Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Paraneoplastic antigen Ma2

Gene

PNMA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Antibodies against PNMA2 are present in sera from patients suffering of paraneoplastic neurological disorders.

GO - Biological processi

Keywordsi

Molecular functionTumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Paraneoplastic antigen Ma2
Alternative name(s):
40 kDa neuronal protein
Onconeuronal antigen Ma2
Paraneoplastic neuronal antigen MM2
Gene namesi
Name:PNMA2
Synonyms:KIAA0883, MA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000240694.8
HGNCiHGNC:9159 PNMA2
MIMi603970 gene
neXtProtiNX_Q9UL42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10687
OpenTargetsiENSG00000240694
PharmGKBiPA33482

Polymorphism and mutation databases

BioMutaiPNMA2
DMDMi37999812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001552022 – 364Paraneoplastic antigen Ma2Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9UL42
MaxQBiQ9UL42
PaxDbiQ9UL42
PeptideAtlasiQ9UL42
PRIDEiQ9UL42
ProteomicsDBi84944

PTM databases

iPTMnetiQ9UL42
PhosphoSitePlusiQ9UL42

Expressioni

Tissue specificityi

Brain-specific. In some cancer patients, specifically expressed by testicular tumor cells.2 Publications

Gene expression databases

BgeeiENSG00000240694 Expressed in 175 organ(s), highest expression level in postcentral gyrus
CleanExiHS_PNMA2
GenevisibleiQ9UL42 HS

Organism-specific databases

HPAiHPA001936

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115926, 50 interactors
IntActiQ9UL42, 45 interactors
MINTiQ9UL42
STRINGi9606.ENSP00000429344

Structurei

3D structure databases

ProteinModelPortaliQ9UL42
SMRiQ9UL42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi333 – 338Poly-Glu6

Sequence similaritiesi

Belongs to the PNMA family.Curated

Phylogenomic databases

eggNOGiENOG410J6QQ Eukaryota
ENOG410Y05Y LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ9UL42
OMAiFKTPNQD
OrthoDBiEOG091G0BG9
PhylomeDBiQ9UL42
TreeFamiTF335054

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR026525 PNMA2
PANTHERiPTHR23095 PTHR23095, 1 hit
PTHR23095:SF16 PTHR23095:SF16, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UL42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR
60 70 80 90 100
LLGKIFRKQE NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT
110 120 130 140 150
EFLERLNLFL EKEGQTVSGM FRALGQEGVS PATVPCISPE LLAHLLGQAM
160 170 180 190 200
AHAPQPLLPM RYRKLRVFSG SAVPAPEEES FEVWLEQATE IVKEWPVTEA
210 220 230 240 250
EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV FGSLESRRTA
260 270 280 290 300
QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVRLEQVMA
310 320 330 340 350
GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE
360
ERDGYGRWNH EGDD
Length:364
Mass (Da):41,509
Last modified:October 24, 2003 - v2
Checksum:i6E417AD96E3F0E93
GO

Sequence cautioni

The sequence BAA74906 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128 – 129GV → AL in AAD02098 (PubMed:10362822).Curated2
Sequence conflicti141L → I in AAD02098 (PubMed:10362822).Curated1
Sequence conflicti257T → P in AAF05625 (PubMed:10362822).Curated1
Sequence conflicti278R → K in AAF05626 (PubMed:10362822).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053597186E → K. Corresponds to variant dbSNP:rs2233701Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037365 mRNA Translation: AAD02098.1
AF083114 mRNA Translation: AAF05625.1
AF083115 mRNA Translation: AAF05626.1
AF286487 mRNA Translation: AAG28165.1
AB020690 mRNA Translation: BAA74906.2 Different initiation.
AK055325 mRNA Translation: BAG51501.1
CH471080 Genomic DNA Translation: EAW63575.1
BC047515 mRNA Translation: AAH47515.1
BC062301 mRNA Translation: AAH62301.1
CCDSiCCDS34868.1
RefSeqiNP_009188.1, NM_007257.5
XP_011542667.1, XM_011544365.2
UniGeneiHs.591838

Genome annotation databases

EnsembliENST00000522362; ENSP00000429344; ENSG00000240694
GeneIDi10687
KEGGihsa:10687
UCSCiuc003xez.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037365 mRNA Translation: AAD02098.1
AF083114 mRNA Translation: AAF05625.1
AF083115 mRNA Translation: AAF05626.1
AF286487 mRNA Translation: AAG28165.1
AB020690 mRNA Translation: BAA74906.2 Different initiation.
AK055325 mRNA Translation: BAG51501.1
CH471080 Genomic DNA Translation: EAW63575.1
BC047515 mRNA Translation: AAH47515.1
BC062301 mRNA Translation: AAH62301.1
CCDSiCCDS34868.1
RefSeqiNP_009188.1, NM_007257.5
XP_011542667.1, XM_011544365.2
UniGeneiHs.591838

3D structure databases

ProteinModelPortaliQ9UL42
SMRiQ9UL42
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115926, 50 interactors
IntActiQ9UL42, 45 interactors
MINTiQ9UL42
STRINGi9606.ENSP00000429344

PTM databases

iPTMnetiQ9UL42
PhosphoSitePlusiQ9UL42

Polymorphism and mutation databases

BioMutaiPNMA2
DMDMi37999812

Proteomic databases

EPDiQ9UL42
MaxQBiQ9UL42
PaxDbiQ9UL42
PeptideAtlasiQ9UL42
PRIDEiQ9UL42
ProteomicsDBi84944

Protocols and materials databases

DNASUi10687
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000522362; ENSP00000429344; ENSG00000240694
GeneIDi10687
KEGGihsa:10687
UCSCiuc003xez.3 human

Organism-specific databases

CTDi10687
DisGeNETi10687
EuPathDBiHostDB:ENSG00000240694.8
GeneCardsiPNMA2
HGNCiHGNC:9159 PNMA2
HPAiHPA001936
MIMi603970 gene
neXtProtiNX_Q9UL42
OpenTargetsiENSG00000240694
PharmGKBiPA33482
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6QQ Eukaryota
ENOG410Y05Y LUCA
GeneTreeiENSGT00530000062986
HOGENOMiHOG000013079
HOVERGENiHBG052488
InParanoidiQ9UL42
OMAiFKTPNQD
OrthoDBiEOG091G0BG9
PhylomeDBiQ9UL42
TreeFamiTF335054

Miscellaneous databases

ChiTaRSiPNMA2 human
GeneWikiiPNMA2
GenomeRNAii10687
PROiPR:Q9UL42
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240694 Expressed in 175 organ(s), highest expression level in postcentral gyrus
CleanExiHS_PNMA2
GenevisibleiQ9UL42 HS

Family and domain databases

InterProiView protein in InterPro
IPR026523 PNMA
IPR026525 PNMA2
PANTHERiPTHR23095 PTHR23095, 1 hit
PTHR23095:SF16 PTHR23095:SF16, 1 hit
PfamiView protein in Pfam
PF14893 PNMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPNMA2_HUMAN
AccessioniPrimary (citable) accession number: Q9UL42
Secondary accession number(s): B3KNY9
, O94959, O95145, Q49A18, Q9UL43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again