RAB22A

Functionⁱ

Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	12 – 20	GTPBy similarity	9
Nucleotide bindingⁱ	60 – 64	GTPBy similarity	5
Nucleotide bindingⁱ	118 – 121	GTPBy similarity	4
Nucleotide bindingⁱ	148 – 150	GTPBy similarity	3

GO - Molecular functionⁱ

GDP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20937701
GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24466322
GTP binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24466322

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endocytosis
Source: UniProtKB
Inferred from direct assayⁱ
- 11870209
endosome organization
Source: UniProtKB
Inferred from expression patternⁱ
- 11870209
intracellular protein transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Rab protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of vesicle size
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24466322

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis, Protein transport, Transport
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rab-22A Short name: Rab-22
Gene namesⁱ	Name:RAB22A Synonyms:RAB22
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124209.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9764 RAB22A
MIMⁱ	612966 gene
neXtProtⁱ	NX_Q9UL26

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	19	S → L: Loss of GTPase activity. 1 Publication		1
Mutagenesisⁱ	64	Q → L: Constitutive GTPase activity. Impairs normal protein trafficking through early endosomes. 2 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57403
Open Targets More...OpenTargetsⁱ	ENSG00000124209
PharmGKBⁱ	PA34112

Polymorphism and mutation databases

BioMutaⁱ	RAB22A
DMDMⁱ	13633614

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000121209	1 – 194	Ras-related protein Rab-22AAdd BLAST		194

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	193	S-geranylgeranyl cysteineBy similarity		1
Lipidationⁱ	194	S-geranylgeranyl cysteineBy similarity		1

Keywords - PTMⁱ

Lipoprotein, Prenylation

Proteomic databases

EPDⁱ	Q9UL26
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UL26
PaxDbⁱ	Q9UL26
PeptideAtlas More...PeptideAtlasⁱ	Q9UL26
PRIDEⁱ	Q9UL26
ProteomicsDBⁱ	84935

PTM databases

iPTMnetⁱ	Q9UL26
PhosphoSitePlusⁱ	Q9UL26

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000124209 Expressed in 233 organ(s), highest expression level in forebrain
CleanExⁱ	HS_RAB22A
Genevisibleⁱ	Q9UL26 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058894 HPA066920

HPAⁱ

HPA058894
HPA066920

Interactionⁱ

Subunit structureⁱ

Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
APPL2	Q8NEU8	6	EBI-399456,EBI-741261
EEA1	Q15075	3	EBI-399456,EBI-298113

Protein-protein interaction databases

BioGridⁱ	121505, 11 interactors
IntActⁱ	Q9UL26, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q9UL26
STRINGⁱ	9606.ENSP00000244040

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UL26
SMRⁱ	Q9UL26
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	34 – 42	Effector regionBy similarity		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119101
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q9UL26
KEGG Orthology (KO) More...KOⁱ	K07891
OMAⁱ	KCDLSDA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HKN
PhylomeDBⁱ	Q9UL26
TreeFamⁱ	TF331262

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9UL26-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ 
        60         70         80         90        100
NELHKFLIWD TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV 
       110        120        130        140        150
KELRQHGPPN IVVAIAGNKC DLIDVREVME RDAKDYADSI HAIFVETSAK 
       160        170        180        190 
NAININELFI EISRRIPSTD ANLPSGGKGF KLRRQPSEPK RSCC

Length:194

Mass (Da):21,855

Last modified:March 1, 2001 - v2

Checksum:ⁱEBC84711DA3F839B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	184	R → K in CAC10538 (Ref. 3) Curated		1
Sequence conflictⁱ	192 – 193	SC → TA in AAL75941 (Ref. 1) Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF125104 mRNA Translation: AAL75941.1 AF091034 mRNA Translation: AAF00047.2 AJ276210 mRNA Translation: CAC10538.1 BT007046 mRNA Translation: AAP35695.1 AK091180 mRNA Translation: BAG52298.1 AL035455 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75496.1 CH471077 Genomic DNA Translation: EAW75497.1 BC015710 mRNA Translation: AAH15710.1 BC063457 mRNA Translation: AAH63457.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33497.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065724.1, NM_020673.2
UniGeneⁱ	Hs.529044

Genome annotation databases

Ensemblⁱ	ENST00000244040; ENSP00000244040; ENSG00000124209
GeneIDⁱ	57403
KEGGⁱ	hsa:57403
UCSC genome browser More...UCSCⁱ	uc002xyz.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UL26	Similar to RAB22A, member RAS oncogene family (Fragment)		HUMAN		77	UniRef100_Q9UL26

Protein	Similar proteins		Species	Score	Length	Source
Q9UL26	Ras-related protein Rab-22A	)	MOUSE		194	UniRef90_Q9UL26
Ras-related protein Rab-22A		CANLF		194
Similar to RAB22A, member RAS oncogene family (Fragment)		HUMAN		77
RAB22A, member RAS oncogene family		FICAL		241
RAB22A, member RAS oncogene family		PANTR		196
+100

Protein	Similar proteins		Species	Score	Length	Source
Q9UL26	Ras-related protein Rab-31	)	HUMAN		194	UniRef50_Q13636
Ras-related protein Rab-31		MOUSE		194
Ras-related protein Rab-31		RAT		194
Ras-related protein Rab-22A		CANLF		194
RAB31 isoform 1		PANTR		195
+510

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF125104 mRNA Translation: AAL75941.1 AF091034 mRNA Translation: AAF00047.2 AJ276210 mRNA Translation: CAC10538.1 BT007046 mRNA Translation: AAP35695.1 AK091180 mRNA Translation: BAG52298.1 AL035455 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75496.1 CH471077 Genomic DNA Translation: EAW75497.1 BC015710 mRNA Translation: AAH15710.1 BC063457 mRNA Translation: AAH63457.1
CCDSⁱ	CCDS33497.1
RefSeqⁱ	NP_065724.1, NM_020673.2
UniGeneⁱ	Hs.529044

3D structure databases

ProteinModelPortalⁱ	Q9UL26
SMRⁱ	Q9UL26
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121505, 11 interactors
IntActⁱ	Q9UL26, 6 interactors
MINTⁱ	Q9UL26
STRINGⁱ	9606.ENSP00000244040

PTM databases

iPTMnetⁱ	Q9UL26
PhosphoSitePlusⁱ	Q9UL26

Polymorphism and mutation databases

BioMutaⁱ	RAB22A
DMDMⁱ	13633614

Proteomic databases

EPDⁱ	Q9UL26
MaxQBⁱ	Q9UL26
PaxDbⁱ	Q9UL26
PeptideAtlasⁱ	Q9UL26
PRIDEⁱ	Q9UL26
ProteomicsDBⁱ	84935

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57403
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000244040; ENSP00000244040; ENSG00000124209
GeneIDⁱ	57403
KEGGⁱ	hsa:57403
UCSCⁱ	uc002xyz.4 human

Organism-specific databases

CTDⁱ	57403
DisGeNETⁱ	57403
EuPathDBⁱ	HostDB:ENSG00000124209.3
GeneCardsⁱ	RAB22A
HGNCⁱ	HGNC:9764 RAB22A
HPAⁱ	HPA058894 HPA066920
MIMⁱ	612966 gene
neXtProtⁱ	NX_Q9UL26
OpenTargetsⁱ	ENSG00000124209
PharmGKBⁱ	PA34112
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0092 Eukaryota ENOG410YCCP LUCA
GeneTreeⁱ	ENSGT00760000119101
HOGENOMⁱ	HOG000233968
HOVERGENⁱ	HBG009351
InParanoidⁱ	Q9UL26
KOⁱ	K07891
OMAⁱ	KCDLSDA
OrthoDBⁱ	EOG091G0HKN
PhylomeDBⁱ	Q9UL26
TreeFamⁱ	TF331262

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8873719 RAB geranylgeranylation

Reactomeⁱ

R-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSⁱ	RAB22A human
GeneWikiⁱ	RAB22A
GenomeRNAiⁱ	57403
Protein Ontology More...PROⁱ	PR:Q9UL26
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124209 Expressed in 233 organ(s), highest expression level in forebrain
CleanExⁱ	HS_RAB22A
Genevisibleⁱ	Q9UL26 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase
Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51419 RAB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RB22A_HUMAN
Accessionⁱ	Q9UL26Primary (citable) accession number: Q9UL26 Secondary accession number(s): B3KR86 , E1P605, Q8TF12, Q9H4E6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - Q9UL26 (RB22A_HUMAN)

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Ras-related protein Rab-22A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Cytoskeleton

Endosome

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ