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Protein

Zinc finger protein 346

Gene

ZNF346

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi75Zinc 1By similarity1
Metal bindingi78Zinc 1By similarity1
Metal bindingi91Zinc 1; via tele nitrogenBy similarity1
Metal bindingi97Zinc 1; via pros nitrogenBy similarity1
Metal bindingi136Zinc 2By similarity1
Metal bindingi139Zinc 2By similarity1
Metal bindingi152Zinc 2; via tele nitrogenBy similarity1
Metal bindingi158Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

GO - Molecular functioni

  • double-stranded RNA binding Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • miRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 346
Alternative name(s):
Just another zinc finger protein
Gene namesi
Name:ZNF346
Synonyms:JAZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113761.11
HGNCiHGNC:16403 ZNF346
MIMi605308 gene
neXtProtiNX_Q9UL40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113761
PharmGKBiPA134898181

Polymorphism and mutation databases

BioMutaiZNF346
DMDMi74735051

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918091 – 294Zinc finger protein 346Add BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UL40
PaxDbiQ9UL40
PeptideAtlasiQ9UL40
PRIDEiQ9UL40
ProteomicsDBi84940
84941 [Q9UL40-2]

PTM databases

iPTMnetiQ9UL40
PhosphoSitePlusiQ9UL40

Expressioni

Gene expression databases

BgeeiENSG00000113761 Expressed in 174 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ZNF346
ExpressionAtlasiQ9UL40 baseline and differential
GenevisibleiQ9UL40 HS

Organism-specific databases

HPAiHPA018485

Interactioni

Subunit structurei

Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117109, 102 interactors
IntActiQ9UL40, 19 interactors
STRINGi9606.ENSP00000350869

Structurei

Secondary structure

1294
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UL40
SMRiQ9UL40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri70 – 104Matrin-type 1Add BLAST35
Zinc fingeri131 – 165Matrin-type 2Add BLAST35
Zinc fingeri182 – 216Matrin-type 3Add BLAST35
Zinc fingeri236 – 270Matrin-type 4Add BLAST35

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQ4K Eukaryota
ENOG4111JFP LUCA
GeneTreeiENSGT00510000046606
HOGENOMiHOG000008682
HOVERGENiHBG061007
InParanoidiQ9UL40
OMAiFTEAQCK
OrthoDBiEOG091G0GWT
PhylomeDBiQ9UL40
TreeFamiTF350019

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits
SUPFAMiSSF57667 SSF57667, 4 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UL40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEYPAPATVQ AADGGAAGPY SSSELLEGQE PDGVRFDRER ARRLWEAVSG
60 70 80 90 100
AQPVGREEVE HMIQKNQCLF TNTQCKVCCA LLISESQKLA HYQSKKHANK
110 120 130 140 150
VKRYLAIHGM ETLKGETKKL DSDQKSSRSK DKNQCCPICN MTFSSPVVAQ
160 170 180 190 200
SHYLGKTHAK NLKLKQQSTK VEALHQNREM IDPDKFCSLC HATFNDPVMA
210 220 230 240 250
QQHYVGKKHR KQETKLKLMA RYGRLADPAV TDFPAGKGYP CKTCKIVLNS
260 270 280 290
IEQYQAHVSG FKHKNQSPKT VASSLGQIPM QRQPIQKDST TLED
Length:294
Mass (Da):32,933
Last modified:May 1, 2000 - v1
Checksum:i095F02E19FBCFBE0
GO
Isoform 2 (identifier: Q9UL40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-58: E → EAQFFPHSRTVIPILVLSETYSLCHP

Note: No experimental confirmation available.
Show »
Length:319
Mass (Da):35,771
Checksum:i42E18B795453AEB0
GO
Isoform 3 (identifier: Q9UL40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-125: Missing.

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,267
Checksum:i5EAB16A18CAE634C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z4J8B7Z4J8_HUMAN
cDNA FLJ52564, moderately similar t...
ZNF346
196Annotation score:
B7Z4N4B7Z4N4_HUMAN
cDNA FLJ60707, moderately similar t...
ZNF346
118Annotation score:
D6RJ07D6RJ07_HUMAN
Zinc finger protein 346
ZNF346
310Annotation score:
B7Z6Q2B7Z6Q2_HUMAN
Zinc finger protein 346, isoform CR...
ZNF346 hCG_41584
135Annotation score:
B7Z6B6B7Z6B6_HUMAN
cDNA FLJ60877, highly similar to Zi...
ZNF346
131Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152H → Y in CAH18475 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01597158E → EAQFFPHSRTVIPILVLSET YSLCHP in isoform 2. 1 Publication1
Alternative sequenceiVSP_05509894 – 125Missing in isoform 3. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083340 mRNA Translation: AAD52018.1
AK131469 mRNA Translation: BAD18614.1
AK295549 mRNA Translation: BAH12103.1
CR749692 mRNA Translation: CAH18475.1
AC027314 Genomic DNA No translation available.
AC027317 Genomic DNA No translation available.
BC007775 mRNA Translation: AAH07775.1
CCDSiCCDS4409.1 [Q9UL40-1]
CCDS78094.1 [Q9UL40-2]
CCDS83052.1 [Q9UL40-3]
RefSeqiNP_001295142.1, NM_001308213.1 [Q9UL40-2]
NP_001295143.1, NM_001308214.1 [Q9UL40-3]
NP_001295148.1, NM_001308219.1
NP_001295152.1, NM_001308223.1
NP_036411.1, NM_012279.3 [Q9UL40-1]
XP_016864784.1, XM_017009295.1 [Q9UL40-1]
XP_016864785.1, XM_017009296.1 [Q9UL40-1]
UniGeneiHs.484259
Hs.671568

Genome annotation databases

EnsembliENST00000358149; ENSP00000350869; ENSG00000113761 [Q9UL40-1]
ENST00000503039; ENSP00000424495; ENSG00000113761 [Q9UL40-2]
ENST00000503425; ENSP00000421212; ENSG00000113761 [Q9UL40-3]
GeneIDi23567
KEGGihsa:23567
UCSCiuc003mfi.4 human [Q9UL40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083340 mRNA Translation: AAD52018.1
AK131469 mRNA Translation: BAD18614.1
AK295549 mRNA Translation: BAH12103.1
CR749692 mRNA Translation: CAH18475.1
AC027314 Genomic DNA No translation available.
AC027317 Genomic DNA No translation available.
BC007775 mRNA Translation: AAH07775.1
CCDSiCCDS4409.1 [Q9UL40-1]
CCDS78094.1 [Q9UL40-2]
CCDS83052.1 [Q9UL40-3]
RefSeqiNP_001295142.1, NM_001308213.1 [Q9UL40-2]
NP_001295143.1, NM_001308214.1 [Q9UL40-3]
NP_001295148.1, NM_001308219.1
NP_001295152.1, NM_001308223.1
NP_036411.1, NM_012279.3 [Q9UL40-1]
XP_016864784.1, XM_017009295.1 [Q9UL40-1]
XP_016864785.1, XM_017009296.1 [Q9UL40-1]
UniGeneiHs.484259
Hs.671568

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MKDNMR-A168-227[»]
2MKNNMR-A168-227[»]
ProteinModelPortaliQ9UL40
SMRiQ9UL40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117109, 102 interactors
IntActiQ9UL40, 19 interactors
STRINGi9606.ENSP00000350869

PTM databases

iPTMnetiQ9UL40
PhosphoSitePlusiQ9UL40

Polymorphism and mutation databases

BioMutaiZNF346
DMDMi74735051

Proteomic databases

EPDiQ9UL40
PaxDbiQ9UL40
PeptideAtlasiQ9UL40
PRIDEiQ9UL40
ProteomicsDBi84940
84941 [Q9UL40-2]

Protocols and materials databases

DNASUi23567
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358149; ENSP00000350869; ENSG00000113761 [Q9UL40-1]
ENST00000503039; ENSP00000424495; ENSG00000113761 [Q9UL40-2]
ENST00000503425; ENSP00000421212; ENSG00000113761 [Q9UL40-3]
GeneIDi23567
KEGGihsa:23567
UCSCiuc003mfi.4 human [Q9UL40-1]

Organism-specific databases

CTDi23567
EuPathDBiHostDB:ENSG00000113761.11
GeneCardsiZNF346
HGNCiHGNC:16403 ZNF346
HPAiHPA018485
MIMi605308 gene
neXtProtiNX_Q9UL40
OpenTargetsiENSG00000113761
PharmGKBiPA134898181
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ4K Eukaryota
ENOG4111JFP LUCA
GeneTreeiENSGT00510000046606
HOGENOMiHOG000008682
HOVERGENiHBG061007
InParanoidiQ9UL40
OMAiFTEAQCK
OrthoDBiEOG091G0GWT
PhylomeDBiQ9UL40
TreeFamiTF350019

Miscellaneous databases

ChiTaRSiZNF346 human
GeneWikiiZNF346
GenomeRNAii23567
PROiPR:Q9UL40
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113761 Expressed in 174 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_ZNF346
ExpressionAtlasiQ9UL40 baseline and differential
GenevisibleiQ9UL40 HS

Family and domain databases

InterProiView protein in InterPro
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SM00451 ZnF_U1, 4 hits
SUPFAMiSSF57667 SSF57667, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN346_HUMAN
AccessioniPrimary (citable) accession number: Q9UL40
Secondary accession number(s): B7Z367, Q68CV9, Q6ZMW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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