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Protein

Proteasome activator complex subunit 2

Gene

PSME2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

  • endopeptidase activator activity Source: GO_Central
  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 2
Alternative name(s):
11S regulator complex subunit beta
Short name:
REG-beta
Activator of multicatalytic protease subunit 2
Proteasome activator 28 subunit beta
Short name:
PA28b
Short name:
PA28beta
Gene namesi
Name:PSME2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100911.13
HGNCiHGNC:9569 PSME2
MIMi602161 gene
neXtProtiNX_Q9UL46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi5721
OpenTargetsiENSG00000100911
PharmGKBiPA33915

Polymorphism and mutation databases

BioMutaiPSME2
DMDMi296453017

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001617852 – 239Proteasome activator complex subunit 2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UL46
MaxQBiQ9UL46
PaxDbiQ9UL46
PeptideAtlasiQ9UL46
PRIDEiQ9UL46
ProteomicsDBi84947
TopDownProteomicsiQ9UL46

2D gel databases

OGPiQ9UL46
REPRODUCTION-2DPAGEiIPI00384051

PTM databases

iPTMnetiQ9UL46
PhosphoSitePlusiQ9UL46
SwissPalmiQ9UL46

Expressioni

Inductioni

By IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000100911 Expressed in 93 organ(s), highest expression level in left adrenal gland
CleanExiHS_PSME2
ExpressionAtlasiQ9UL46 baseline and differential
GenevisibleiQ9UL46 HS

Organism-specific databases

HPAiHPA062661

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111693, 60 interactors
CORUMiQ9UL46
IntActiQ9UL46, 26 interactors
MINTiQ9UL46
STRINGi9606.ENSP00000216802

Structurei

3D structure databases

ProteinModelPortaliQ9UL46
SMRiQ9UL46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

eggNOGiKOG4470 Eukaryota
ENOG410XQVX LUCA
GeneTreeiENSGT00510000046374
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ9UL46
KOiK06697
PhylomeDBiQ9UL46
TreeFamiTF106236

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9UL46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED
60 70 80 90 100
SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVHK CGFLPGNEKV
110 120 130 140 150
LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV
160 170 180 190 200
NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG
210 220 230
ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
Length:239
Mass (Da):27,402
Last modified:May 18, 2010 - v4
Checksum:i98A30D83B3F93A91
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM70H0YM70_HUMAN
Proteasome activator complex subuni...
PSME2
228Annotation score:
A0A087X1Z3A0A087X1Z3_HUMAN
Proteasome activator complex subuni...
PSME2
254Annotation score:
H0YKU2H0YKU2_HUMAN
Proteasome activator complex subuni...
PSME2
85Annotation score:
H0YLD2H0YLD2_HUMAN
Proteasome activator complex subuni...
PSME2
48Annotation score:
H0YLG1H0YLG1_HUMAN
Proteasome activator complex subuni...
PSME2
39Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229N → T in BAA08205 (PubMed:7789512).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06311189H → P3 PublicationsCorresponds to variant dbSNP:rs7146672Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079558 Genomic DNA Translation: AAF02218.1
D45248 mRNA Translation: BAA08205.1
AL136295 Genomic DNA No translation available.
BC004368 mRNA Translation: AAH04368.1
BC019885 mRNA Translation: AAH19885.1
BC072025 mRNA Translation: AAH72025.1
CCDSiCCDS9614.1
PIRiI53518
RefSeqiNP_002809.2, NM_002818.2
UniGeneiHs.434081
Hs.512410

Genome annotation databases

EnsembliENST00000216802; ENSP00000216802; ENSG00000100911
ENST00000645325; ENSP00000495790; ENSG00000284889
GeneIDi5721
KEGGihsa:5721
UCSCiuc001wmj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079558 Genomic DNA Translation: AAF02218.1
D45248 mRNA Translation: BAA08205.1
AL136295 Genomic DNA No translation available.
BC004368 mRNA Translation: AAH04368.1
BC019885 mRNA Translation: AAH19885.1
BC072025 mRNA Translation: AAH72025.1
CCDSiCCDS9614.1
PIRiI53518
RefSeqiNP_002809.2, NM_002818.2
UniGeneiHs.434081
Hs.512410

3D structure databases

ProteinModelPortaliQ9UL46
SMRiQ9UL46
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111693, 60 interactors
CORUMiQ9UL46
IntActiQ9UL46, 26 interactors
MINTiQ9UL46
STRINGi9606.ENSP00000216802

PTM databases

iPTMnetiQ9UL46
PhosphoSitePlusiQ9UL46
SwissPalmiQ9UL46

Polymorphism and mutation databases

BioMutaiPSME2
DMDMi296453017

2D gel databases

OGPiQ9UL46
REPRODUCTION-2DPAGEiIPI00384051

Proteomic databases

EPDiQ9UL46
MaxQBiQ9UL46
PaxDbiQ9UL46
PeptideAtlasiQ9UL46
PRIDEiQ9UL46
ProteomicsDBi84947
TopDownProteomicsiQ9UL46

Protocols and materials databases

DNASUi5721
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216802; ENSP00000216802; ENSG00000100911
ENST00000645325; ENSP00000495790; ENSG00000284889
GeneIDi5721
KEGGihsa:5721
UCSCiuc001wmj.4 human

Organism-specific databases

CTDi5721
DisGeNETi5721
EuPathDBiHostDB:ENSG00000100911.13
GeneCardsiPSME2
HGNCiHGNC:9569 PSME2
HPAiHPA062661
MIMi602161 gene
neXtProtiNX_Q9UL46
OpenTargetsiENSG00000100911
PharmGKBiPA33915
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4470 Eukaryota
ENOG410XQVX LUCA
GeneTreeiENSGT00510000046374
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ9UL46
KOiK06697
PhylomeDBiQ9UL46
TreeFamiTF106236

Enzyme and pathway databases

ReactomeiR-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-69481 G2/M Checkpoints
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9020702 Interleukin-1 signaling
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiPSME2 human
GeneWikiiPSME2
GenomeRNAii5721
PROiPR:Q9UL46
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100911 Expressed in 93 organ(s), highest expression level in left adrenal gland
CleanExiHS_PSME2
ExpressionAtlasiQ9UL46 baseline and differential
GenevisibleiQ9UL46 HS

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSME2_HUMAN
AccessioniPrimary (citable) accession number: Q9UL46
Secondary accession number(s): Q15129
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 173 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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