UniProtKB - Q9UL26 (RB22A_HUMAN)
Protein
Ras-related protein Rab-22A
Gene
RAB22A
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 20 | GTPBy similarity | 9 | |
Nucleotide bindingi | 60 – 64 | GTPBy similarity | 5 | |
Nucleotide bindingi | 118 – 121 | GTPBy similarity | 4 | |
Nucleotide bindingi | 148 – 150 | GTPBy similarity | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
GO - Biological processi
- endocytosis Source: UniProtKB
- endosome organization Source: UniProtKB
- intracellular protein transport Source: GO_Central
- Rab protein signal transduction Source: GO_Central
- regulation of vesicle size Source: UniProtKB
Keywordsi
Biological process | Endocytosis, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-8873719 RAB geranylgeranylation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-22AShort name: Rab-22 |
Gene namesi | Name:RAB22A Synonyms:RAB22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9764 RAB22A |
MIMi | 612966 gene |
neXtProti | NX_Q9UL26 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor Curated
Endosome
- Endosome membrane By similarity; Lipid-anchor Curated
- Early endosome 1 Publication
- Late endosome By similarity
Other locations
- ruffle 1 Publication
- Cytoplasmic vesicle 1 Publication
- phagosome 1 Publication
- phagosome membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.1 Publication
Cytoskeleton
- actin cytoskeleton Source: Ensembl
Endosome
- early endosome Source: UniProtKB
- endosome membrane Source: UniProtKB-SubCell
- late endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- phagocytic vesicle Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- ruffle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | S → L: Loss of GTPase activity. 1 Publication | 1 | |
Mutagenesisi | 64 | Q → L: Constitutive GTPase activity. Impairs normal protein trafficking through early endosomes. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 57403 |
OpenTargetsi | ENSG00000124209 |
PharmGKBi | PA34112 |
Miscellaneous databases
Pharosi | Q9UL26 |
Polymorphism and mutation databases
BioMutai | RAB22A |
DMDMi | 13633614 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121209 | 1 – 194 | Ras-related protein Rab-22AAdd BLAST | 194 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 193 | S-geranylgeranyl cysteineBy similarity | 1 | |
Lipidationi | 194 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, PrenylationProteomic databases
EPDi | Q9UL26 |
jPOSTi | Q9UL26 |
MassIVEi | Q9UL26 |
MaxQBi | Q9UL26 |
PaxDbi | Q9UL26 |
PeptideAtlasi | Q9UL26 |
PRIDEi | Q9UL26 |
ProteomicsDBi | 84935 |
PTM databases
iPTMneti | Q9UL26 |
PhosphoSitePlusi | Q9UL26 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124209 Expressed in 233 organ(s), highest expression level in forebrain |
Genevisiblei | Q9UL26 HS |
Organism-specific databases
HPAi | HPA058894 HPA066920 |
Interactioni
Subunit structurei
Binary interactionsi
Protein-protein interaction databases
BioGridi | 121505, 11 interactors |
IntActi | Q9UL26, 9 interactors |
MINTi | Q9UL26 |
STRINGi | 9606.ENSP00000244040 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 34 – 42 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0092 Eukaryota ENOG410YCCP LUCA |
GeneTreei | ENSGT00940000157009 |
HOGENOMi | HOG000233968 |
InParanoidi | Q9UL26 |
KOi | K07891 |
OMAi | FAKAQYW |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q9UL26 |
TreeFami | TF331262 |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase |
Pfami | View protein in Pfam PF00071 Ras, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00231 small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419 RAB, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9UL26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALRELKVCL LGDTGVGKSS IVWRFVEDSF DPNINPTIGA SFMTKTVQYQ
60 70 80 90 100
NELHKFLIWD TAGQERFRAL APMYYRGSAA AIIVYDITKE ETFSTLKNWV
110 120 130 140 150
KELRQHGPPN IVVAIAGNKC DLIDVREVME RDAKDYADSI HAIFVETSAK
160 170 180 190
NAININELFI EISRRIPSTD ANLPSGGKGF KLRRQPSEPK RSCC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | R → K in CAC10538 (Ref. 3) Curated | 1 | |
Sequence conflicti | 192 – 193 | SC → TA in AAL75941 (Ref. 1) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125104 mRNA Translation: AAL75941.1 AF091034 mRNA Translation: AAF00047.2 AJ276210 mRNA Translation: CAC10538.1 BT007046 mRNA Translation: AAP35695.1 AK091180 mRNA Translation: BAG52298.1 AL035455 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75496.1 CH471077 Genomic DNA Translation: EAW75497.1 BC015710 mRNA Translation: AAH15710.1 BC063457 mRNA Translation: AAH63457.1 |
CCDSi | CCDS33497.1 |
RefSeqi | NP_065724.1, NM_020673.2 |
Genome annotation databases
Ensembli | ENST00000244040; ENSP00000244040; ENSG00000124209 |
GeneIDi | 57403 |
KEGGi | hsa:57403 |
UCSCi | uc002xyz.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF125104 mRNA Translation: AAL75941.1 AF091034 mRNA Translation: AAF00047.2 AJ276210 mRNA Translation: CAC10538.1 BT007046 mRNA Translation: AAP35695.1 AK091180 mRNA Translation: BAG52298.1 AL035455 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75496.1 CH471077 Genomic DNA Translation: EAW75497.1 BC015710 mRNA Translation: AAH15710.1 BC063457 mRNA Translation: AAH63457.1 |
CCDSi | CCDS33497.1 |
RefSeqi | NP_065724.1, NM_020673.2 |
3D structure databases
SMRi | Q9UL26 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 121505, 11 interactors |
IntActi | Q9UL26, 9 interactors |
MINTi | Q9UL26 |
STRINGi | 9606.ENSP00000244040 |
PTM databases
iPTMneti | Q9UL26 |
PhosphoSitePlusi | Q9UL26 |
Polymorphism and mutation databases
BioMutai | RAB22A |
DMDMi | 13633614 |
Proteomic databases
EPDi | Q9UL26 |
jPOSTi | Q9UL26 |
MassIVEi | Q9UL26 |
MaxQBi | Q9UL26 |
PaxDbi | Q9UL26 |
PeptideAtlasi | Q9UL26 |
PRIDEi | Q9UL26 |
ProteomicsDBi | 84935 |
Protocols and materials databases
DNASUi | 57403 |
Genome annotation databases
Ensembli | ENST00000244040; ENSP00000244040; ENSG00000124209 |
GeneIDi | 57403 |
KEGGi | hsa:57403 |
UCSCi | uc002xyz.4 human |
Organism-specific databases
CTDi | 57403 |
DisGeNETi | 57403 |
GeneCardsi | RAB22A |
HGNCi | HGNC:9764 RAB22A |
HPAi | HPA058894 HPA066920 |
MIMi | 612966 gene |
neXtProti | NX_Q9UL26 |
OpenTargetsi | ENSG00000124209 |
PharmGKBi | PA34112 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0092 Eukaryota ENOG410YCCP LUCA |
GeneTreei | ENSGT00940000157009 |
HOGENOMi | HOG000233968 |
InParanoidi | Q9UL26 |
KOi | K07891 |
OMAi | FAKAQYW |
OrthoDBi | 1340129at2759 |
PhylomeDBi | Q9UL26 |
TreeFami | TF331262 |
Enzyme and pathway databases
Reactomei | R-HSA-8873719 RAB geranylgeranylation |
Miscellaneous databases
ChiTaRSi | RAB22A human |
GeneWikii | RAB22A |
GenomeRNAii | 57403 |
Pharosi | Q9UL26 |
PROi | PR:Q9UL26 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124209 Expressed in 233 organ(s), highest expression level in forebrain |
Genevisiblei | Q9UL26 HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase |
Pfami | View protein in Pfam PF00071 Ras, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
TIGRFAMsi | TIGR00231 small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419 RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RB22A_HUMAN | |
Accessioni | Q9UL26Primary (citable) accession number: Q9UL26 Secondary accession number(s): B3KR86 Q9H4E6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | October 16, 2019 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot