVRQQ GPRVRRGISR LWLRVLLRLS PMAFRALQGC GAVGDRGLFA 
      1010       1020       1030       1040       1050
LYPKTNKDGF RSRLPVPGPR RRNPRTTQHP LALLARVWVL CKGWNWRLAR 
      1060       1070       1080       1090       1100
ASQGLASHLP PWAIHTLASW GLLRGERPTR IPRLLPRSQR QLGPPASRQP 
      1110       1120 
LPGTLAGRRS RTRQSRALPP WR

Note: No experimental confirmation available.

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Length:1,122

Mass (Da):126,204

Checksum:ⁱ3F00D8F3E84DF679

Sequence cautionⁱ

The sequence AAQ89301 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAA74904 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	189	M → T in AAI51222 (Ref. 7) Curated	1
Sequence conflictⁱ	189	M → T in AAI42664 (Ref. 7) Curated	1
Sequence conflictⁱ	1211	R → H in AAD45616 (PubMed:10660600).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_015967	1 – 173	Missing in isoform 3. 1 PublicationAdd BLAST	173
Alternative sequenceⁱVSP_015968	174 – 218	SIMAP…TCIEL → MMGTSQGHVARKSRNWGLNP SRLSSIPLSSTPCHLSPSSL SPFSV in isoform 3. 1 PublicationAdd BLAST	45
Alternative sequenceⁱVSP_015969	745 – 1049	VRAGQ…LGAAW → SKELQIKKQFQETCKIQTRQ YKALRAHLLETTPKAQHKSL LKRLKEEQTRKLAILAEQYD QSISEMLSSQALRLDETQEA EFQALRQQLQQELELLNAYQ SKIKIRTESQHERELRELEQ RVALRRALLEQRVEEELLAL QTGRSERIRSLLERQAREIE AFDAESMRLGFSSMALGGIP AEAAAQGYPAPPPAPAWPSR PVPRSGAHWSHGPPPPGMPP PAWRQPSLLAPPGPPNWLGP PTQSGTPRGGALLLLRNSPQ PLRRAASGGSGSENVGPPAA AVPGPLSRSTSVASHILNGS SHFYS in isoform 2. 4 PublicationsAdd BLAST	305
Alternative sequenceⁱVSP_044894	745 – 857	Missing in isoform 4. 1 PublicationAdd BLAST	113
Alternative sequenceⁱVSP_015970	1050 – 1235	Missing in isoform 2. 4 PublicationsAdd BLAST	186

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF061943 mRNA Translation: AAD45616.1 AF263313 mRNA Translation: AAG38503.1 AB020688 mRNA Translation: BAA74904.2 Different initiation. AK291473 mRNA Translation: BAF84162.1 AL137701 mRNA Translation: CAB70882.1 AC093512 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79963.1 CH471238 Genomic DNA Translation: EAW79964.1 BC136653 mRNA Translation: AAI36654.1 BC136655 mRNA Translation: AAI36656.1 BC142663 mRNA Translation: AAI42664.1 BC144344 mRNA Translation: AAI44345.1 BC151221 mRNA Translation: AAI51222.1 BC152413 mRNA Translation: AAI52414.1 AY358942 mRNA Translation: AAQ89301.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10662.1 [Q9UL54-2] CCDS10663.1 [Q9UL54-1] CCDS58448.1 [Q9UL54-4]
PIRⁱ	T46444
NCBI Reference Sequences More...RefSeqⁱ	NP_001238972.1, NM_001252043.1 [Q9UL54-4] NP_004774.1, NM_004783.3 [Q9UL54-2] NP_057235.2, NM_016151.3 [Q9UL54-1]
UniGeneⁱ	Hs.291623

Genome annotation databases

Ensemblⁱ	ENST00000279394; ENSP00000279394; ENSG00000149930 [Q9UL54-2] ENST00000308893; ENSP00000310094; ENSG00000149930 [Q9UL54-1] ENST00000416441; ENSP00000393048; ENSG00000149930 [Q9UL54-3] ENST00000543033; ENSP00000440336; ENSG00000149930 [Q9UL54-4]
GeneIDⁱ	9344
KEGGⁱ	hsa:9344
UCSC genome browser More...UCSCⁱ	uc002dva.3 human [Q9UL54-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UL54	Serine/threonine-protein kinase TAO2		MOUSE		1240	UniRef90_Q9UL54
Serine/threonine-protein kinase TAO2	)	RAT		1235
TAOK2 protein (Fragment)		HUMAN		1426
TAO kinase 2		OTOGA		1416
Uncharacterized protein		NOMLE		1246
+168
Q9UL54-2	Isoform 2 of Serine/threonine-protein kinase TAO2		MOUSE		1055	UniRef90_Q6ZQ29-2
Serine/threonine-protein kinase TAO2		TUPCH		1270
Serine/threonine-protein kinase TAO2		RAT		1056
serine/threonine-protein kinase TAO2 isoform X3		MESAU		1055
serine/threonine-protein kinase TAO2 isoform X3		DIPOR		1055
+149
Q9UL54-3	TAOK2 isoform 5		PONAB		1062	UniRef90_Q9UL54-3
TAOK2 isoform 4		PANTR		1062
Uncharacterized protein		PROCO		1055
Uncharacterized protein		FELCA		1047
serine/threonine-protein kinase TAO2 isoform X3		ERIEU		1012
+3
Q9UL54-4	serine/threonine-protein kinase TAO2 isoform X2		LIPVE		1123	UniRef90_Q9UL54-4
TAO kinase 2		PANTR		1122
Uncharacterized protein		MACMU		1122
Uncharacterized protein		MACFA		1122
Uncharacterized protein		MACNE		1122
+27

Protein	Similar proteins		Species	Score	Length	Source
Q9UL54	Serine/threonine-protein kinase TAO2		MOUSE		1240	UniRef50_Q9UL54
Serine/threonine-protein kinase TAO2	)	RAT		1235
TAOK2 protein (Fragment)		HUMAN		1426
TAO kinase 2		OTOGA		1416
Uncharacterized protein		NOMLE		1246
+184
Q9UL54-2	Isoform 2 of Serine/threonine-protein kinase TAO2		MOUSE		1055	UniRef50_Q6ZQ29-2
Serine/threonine-protein kinase TAO2		TUPCH		1270
Serine/threonine-protein kinase TAO2		RAT		1056
serine/threonine-protein kinase TAO2 isoform X3		MESAU		1055
Serine/threonine-protein kinase TAO2-like protein		CRIGR		1055
+166
Q9UL54-3	TAOK2 isoform 4		PANTR		1062	UniRef50_Q9UL54-3
TAOK2 isoform 5		PONAB		1062
Uncharacterized protein		PROCO		1055
Uncharacterized protein		FELCA		1047
serine/threonine-protein kinase TAO2 isoform X3		ERIEU		1012
+6
Q9UL54-4	serine/threonine-protein kinase TAO2 isoform X2		LIPVE		1123	UniRef50_Q9UL54-4
TAO kinase 2		PANTR		1122
TAOK2 isoform 6		PONAB		1122
Uncharacterized protein		NOMLE		1122
Uncharacterized protein		COLAP		1122
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF061943 mRNA Translation: AAD45616.1 AF263313 mRNA Translation: AAG38503.1 AB020688 mRNA Translation: BAA74904.2 Different initiation. AK291473 mRNA Translation: BAF84162.1 AL137701 mRNA Translation: CAB70882.1 AC093512 Genomic DNA No translation available. CH471238 Genomic DNA Translation: EAW79963.1 CH471238 Genomic DNA Translation: EAW79964.1 BC136653 mRNA Translation: AAI36654.1 BC136655 mRNA Translation: AAI36656.1 BC142663 mRNA Translation: AAI42664.1 BC144344 mRNA Translation: AAI44345.1 BC151221 mRNA Translation: AAI51222.1 BC152413 mRNA Translation: AAI52414.1 AY358942 mRNA Translation: AAQ89301.1 Different initiation.
CCDSⁱ	CCDS10662.1 [Q9UL54-2] CCDS10663.1 [Q9UL54-1] CCDS58448.1 [Q9UL54-4]
PIRⁱ	T46444
RefSeqⁱ	NP_001238972.1, NM_001252043.1 [Q9UL54-4] NP_004774.1, NM_004783.3 [Q9UL54-2] NP_057235.2, NM_016151.3 [Q9UL54-1]
UniGeneⁱ	Hs.291623

3D structure databases

ProteinModelPortalⁱ	Q9UL54
SMRⁱ	Q9UL54
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114750, 19 interactors
IntActⁱ	Q9UL54, 11 interactors
STRINGⁱ	9606.ENSP00000310094

Chemistry databases

BindingDBⁱ	Q9UL54
ChEMBLⁱ	CHEMBL1075195
DrugBankⁱ	DB04522 Phosphonoserine

PTM databases

iPTMnetⁱ	Q9UL54
PhosphoSitePlusⁱ	Q9UL54

Polymorphism and mutation databases

BioMutaⁱ	TAOK2
DMDMⁱ	116242813

Proteomic databases

EPDⁱ	Q9UL54
PaxDbⁱ	Q9UL54
PeptideAtlasⁱ	Q9UL54
PRIDEⁱ	Q9UL54
ProteomicsDBⁱ	84953 84954 [Q9UL54-2] 84955 [Q9UL54-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000279394; ENSP00000279394; ENSG00000149930 [Q9UL54-2] ENST00000308893; ENSP00000310094; ENSG00000149930 [Q9UL54-1] ENST00000416441; ENSP00000393048; ENSG00000149930 [Q9UL54-3] ENST00000543033; ENSP00000440336; ENSG00000149930 [Q9UL54-4]
GeneIDⁱ	9344
KEGGⁱ	hsa:9344
UCSCⁱ	uc002dva.3 human [Q9UL54-1]

Organism-specific databases

CTDⁱ	9344
DisGeNETⁱ	9344
EuPathDBⁱ	HostDB:ENSG00000149930.17
GeneCardsⁱ	TAOK2
HGNCⁱ	HGNC:16835 TAOK2
HPAⁱ	HPA010650
MIMⁱ	613199 gene
neXtProtⁱ	NX_Q9UL54
OpenTargetsⁱ	ENSG00000149930
PharmGKBⁱ	PA134907964
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0577 Eukaryota ENOG410Y259 LUCA
GeneTreeⁱ	ENSGT00920000148968
HOGENOMⁱ	HOG000236358
HOVERGENⁱ	HBG094024
InParanoidⁱ	Q9UL54
KOⁱ	K04429
OMAⁱ	LRDHTAW
OrthoDBⁱ	EOG091G01CN
PhylomeDBⁱ	Q9UL54
TreeFamⁱ	TF351444

Enzyme and pathway databases

SignaLinkⁱ	Q9UL54
SIGNORⁱ	Q9UL54

Miscellaneous databases

GeneWikiⁱ	TAOK2
GenomeRNAiⁱ	9344
Protein Ontology More...PROⁱ	PR:Q9UL54
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149930 Expressed in 178 organ(s), highest expression level in right testis
CleanExⁱ	HS_TAOK2
Genevisibleⁱ	Q9UL54 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAOK2_HUMAN
Accessionⁱ	Q9UL54Primary (citable) accession number: Q9UL54 Secondary accession number(s): A5PKY1 Q9NSW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
	Last sequence update:	October 17, 2006
	Last modified:	September 12, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9UL54 (TAOK2_HUMAN)

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Serine/threonine-protein kinase TAO2

TAOK2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Other locations

Cytoskeleton

Cytosol

Nucleus

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

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Proteomic databases

Protocols and materials databases

Genome annotation databases

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Phylogenomic databases

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Miscellaneous databases

Gene expression databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ