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Protein

Trafficking protein particle complex subunit 2-like protein

Gene

TRAPPC2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.1 Publication

GO - Molecular functioni

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • protein complex oligomerization Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 2-like protein
Gene namesi
ORF Names:HSPC126
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000167515.10
HGNCiHGNC:30887 TRAPPC2L
MIMi610970 gene
neXtProtiNX_Q9UL33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167515
PharmGKBiPA145147879

Polymorphism and mutation databases

BioMutaiTRAPPC2L
DMDMi74721024

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944511 – 140Trafficking protein particle complex subunit 2-like proteinAdd BLAST140

Proteomic databases

EPDiQ9UL33
PaxDbiQ9UL33
PeptideAtlasiQ9UL33
PRIDEiQ9UL33
ProteomicsDBi84936
84937 [Q9UL33-2]

PTM databases

iPTMnetiQ9UL33
PhosphoSitePlusiQ9UL33

Expressioni

Tissue specificityi

Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line.1 Publication

Gene expression databases

BgeeiENSG00000167515 Expressed in 222 organ(s), highest expression level in right adrenal gland
CleanExiHS_TRAPPC2L
ExpressionAtlasiQ9UL33 baseline and differential
GenevisibleiQ9UL33 HS

Organism-specific databases

HPAiHPA041714

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A. Interacts with TRAPPC6A.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119681, 38 interactors
CORUMiQ9UL33
IntActiQ9UL33, 31 interactors
MINTiQ9UL33
STRINGi9606.ENSP00000301021

Structurei

3D structure databases

ProteinModelPortaliQ9UL33
SMRiQ9UL33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3444 Eukaryota
ENOG4111IEZ LUCA
GeneTreeiENSGT00510000047505
HOGENOMiHOG000230646
HOVERGENiHBG056603
KOiK20301
PhylomeDBiQ9UL33
TreeFamiTF323920

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR006722 Sedlin
PANTHERiPTHR12403 PTHR12403, 1 hit
PfamiView protein in Pfam
PF04628 Sedlin_N, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UL33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVCIAVIAK ENYPLYIRST PTENELKFHY MVHTSLDVVD EKISAMGKAL
60 70 80 90 100
VDQRELYLGL LYPTEDYKVY GYVTNSKVKF VMVVDSSNTA LRDNEIRSMF
110 120 130 140
RKLHNSYTDV MCNPFYNPGD RIQSSRAFDN MVTSMMIQVC
Length:140
Mass (Da):16,146
Last modified:May 1, 2000 - v1
Checksum:i4549BCA7CE9566DC
GO
Isoform 2 (identifier: Q9UL33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: Missing.

Show »
Length:139
Mass (Da):16,059
Checksum:i027C66E8D9B96662
GO

Sequence cautioni

The sequence BAC86686 differs from that shown. Intron retention.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026641125Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089106 mRNA Translation: AAF00568.1
AF161524 mRNA Translation: AAF29139.1
AK126779 mRNA Translation: BAC86686.1 Sequence problems.
AK311885 mRNA Translation: BAG34826.1
AC092384 Genomic DNA No translation available.
BC011369 mRNA Translation: AAH11369.1
BC018024 mRNA Translation: AAH18024.1
BC105809 mRNA Translation: AAI05810.1
CCDSiCCDS10971.1 [Q9UL33-1]
RefSeqiNP_001305453.1, NM_001318524.1
NP_001305454.1, NM_001318525.1 [Q9UL33-2]
NP_001305455.1, NM_001318526.1
NP_001305456.1, NM_001318527.1
NP_001305457.1, NM_001318528.1
NP_001305458.1, NM_001318529.1
NP_001305459.1, NM_001318530.1
NP_001305461.1, NM_001318532.1
NP_057293.1, NM_016209.4 [Q9UL33-1]
UniGeneiHs.461722
Hs.732161

Genome annotation databases

EnsembliENST00000301021; ENSP00000301021; ENSG00000167515 [Q9UL33-1]
GeneIDi51693
KEGGihsa:51693
UCSCiuc002fmg.4 human [Q9UL33-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089106 mRNA Translation: AAF00568.1
AF161524 mRNA Translation: AAF29139.1
AK126779 mRNA Translation: BAC86686.1 Sequence problems.
AK311885 mRNA Translation: BAG34826.1
AC092384 Genomic DNA No translation available.
BC011369 mRNA Translation: AAH11369.1
BC018024 mRNA Translation: AAH18024.1
BC105809 mRNA Translation: AAI05810.1
CCDSiCCDS10971.1 [Q9UL33-1]
RefSeqiNP_001305453.1, NM_001318524.1
NP_001305454.1, NM_001318525.1 [Q9UL33-2]
NP_001305455.1, NM_001318526.1
NP_001305456.1, NM_001318527.1
NP_001305457.1, NM_001318528.1
NP_001305458.1, NM_001318529.1
NP_001305459.1, NM_001318530.1
NP_001305461.1, NM_001318532.1
NP_057293.1, NM_016209.4 [Q9UL33-1]
UniGeneiHs.461722
Hs.732161

3D structure databases

ProteinModelPortaliQ9UL33
SMRiQ9UL33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119681, 38 interactors
CORUMiQ9UL33
IntActiQ9UL33, 31 interactors
MINTiQ9UL33
STRINGi9606.ENSP00000301021

PTM databases

iPTMnetiQ9UL33
PhosphoSitePlusiQ9UL33

Polymorphism and mutation databases

BioMutaiTRAPPC2L
DMDMi74721024

Proteomic databases

EPDiQ9UL33
PaxDbiQ9UL33
PeptideAtlasiQ9UL33
PRIDEiQ9UL33
ProteomicsDBi84936
84937 [Q9UL33-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301021; ENSP00000301021; ENSG00000167515 [Q9UL33-1]
GeneIDi51693
KEGGihsa:51693
UCSCiuc002fmg.4 human [Q9UL33-1]

Organism-specific databases

CTDi51693
EuPathDBiHostDB:ENSG00000167515.10
GeneCardsiTRAPPC2L
H-InvDBiHIX0019527
HGNCiHGNC:30887 TRAPPC2L
HPAiHPA041714
MIMi610970 gene
neXtProtiNX_Q9UL33
OpenTargetsiENSG00000167515
PharmGKBiPA145147879
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3444 Eukaryota
ENOG4111IEZ LUCA
GeneTreeiENSGT00510000047505
HOGENOMiHOG000230646
HOVERGENiHBG056603
KOiK20301
PhylomeDBiQ9UL33
TreeFamiTF323920

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

GenomeRNAii51693
PROiPR:Q9UL33
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167515 Expressed in 222 organ(s), highest expression level in right adrenal gland
CleanExiHS_TRAPPC2L
ExpressionAtlasiQ9UL33 baseline and differential
GenevisibleiQ9UL33 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR006722 Sedlin
PANTHERiPTHR12403 PTHR12403, 1 hit
PfamiView protein in Pfam
PF04628 Sedlin_N, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPC2L_HUMAN
AccessioniPrimary (citable) accession number: Q9UL33
Secondary accession number(s): B2R4M9, Q6ZTA7, Q9NZZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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