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Entry version 161 (08 May 2019)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger protein 236

Gene

ZNF236

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri37 – 59C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri66 – 88C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri93 – 115C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri285 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri967 – 989C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1045C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1051 – 1073C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1167 – 1189C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1195 – 1217C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1223 – 1245C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1251 – 1273C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1657 – 1680C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1708C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1722 – 1744C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1750 – 1772C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1778 – 1801C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 236
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF236
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13028 ZNF236

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604760 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UL36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7776

Open Targets

More...
OpenTargetsi
ENSG00000130856

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37606

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF236

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453040

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474761 – 1845Zinc finger protein 236Add BLAST1845

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UL36

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UL36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UL36

PeptideAtlas

More...
PeptideAtlasi
Q9UL36

PRoteomics IDEntifications database

More...
PRIDEi
Q9UL36

ProteomicsDB human proteome resource

More...
ProteomicsDBi
84938
84939 [Q9UL36-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UL36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UL36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expression levels are highest in skeletal muscle and brain, intermediate in heart, pancreas, and placenta, and lowest in kidney, liver, and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130856 Expressed in 218 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UL36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UL36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008600

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113558, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253159

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UL36

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri66 – 88C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri93 – 115C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri121 – 143C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri285 – 308C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri657 – 679C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri685 – 707C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri741 – 763C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri967 – 989C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri995 – 1017C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1023 – 1045C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1051 – 1073C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1167 – 1189C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1195 – 1217C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1223 – 1245C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1251 – 1273C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1657 – 1680C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1708C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1722 – 1744C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1750 – 1772C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1778 – 1801C2H2-type 30PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156787

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168751

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UL36

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UL36

TreeFam database of animal gene trees

More...
TreeFami
TF350781

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 30 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 30 hits
PS50157 ZINC_FINGER_C2H2_2, 30 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: Q9UL36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLCGLLERC WLHHDPDGVL TLNAENTNYA YQVPNFHKCE ICLLSFPKES
60 70 80 90 100
QFQRHMRDHE RNDKPHRCDQ CPQTFNVEFN LTLHKCTHSG EDPTCPVCNK
110 120 130 140 150
KFSRVASLKA HIMLHEKEEN LICSECGDEF TLQSQLAVHM EEHRQELAGT
160 170 180 190 200
RQHACKACKK EFETSSELKE HMKTHYKIRV SSTRSYNRNI DRSGFTYSCP
210 220 230 240 250
HCGKTFQKPS QLTRHIRIHT GERPFKCSEC GKAFNQKGAL QTHMIKHTGE
260 270 280 290 300
KPHACAFCPA AFSQKGNLQS HVQRVHSEVK NGPTYNCTEC SCVFKSLGSL
310 320 330 340 350
NTHISKMHMG GPQNSTSSTE TAHVLTATLF QTLPLQQTEA QATSASSQPS
360 370 380 390 400
SQAVSDVIQQ LLELSEPAPV ESGQSPQPGQ QLSITVGINQ DILQQALENS
410 420 430 440 450
GLSSIPAAAH PNDSCHAKTS APHAQNPDVS SVSNEQTDPT DAEQEKEQES
460 470 480 490 500
PEKLDKKEKK MIKKKSPFLP GSIREENGVR WHVCPYCAKE FRKPSDLVRH
510 520 530 540 550
IRIHTHEKPF KCPQCFRAFA VKSTLTAHIK THTGIKAFKC QYCMKSFSTS
560 570 580 590 600
GSLKVHIRLH TGVRPFACPH CDKKFRTSGH RKTHIASHFK HTELRKMRHQ
610 620 630 640 650
RKPAKVRVGK TNIPVPDIPL QEPILITDLG LIQPIPKNQF FQSYFNNNFV
660 670 680 690 700
NEADRPYKCF YCHRAYKKSC HLKQHIRSHT GEKPFKCSQC GRGFVSAGVL
710 720 730 740 750
KAHIRTHTGL KSFKCLICNG AFTTGGSLRR HMGIHNDLRP YMCPYCQKTF
760 770 780 790 800
KTSLNCKKHM KTHRYELAQQ LQQHQQAASI DDSTVDQQSM QASTQMQVEI
810 820 830 840 850
ESDELPQTAE VVAANPEAML DLEPQHVVGT EEAGLGQQLA DQPLEADEDG
860 870 880 890 900
FVAPQDPLRG HVDQFEEQSP AQQSFEPAGL PQGFTVTDTY HQQPQFPPVQ
910 920 930 940 950
QLQDSSTLES QALSTSFHQQ SLLQAPSSDG MNVTTRLIQE SSQEELDLQA
960 970 980 990 1000
QGSQFLEDNE DQSRRSYRCD YCNKGFKKSS HLKQHVRSHT GEKPYKCKLC
1010 1020 1030 1040 1050
GRGFVSSGVL KSHEKTHTGV KAFSCSVCNA SFTTNGSLTR HMATHMSMKP
1060 1070 1080 1090 1100
YKCPFCEEGF RTTVHCKKHM KRHQTVPSAV SATGETEGGD ICMEEEEEHS
1110 1120 1130 1140 1150
DRNASRKSRP EVITFTEEET AQLAKIRPQE SATVSEKVLV QSAAEKDRIS
1160 1170 1180 1190 1200
ELRDKQAELQ DEPKHANCCT YCPKSFKKPS DLVRHVRIHT GEKPYKCDEC
1210 1220 1230 1240 1250
GKSFTVKSTL DCHVKTHTGQ KLFSCHVCSN AFSTKGSLKV HMRLHTGAKP
1260 1270 1280 1290 1300
FKCPHCELRF RTSGRRKTHM QFHYKPDPKK ARKPMTRSSS EGLQPVNLLN
1310 1320 1330 1340 1350
SSSTDPNVFI MNNSVLTGQF DQNLLQPGLV GQAILPASVS AGGDLTVSLT
1360 1370 1380 1390 1400
DGSLATLEGI QLQLAANLVG PNVQISGIDA ASINNITLQI DPSILQQTLQ
1410 1420 1430 1440 1450
QGNLLAQQLT GEPGLAPQNS SLQTSDSTVP ASVVIQPISG LSLQPTVTSA
1460 1470 1480 1490 1500
NLTIGPLSEQ DSVLTTNSSG TQDLTQVMTS QGLVSPSGGP HEITLTINNS
1510 1520 1530 1540 1550
SLSQVLAQAA GPTATSSSGS PQEITLTISE LNTTSGSLPS TTPMSPSAIS
1560 1570 1580 1590 1600
TQNLVMSSSG VGGDASVTLT LADTQGMLSG GLDTVTLNIT SQGQQFPALL
1610 1620 1630 1640 1650
TDPSLSGQGG AGSPQVILVS HTPQSASAAC EEIAYQVAGV SGNLAPGNQP
1660 1670 1680 1690 1700
EKEGRAHQCL ECDRAFSSAA VLMHHSKEVH GRERIHGCPV CRKAFKRATH
1710 1720 1730 1740 1750
LKEHMQTHQA GPSLSSQKPR VFKCDTCEKA FAKPSQLERH SRIHTGERPF
1760 1770 1780 1790 1800
HCTLCEKAFN QKSALQVHMK KHTGERPYKC AYCVMGFTQK SNMKLHMKRA
1810 1820 1830 1840
HSYAGALQES AGHPEQDGEE LSRTLHLEEV VQEAAGEWQA LTHVF
Length:1,845
Mass (Da):203,704
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEC98655EEC0DB09
GO
Isoform A (identifier: Q9UL36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1530-1558: ELNTTSGSLPSTTPMSPSAISTQNLVMSS → GSRSVQHSVGPQECGSVEALYLENSSDKT
     1559-1845: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,558
Mass (Da):172,707
Checksum:i03A7F013E023EF14
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QQL1J3QQL1_HUMAN
Zinc finger protein 236
ZNF236
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JID5J9JID5_HUMAN
Zinc finger protein 236
ZNF236
1,847Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCW3A0A2R8YCW3_HUMAN
Zinc finger protein 236
ZNF236
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1544M → T in AAD55329 (PubMed:10458916).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057410166S → L. Corresponds to variant dbSNP:rs2276211Ensembl.1
Natural variantiVAR_065094613I → V3 PublicationsCorresponds to variant dbSNP:rs608433Ensembl.1
Natural variantiVAR_057411614P → S. Corresponds to variant dbSNP:rs8093707Ensembl.1
Natural variantiVAR_057412643S → G. Corresponds to variant dbSNP:rs3794873Ensembl.1
Natural variantiVAR_057413818A → T. Corresponds to variant dbSNP:rs3752078Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069071530 – 1558ELNTT…LVMSS → GSRSVQHSVGPQECGSVEAL YLENSSDKT in isoform A. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0069081559 – 1845Missing in isoform A. 1 PublicationAdd BLAST287

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF085244 mRNA Translation: AAD55329.1
AF085243 mRNA Translation: AAD55328.1
AC027575 Genomic DNA No translation available.
AC093330 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66587.1
BC140859 mRNA Translation: AAI40860.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42447.1 [Q9UL36-1]

NCBI Reference Sequences

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RefSeqi
NP_001293018.1, NM_001306089.1
NP_031371.3, NM_007345.3 [Q9UL36-1]
XP_011524467.1, XM_011526165.2 [Q9UL36-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000253159; ENSP00000253159; ENSG00000130856 [Q9UL36-1]
ENST00000543926; ENSP00000444524; ENSG00000130856 [Q9UL36-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7776

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7776

UCSC genome browser

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UCSCi
uc002lmi.4 human [Q9UL36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085244 mRNA Translation: AAD55329.1
AF085243 mRNA Translation: AAD55328.1
AC027575 Genomic DNA No translation available.
AC093330 Genomic DNA No translation available.
CH471117 Genomic DNA Translation: EAW66587.1
BC140859 mRNA Translation: AAI40860.1
CCDSiCCDS42447.1 [Q9UL36-1]
RefSeqiNP_001293018.1, NM_001306089.1
NP_031371.3, NM_007345.3 [Q9UL36-1]
XP_011524467.1, XM_011526165.2 [Q9UL36-1]

3D structure databases

SMRiQ9UL36
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113558, 2 interactors
STRINGi9606.ENSP00000253159

PTM databases

iPTMnetiQ9UL36
PhosphoSitePlusiQ9UL36

Polymorphism and mutation databases

BioMutaiZNF236
DMDMi296453040

Proteomic databases

EPDiQ9UL36
jPOSTiQ9UL36
PaxDbiQ9UL36
PeptideAtlasiQ9UL36
PRIDEiQ9UL36
ProteomicsDBi84938
84939 [Q9UL36-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253159; ENSP00000253159; ENSG00000130856 [Q9UL36-1]
ENST00000543926; ENSP00000444524; ENSG00000130856 [Q9UL36-2]
GeneIDi7776
KEGGihsa:7776
UCSCiuc002lmi.4 human [Q9UL36-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7776
DisGeNETi7776

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF236
HGNCiHGNC:13028 ZNF236
HPAiHPA008600
MIMi604760 gene
neXtProtiNX_Q9UL36
OpenTargetsiENSG00000130856
PharmGKBiPA37606

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156787
HOGENOMiHOG000168751
InParanoidiQ9UL36
OrthoDBi1318335at2759
PhylomeDBiQ9UL36
TreeFamiTF350781

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF236 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7776

Protein Ontology

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PROi
PR:Q9UL36

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130856 Expressed in 218 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9UL36 baseline and differential
GenevisibleiQ9UL36 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 17 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 30 hits
SUPFAMiSSF57667 SSF57667, 16 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 30 hits
PS50157 ZINC_FINGER_C2H2_2, 30 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN236_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UL36
Secondary accession number(s): B2RTX9, Q9UL37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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