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UniProtKB - Q9UL36 (ZN236_HUMAN)

Entry version 169 (07 Oct 2020)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Zinc finger protein 236

Gene

ZNF236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri37 – 59C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri66 – 88C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri93 – 115C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri285 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri967 – 989C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1045C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1051 – 1073C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1167 – 1189C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1195 – 1217C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1223 – 1245C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1251 – 1273C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1657 – 1680C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1708C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1722 – 1744C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1750 – 1772C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1778 – 1801C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UL36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 236
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF236
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000130856.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:13028, ZNF236

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604760, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UL36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7776

Open Targets

More...OpenTargetsi		ENSG00000130856

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37606

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UL36, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF236

Domain mapping of disease mutations (DMDM)

More...DMDMi		296453040

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474761 – 1845Zinc finger protein 236Add BLAST1845

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UL36

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UL36

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UL36

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UL36

PeptideAtlas

More...PeptideAtlasi		Q9UL36

PRoteomics IDEntifications database

More...PRIDEi		Q9UL36

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		84938 [Q9UL36-1]
84939 [Q9UL36-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UL36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UL36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130856, Expressed in corpus callosum and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UL36, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UL36, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130856, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113558, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q9UL36, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000253159

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UL36, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UL36

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri66 – 88C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri93 – 115C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri285 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri967 – 989C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1045C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1051 – 1073C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1167 – 1189C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1195 – 1217C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1223 – 1245C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1251 – 1273C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1657 – 1680C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1708C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1722 – 1744C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1750 – 1772C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1778 – 1801C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002361_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UL36

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UL36

TreeFam database of animal gene trees

More...TreeFami		TF350781

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 16 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 30 hits
PS50157, ZINC_FINGER_C2H2_2, 30 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q9UL36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLCGLLERC WLHHDPDGVL TLNAENTNYA YQVPNFHKCE ICLLSFPKES 
        60         70         80         90        100
QFQRHMRDHE RNDKPHRCDQ CPQTFNVEFN LTLHKCTHSG EDPTCPVCNK 
       110        120        130        140        150
KFSRVASLKA HIMLHEKEEN LICSECGDEF TLQSQLAVHM EEHRQELAGT 
       160        170        180        190        200
RQHACKACKK EFETSSELKE HMKTHYKIRV SSTRSYNRNI DRSGFTYSCP 
       210        220        230        240        250
HCGKTFQKPS QLTRHIRIHT GERPFKCSEC GKAFNQKGAL QTHMIKHTGE 
       260        270        280        290        300
KPHACAFCPA AFSQKGNLQS HVQRVHSEVK NGPTYNCTEC SCVFKSLGSL 
       310        320        330        340        350
NTHISKMHMG GPQNSTSSTE TAHVLTATLF QTLPLQQTEA QATSASSQPS 
       360        370        380        390        400
SQAVSDVIQQ LLELSEPAPV ESGQSPQPGQ QLSITVGINQ DILQQALENS 
       410        420        430        440        450
GLSSIPAAAH PNDSCHAKTS APHAQNPDVS SVSNEQTDPT DAEQEKEQES 
       460        470        480        490        500
PEKLDKKEKK MIKKKSPFLP GSIREENGVR WHVCPYCAKE FRKPSDLVRH 
       510        520        530        540        550
IRIHTHEKPF KCPQCFRAFA VKSTLTAHIK THTGIKAFKC QYCMKSFSTS 
       560        570        580        590        600
GSLKVHIRLH TGVRPFACPH CDKKFRTSGH RKTHIASHFK HTELRKMRHQ 
       610        620        630        640        650
RKPAKVRVGK TNIPVPDIPL QEPILITDLG LIQPIPKNQF FQSYFNNNFV 
       660        670        680        690        700
NEADRPYKCF YCHRAYKKSC HLKQHIRSHT GEKPFKCSQC GRGFVSAGVL 
       710        720        730        740        750
KAHIRTHTGL KSFKCLICNG AFTTGGSLRR HMGIHNDLRP YMCPYCQKTF 
       760        770        780        790        800
KTSLNCKKHM KTHRYELAQQ LQQHQQAASI DDSTVDQQSM QASTQMQVEI 
       810        820        830        840        850
ESDELPQTAE VVAANPEAML DLEPQHVVGT EEAGLGQQLA DQPLEADEDG 
       860        870        880        890        900
FVAPQDPLRG HVDQFEEQSP AQQSFEPAGL PQGFTVTDTY HQQPQFPPVQ 
       910        920        930        940        950
QLQDSSTLES QALSTSFHQQ SLLQAPSSDG MNVTTRLIQE SSQEELDLQA 
       960        970        980        990       1000
QGSQFLEDNE DQSRRSYRCD YCNKGFKKSS HLKQHVRSHT GEKPYKCKLC 
      1010       1020       1030       1040       1050
GRGFVSSGVL KSHEKTHTGV KAFSCSVCNA SFTTNGSLTR HMATHMSMKP 
      1060       1070       1080       1090       1100
YKCPFCEEGF RTTVHCKKHM KRHQTVPSAV SATGETEGGD ICMEEEEEHS 
      1110       1120       1130       1140       1150
DRNASRKSRP EVITFTEEET AQLAKIRPQE SATVSEKVLV QSAAEKDRIS 
      1160       1170       1180       1190       1200
ELRDKQAELQ DEPKHANCCT YCPKSFKKPS DLVRHVRIHT GEKPYKCDEC 
      1210       1220       1230       1240       1250
GKSFTVKSTL DCHVKTHTGQ KLFSCHVCSN AFSTKGSLKV HMRLHTGAKP 
      1260       1270       1280       1290       1300
FKCPHCELRF RTSGRRKTHM QFHYKPDPKK ARKPMTRSSS EGLQPVNLLN 
      1310       1320       1330       1340       1350
SSSTDPNVFI MNNSVLTGQF DQNLLQPGLV GQAILPASVS AGGDLTVSLT 
      1360       1370       1380       1390       1400
DGSLATLEGI QLQLAANLVG PNVQISGIDA ASINNITLQI DPSILQQTLQ 
      1410       1420       1430       1440       1450
QGNLLAQQLT GEPGLAPQNS SLQTSDSTVP ASVVIQPISG LSLQPTVTSA 
      1460       1470       1480       1490       1500
NLTIGPLSEQ DSVLTTNSSG TQDLTQVMTS QGLVSPSGGP HEITLTINNS 
      1510       1520       1530       1540       1550
SLSQVLAQAA GPTATSSSGS PQEITLTISE LNTTSGSLPS TTPMSPSAIS 
      1560       1570       1580       1590       1600
TQNLVMSSSG VGGDASVTLT LADTQGMLSG GLDTVTLNIT SQGQQFPALL 
      1610       1620       1630       1640       1650
TDPSLSGQGG AGSPQVILVS HTPQSASAAC EEIAYQVAGV SGNLAPGNQP 
      1660       1670       1680       1690       1700
EKEGRAHQCL ECDRAFSSAA VLMHHSKEVH GRERIHGCPV CRKAFKRATH 
      1710       1720       1730       1740       1750
LKEHMQTHQA GPSLSSQKPR VFKCDTCEKA FAKPSQLERH SRIHTGERPF 
      1760       1770       1780       1790       1800
HCTLCEKAFN QKSALQVHMK KHTGERPYKC AYCVMGFTQK SNMKLHMKRA 
      1810       1820       1830       1840 
HSYAGALQES AGHPEQDGEE LSRTLHLEEV VQEAAGEWQA LTHVF
Length:1,845
Mass (Da):203,704
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEC98655EEC0DB09
GO
Isoform A (identifier: Q9UL36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1530-1558: ELNTTSGSLPSTTPMSPSAISTQNLVMSS → GSRSVQHSVGPQECGSVEALYLENSSDKT
     1559-1845: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,558
Mass (Da):172,707
Checksum:i03A7F013E023EF14
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQL1J3QQL1_HUMAN
Zinc finger protein 236
ZNF236
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JID5J9JID5_HUMAN
Zinc finger protein 236
ZNF236
1,847Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCW3A0A2R8YCW3_HUMAN
Zinc finger protein 236
ZNF236
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1544M → T in AAD55329 (PubMed:10458916).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057410166S → L. Corresponds to variant dbSNP:rs2276211Ensembl.1
Natural variantiVAR_065094613I → V3 PublicationsCorresponds to variant dbSNP:rs608433Ensembl.1
Natural variantiVAR_057411614P → S. Corresponds to variant dbSNP:rs8093707EnsemblClinVar.1
Natural variantiVAR_057412643S → G. Corresponds to variant dbSNP:rs3794873Ensembl.1
Natural variantiVAR_057413818A → T. Corresponds to variant dbSNP:rs3752078Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069071530 – 1558ELNTT…LVMSS → GSRSVQHSVGPQECGSVEAL YLENSSDKT in isoform A. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0069081559 – 1845Missing in isoform A. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF085244 mRNA Translation: AAD55329.1
AF085243 mRNA Translation: AAD55328.1
AC027575 Genomic DNA No translation available.
AC093330 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66587.1
BC140859 mRNA Translation: AAI40860.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42447.1 [Q9UL36-1]

NCBI Reference Sequences

More...RefSeqi		NP_001293018.1, NM_001306089.1
NP_031371.3, NM_007345.3 [Q9UL36-1]
XP_011524467.1, XM_011526165.2 [Q9UL36-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253159; ENSP00000253159; ENSG00000130856 [Q9UL36-1]
ENST00000543926; ENSP00000444524; ENSG00000130856 [Q9UL36-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7776

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7776

UCSC genome browser

More...UCSCi		uc002lmi.4, human [Q9UL36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085244 mRNA Translation: AAD55329.1
AF085243 mRNA Translation: AAD55328.1
AC027575 Genomic DNA No translation available.
AC093330 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66587.1
BC140859 mRNA Translation: AAI40860.1
CCDSiCCDS42447.1 [Q9UL36-1]
RefSeqiNP_001293018.1, NM_001306089.1
NP_031371.3, NM_007345.3 [Q9UL36-1]
XP_011524467.1, XM_011526165.2 [Q9UL36-1]

3D structure databases

SMRiQ9UL36
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113558, 6 interactors
IntActiQ9UL36, 1 interactor
STRINGi9606.ENSP00000253159

PTM databases

iPTMnetiQ9UL36
PhosphoSitePlusiQ9UL36

Polymorphism and mutation databases

BioMutaiZNF236
DMDMi296453040

Proteomic databases

EPDiQ9UL36
jPOSTiQ9UL36
MassIVEiQ9UL36
PaxDbiQ9UL36
PeptideAtlasiQ9UL36
PRIDEiQ9UL36
ProteomicsDBi84938 [Q9UL36-1]
84939 [Q9UL36-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1786, 38 antibodies

Genome annotation databases

EnsembliENST00000253159; ENSP00000253159; ENSG00000130856 [Q9UL36-1]
ENST00000543926; ENSP00000444524; ENSG00000130856 [Q9UL36-2]
GeneIDi7776
KEGGihsa:7776
UCSCiuc002lmi.4, human [Q9UL36-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7776
DisGeNETi7776
EuPathDBiHostDB:ENSG00000130856.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF236
HGNCiHGNC:13028, ZNF236
HPAiENSG00000130856, Low tissue specificity
MIMi604760, gene
neXtProtiNX_Q9UL36
OpenTargetsiENSG00000130856
PharmGKBiPA37606

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000156787
HOGENOMiCLU_002361_0_0_1
InParanoidiQ9UL36
OrthoDBi1318335at2759
PhylomeDBiQ9UL36
TreeFamiTF350781

Enzyme and pathway databases

PathwayCommonsiQ9UL36

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7776, 340 hits in 896 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF236, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7776
PharosiQ9UL36, Tbio

Protein Ontology

More...PROi		PR:Q9UL36
RNActiQ9UL36, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130856, Expressed in corpus callosum and 230 other tissues
ExpressionAtlasiQ9UL36, baseline and differential
GenevisibleiQ9UL36, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 17 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 30 hits
SUPFAMiSSF57667, SSF57667, 16 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 30 hits
PS50157, ZINC_FINGER_C2H2_2, 30 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN236_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UL36
Secondary accession number(s): B2RTX9, Q9UL37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: October 7, 2020
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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