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Protein

Ras-related protein Rab-22A

Gene

RAB22A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20GTPBy similarity9
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4
Nucleotide bindingi148 – 150GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: UniProtKB
  • endosome organization Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • Rab protein signal transduction Source: GO_Central
  • regulation of vesicle size Source: UniProtKB

Keywordsi

Biological processEndocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-22A
Short name:
Rab-22
Gene namesi
Name:RAB22A
Synonyms:RAB22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124209.3
HGNCiHGNC:9764 RAB22A
MIMi612966 gene
neXtProtiNX_Q9UL26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi19S → L: Loss of GTPase activity. 1 Publication1
Mutagenesisi64Q → L: Constitutive GTPase activity. Impairs normal protein trafficking through early endosomes. 2 Publications1

Organism-specific databases

DisGeNETi57403
OpenTargetsiENSG00000124209
PharmGKBiPA34112

Polymorphism and mutation databases

BioMutaiRAB22A
DMDMi13633614

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212091 – 194Ras-related protein Rab-22AAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi193S-geranylgeranyl cysteineBy similarity1
Lipidationi194S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ9UL26
MaxQBiQ9UL26
PaxDbiQ9UL26
PeptideAtlasiQ9UL26
PRIDEiQ9UL26
ProteomicsDBi84935

PTM databases

iPTMnetiQ9UL26
PhosphoSitePlusiQ9UL26

Expressioni

Gene expression databases

BgeeiENSG00000124209 Expressed in 233 organ(s), highest expression level in forebrain
CleanExiHS_RAB22A
GenevisibleiQ9UL26 HS

Organism-specific databases

HPAiHPA058894
HPA066920

Interactioni

Subunit structurei

Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809).By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi121505, 11 interactors
IntActiQ9UL26, 6 interactors
MINTiQ9UL26
STRINGi9606.ENSP00000244040

Structurei

3D structure databases

ProteinModelPortaliQ9UL26
SMRiQ9UL26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9UL26
KOiK07891
OMAiKCDLSDA
OrthoDBiEOG091G0HKN
PhylomeDBiQ9UL26
TreeFamiTF331262

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UL26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ
60 70 80 90 100
NELHKFLIWD TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV
110 120 130 140 150
KELRQHGPPN IVVAIAGNKC DLIDVREVME RDAKDYADSI HAIFVETSAK
160 170 180 190
NAININELFI EISRRIPSTD ANLPSGGKGF KLRRQPSEPK RSCC
Length:194
Mass (Da):21,855
Last modified:March 1, 2001 - v2
Checksum:iEBC84711DA3F839B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184R → K in CAC10538 (Ref. 3) Curated1
Sequence conflicti192 – 193SC → TA in AAL75941 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125104 mRNA Translation: AAL75941.1
AF091034 mRNA Translation: AAF00047.2
AJ276210 mRNA Translation: CAC10538.1
BT007046 mRNA Translation: AAP35695.1
AK091180 mRNA Translation: BAG52298.1
AL035455 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75496.1
CH471077 Genomic DNA Translation: EAW75497.1
BC015710 mRNA Translation: AAH15710.1
BC063457 mRNA Translation: AAH63457.1
CCDSiCCDS33497.1
RefSeqiNP_065724.1, NM_020673.2
UniGeneiHs.529044

Genome annotation databases

EnsembliENST00000244040; ENSP00000244040; ENSG00000124209
GeneIDi57403
KEGGihsa:57403
UCSCiuc002xyz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125104 mRNA Translation: AAL75941.1
AF091034 mRNA Translation: AAF00047.2
AJ276210 mRNA Translation: CAC10538.1
BT007046 mRNA Translation: AAP35695.1
AK091180 mRNA Translation: BAG52298.1
AL035455 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75496.1
CH471077 Genomic DNA Translation: EAW75497.1
BC015710 mRNA Translation: AAH15710.1
BC063457 mRNA Translation: AAH63457.1
CCDSiCCDS33497.1
RefSeqiNP_065724.1, NM_020673.2
UniGeneiHs.529044

3D structure databases

ProteinModelPortaliQ9UL26
SMRiQ9UL26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121505, 11 interactors
IntActiQ9UL26, 6 interactors
MINTiQ9UL26
STRINGi9606.ENSP00000244040

PTM databases

iPTMnetiQ9UL26
PhosphoSitePlusiQ9UL26

Polymorphism and mutation databases

BioMutaiRAB22A
DMDMi13633614

Proteomic databases

EPDiQ9UL26
MaxQBiQ9UL26
PaxDbiQ9UL26
PeptideAtlasiQ9UL26
PRIDEiQ9UL26
ProteomicsDBi84935

Protocols and materials databases

DNASUi57403
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244040; ENSP00000244040; ENSG00000124209
GeneIDi57403
KEGGihsa:57403
UCSCiuc002xyz.4 human

Organism-specific databases

CTDi57403
DisGeNETi57403
EuPathDBiHostDB:ENSG00000124209.3
GeneCardsiRAB22A
HGNCiHGNC:9764 RAB22A
HPAiHPA058894
HPA066920
MIMi612966 gene
neXtProtiNX_Q9UL26
OpenTargetsiENSG00000124209
PharmGKBiPA34112
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9UL26
KOiK07891
OMAiKCDLSDA
OrthoDBiEOG091G0HKN
PhylomeDBiQ9UL26
TreeFamiTF331262

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRAB22A human
GeneWikiiRAB22A
GenomeRNAii57403
PROiPR:Q9UL26
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124209 Expressed in 233 organ(s), highest expression level in forebrain
CleanExiHS_RAB22A
GenevisibleiQ9UL26 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB22A_HUMAN
AccessioniPrimary (citable) accession number: Q9UL26
Secondary accession number(s): B3KR86
, E1P605, Q8TF12, Q9H4E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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